Constant Workload Research Articles

Novel evidence on the effect of tramadol on self-paced high-intensity cycling

ABSTRACT The use of tramadol is a controversial topic in cycling. In order to provide novel evidence on this issue, we tested 29 participants in a pre-loaded cycling time trial (TT; a 20-min TT preceded by 40-min of constant work-rate at 60% of the VO2max) after ingesting 100 mg of tramadol (vs placebo and paracetamol (1.5 g)). Participants performed the Psychomotor Vigilance Task (PVT) at rest and a Sustained Attention to Response Task (SART) during the 60 min of exercise. Oscillatory electroencephalography (EEG) activity was measured throughout the exercise. The results showed higher mean power output during the 20-min TT in the tramadol vs. paracetamol condition, but no reliable difference was reported between tramadol and placebo (nor paracetamol vs. placebo). Tramadol resulted in faster responses in the PVT and higher heart rate during exercise. The main effect of substance was reliable in the SART during the 40-min constant workload (no during the 20-min TT), with slower reaction time, but better accuracy for tramadol and paracetamol than for placebo. This study supports the increased behavioural and neural efficiency at rest for tramadol but not the proposed ergogenic or cognitive (harmful) effect of tramadol (vs. placebo) during self-paced high-intensity cycling.

The effect of 10 days of energy-deficit diet and high-intensity exercise training on the plasma high-density-lipoprotein (HDL) level among healthy collegiate males

ABSTRACT An energy-deficit (ED) diet increases lipid mobilisation, while endurance exercise improves lipid profile by promoting formation of high-density lipoproteins (HDLs) among moderately active population. However, it is not clear whether ED with high-intensity exercise training can improve lipid profiles. Therefore, 20 recreationally active males (20.3 ± 2.7 years old with peak oxygen consumption (O2peak) of 2.8 ± 0.2 L min−1) with HDL concentration of 1.44 ± 0.32 mmol L−1, were evenly allocated to either an ED group (1590 ± 79 kcal day−1: 40% of total caloric omitted at lunchtime) or a control (CON) group (2570 ± 139 kcal day−1). Participants in both groups performed high-intensity cycling at 90% O2peak at a constant workload for 8 min, 2 h after breakfast on day D0, D2, D4, D6, D8 and D10 (Dn is day number), after which blood samples were collected. In ED, compared to D0, triglycerides (TG) decreased on D6-10 (p < .01) while total low-density lipoprotein (LDL), total cholesterol (TC) increased on D2-10, while HDL progressively increased on D6-10 (p = .01) with a final value of 1.67 ± 0.24 mmol L−1. In CON, there were no changes in TG, TC and HDL while LDL was reduced on D8-10 (p = .01). Moreover, the proportions of TC/HDL and LDL/HDL increased in ED on D2-10 and D2-8 (p = .05), respectively, while LDL/HDL in CON was reduced on D8-10 (p = .01). In brief, 10 days of ED and a series of high-intensity exercise sessions show progressive elevation of HDL which suggest longer period is required to observe changes in lipid ratios.

Comparison of respiratory muscle strength and endurance, maximal oxygen consumption, and fatigue in colorectal cancer survivors with healthy adults.

This study aimed to evaluate respiratory muscle strength and endurance, maximal oxygen consumption, and fatigue of colorectal cancer (CRC) survivors and compare them with healthy individuals. Demographic and clinical characteristics were recorded. Respiratory muscle strength (maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP)) was measured using an electronic mouth pressure device, and respiratory muscle endurance was assessed using a constant workload protocol with linear workload device. Peak oxygen consumption (VO2peak) was measured using the cardiopulmonary exercise test (CPET) with modified Bruce protocol. Fatigue was assessed using the Brief Fatigue Inventory (BFI). The patients had similar demographic characteristics (p > 0.05). MEP (cmH2O and %predicted) were lower in the CRC group than in healthy controls (p < 0.05). MIP (cmH2O and %predicted) and test duration did not differ between the groups (p > 0.05). VO2peak (ml/min and %predicted) and VO2peak/kg (%predicted) were significantly lower in the CRC group (p < 0.05). BFI score differed significantly in the CRC and control groups (p < 0.05). Respiratory muscle strength, maximal exercise capacity, and fatigue are adversely affected in CRC survivors. Cancer treatment may cause loss of muscle strength and impair energy metabolism and oxygen transmission. These changes can result in decreased exercise capacity and respiratory muscle strength and increased fatigue. Studies examining the effects of different exercise training programs in CRC survivors are needed.

Eccentric cycling ergometer to address skeletal muscle dysfunction in hospitalised patients: ergometer design, construction and demonstration

PurposeContinuous eccentric cycling has demonstrated metabolic efficiency when compared with equivalent concentric workloads. The profile of continuous eccentric cycling is well suited to hospitalised patients, however, its application has been...

Endurance and Sprint Training Improve Glycemia and V˙O2peak but only Frequent Endurance Benefits Blood Pressure and Lipidemia.

Sprint interval training (SIT) has gained popularity as a time-effective alternative to moderate-intensity endurance training (END). However, whether SIT is equally effective for decreasing cardiometabolic risk factors remains debatable, as many beneficial effects of exercise are thought to be transient, and unlike END, SIT is not recommended daily. Therefore, in line with current exercise recommendations, we examined the ability of SIT and END to improve cardiometabolic health in overweight/obese males. Twenty-three participants were randomized to perform 6 wk of constant workload SIT (3 d·wk-1, 4-6 × 30 s ~170% Wpeak, 2 min recovery, n = 12) or END (5 d·wk-1, 30-40 min, ~60% Wpeak, n = 11) on cycle ergometers. Aerobic capacity (V˙O2peak), body composition, blood pressure (BP), arterial stiffness, endothelial function, glucose and lipid tolerance, and free-living glycemic regulation were assessed pre- and posttraining. Both END and SIT increased V˙O2peak (END ~15%, SIT ~5%) and glucose tolerance (~20%). However, only END decreased diastolic BP, abdominal fat, and improved postprandial lipid tolerance, representing improvements in cardiovascular risk factors that did not occur after SIT. Although SIT, but not END, increased endothelial function, arterial stiffness was not altered in either group. Indices of free-living glycemic regulation were improved after END and trended toward an improvement after SIT (P = 0.06-0.09). However, glycemic control was better on exercise compared with rest days, highlighting the importance of exercise frequency. Furthermore, in an exploratory nature, favorable individual responses (V˙O2peak, BP, glucose tolerance, lipidemia, and body fat) were more prevalent after END than low-frequency SIT. As only high-frequency END improved BP and lipid tolerance, free-living glycemic regulation was better on days that participants exercised, and favorable individual responses were consistent after END, high-frequency END may favorably improve cardiometabolic health.

Reduced Variability of Endurance Time in New Protocols for Exercise Tests in COPD.

PurposeFor exercise testing of COPD patients, a standard endurance test (ET) with constant workload is recommended. The test suffers from large inter-individual variability and need for large sample sizes in order to evaluate treatment effects.MethodsA new protocol for ET in COPD was designed. In contrast to the standard ET, the new ET involved an increasing workload in order to reduce the standard deviation of endurance time. Two new ETs were compared with the standard ET. In Study A, the new ET started at 75% of the patient’s maximum workload (WMAX) and increased stepwise with 3%/2 min until exhaustion. Study B started at 70% of WMAX and increased linearly with 1%/min.ResultsIn Study A, that included 15 patients, the standard deviation and range for endurance time and work capacity were narrower for the new versus the standard ET. However, the higher mean workload at end and the low mean work capacity relative to the standard ET indicated that the stepwise increase was too aggressive. In Study B, that included 18 patients, with a modified protocol, the averages for endurance time, workload at end and work capacity were similar for new and standard ET, while the standard deviations and ranges for endurance time and work capacity were kept more narrow in the new ET. The variances for endurance time were not equal between the standard ET and the two new ETs (p<0.05 for both according to Levene’s test).ConclusionThe new ET reduced the number of patients with extreme endurance times (short and long) compared to the standard test. The new test showed a significant lower variance for endurance time, which potentially can lead to fewer patients needed in comparative studies. The overall best results were observed with a low linear increase during endurance.

Evaluation of Heart Rate, Work Rate and O2 Uptake Relationships During Constant Load Exercise Test Work Load at the Anaerobic Threshold in Healthy Male

Objectives: During an incremental exercise test, increased metabolic demands of exercising muscle should be compensated with increased O2 uptake and heart rate until to their maximal levels. Anaerobic threshold (AT) describes the point of metabolic transition from aerobic to anaerobic metabolism and reflect moderate exercise intensity. The aim of this study was to evaluate O2 uptake to heart beat ratio (O2 pulse) and heat rate to work rate ratio (HR/WR) in response to constant load exercise at work load corresponded to AT.&#x0D; Method: Twelve healthy young male subjects initially performed an incremental exercise test (15 W/min) until exhaustion. Then, each subject performed a 30 min of constant load exercise test that work load at their AT on separate days. Pulmonary gas exchange parameters were measured breath-by breath using a metabolic gas analyser. Cardiac parameters were followed continuously beat-by beat using a 12 lead ECG. AT estimated non-invasively using V-slope method.&#x0D; Results: The heart rate for each watt of work production (HR/WR) was ranged between 0.97 beat/min/W to 1.76 beat/min/W and averaged 1.25±0.2 beat/min/W. The O2 pulse was ranged between 10.56 mL/min/beat to 16.15 mL/min/beat and averaged 13.38±1.5 mL/min/beat at the end of the test. A negative statistically significant correlation (R = - 0.90316, p

Comparison of two different cooling systems in alleviating thermal and physiological strain during prolonged exercise in the heat

This study compared the efficacy of an ice vest comprising of water (WATER) or a water-carbon (CARBON) emulsion on thermophysiological responses to strenuous exercise in the heat. Twelve male cyclists completed three 50-minute constant workload trials (55% of peak power output, ambient temperature 30.4 ± 0.6°C) with WATER, CARBON, and without ice vest (CONTROL), respectively. The increase in core body temperature (Tcore) was lower in WATER at 40 (−0.49 ± 0.34 °C) and 50 minutes (−0.48 ± 0.48 °C) and in CARBON at 30 (−0.41 ± 0.48 °C), 40 (−0.54 ± 0.51 °C), and 50 minutes (−0.67 ± 0.62 °C) as compared to CONTROL (p < 0.05, ES > 0.8). While heart rate and blood lactate kinetics did not differ between the conditions, statistical main effects in favour of both WATER and CARBON were found for thermal sensation (condition p < 0.001 and interaction p < 0.01) and rating of perceived exertion (condition p < 0.05). Per-cooling with CARBON and WATER similarly reduced Tcore but not physiological strain during prolonged exercise in the heat. Practitioner Summary: Exercise in the heat is characterised by increases in thermophysiological strain. Both per-cooling with a novel carbon-based and a conventional water-based ice vest were shown to reduce core temperature significantly. However, due to its lower mass, the carbon-based system may be recommended especially for weight-bearing sports.

Exercise Hemodynamics in the Prognosis of Patients with Pulmonary Arterial Hypertension

Background: Assessment of prognosis is of major importance when deciding on a therapeutic strategy in patients with pulmonary arterial hypertension (PAH). Objectives: The aim of this study was to investigate the prognostic value of pulmonary hemodynamics during exercise and changes during treatment in patients with PAH. Methods: Consecutive incident patients (n = 49) with PAH undergoing right heart catheterization at rest and during a constant workload cycle exercise in supine position were included. Predictors of survival were identified at baseline using Cox proportional hazard regression models in a univariate analysis unadjusted and adjusted for age and gender. Results: During a median follow-up period of 42 months, 13 (27%) of the 49 patients studied died. Two predictors of death were found: rest-to-exercise changes in heart rate and systolic pulmonary artery pressure. Adjusted hazard ratios were 0.92 (95% CI 0.86–0.99) and 0.93 (95% CI 0.88–0.99), respectively. These 2 variables were correlated with each other (r = 0.55, p < 0.001). Conclusions: Rest-to-exercise changes in heart rate and systolic pulmonary artery pressure measured at diagnosis are predictors of survival in patients with PAH. These measurements taken from an exercise test reflect right ventricular function.

Endocrine and Metabolic Responses to Endurance Exercise Under Hot and Hypoxic Conditions.

PurposeWe explored the effect of heat stress during an acute endurance exercise session in hypoxia on endocrine and metabolic responses.MethodsA total of 12 healthy males cycled at a constant workload (60% of the power output associated with their maximal oxygen uptake under each respective condition) for 60 min in three different environments: exercise under hot and hypoxia (H+H; fraction of inspiratory oxygen or FiO2: 14.5%, 32°C), exercise under hypoxia (HYP; FiO2: 14.5%, 23°C), and exercise under normoxia (NOR; FiO2: 20.9%, 23°C). After completing the exercise, participants remained in the chamber for 3 h to evaluate metabolic and endocrine responses under each environment. Changes in muscle oxygenation (only during exercise), blood variables, arterial oxygen saturation, and muscle temperature were determined up to 3 h after exercise.ResultsSerum erythropoietin (EPO) level was increased to similar levels in both H+H and HYP at 3 h after exercise compared with before exercise (P < 0.05), whereas no significant increase was found under NOR. No significant difference between H+H and HYP was observed in the serum EPO level, blood lactate level, or muscle oxygenation at any time (P > 0.05). Exercise-induced serum growth hormone (GH) elevation was significantly greater in H+H compared with HYP (P < 0.05) and HYP showed significantly lower value than NOR (P < 0.05). Arterial oxygen saturation during exercise was significantly lower in H+H and HYP compared with NOR (P < 0.05). Furthermore, H+H showed higher value compared with HYP (P < 0.05).ConclusionThe serum EPO level increased significantly with endurance exercise in hypoxia. However, the addition of heat stress during endurance exercise in hypoxia did not augment the EPO response up to 3 h after completion of exercise. Exercise-induced GH elevation was significantly augmented when the hot exposure was combined during endurance exercise in hypoxia. Muscle oxygenation levels during endurance exercise did not differ significantly among the conditions. These findings suggest that combined hot and hypoxic stresses during endurance exercise caused some modifications of metabolic and endocrine regulations compared with the same exercise in hypoxia.

Effects of Pulmonary Hypertension on Exercise Capacity in Patients With Chronic Obstructive Pulmonary Disease

IntroductionThe impact of pulmonary hypertension (PH) on exercise tolerance in chronic obstructive pulmonary disease (COPD) has not been fully elucidated. It is necessary to characterize pulmonary hemodynamics in patients with moderate to severe COPD in order to improve their management. The aim of the study was to determine whether in COPD the presence of PH is associated with reduced exercise tolerance in a cohort of stable COPD patients. MethodsCross-sectional analysis of 174 COPD patients clinically stable: 109 without PH and 65 with PH (COPD-PH). We assessed socio-demographic data, lung function, quality of life, dyspnea, cardiopulmonary exercise testing (CPET), constant workload endurance time (CWET), and six-minute walk test (6MWT). We elaborated a logistic regression model to explore the impact of PH on exercise capacity in COPD patients. ResultsCOPD-PH patients showed lower exercise capacity both at maximal (CPET) (43(20) versus 68(27) Watts and 50(19)% versus 71(18)% predicted peak oxygen consumption (VO2peak), COPD-PH and COPD, respectively), and at submaximal tests (6MWT) (382(94) versus 486(95) m). In addition, the COPD-PH group had lower endurance time than the non-PH COPD group (265(113) s and 295(164) s, respectively). ConclusionsThe presence of PH is an independent factor that impairs exercise capacity in COPD.

Relationship between maximal aerobic power with aerobic fitness as a function of signal-to-noise ratio.

Efforts to better understand cardiorespiratory health are relevant for the future development of optimized physical activity programs. We aimed to explore the impact of the signal quality on the expected associations between the ability of the aerobic system in supplying energy as fast as possible during moderate exercise transitions with its maximum capacity to supply energy during maximal exertion. It was hypothesized that a slower aerobic system response during moderate exercise transitions is associated with a lower maximal aerobic power; however, this relationship relies on the quality of the oxygen uptake data set. Forty-three apparently healthy participants performed a moderate constant work rate (CWR) followed by a pseudorandom binary sequence (PRBS) exercise protocol on a cycle ergometer. Participants also performed a maximum incremental cardiopulmonary exercise testing (CPET). The maximal aerobic power was evaluated by the peak oxygen uptake during the CPET, and the aerobic fitness was estimated from different approaches for oxygen uptake dynamics analysis during the CWR and PRBS protocols at different levels of signal-to-noise ratio. The product moment correlation coefficient was used to evaluate the correlation level between variables. Aerobic fitness was correlated with maximum aerobic power, but this correlation increased as a function of the signal-to-noise ratio. Aerobic fitness is related to maximal aerobic power; however, this association appeared to be highly dependent on the data quality and analysis for aerobic fitness evaluation. Our results show that simpler moderate exercise protocols might be as good as maximal exertion exercise protocols to obtain indexes related to cardiorespiratory health.NEW & NOTEWORTHY Optimized methods for cardiorespiratory health evaluation are of great interest for public health. Moderate exercise protocols might be as good as maximum exertion exercise protocols to evaluate cardiorespiratory health. Pseudorandom or constant workload moderate exercise can be used to evaluate cardiorespiratory health.

Carbohydrate Mouth Rinse Mitigates Mental Fatigue Effects on Maximal Incremental Test Performance, but Not in Cortical Alterations

Detrimental mental fatigue effects on exercise performance have been documented in constant workload and time trial exercises, but effects on a maximal incremental test (MIT) remain poorly investigated. Mental fatigue-reduced exercise performance is related to an increased effort sensation, likely due to a reduced prefrontal cortex (PFC) activation and inhibited spontaneous behavior. Interestingly, only a few studies verified if centrally active compounds may mitigate such effects. For example, carbohydrate (CHO) mouth rinse potentiates exercise performance and reduces effort sensation, likely through its effects on PFC activation. However, it is unknown if this centrally mediated effect of CHO mouth rinse may mitigate mental fatigue-reduced exercise performance. After a proof-of-principle study, showing a mental fatigue-reduced MIT performance, we observed that CHO mouth rinse mitigated MIT performance reductions in mentally fatigued cyclists, regardless of PFC alterations. When compared to placebo, mentally fatigued cyclists improved MIT performance by 2.24–2.33% when rinsing their mouth with CHO during MIT. However, PFC and motor cortex activation during MIT in both CHO and placebo mouth rinses were greater than in mental fatigue. Results showed that CHO mouth rinse mitigated the mental fatigue-reduced MIT performance, but challenged the role of CHO mouth rinse on PFC and motor cortex activation.

The Role Of Exercise Intensity In Cell Signaling: Is There A Repeated-bout Effect?

PURPOSE: Acute exercise elicits a temporary change in redox balance resulting in activation of antioxidant related gene expression and enzymes. We have previously shown in men that the type of acute exercise stimulus, constant workload (CW) vs. high intensity interval protocol (HIIP) results in different redox responses despite no differences in mean VO2. The present study tested whether these results translate to women. In addition, we asked whether the responses are amplified through a repeated bout effect, by comparing the responses after 1 bout to those after 3 bouts. It was hypothesized that HIIP would render greater cell signaling response compared to CW and that differences would be amplified after 3 sessions. METHODS: Healthy women ages 30-45y participated in this study in a randomized, cross-over design (n=12, projected) with a 2-week washout period between trials. Each participant completed a VO2max on a cycle ergometer to establish the workload for the exercise trials. Subjects were randomized to complete either CW or HIIP sessions first. Each trial occurred every other day for 5 days. A second VO2max was performed prior to the second trial to ascertain that VO2 max had not changed from baseline. CW consisted of 30-min of cycling at 70% VO2max. HIIP consisted of a 9-min ramp-up, 7 intervals of 1-min “all out” intervals at 90-100% VO2max followed by 2-min recovery for a total of 30-min of cycling. Blood draws were taken pre-, and 10- 30-, and 60-min post exercise during the first and third exercise session of each trial. Cell signaling was measured by nuclear localization of Nrf2 as well as protein abundance of GCLC and GSR in PBMCs. GR enzyme activity was measured in erythrocyte lysate. RESULTS: To date, 5 women have enrolled in the study and testing is still underway. The average intensity of the CW trial is 70.3% and the average intensity of the HIIP intervals is 91.7% VO2max. The early data show a trend for increased nuclear Nrf2 and GSR protein abundance HIIP compared to CW, and an amplification of the response after 3 sessions. CONCLUSION: These preliminary data suggest that delivering an exercise stimulus in short “pulses” of high intensity such as the HIIP elicits a greater protective signaling response as compared to a block of moderate CW exercise, and furthermore that these effects are amplified by a repeated bout effect.

Expiratory Flow Limitation at Different Exercise Intensities in Coronary Artery Disease

Introduction Expiratory flow limitation (EFL) during moderate intensity exercise is present in patients with myocardial infarction (MI), whereas in healthy subjects it occurs only at a high intensity. However, it is unclear whether this limitation already manifests in those with stable coronary artery disease (CAD) (without MI). Materials and Methods Forty-one men aged 40–65 years were allocated into (1) recent MI (RMI) group (n = 8), (2) late MI (LMI) group (n = 12), (3) stable CAD group (n = 9), and (4) healthy control group (CG) (n = 12). All participants underwent two cardiopulmonary exercise tests at a constant workload (moderate and high intensity), and EFL was evaluated at the end of each exercise workload. Results During moderate intensity exercise, the RMI and LMI groups presented with a significantly higher number of participants with EFL compared to the CG (p < 0.05), while no significant difference was observed among groups at high intensity exercise (p > 0.05). Moreover, EFL was only present in MI groups during moderate intensity exercise, whereas at high intensity all groups presented EFL. Regarding the degree of EFL, the RMI and LMI groups showed significantly higher values at moderate intensity exercise in relation to the CG. At high intensity exercise, significantly higher values for the degree of EFL were observed only in the LMI group. Conclusion The ventilatory limitation at moderate intensity exercise may be linked to the pulmonary consequences of the MI, even subjects with preserved cardiac and pulmonary function at rest, and not to CAD per se.

NIV Is not Adequate for High Intensity Endurance Exercise in COPD.

Noninvasive ventilation (NIV) during exercise has been suggested to sustain higher training intensity but the type of NIV interface, patient-ventilator asynchronies (PVA) or technological limitation of the ventilator may interfere with exercise. We assessed whether these parameters affect endurance exercise capacity in severe COPD patients. In total, 21 patients with severe COPD not eligible to home NIV performed three constant workload tests. The first test was carried out on spontaneous breathing (SB) and the following ones with NIV and a nasal or oronasal mask in a randomized order. PVA and indicators of ventilator performance were assessed through a comprehensive analysis of the flow pressure tracing raw data from the ventilator. The time limit was significantly reduced with both masks (406 s (197–666), 240 s (131–385) and 189 s (115–545), p < 0.01 for tests in SB, with oronasal and nasal mask, respectively). There were few PVA with an oronasal mask (median: 3.4% (1.7–5.2)) but the ventilator reached its maximal generating capacity (median flowmax: 208.0 L/s (189.5–224.8) while inspiratory pressure dropped throughout exercise (from 10.1 (9.4–11.4) to 8.8 cmH2O (8.6–10.8), p < 0.01). PVA were more frequent with nasal mask (median: 12.8% (3.2–31.6), p < 0.01). Particularly, the proportion of patients with ineffective efforts > 10% was significantly higher with nasal interface (0% versus 33.3%, p < 0.01). NIV did not effectively improve endurance capacity in COPD patients not acclimated to home NIV. This was due to a technological limitation of the ventilator for the oronasal mask and the consequence either of an insufficient pressure support or a technological limitation for the nasal mask.

Transitions Between Low and High Levels of Mental Workload can Improve Multitasking Performance

OCCUPATIONAL APPLICATIONS Complex and dynamic environments including military operations, healthcare, aviation, and driving require operators to transition seamlessly between levels of mental workload. However, little is known about how the rate of an increase in workload impacts multitasking performance, especially in the context of real-world tasks. We evaluated both gradual and sudden workload increases in the dynamic multitasking environment of an Unmanned Aerial Vehicle (UAV) command and control testbed and compared them to constant workload. Workload transitions were found to improve response time and accuracy compared to when workload was held constant at low or high. These results suggest that workload transitions may allow operators to better regulate mental resources. These findings can also inform the design of operations and technology to assist operators’ management of cognitive resources, which include negating the adverse effects of vigilance decrements during low workload periods and data overload during high workload periods.

Investigating the workload, readiness and physical performance changes during intensified 3-week preparation periods in female national Under18 and Under20 basketball teams

ABSTRACTThis study aimed to investigate between- and within-team changes in workload [PlayerLoad (PL), training impulse (TRIMP) and session rate of perceived exertion training load (sRPE-TL)], readiness [heart rate variability (HRV)], and physical performance [20-m sprint test (including 10-m split time), countermovement jump (CMJ) and yo-yo intermittent recovery test level 1 (YYIR1)] during 3-week intensified preparation periods in female, national Under18 (n = 12, age = 18.0 ± 0.5y, stature = 180.4 ± 7.5 cm, body mass = 72.7 ± 9.3 kg) and Under20 (n = 12, age = 19.6 ± 0.8y, stature = 178.6 ± 6.4 cm, body mass = 68.0 ± 5.9 kg) basketball teams. Under18 team revealed small-to-moderate statistically significantly higher values in workload [PL: p = 0.010; ES = Small; TRIMP: p = 0.004; ES = Moderate; sRPE-TL: p < 0.001; ES = Moderate] and moderately lower readiness values (p = 0.023; ES = Moderate) compared to Under20. Within-team analysis showed no differences in workload in Under20 and statistically significant reduction (p < 0.05) in Week3 (taper period) in Under18. Pre- and post-preparation changes showed Under18 increasing only YYIR1 performance (p < 0.001; ES = Very large). Differently, Under20 statistically improved in 10-m split time (p = 0.003; ES = Moderate), CMJ (p = 0.025; ES = Moderate) and YYIR1 (p < 0.001; ES = Large). A constant adequate workload positively benefits players’ readiness and physical performances during short intensified preparation periods. Conversely, using high workload with periodization strategies encompassing short overload and taper phases induced positive changes on players’ aerobic performance, lower readiness values and no changes in anaerobic performances.

Effects of an individualized exercise training program on severity markers of obstructive sleep apnea syndrome: a randomised controlled trial

ObjectiveObstructive sleep apnea (OSA) is a high prevalent disorder with severe consequences including sleepiness, metabolic, and cardiovascular disorders. The aim of this study was to assess the effect of an individualized exercise-training (IET) program with educational sessions vs educational sessions alone on severity markers of OSA over an eight-week duration. MethodsThis was a randomised, controlled, parallel-design study. In sum, 64 patients with moderate-to-severe OSA (apnea-hypopnea index AHI 15–45/hour), low physical activity level (Voorrips<9), body-mass index (BMI) <40 kg/m2 were included in intervention group (IG) or control group (CG), and 54 patients finished the study. All underwent polysomnography (PSG), multiple sleep latency test (MSLT), constant workload exercise test, blood samples and fulfilled questionnaires twice. The primary endpoint was the change in apnea-hypopnea (AHI) at eight weeks from baseline. Main secondary endpoints were daytime sleepiness assessed by questionnaire and objective tests. ResultsNo significant between-group differences were found for changes in AHI. A reduction in AHI was found in IG only (p = 0.005). Compared to CG, exercise training leads to a greater decrease in AHI during REM sleep (p = 0.0004), with a significant increase in mean daytime sleep latency (p = 0.02). Between-group differences were significant for weight reduction, severity of fatigue, insomnia and depressive symptoms with trend for sleepiness symptoms. ConclusionsIn adult patients with moderate-to-severe OSA, IET did not decrease AHI compared to the control group but improved markers of severity of OSA, in particular AHI in rapid eye movement (REM) sleep and objective daytime sleepiness. Adding personalized exercise training to the management of patients with OSA should be considered. ClinicalTrials.gov identifierNCT01256307.

The Effects of Dehydration on Metabolic and Neuromuscular Functionality During Cycling.

This study aimed to determine the effects of dehydration on metabolic and neuromuscular functionality performance during a cycling exercise. Ten male subjects (age 23.4 ± 2.7 years; body weight 74.6 ± 10.4 kg; height 177.3 ± 4.6 cm) cycled at 65% VO2max for 60 min followed by a time-to-trial (TT) at 95% VO2max, in two different conditions: dehydration (DEH) and hydration (HYD). The bioelectrical impedance vector analysis (BIVA) and body weight measurements were performed to assess body fluid changes. Heart rate (HR), energy cost, minute ventilation, oxygen uptake, and metabolic power were evaluated during the experiments. In addition, neuromuscular activity of the vastus medialis and biceps femoris muscles were assessed by surface electromyography. After exercise induced dehydration, the bioimpedance vector significantly lengthens along the major axis of the BIVA graph, in conformity with the body weight change (−2%), that indicates a fluid loss. Metabolic and neuromuscular parameters significantly increased during TT at 95% VO2max with respect to constant workload at 65% of VO2max. Dehydration during a one-hour cycling test and subsequent TT caused a significant increase in HR, while neuromuscular function showed a lower muscle activation in dehydration conditions on both constant workload and on TT. Furthermore, a significant difference between HYD and DEH for TT duration was found.