The thermomechanical response of Ti−6A1−4V modified with 2.9 pct B produced by a blended powder metallurgy route was studied with isothermal constant strain-rate hot compression tests in the temperature range 850°C to 1200°C and strain rate range 10−3 to 10s−1. Detailed analyses of the flow stress data were conducted to identify various microstructural deformation and damage mechanisms during hot working by applying available materials modeling techniques. In the α+β phase field, cavitation at the matrix/TiB interfaces and TiB particle fracture occurs at low strain rates (<10−1 s−1), while adiabatic shear banding also occurs at high strain rates. At low strain rates, the β phase deforms superplastically due to the stabilization of a fine grain size by the TiB particles. Grain boundary and matrix/TiB interface sliding with simultaneous diffusional accommodation are observed to contribute to the β superplasticity. The deformation behavior at high strain rates in the β-phase field is similar to that of the α+β phase field, with microstructural manifestations of extensive cavitation at the matrix/TiB interfaces and TiB particle fracture.