DURING the last four years we have been intensely interested in the urologic complications of late carcinomatous cervix. In going over 27 consecutive autopsy records of carcinomatous cervix in patients who died on our service, we found that ureteral obstruction with associated renal damage occurred in 22 of the cases, and in only five patients did distant metastasis have the opportunity to develop. Carcinoma of the cervix, as you know, may extend in one of three ways, namely, either posteriorly, with invasion of the rectal wall, anteriorly to the bladder wall, or laterally into the broad ligament. With posterior extension, the symptoms are rectal pain, obstipation, tenesmus, and rectal bleeding. With extension to the bladder, dysuria, frequency of urination, and hematuria are the important signs. Here differentiation must often be made from an old radium burn, since practically all of these cases have had intensive radium therapy. Cystoscopic examination in late carcinoma of the cervix with anterior extension will often reveal large masses of bullous edema with areas of papillary projections and, finally, the formation of a vesico-vaginal fistula. However, the greatest number of cases in our series presented themselves with signs and symptoms of ureteral obstruction. Usually, the patient complains of a constant dull pain located deep in the groin, referred to the thigh and leg, and often simulating an attack of sciatica. The pain may be referred to the sacrum, simulating sacro-iliac disease, or, what is most common, to one or both kidneys, especially when complete occlusion of the ureter has taken place. As infection intervenes secondary to this obstruction, and its associated urinary stasis, chills and fever commonly occur, with anorexia, general malaise, and prostration. The urine often is turbid. However, with complete unilateral occlusion, the urine may be persistently clear, although evidences of a large hydronephrosis are present. Gastro-intestinal symptoms are usually pronounced and are associated with the hydronephritic condition which is present. This type of patient often develops a marked distaste for food; we have had patients gain from 10 to 100 pounds after the obstruction has been removed and their appetites have returned. Physical examination with the finger in the rectum or the vagina reveals some degree of induration of the parametria. However, cystoscopy and ureteral catheterization establish the diagnosis very positively. We have found these obstructions to be unilateral in about 75 per cent of the cases. Ureteral catheterization meets with obstruction in the terminal portion of the ureter, and in most cases nothing will go by the point of obstruction, and sodium iodide injected through the catheter for ureteral pyelography will regurgitate back into the bladder.
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