Constant Load Tests Research Articles

Pulmonary gas exchange in relation to exercise pulmonary hypertension in patients with heart failure with preserved ejection fraction.

Exercise pulmonary hypertension (ePH), defined as a mean pulmonary artery pressure (mPAP)/cardiac output (Qc) slope >3 WU during exercise, is common in patients with heart failure with preserved ejection fraction (HFpEF). However, the pulmonary gas exchange-related effects of an exaggerated ePH (EePH) response are not well-defined, especially in relation to dyspnea on exertion (DOE) and exercise intolerance. 48 HFpEF patients underwent invasive (pulmonary and radial artery catheters) constant-load (20W) and maximal incremental cycle testing. Hemodynamic measurements (mPAP and Qc), arterial blood and expired gases, and ratings of breathlessness (RPB, Borg 0-10) were obtained. The mPAP/Qc slope was calculated from rest-to-20W. Those with a mPAP/Qc slope >4.2 (median) were classified as HFpEF+EePH (n=24) and those with a mPAP/Qc slope <4.2 were classified as HFpEF (without EePH) (n=24). The A-aDO2, VD/VT (Bohr equation), and the VE/VCO2 slope (from rest-to-20W) were calculated. PaO2 was lower (p=0.03), and VD/VT was higher (p=0.03) at peak exercise in HFpEF+EePH compared with HFpEF. A-aDO2 was similar at peak exercise between groups (p=0.14); however, HFpEF+EePH achieved the peak A-aDO2 at a lower peak work rate (p<0.01). The VE/VCO2 slope was higher in HFpEF+EePH compared with HFpEF (p=0.01). RPB was ≥1-unit higher at 20W and VO2peak was lower (p<0.01) in HFpEF+EePH compared with HFpEF. These data suggest that EePH contributes to pulmonary gas exchange impairments during exercise by causing a V/Q mismatch that provokes both ventilatory inefficiency and hypoxemia, both of which seem to contribute to DOE and exercise intolerance in patients with HFpEF.

Revealing grain refinement and hydrogen trapping mechanism for anti-hydrogen susceptibility of Nb-alloyed 34MnB5 press hardened steel

Hydrogen embrittlement (HE) extant a substantial concern to press-hardened steel (PHS) owing to superior strength. The high strength to light-weight automobile structures necessitates the advancement of superior HE resistance PHS. This study investigated the HE susceptibility of Nb-microalloyed PHS by slow strain rate tensile testing, u-shaped constant bending load test, and thermal desorption spectroscopy. Nb enhances microstructure and HE resistance by introducing retained austenite, refining prior austenite grains (21.14–13.73 μm), forming low-angle grain boundaries, and nano-scale precipitates. Nb-alloyed steel exhibits no-cracking over 300 h under high pre-bending stress and decreases elongation loss up to 48% in hydrogen environment as compared to Nb-free steel. Diffusible H-content in 0.12 wt% Nb-steel reduces to 14.9% of that in Nb-free steel owing to enhanced hydrogen traps, the Fcc/Bcc matrix, and carbide precipitation. The multi-phase microstructure with nano-scale NbC precipitation impeded the localized H-dispersion, enhancing the HE resistance in PHS despite its high strength.

Effect of Spherical θ Precipitation in 1.5 GPa Grade Tempered Martensitic Steel on the Occurrence of Delayed Fracture

The objective of this study is to clarify the effect of spherical cementite (θ) precipitation on the occurrence of delayed fracture in 1.5 GPa grade tempered martensitic steels. Constant load tests were performed with a cathodically charged specimen. A 1GPa-load was applied to the specimen, and cathodic charging was performed in 3% NaCl + 3 g/L NH4SCN solution. The specimen of steel without spherical θ did not fracture at the current density of 5 A·m−2 or even by increasing to 50 A·m−2. On the other hand, the specimen of steel with spherical θ fractured after 0.2 h at 5 A·m−2. The strain around the spherical θ after 30%-rolling observed by transmission electron backscatter diffraction showed that the local deformation around the spherical θ was larger than that in the whole measurement field by 3.05 × 1014 m−2 in terms of geometrically necessary dislocation density. In the hydrogen desorption curve by thermal desorption analysis, steel with spherical θ after 30%-rolling showed a larger hydrogen desorption peak around 250 °C than steel without spherical θ. The value of the activation energy of the 250 °C-peak was 109.2 kJ·mol−1. From these results, the 250 °C-peak is inferred to be hydrogen at the disordered interface of θ/tempered martensite. Transmission electron microscopy observation showed cracks and voids on the spherical θ near the delayed fracture surface. These results indicate that the precipitation of spherical θ facilitates the occurrence of delayed fracture. Cracks appear to form around spherical θ.

Factors affecting the tensile strength of bituminous geomembrane seams

The tensile shear strength, break location, and constant tensile load failure times are examined for seams made from one 4 mm-thick bituminous geomembrane (BGM) product, with corresponding observations specific to that material. In short-term tests, failure is observed within the sheet material once the seam strength exceeded 0.8 times that of the sheet material. The effects of seam thickness reduction and overlap width on seam strength are examined for two methods of seaming. Seams with a short-term strength meeting or exceeding 80% of the sheet strength are subjected to constant tensile loads between 18 and 55% of sheet ultimate strength and the time to failure is reported. The relationship between short-term seam strength and time to failure under sustained load and thickness reduction and squeeze-out is investigated. Constant tensile load testing is proposed as a construction quality assurance procedure to assess the degree of geotextile engagement of field seams.

Study on the corrosion and damage behaviours of P110 tubing of deep shale gas wells

This study conducts weight loss corrosion experiments by a high-temperature autoclave to investigate the corrosion behaviours and the damage rules of mechanical properties of P110 tubing under coupling working conditions of multiple factors (temperature 50–155 °C, CO2 content 1%–2%, Cl− content 10,000–20,000 mg/L). It analyses the characteristics of corrosion products of P110 steel using X-ray diffraction, scanning electron microscopy, and energy dispersive spectroscopy (EDS). In addition, the 3D morphology and size of local corrosion pits are measured microscopically. The mechanical properties’ damage behaviours at different tubing positions are analysed by constant-load tensile stress corrosion tests. The results showed that the average corrosion rate of the tubing reaches the maximum value of 1.627 mm/a at the middle section of the shale gas well. With an increase in temperature and CO2 partial pressure, the depth of the local corrosion pits on the tubing rises from 3.8 to 25.0 μm. The yield strength and tensile strength of the tubing at the bottom-hole section reduced by less than 8%, and the coupling damage effect of stress and corrosive mediums is serious. The tubing shows a sensitivity to stress corrosion cracking at the bottom-hole section. It was recommended that corrosion inhibitors should be cyclically added to inhibit CO2 corrosion to control the corrosion rate of the tubing within the range of medium-degree corrosion, thus ensuring that the strength reduction of P110 tubing under the corrosion working conditions containing CO2 and sulphate-reducing bacteria coupled with tensile stress is within the controllable range of safety factor.

Effect of Load Cycling on High Temperature Creep of 316L Stainless Steel

For components in concentrating solar thermal plants, the creep mechanism will cause a significant portion of material damage to receivers, storage tanks, turbines and pipework. These components will undergo conditions where loads, temperature, or both load and temperature are not constatnly applied. This creep damage process will not resemble the constant load creep tests used to characterise creep of materials. Therefore, creep tests incorporating a load cycle were undertaken to obtain a better understanding of how high temperature materials respond to these cyclic conditions. These tests showed that when time under load was considered, creep undertaken under load cycling conditions were accelerated relative to constant load conditions. A modified Larson-Miller approach was used to assess this effect and determine an equivalent stress where constant load test data agrees with the cycled test data. This found that cycling the load was equivalent to if the system were under 3 and 7 MPa higher stress, for tests which were loaded for 12 hrs and 6 hrs per 24 hrs respectively. This could be a potential approach to simply and easily consider these load cycling effects for design and life analysis.

Analysis, Assessment, and Mitigation of Stress Corrosion Cracking in Austenitic Stainless Steels in the Oil and Gas Sector: A Review

This comprehensive review examines the phenomena of stress corrosion cracking (SCC) and chloride-induced stress corrosion cracking (Cl-SCC) in materials commonly used in the oil and gas industry, with a focus on austenitic stainless steels. The study reveals that SCC initiation can occur at temperatures as low as 20 °C, while Cl-SCC propagation rates significantly increase above 60 °C, reaching up to 0.1 mm/day in environments with high chloride concentrations. Experimental methods such as Slow Strain Rate Tests (SSRTs), Small Punch Tests (SPTs), and Constant-Load Tests (CLTs) were employed to quantify the impacts of temperature, chloride concentration, and pH on SCC susceptibility. The results highlight the critical role of these factors in determining the susceptibility of materials to SCC. The review emphasizes the importance of implementing various mitigation strategies to prevent SCC, including the use of corrosion-resistant alloys, protective coatings, cathodic protection, and corrosion inhibitors. Additionally, regular monitoring using advanced sensor technologies capable of detecting early signs of SCC is crucial for preventing the onset of SCC. The study concludes with practical recommendations for enhancing infrastructure resilience through meticulous material selection, comprehensive environmental monitoring, and proactive maintenance strategies, aimed at safeguarding operational integrity and ensuring environmental compliance. The review underscores the significance of considering the interplay between mechanical stresses and corrosive environments in the selection and application of materials in the oil and gas industry. Low pH levels and high temperatures facilitate the rapid progression of SCC, with experimental results indicating that stainless steel forms passive films with more defects under these conditions, reducing corrosion resistance. This interplay highlights the need for a comprehensive understanding of the complex interactions between materials, environments, and mechanical stresses to ensure the long-term integrity of critical infrastructure.

Crack propagation process and lifetime prediction method of concrete-rock interface under constant loading

This study investigated the crack propagation processes and established the lifetime prediction methods of the concrete-rock interfaces under constant loading. Firstly, the constant loading tests were performed under three-point bending loading on the composite concrete-rock beams with three kinds of interfaces, i.e. natural, 4 × 4, and 7 × 7 interfaces, and under three constant load levels, i.e. initial cracking load, 80 % and 97 % of the peak loads. Then, the clip gauge method and digital image correlation method were employed to detect the crack lengths under constant loading. Finally, the effects of constant load levels on fracture properties of the concrete-rock interfaces were analyzed and the crack propagation processes under constant loading were discussed. The results indicated that the clip gauge method was an available and accurate method to detect the crack lengths of the concrete-rock interfaces under constant loading. Crack propagation processes and crack mouth opening processes under constant loading exhibited the three-stage feature, i.e. deceleration stage, uniform stage and acceleration stage. In addition, the logarithms of the constant loading lifetimes showed an approximate linear relationship with the logarithms of the crack mouth uniform opening rates, and a quantitative relationship was established by using the linear regression analysis to establish the lifetime prediction methods. This study proposed a practical method to predict the service life of concrete structure-bedrock interface. When the crack mouth uniform opening stage was recognized, the lifetime of concrete structure-bedrock interface in service can be predicted by substituting the crack mouth uniform opening rate into the pre-established prediction model. This study can provide the theoretical support for the safety assessment of the concrete structure-bedrock interface in service.

INSCYD physiological performance software is valid to determine the maximal lactate steady state in male and female cyclists.

The maximal lactate steady state (MLSS) is defined as the highest workload that can be maintained without blood lactate accumulation over time. The power output at MLSS (PMLSS) is regularly implemented to define training zones, quantify training progress, or predict race performance. The gold standard methodology for MLSS determination requires two to five trials of constant-load exercise, which limits the practical application in training. The INSCYD software can calculate the PMLSS (PMLSSINSCYD) based on physiological data that can be obtained during a ∼1 h laboratory visit. However, to the best of our knowledge, the validity of the most recent software version has not yet been investigated. This study aimed to assess the validity of the software's calculations on PMLSS in cycling. The data for this study were retrieved from two published scientific sources. Thirty-one cyclists (19 males, 12 females) performed a 15 s sprint to estimate the VLamax, a ramp test for the assessment, and two to five constant-load tests to determine the PMLSS. The INSCYD software was used to calculate the PMLSS based on the , VLamax, sex, body mass, and body composition. The PMLSSINSCYD was higher than the PMLSS in the entire sample (mean difference: 4.6 W, p < 0.05, 95% CI 0.8-8.3 W) and in men (mean difference: 6.6 W, p < 0.05, 95% CI 1.3-11.8 W), but not in women (mean difference: 0.8 W, n.s., 95% CI -3.7 to 5.3 W), which was within the typical error of the PMLSS estimations (∼3%). In 12 subjects (nine males, three females), the PMLSSINSCYD differed by 3.1-7.3% compared to the MLSS. The Pearson correlations between the measured PMLSS and the calculated PMLSS (PMLSSINSCYD) were very strong in men (r = 0.974, p < 0.001, 95% CI 0.933-0.99), women (r = 0.984, p < 0.001, 95% CI 0.931-0.996), and for the entire sample (r = 0.992, p < 0.001, 95% CI 0.982-0.996). In conclusion, the PMLSS can be accurately calculated using the INSCYD software, but it still requires advanced testing equipment to collect valid and VLamax data.

The influence of microstructural heterogeneities on high-temperature mechanical properties of additively manufactured γ'-forming Ni-based alloys

AbstractAdditive manufacturing (AM) of metallic materials yields distinctive hierarchical and heterogeneous microstructures owing to the complex thermal conditions during the build-up process. Consequently, the knowledge gained from creep properties of conventionally manufactured (CM) Ni-based alloys cannot be directly applied to AM-processed alloys. Furthermore, insufficient creep life has posed a significant challenge in the development of Ni-based superalloys fabricated by laser powder bed fusion (LPBF), one of the most important AM techniques. Nevertheless, limited research has been conducted to understand their creep behavior due to the time-consuming nature of creep testing and extended research cycles. This study delves into investigating the creep behavior of an additively manufactured, precipitation-strengthened Ni-based alloy (NiCrAl) in comparison to its CM counterpart, focusing on the structure-property relationships. Constant-load creep tests were conducted at temperatures of 750 °C and 950 °C up to a maximum duration of nearly 1500 h. Although both the AM and CM states demonstrated high creep activation energy and creep exponents, indicative of a dislocation climb mechanism, the AM state demonstrated inferior creep life and ductility compared to the CM state for creep times below 500 h. To gain deeper insights into the underlying mechanisms, multi-scale microstructural characterization was performed to understand the effect of the AM-inherent microstructure. Overall, this study provides a comprehensive understanding of the creep behavior of Alloy 699XA after AM and CM processes, emphasizing the significance of AM-specific microstructural heterogeneities.

Cardiorespiratory Fitness in Children with Obesity and Respiratory Symptoms

Study Objective: Physical fitness (i.e., VȮ2max in ml/min/kg) is decreased in children with obesity. However, cardiorespiratory fitness (i.e., VȮ2max as a percent of predicted based on ideal body mass) is preserved in children with obesity. Unfortunately, many children with obesity suffer from obesity-related respiratory symptoms such as exertional dyspnea, which could make them reluctant to exercise and thus decrease both their physical fitness and cardiorespiratory fitness. Thus, we hypothesized that both physical fitness and cardiorespiratory fitness will be decreased in children with obesity and respiratory symptoms. Methods: Body composition (DXA) was measured on children aged 8-12yrs without obesity (‘CWOO’; n=25; 15th≤BMI≤85th percentile), with obesity (‘CWO’; n=49; BMI≥95th percentile), and with obesity and respiratory symptoms (‘CWORS’; n=14; BMI≥95th percentile). On a separate day, participants completed an incremental exercise test to volitional exhaustion. After 15min of seated rest, participants then performed a constant-load supramaximal verification test at 105% of the peak work rate. The highest VȮ2 from the incremental or verification test was recorded as VȮ2max. BMI-for-age data from the CDC were used to calculate ‘ideal’ body mass (BM) at the 50th percentile for CWO, CWORS, and CWOO who were above the 50th BMI percentile. Percent predicted VȮ2max was calculated using sex-specific prediction equations developed by Cooper et al. (2016). A one-way ANOVA with post hoc tests was used to determine differences among groups (i.e., CWOO, CWO, and CWORS). Significance was set at p &lt; 0.05. Results: Age in years was slightly but significantly greater in CWOO (11.0±1.1) vs. CWORS (10.2±1.1), but similar between CWO (10.4±1.3) and the other two groups. Height was not significantly different between groups. BM in kg was similar between CWO (60.18±15.65) and CWORS (63.16±13.10), and significantly higher than CWOO (39.18±7.11). There were no significant differences in BMI (% of the 95th percentile), fat mass, % fat, or circumference measures between CWO and CWORS. VȮ2max in L/min was not different between groups (CWOO, 1.48±0.35; CWO, 1.59±0.32; CWORS, 1.57±0.30). VȮ2max in % predicted was not different between groups (CWOO, 97±12; CWO, 96±12; CWORS, 91±12). VȮ2max in ml/min/kg was similar between CWO (27.0±3.7) and CWORS (25.2±3.5), but significantly greater in CWOO (37.9±7.1) vs. the other two groups. Conclusion: Cardiorespiratory fitness is not affected in children with obesity and respiratory symptoms. Thus, the origin of symptoms in children with obesity and respiratory symptoms is probably not related to deconditioning. These findings are important to inform healthcare providers who examine fitness and associations with chronic disease in children with obesity. NIH R01 HL136643, King Charitable Foundation Trust, Cain Foundation, unrestricted gift from Dr. Pepper Snapple, and Texas Health Presbyterian Hospital Dallas. Dr. Daniel Wilhite was funded by an NIH Administrative Supplement to Promote Diversity in Health-Related Research (HL136643-01S1). This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Creep behavior and fracture mechanism of an additively manufactured 316L stainless steel with extraordinary creep resistance

The creep behaviors of laser powder bed fusion (LPBF) additively manufactured (AM) 316L stainless steel (SS) and its recrystallized (Re) counterpart were investigated via uniaxial constant-load creep tests at 600 °C with nominal stress levels ranging from 235 to 360 MPa. Anisotropic creep behavior was observed in AM 316L SS, with superior creep resistance but inferior creep ductility in the horizontal sample (loaded perpendicular to the build direction (BD)) compared to the vertical sample (loaded parallel to the BD). This superior creep resistance was likely resulted from shorter dislocation slip distance and the inferior creep ductility was due to faster propagation of cracks along the columnar grain boundaries. Compared with both the Re counterpart and conventional 316L SS, AM 316L SS in this study exhibited an extraordinary creep resistance at various stress levels, with the minimum creep rate being two to three orders of magnitude lower and much longer creep life. This exceptional creep resistance of AM 316L SS was attributed to the presence of dislocation cells that impeded the deformation-induced dislocations. This led to a remarkably low rate of creep deformation and delayed the creep crack initiation, ultimately resulting in a long creep life. The gradual development of the precipitate films enriched with Mo, Si and Cr along high-angle grain boundaries, following prolonged exposure to high temperatures, was found to restrict the creep ductility in AM 316L under low stress conditions. Nevertheless, the study demonstrates that the stable dislocation cells are beneficial in enhancing the high-temperature creep resistance of AM 316L SS.

Comparison between slow strain rate test and constant load test on notched specimens for HSLA steels HE susceptibility evaluation

The assessment of hydrogen embrittlement (HE) susceptibility in high-strength steels, intended for use in subsea components that are exposed to cathodic protection for corrosion control, is of great importance. Therefore, the present study investigates the behavior of AISI 4340 steel with hardness of 32, 36 and 40 HRC. The investigation involves employing slow strain rate test (nSSRT) and constant load test (CLT) on notched specimens with three different notch root radii. These tests were carried out under two different levels of cathodic protection (−1100 and −950 mVAg|AgCl) in a 3.5 % wt NaCl aqueous solution. The outcomes from the tests on notched specimens were compared with the hydrostatic stress profile obtained through finite element analysis (FEA). Additionally, the post-test fracture surfaces were analyzed using scanning electron microscopy (SEM). The test results revealed a higher hydrogen embrittlement index (HEI) with increasing material hardness and the applied cathodic potential. Moreover, a smaller notch radius was associated with a higher HEI. A clear correlation was observed between HEI and the extent of intergranular fracture in the test samples. Furthermore, the results from the nSSRT tests were correlated with the threshold stress (σth) obtained from CLT. It was evident that a relationship of σth = 90 %σnSSRT_min could be employed for a faster determination of this parameter.

Influence of corrosion fatigue on the stress gradient effect of the aluminium alloy EN AW-6082 T6

This study investigates the influence of corrosion fatigue on the fatigue strength of the aluminium alloy EN AW-6082 T6 with regard to the stress gradient. The experimental design involves varying loading conditions and specimen geometries to facilitate testing under three distinct stress gradients: tension/compression (0mm-1), rotary bending (0.2mm-1), notched rotary bending (5.3mm-1). Reference constant loading tests in air as well as continuously irrigated corrosion fatigue tests in a 5wt% NaCl-solution are conducted with a constant stress ratio of R =−1. The results reveal a substantial reduction in fatigue strength due to corrosion fatigue across all three stress gradients. The slope of the S-N curves drops by a factor of at least two and no second slope of the S-N curves is found within the tested load cycle range (up to 107). The study demonstrates a significant increase in the support factor for tests conducted in the corrosive environment. This discrepancy becomes more pronounced towards higher stress gradients and lower load cycle numbers. The application of the support factor derived from tests in a non-corrosive atmosphere is shown to be conservative, emphasizing the significance of accounting for corrosion effects in assessing fatigue behaviour.

Skeletal muscle mitochondrial correlates of critical power and W' in healthy active individuals.

The asymptote (critical power; CP) and curvature constant (W') of the hyperbolic power-duration relationship can predict performance within the severe-intensity exercise domain. However, the extent to which these parameters relate to skeletal muscle mitochondrial content and respiratory function is not known. Fifteen males (peak O2 uptake, 52.2±8.7mLkg-1min-1; peak work rate, 366±40W; and gas exchange threshold, 162±41W) performed three to five constant-load tests to task failure for the determination of CP (246±44W) and W' (18.6±4.1kJ). Skeletal muscle biopsies were obtained from the vastus lateralis to determine citrate synthase (CS) activity, as a marker of mitochondrial content, and the ADP-stimulated respiration (P) and maximal electron transfer (E) through mitochondrial complexes (C) I-IV. The CP was positively correlated with CS activity (absolute CP, r=0.881, P<0.001; relative CP, r=0.751, P=0.001). The W' was not correlated with CS activity (P>0.05). Relative CP was positively correlated with mass-corrected CI+IIE (r=0.659, P=0.038), with absolute CP being inversely correlated with CS activity-corrected CIVE (r=-0.701, P=0.024). Relative W' was positively correlated with CS activity-corrected CI+IIP (r=0.713, P=0.021) and the phosphorylation control ratio (r=0.661, P=0.038). There were no further correlations between CP or W' and mitochondrial respiratory variables. These findings support the assertion that skeletal muscle mitochondrial oxidative capacity is positively associated with CP and that this relationship is strongly determined by mitochondrial content.

Heart rate variability: Obtaining the stress score from SDNN values

BACKGROUND: Heart Rate Variability (HRV) is a non-invasive method of assessing the autonomic nervous system response during exercise and fatigue. OBJECTIVE: The aim of the study was to analyze the validity and feasibility of the stress score index (SS) calculated from SDNN values during exercise. METHODS: 18 Men performed 2 running tests: 1) incremental exercise test; 2) 10-minute constant load test. Subjects underwent HRV analysis during the constant load test, before both tests, and afterward in a seated position at 3 intervals (0’–5’, 5’–10’, 10’–15’). The relationship between SDNN and SD2 was analyzed before, during, and after the test. SS was calculated as 1/SD2*1000. The Bland-Altman test analyzed the reliability of ESS. The bias, limits of agreement (LoA), standard deviation of difference, intraclass correlation (ICC), and person coefficient were calculated. RESULTS: The bias was 0.15 ± 2.54 (UperLOA: 2.54; LowerLOA: -2.23). In all conditions, SD2 and SDNN showed a positive linear relationship (r2 = 0.986); SS and ESS were correlated; and SS and ESS described a positive linear relationship (r2 = 0.993). CONCLUSIONS: The SS index calculation from SDNN is a reliable alternative during exercise.

Assessing fracture toughness of vintage and modern X65 pipeline steels under in situ electrochemical hydrogen charging using advanced testing methodology

The susceptibility of pipeline steels to hydrogen embrittlement, which can significantly impair mechanical performance, especially fracture toughness, is a critical issue in infrastructure integrity. This study evaluates the fracture toughness of modern and vintage API X65 steels under cathodic polarization (CP) conditions, employing methods such as rising displacement testing, stepwise rising constant load testing, and constant load testing. Tearing crack growth was detected at crack tip opening displacements (CTODs) of 0.032 to 0.055 mm while subsequent crack arrest under constant force loading was observed with CTOD thresholds of 0.148 mm and 0.255 mm for modern and vintage X65, respectively. Electron channelling contrast imaging demonstrated that arrested cracks in both steels exhibited reduced plasticity and a higher propensity for crack branching compared to propagating cracks. These findings highlight the need for tailored strategies to mitigate the effects of hydrogen embrittlement in pipeline materials and underscore the differences in damage tolerance between steel generations.

Inspiratory muscle endurance is similarly reduced in the early and late stages of chronic Chagas heart disease.

Inspiratory muscle strength (IMS) appears to be reduced in subjects with chronic Chagas heart disease (CHD), especially in the presence of heart failure (HF). However, only one study about IMS and inspiratory muscle endurance (IME) in those with CHD without heart failure is available. This study aimed to compare IMS and IME in subjects with CHD in the presence and absence of HF. This is a cross-sectional study in which 30 CHD adult patients were divided into CHD-CC group (initial phase of CHD, without HF; n = 15) and CHD-HF group (advanced phase of CHD, with HF; n = 15). We assessed IMS by maximum inspiratory pressure (MIP) and IME by incremental (Pthmax) and constant load (TLim) tests. Reduced IMS and IME were considered by predicted MIP values <70% and Pthmax/MIP <75%, respectively. Inspiratory muscle weakness (IMW) was more frequent in CHD-HF than in CHD-CC (46.7% vs. 13.3%; p = 0.05), and both groups had high frequencies of reduced IME (93.3% CHD-CC vs. 100.0% CHD-HF; p = 0.95). Age-adjusted logistic regression analysis using HF as a dependent variable showed that HF was associated with an increased chance of IMW compared with the CHD-CC group (OR = 7.47; p = 0.03; 95% CI 1.20-46.19). This study suggests that, in patients with CHD, HF is associated with IMW, and that reduction of IME is already present in the initial phase, similar to the advanced phase with HF.

Enhancing exercise tolerance in interstitial lung disease with high-flow nasal cannula oxygen therapy: A randomized crossover trial.

Interstitial lung disease (ILD) is characterized by dyspnoea on exertion and exercise-induced hypoxaemia. High-flow nasal cannula (HFNC) therapy reduces the respiratory workload through higher gas flow and oxygen supplementation, which may affect exercise tolerance. This study aimed to examine the effects of oxygen and gas flow rates through HFNC therapy on exercise tolerance in ILD patients. We conducted three-treatment crossover study. All ILD patients performed the exercises on room air (ROOM AIR setting: flow, 0 L/min; fraction of inspired oxygen [FiO2], 0.21), HFNC (FLOW setting: flow 40 L/min, FiO2 0.21), and HFNC with oxygen supplementation (FLOW + OXYGEN setting: flow 40 L/min, FiO2 0.6). The primary endpoint was the endurance time, measured using constant-load cycle ergometry exercise testing at a peak work rate of 80%. Twenty-five participants (10 men, 71.2 ± 6.7 years) were enrolled. The increase in exercise duration between the ROOM AIR and FLOW was 46.3 s (95% CI, -6.1 to 98.7; p = 0.083), and the FLOW and FLOW + OXYGEN was 91.5 s (39.1-143.9; p < 0.001). The percutaneous oxygen saturation (SpO2) at rest was significantly higher with the FLOW + OXYGEN setting than with the ROOM AIR and FLOW settings, and the difference persisted during exercise. At equivalent time points during exercise, the SpO2 with the FLOW setting was significantly higher than that with the ROOM AIR setting. Oxygen supplementation in HFNC therapy improved exercise tolerance and SpO2. We found that gas flow alone did not improve exercise tolerance, but improved SpO2 during exercise.

It’s not just the heart: respiratory limitations to constant-load exercise in adult Fontan patients and potential implications for rehabilitation

Introduction Congenital heart defects may require surgical intervention such as the Fontan procedure that connects the systemic venous return to the pulmonary arteries. Although this procedure has increased survival, it results in reduced exercise capacity; which is reduced not only due to cardiovascular factors, but respiratory limitations as well. However, there is a lack of evidence outlining ventilatory limitations during constant-load exercise, which better represents exercise in cardiac rehabilitation programs and non-laboratory based exercise. Therefore, the aim of the present study was to compare responses to constant-load exercise in adult Fontan patients with those of healthy well-matched controls. Methods 14 adult Fontan patients (5F, 27 ± 6yrs) were recruited with 14 healthy matched controls. Participants performed forced vital capacity (FVC), as well as maximal inspiratory and and expiratory pressure assessments (MIP and MEP, respectively). Patients performed an incremental cycling test (ICT) to exhaustion to determine peak work rate. Following a period of recovery, patients performed a constant-load cycling test (CLCT) at 70% of peak ICT work rate until exhaustion. Healthy subjects reproduced the exercise of their matched patient. Cardiorespiratory variables and heart rate (HR) were measured using a metabolic cart and a 12-lead electrocardiogram, respectively. Participants were asked to rate their perception of breathlessness and respiratory exertion via a visual analogue scale every 2 min and at peak exercise. Patients without cardiac pacemakers underwent involuntary assessments of respiratory muscle contractility via phrenic (n = 8) nerve magnetic stimulation before and following exercise to quantify respiratory muscle fatigue. Results Patients showed significantly reduced FVC, MIP and MEP compared to controls (all p &lt; 0.025). Patients’ time-to-exhaustion during the CLCT was 7.1 ± 3.3 min. During CLCT vs. the ICT, patients reached maximal HR, respiratory rate (fR), breathlessness, respiratory exertion, and leg exertion. End-exercise V̇O2 during the CLCT did not reach ICT values, with a mean difference of 1.5 ml/kg/min (p = 0.017). Controls did not reach peak ICT responses during the CLCT. During the CLCT, patients displayed significantly elevated minute ventilation (V̇E; mean difference = 21.5 L/min), fR (mean difference = 13.8 breaths-per-minute), breathlessness (mean difference = 3.4 points), and respiratory exertion (mean difference = 2.3 points), along with significantly decreased ventilatory reserve (V̇E/maximal voluntary ventilation; mean difference = 27.5%; all p &lt; 0.002). Following the CLCT, Fontan patients showed a larger decrease in involuntary respiratory muscle contractility (15 ± 12% vs. 2 ± 11%). Finally, a decreased ventilatory reserve was significantly correlated with decreased MIP (r = 0.723, p = 0.003) and MEP (r = 0.623, p = 0.042). Discussion/Conclusion Fontan patients had a lower-than-expected time-to-exhausiton, in part due to their abnormal ventilatory response. First, the increased pulmonary restriction in the Fontan patients likely led to increased V̇E driven by a high fR during exercise. Second, Fontan patients showed decreased ventilatory reserve - which was significantly associated with respiratory muscle weakness. Third, patients showed significantly increased respiratory muscle fatigue following exercise. Collectively, these factors likely contributed to the increased breathlessness and respiratory exertion in patients, leading to increased exercise limitation. Given this, and the fact that patients reached near maximal physiological responses during the CLCT, it’s possible that patients may benefit more from aerobic training at less than 70% of peak word rate, or from interval-training with significant recovery time.