ABSTRACT Introduction: Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that has gained significant interest in both clinical and research settings. It involves applying a low, constant electrical current to the scalp to modulate neuronal activity. tDCS is valued for its cost-effectiveness, portability, and simplicity compared to other brain stimulation methods such as transcranial magnetic stimulation (TMS). This article explores the historical context, mechanisms, and clinical applications of tDCS, highlighting its potential in treating neurological and psychiatric disorders and enhancing cognitive functions. Objectives: The noninvasive brain stimulation method known as tDCS has drawn a lot of attention in both clinical and scientific contexts. To alter neuronal activity, a low, steady electrical current is applied to the scalp. When compared to other brain stimulation techniques such as TMS, tDCS is prized for its affordability, mobility, and ease of use. The historical background, workings, and clinical uses of tDCS are examined in this article, with an emphasis on how it may be used to cure mental and neurological conditions as well as improve cognitive abilities. Methods: tDCS, a noninvasive brain stimulation technique, has garnered significant interest in both clinical and scientific settings. A low, constant electrical current is given to the scalp to change neural activity. tDCS is valued for its cost, portability, and simplicity of usage in contrast to other brain stimulation methods such as TMS. This article explores the history, mechanism, and clinical applications of tDCS, focusing on its potential for treating neurological and mental disorders and enhancing cognitive function. Results: Participants’ depression levels significantly decreased, according to the study. By the end of the intervention, over 50% of the participants had responded, and at the 1-month follow-up, this percentage had risen to almost 77%. Only minor, self-limiting adverse effects, such as tingling and soreness at the stimulation site, were experienced during the well-tolerated treatment. These results show that tDCS is effective in treating depression and is in line with international research. Conclusion: The tDCS significantly reduces depression symptoms and is a well-tolerated and successful supplementary treatment for treatment resistant depression. The study encourages more research into the therapeutic uses of tDCS, especially for people who do not react to conventional antidepressant drugs. Notwithstanding the encouraging outcomes, the study admits its shortcomings, including its limited sample size and lack of a control group. To maximize the use of TDCS in clinical practice, future studies should concentrate on maintenance procedures, long-term effects, and customized treatment strategies.
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