Constant Number Research Articles

Synthesis, optical properties, DNA, β-cyclodextrin interactions, and antioxidant evaluation of novel isoxazolidine derivative (ISoXD2): A multispectral and computational analysis

ISoXD2 are well explored among versatile and outstanding class of pharmacophores for the preparation and discovery of drugs. Herein, the electronic absorption and emission spectra of ISoXD2 were investigated in three different solvents. The observed transition was attributed to π-π* with charge transfer character. Changes in the excited state and shift of the absorption and emission peaks to longer wavelengths are observed as a result of increasing solvent polarity, due to the interactions between the ISoXD2 molecule and the solvent molecules surrounding it. Changing the solvent confirms its solvatochromic effect. UV–vis and fluorescence analysis revealed that ISoXD2 binds to deoxyribonucleic acid (DNA) by intercalation mode, with a stoichiometric ratio of 1:1.5. Moreover, the fluorescence intensity of DNA bound to ethidium bromide (EB) in the presence of ISoXD2 was investigated. From this analysis, the Stern-Volmer quenching constant (Ksv), quenching rate constant (kq), binding constant (Kb) and binding sites number (n) were found to be 5.654 × 103 M−1, 2.827 × 1011 M−1 s−1, 3.81 × 104 M−1 and 1.225, respectively. The interaction between ISoXD2 and β-CD was investigated through absorption spectra analysis. Kb for this interaction was determined to be 4.9 × 104 M−1. The free radical-scavenging ability of the prepared ISoXD2, examined by DPPH and ABTS assays have shown a good antioxidant activity. Furthermore, modeling study was conducted to explore their plausible binding mechanism with ISoXD2 and to support the experimental results.

The Price of Active Security in Cryptographic Protocols

We construct the first actively-secure Multi-Party Computation (MPC) protocols with an arbitrary number of parties in the dishonest majority setting, for an arbitrary field F\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${\\mathbb {F}}$$\\end{document} with constant communication overhead over the “passive-GMW” protocol (Goldreich, Micali and Wigderson, STOC ‘87). Our protocols rely on passive implementations of Oblivious Transfer (OT) in the Boolean setting and Oblivious Linear function Evaluation (OLE) in the arithmetic setting. Previously, such protocols were only known over sufficiently large fields (Genkin et al. STOC ‘14) or a constant number of parties (Ishai et al. CRYPTO ‘08). Conceptually, our protocols are obtained via a new compiler from a passively-secure protocol for a distributed multiplication functionality FMULT\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${{{\\mathcal {F}}}}_{\\scriptscriptstyle \ extrm{MULT}}$$\\end{document}, to an actively-secure protocol for general functionalities. Roughly, FMULT\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${{{\\mathcal {F}}}}_{\\scriptscriptstyle \ extrm{MULT}}$$\\end{document} is parameterized by a linear-secret sharing scheme S\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${{{\\mathcal {S}}}}$$\\end{document}, where it takes S\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${{{\\mathcal {S}}}}$$\\end{document}-shares of two secrets and returns S\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${{{\\mathcal {S}}}}$$\\end{document}-shares of their product. We show that our compilation is concretely efficient for sufficiently large fields, resulting in an overhead of 2 when securely computing natural circuits. Our compiler has two additional benefits: (1) It can rely on any passive implementation of FMULT\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${{{\\mathcal {F}}}}_{\\scriptscriptstyle \ extrm{MULT}}$$\\end{document}, which, besides the standard implementation based on OT (for Boolean) and OLE (for arithmetic), allows us to rely on implementations based on threshold cryptosystems (Cramer et al. Eurocrypt ‘01), and (2) it can rely on weaker-than-passive (i.e., imperfect/leaky) implementations, which in some parameter regimes yield actively-secure protocols with overhead less than 2. Instantiating this compiler with an “honest-majority” implementation of FMULT\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${{{\\mathcal {F}}}}_{\\scriptscriptstyle \ extrm{MULT}}$$\\end{document}, we obtain the first honest-majority protocol (with up to one-third corruptions) for Boolean circuits with constant communication overhead over the best passive protocol (Damgård and Nielsen, CRYPTO ‘07).

Applicability of measurement-based quantum computation towards physically-driven variational quantum eigensolver

Variational quantum algorithms are considered one of the most promising methods for obtaining near-term quantum advantages; however, most of these algorithms are only expressed in the conventional quantum circuit scheme. The roadblock to developing quantum algorithms with the measurement-based quantum computation (MBQC) scheme is resource cost. Recently, we discovered that the realization of multi-qubit rotation operations only requires a constant number of single-qubit measurements with the MBQC scheme, providing a potential advantage in terms of resource cost. The structure of the Hamiltonian variational ansatz aligns well with this characteristic. Thus, we propose an efficient measurement-based quantum algorithm for quantum many-body system simulation tasks, called measurement-based Hamiltonian variational ansatz (MBHVA). We then demonstrate its effectiveness, efficiency, and advantages with the two-dimensional Heisenberg model and the Fermi–Hubbard chain. Numerical experiments show that MBHVA can have similar performance as circuit-based ansatz, and is expected to reduce operation counts during execution compared to quantum circuits, bringing the advantage of running time. We conclude that the MBQC scheme is potentially feasible for achieving near-term quantum advantages in the noisy intermediate-scale quantum era, especially in the presence of large multi-qubit rotation operations.

Analysis of the effectiveness of the use of short piles as part of a columnar pile foundation

The realization of the operation of the grid and piles as a part of the columnar pile foundation, depending on the length of the piles, the method of arranging the piles, the distance between the piles and the type of soil with a constant number of piles, has been studied. The degree of implementation of the load-bearing capacity of the piles and the degree of implementation of the grid work as part of the pile foundation were analyzed. To solve the tasks set in this work, mathematical modeling by the finite element method of the joint operation of the pile foundation elements with the soil base and the separate operation of the pile and grid as a shallow foundation was performed in the "Plaxis 3D Foundation" software complex. It was established that the implementation of the load-bearing capacity of piles in the composition of the foundation with a large distance between the piles is much better. The length of the piles also affects the degree of their implementation. When the length increases, the bearing capacity of the piles is realized less. The greatest implementation of the load-bearing capacity of piles in the composition of the foundation is observed for short piles. The realization of the pressure under the sole of the grid with an increase in the pitch of the piles also improves, the realization of the load-bearing capacity of the grid is from 8 to 50%, which allows to raise the load-bearing capacity of the foundation. For sandy and clay soils, the nature of the redistribution of forces between the elements of the columnar pile foundation is similar. For foundations made of drilled piles, the degree of realization of pressure under the sole of the grate, as well as the degree of realization of the load-bearing capacity of the piles, is higher than for foundations made of driven piles. The guiding factor is the length of the piles. The economic efficiency of the transition in homogeneous soils from a bush made of long piles with a standard minimum step to a bush made of short piles with an increased distance between the piles was investigated. By taking into account the joint operation of piles and grid, a bush made of short piles with larger dimensions of the grid provides the same bearing capacity as a bush made of long piles with a compact grid. Despite the significant increase in the volume of concrete grating and the number of fittings with an increase in the pitch of the piles, cost savings on the cost of piles provide an economic effect of using bushes from short piles with wide gratings up to 35%.

Effect of Salt Content on Solubilization of Hydrophobic Polymer by Wormlike Micelles of Ionic Surfactant

The effect of concentration of inorganic salt KCl on solubilization of hydrophobic polymer poly(4-vinylpyridine) (P4VP) in aqueous solutions of ionic surfactant potassium oleate was experimentally investigated. As was shown by rheology, in the range of concentrations from 1 to 5 wt.% of salt the polymer-free solutions of surfactant mainly contain linear wormlike micelles (WLMs). The formation of branched WLMs was observed in the solutions containing 5-9 wt.% of KCl. In the presence of higher salt content the phase separation occurred, indicating the formation of a highly branched saturated network of WLMs. Enhanced screening of the charged groups of potassium oleate by oppositely charged ions of KCl caused elongation and branching of micelles that reflected in zero-shear viscosity of the solutions passing through the maximum. In the phase diagram, the saturation concentration with P4VP of both linear and branched WLMs decreased with increasing salt content. In the case of linear WLMs, this could be explained by the constant number of embedded polymer chains per 1 WLM, while simultaneously decreasing number of WLMs in the system. As for the branched WLMs, it was caused by shortening of the linear parts of micelles due to the formation of branching points. For this reason, almost no P4VP was dissolved in the solution containing the highly branched saturated network.

Configuration entropy and potential energy landscape in thermodynamics and dynamics of supercooled liquids

In thermodynamics of supercooled liquids, sub-molecular units, referred to as “beads,” are used. It has been reported that all thermodynamic functions as well as the parameters in the empirical distribution functions of the potential energy landscape approach appear to be explicit functions of the number of beads in molecules. This finding opens the possibility of measuring the number of beads from each of these functions and estimating the configuration and vibration components in their formation. An enthalpy factor has been introduced and found that within the temperature domain of the invariable enthalpy factor, the molecules partition to a constant number of beads. A correlation has been observed between temperature dependence of the potential barriers, restricting cooperative rearrangement of beads and heat capacity of liquids. Relations connecting the landscape approach with the number of beads in the molecules have been estimated. The molecular equation for configuration entropy obtained can provide guidance for the development of new materials with a desirable configuration entropy. A method for predicting thermodynamic and statistical quantities of supercooled liquids from kinetics is also suggested.

Treatment trends for undescended testis and impact of guideline changes a medical health care analysis of orchidopexy and cryptorchidism in Germany between 2006 und 2020

BackgroundThe last decades revealed new scientific knowledge regarding the fertility and potential malignancy of undescended testis AQ2(UDT). Accordingly, many guidelines changed their recommendation concerning timing of therapy, with the goal of an earlier time of surgery.MethodsWe analyzed the number of new diagnosis and performed surgeries in predefined age groups provided by the obligatory annual reports of German hospitals in the reimbursement.INFO”-tool between 2006 and 2020.ResultsOverall, 124,741 cases were analyzed. We showed a slight increase in performed surgeries in the first year by 2% per year with a main increase till 2011, a constant number of surgeries between first and 4th year and a decrease of surgeries between 5 and 14th year of living with a main decrease till 2009 by 3% per year.ConclusionEven if our results illustrate an increasing adaption of the guideline’s recommendation, there is still a significant number of patients who receive later treatment. More research about the reasons and circumstances for the latter is needed.

Nanofluid heat transfer enhancement in microchannels: Investigating phases interactions using multiphase Eulerian model

This study employs a robust multiphase Eulerian model to mimic heat transfer enhancement using nanofluids in a circular microchannel. Unlike the Eulerian models reported in the literature, the current model incorporates phase interactions, and its accuracy is significantly improved by integrating collision viscosity, kinetic viscosity, and frictional viscosity. Comparative analysis against other models like mixture and discrete phase models demonstrates superior performance of the current model, particularly for solid particle volume fractions exceeding 1 %. The model evaluates water-based nanofluids (Ag NPs, MgO, ZnO, Al2O3, ZrO2, SiO2) in circular microchannels. Ag NPs/water excels at low volume fractions and high Reynolds numbers, while MgO/water performs better at higher volume fractions. Moreover, the analysis of the Euler number indicates a decreasing trend with increasing Reynolds number across all nanofluids. However, no notable variation in the Euler number is observed when maintaining constant volume fraction and Reynolds number. Ultimately, the model is applied to obtain bulk fluid properties, such as viscosity and thermal conductivity, after suspending the nanoparticles. Subsequently, these properties were incorporated into the single-phase model. Utilizing these derived bulk properties was found to substantially enhance the accuracy of the single-phase model, demonstrating its reliability by yielding results within 13.52 % of experimental data.

Multiplex: TBC-Based Authenticated Encryption with Sponge-Like Rate

Authenticated Encryption (AE) modes of operation based on Tweakable Block Ciphers (TBC) usually measure efficiency in the number of calls to the underlying primitive per message block. On the one hand, many existing solutions reach a primitive-rate of 1, meaning that each n-bit block of message asymptotically needs a single call to the TBC with output length n. On the other hand, while these modes look optimal in a blackbox setting, they become less attractive when leakage comes into play, since all these calls must then be equally well protected to maintain security. Leakage-resistant modes improve this situation, by generating ephemeral keys every constant number of calls. However, rekeying is inherently suboptimal in primitive-rate, since a TBC call can only be used either to refresh a key or to encrypt a block. Even worse, existing solutions achieving almost n bits of security for n-bit secret keys have at most a primitive-rate 2/3. Hence the question: Can we design a highly-secure TBC-based rekeying mode with “nearly optimal” primitive-rate? We answer this question positively with Multiplex, a new mode that has primitive-rate d/(d + 1) given a TBC with a dn-bit tweak. Multiplex achieves n − log2(dn) bits of security for both (i) misuse-resilience CCA confidentiality security in the blackbox setting and (ii) Ciphertext Integrity with Misuse-resistant and unbounded Leakage in encryption and decryption (CIML2). It also provides (iii) confidentiality with leakage up to the birthday bound. Furthermore, Multiplex can run d + 1 calls in parallel in each iteration. The combination of these features gives a mode of operation that inherits most of the good implementation features and flexibility of a sponge construction – therefore paving the way towards sound comparisons between TBC-based and permutation-based AE.

Multisubstrate specificity shaped the complex evolution of the aminotransferase family across the tree of life

Aminotransferases (ATs) are an ancient enzyme family that play central roles in core nitrogen metabolism, essential to all organisms. However, many of the AT enzyme functions remain poorly defined, limiting our fundamental understanding of the nitrogen metabolic networks that exist in different organisms. Here, we traced the deep evolutionary history of the AT family by analyzing AT enzymes from 90 species spanning the tree of life (ToL). We found that each organism has maintained a relatively small and constant number of ATs. Mapping the distribution of ATs across the ToL uncovered that many essential AT reactions are carried out by taxon-specific AT enzymes due to wide-spread nonorthologous gene displacements. This complex evolutionary history explains the difficulty of homology-based AT functional prediction. Biochemical characterization of diverse aromatic ATs further revealed their broad substrate specificity, unlike other core metabolic enzymes that evolved to catalyze specific reactions today. Interestingly, however, we found that these AT enzymes that diverged over billion years share common signatures of multisubstrate specificity by employing different nonconserved active site residues. These findings illustrate that AT family enzymes had leveraged their inherent substrate promiscuity to maintain a small yet distinct set of multifunctional AT enzymes in different taxa. This evolutionary history of versatile ATs likely contributed to the establishment of robust and diverse nitrogen metabolic networks that exist throughout the ToL. The study provides a critical foundation to systematically determine diverse AT functions and underlying nitrogen metabolic networks across the ToL.

What is the appropriate measure of radiology workload: Study or image numbers?

Previous studies assessing the volume of radiological studies rarely considered the corresponding number of images. We aimed to quantify the increases in study and image numbers per radiologist in a tertiary healthcare network to better understand the demands on imaging services. Using the Picture Archiving and Communication System (PACS), the number of images per study was obtained for all diagnostic studies reported by in-house radiologists at a tertiary healthcare network in Melbourne, Australia, between January 2009 and December 2022. Payroll data was used to obtain the numbers of full-time equivalent radiologists. Across all modalities, there were 4,462,702 diagnostic studies and 1,116,311,209 images. The number of monthly studies increased from 17,235 to 35,152 (104%) over the study period. The number of monthly images increased from 1,120,832 to 13,353,056 (1091%), with computed tomography (CT) showing the greatest absolute increase of 9,395,653 images per month (1476%). There was no increase in the monthly studies per full-time equivalent radiologist; however, the number of monthly image slices per radiologist increased 399%, from 48,781 to 243,518 (Kendall Tau correlation coefficient 0.830, P-value < 0.0001). The number of monthly images per radiologist increased substantially from 2009 to 2022, despite a relatively constant number of monthly studies per radiologist. Our study suggests that using the number of studies as an isolated fundamental data set underestimates the true radiologist's workload. We propose that the increased volume of images examined by individual radiologists may more appropriately reflect true work demand and may add more weight to future workforce planning.

General hydrodynamic features of elastoviscoplastic fluid flows through randomised porous media

A numerical study of yield-stress fluids flowing in porous media is presented. The porous media is randomly constructed by non-overlapping mono-dispersed circular obstacles. Two class of rheological models are investigated: elastoviscoplastic fluids (i.e. Saramito model) and viscoplastic fluids (i.e. Bingham model). A wide range of practical Weissenberg and Bingham numbers is studied at three different levels of porosities of the media. The emphasis is on revealing some physical transport mechanisms of yield-stress fluids in porous media when the elastic behaviour of this kind of fluids is incorporated. Thus, computations of elastoviscoplastic fluids are performed and are compared with the viscoplastic fluid flow properties. At a constant Weissenberg number, the pressure drop increases both with the Bingham number and the solid volume fraction of obstacles. However, the effect of elasticity is less trivial. At low Bingham numbers, the pressure drop of an elastoviscoplastic fluid increases compared to a viscoplastic fluid, while at high Bingham numbers we observe drag reduction by elasticity. At the yield limit (i.e. infinitely large Bingham numbers), elasticity of the fluid systematically promotes yielding: elastic stresses help the fluid to overcome the yield stress resistance at smaller pressure gradients. We observe that elastic effects increase with both Weissenberg and Bingham numbers. In both cases, elastic effects finally make the elastoviscoplastic flow unsteady, which consequently can result in chaos and turbulence.Graphical abstract

Hybrid Quadrupole Mass Filter - Radial Ejection Linear Ion Trap and Intelligent Data Acquisition Enable Highly Multiplex Targeted Proteomics.

Targeted mass spectrometry (MS) methods are powerful tools for selective and sensitive analysis of peptides identified by global discovery experiments. Selected reaction monitoring (SRM) is currently the most widely accepted MS method in the clinic, due to its reliability and analytical performance. However, due to limited throughput and the difficulty in setting up and analyzing large scale assays, SRM and parallel reaction monitoring (PRM) are typically used only for very refined assays of on the order of 100 targets or less. Here we introduce a new MS platform with a quadrupole mass filter, collision cell, linear ion trap architecture that has increased acquisition rates compared to the analogous hardware found in the Orbitrap™ Tribrid™ series instruments. The platform can target more analytes than existing SRM and PRM instruments - in the range of 5000 to 8000 peptides per hour. This capability for high multiplexing is enabled by acquisition rates of 70-100 Hz for peptide applications, and the incorporation of real-time chromatogram alignment that adjusts for retention time drift and enables narrow time scheduled acquisition windows. Finally, we describe a Skyline external software tool that implements the building of targeted methods based on data independent acquisition chromatogram libraries or unscheduled analysis of heavy labeled standards. We show that the platform delivers ~10x lower LOQs than traditional SRM analysis for a highly multiplex assay and also demonstrate how analytical figures of merit change while varying method duration with a constant number of analytes, or by keeping a constant time duration while varying the number of analytes.

The unreasonable effectiveness of early discarding after one epoch in neural network hyperparameter optimization

To reach high performance with deep learning, hyperparameter optimization (HPO) is essential. This process is usually time-consuming due to costly evaluations of neural networks. Early discarding techniques limit the resources granted to unpromising candidates by observing the empirical learning curves and canceling neural network training as soon as the lack of competitiveness of a candidate becomes evident. Despite two decades of research, little is understood about the trade-off between the aggressiveness of discarding and the loss of predictive performance. Our paper studies this trade-off for several commonly used discarding techniques such as successive halving and learning curve extrapolation. Our surprising finding is that these commonly used techniques offer minimal to no added value compared to the simple strategy of discarding after a constant number of epochs of training. The chosen number of epochs mostly depends on the available compute budget. We call this approach i-Epoch (i being the constant number of epochs with which neural networks are trained) and suggest to assess the quality of early discarding techniques by comparing how their Pareto-Front (in consumed training epochs and predictive performance) complement the Pareto-Front of i-Epoch.

The deltoid ligament is constantly formed by four fascicles reaching the navicular, spring ligament complex, calcaneus and talus.

The medial collateral ligament of the ankle, or deltoid ligament, can be injured in up to 40% of patients who sustain an ankle inversion sprain. Reporting injuries of the deltoid ligament is not easy due to confusion in the current anatomical descriptions, with up to 16 fascicles described, with variable frequencies. The purpose of this study was to clarify the anatomy of the deltoid ligament. Thirty-two fresh-frozen ankle specimens were used for this study. Careful dissection was undergone until full visualization of the deltoid ligament was achieved and measurements taken. The deltoid ligament was found to have four constant fascicles in two layers. The superficial layer consists of the tibionavicular, tibiospring and tibiocalcaneal fascicles, while the deep layer consists of the tibiotalar fascicle. Measurements of these fascicles are given in detail. The tibiotalar fascicle and the anterior part of the tibionavicular fascicle were found to be intra-articular structures. The deltoid ligament has a constant number of fascicles divided into a superficial and a deep layer. This clarification of the anatomy and terminology of the deltoid ligament and its fascicles will help clinical view, diagnosis and (interdoctor)communication and treatment. The ligamentous fibres of the deep layer, as well as the anterior fibres of the superficial layer (tibionavicular fascicle) are intra-articular, which could negatively impact its healing capacity, explaining chronicity of these types of injuries. Not applicable (cadaveric study).

Numerical simulation of combined effects of a vertical magnetic field and thermal radiation on natural convection of non-Newtonian fluids confined between circular and square concentric cylinders

BackgroundThis study addresses magnetohydrodynamic (MHD) natural convection involving non-Newtonian fluids. Focusing on the annular region between concentric circular and square cylinders, the research examines the impact of a vertical magnetic field and thermal radiation. MethodsThe Multiple Relaxation Time Lattice Boltzmann Method (MRT-LBM) is employed to simulate momentum and energy interactions in non-Newtonian fluid. Control parameters like Rayleigh number, Hartmann number, Radiation parameter, aspect ratio, square cylinder subdivision, and power-law index are systematically varied, while maintaining a constant Prandtl number. Significant findingsUsing shear-thinning fluid (n < 1) significantly improves cooling, particularly in conjunction with radiation effect. Correlations for the mean Nusselt number are established, offering insights. Results emphasize the substantial influence of parameters like Ra, Rd, and AR. High values of the latter promote the flow intensity and heat evacuation. For n < 1, increasing Ra from 103 to 5 × 104 results in a substantial increase in the heat transfer rate reaching 65 %. For shear-thickening fluid, the heat transfer rate is reduced by 25.31 % at Ra = 5 × 104 when Ha is increased from 0 to 50 in the absence of radiation. In addition, radiation enhances the heat transfer rate by 71.41 % by incrementing Rd from 0 to 0.8 for Ha = 0. The most pronounced effect of the radiation parameter is observed in the cases of Newtonian and shear-thickening fluids. Conversely, Ha and n act by reduction effects on the outputs of the problem. The attenuating effect of the magnetic field is more pronounced in the case of shear-thinning fluids. The plot of mean Nusselt number vs. AR shows an hysteresis phenomenon due to the existence of multiple steady solutions in a range of this parameter. In the latter range of AR, heat transfer induced by multicellular flow is higher than that induced by bicellular one. Heat transfer is somewhat enhanced by the RC configuration, compared to SC one.

Research on AGV composition algorithm based on variable and complex environment

Aiming at the traditional Gmapping algorithm with constant number of particles, which lead to the failure of composition in variable and complex environments, based on SLAM mapping technology, this paper proposed an Adaptive Sampling (AS) algorithm, which increased the number of sampling particles when the fluctuation of the 2D laser point cloud is larger than a certain threshold, and the experimental results shown that the algorithm was able to reasonably utilize the system resources, and effectively enhanced the algorithm’s ability to compose maps in a variable and complex environment. In addition, in order to make the system have a better effect of building maps in complex environments, this paper also integrated the firefly algorithm (AF) with it, and utilized AF’s high aggregation ability to improve the distribution of sampling particles, which then improved the estimation ability of the filter. Verified by offline real environment experiments, the results shown that the optimized algorithm significantly improves the map building ability of the system.

Insight into the bidirectional dynamics of hyperbolic tangent hybrid nanomaterial subject to Nield’s conditions using numerical approach

A hyperbolic tangent fluid model characterized by shear rate dependent viscosity together with the effects of hybrid nanoparticles, Brownian motion, thermo-diffusion, and Nield’s conditions, is utilized for thermal enhancement purpose. Five percent copper nanoparticles and twenty percent alumina nanoparticles are submerged into ethylene glycol with the parametric influence of tangent hyperbolic fluid to obtain the tangent hyperbolic hybrid nano suspension. Numerical solutions of the nondimensionalized conservation laws are found by the Keller-box method. The influence of various parametric factors on velocity, temperature, concentration, Nusselt number, and Sherwood number has been discussed. A constant Nusselt number is noted with the influence of Nield’s constraints. A 90% increase in thermal conductivity is achieved by dispersing 5% copper and 20% alumina nanoparticles into the ethylene glycol with the influence of hyperbolic tangent fluid. The error and convergence analysis of the numerical solution have been discussed, along with the validation of the obtained numerical results.

A Fast GPU Schedule For À-Trous Wavelet-Based Denoisers

Given limitations of contemporary graphics hardware, real-time ray-traced global illumination is only estimated using a few samples per pixel. This consequently causes stochastic noise in the resulting frame sequences which requires wide filter support during denoising for temporally stable estimates. The edge avoiding à-trous wavelet transform amortizes runtime cost by hierarchical filtering using a constant number of increasingly dilated taps in each iteration. While the number of taps stays constant, the runtime of each iteration increases in these usually memory-throughput bound shaders with increasing dilation, because the increasing non-locality negatively impacts cache hit rates. We present a scheduling approach that optimizes usage of the memory subsystem by permutating global invocation indices in such a way that each wavelet filter iteration is applied through undilated taps. In contrast to prior approaches, our method has identical performance characteristics in each iteration, effectively decreasing maintenance cost and improving performance predictability. Furthermore, we are able to leverage on-chip memory and hardware texture interpolation. Our permutation strategy is trivial to integrate into existing wavelet filters as a permutation before and after each level of the wavelet filter. We achieve speedups between 1.3 and 3.8 for usual wavelet configurations in Monte Carlo denoising and computational photography.

Exploring the effects of saccharides on the solvation behaviour of L-Citrulline in aqueous medium: Volumetric, transition state theory, transfer parameters and spectroscopic approach

This study examines the volumetric, viscometric and UV–vis characteristics of L-Citrulline in water and aqueous saccharides at atmospheric pressure across the whole concentration range and the absorber operating temperature range of 293.15 K -313.15 K. Density, partial molar volume, apparent molar isobaric expansion, Hepler's constant and hydration number were among the examined volumetric parameters, and viscosity coefficients, viscosity deviation and free energy for viscous flow activation were among the examined viscometric parameters. Stronger interactions between L-Citrulline and L-Arabinose were indicated by the increase in the transfer characteristics in the following order: L-Arabinose > D-xylose. A comparison of the taste behaviours of L-Citrulline in water and in an aqueous solution of saccharides has also been attempted. L-Citrulline interacts with all solvents in a significant way, as evidenced by the UV–visible spectra suggested by the shift in UV–visible absorption maxima that correspond with a rise in L-Citrulline content in the solvent systems chosen.