Fatigue design of structural components under multiaxial loading often relies on fatigue life calculations based on a post-processing of the full-field elastic stress/strain maps obtained from finite element (FE) analysis. In the present article, a post-processing tool is adopted to compute the fatigue life of a structural component, and multiaxial fatigue assessment is carried out by considering different criteria such as that of Smith-Watson-Topper and of Fatemi-Socie. The present paper focuses on a specific structural component related to a quarter-turn heavy-duty valve actuator, called scotch yoke, commonly used in many application sectors such as oil & gas, power and chemical industries. The fatigue assessment of the component is carried out by employing a full-model FE analysis, considering fillet-welded joints exposed to in-phase constant amplitude cyclic bending-torsion fatigue load with load ratio R=-1, with applied maximum load according to EN 15714-3, which is the standard in the valve actuator sector. The elastic stress/strain field extracted from the FE model is used to perform the fatigue assessment of the fillet-welded joints, where the potential fatigue crack initiation points (weld toe and weld root) are described by adopting an effective radius at the weld notches.