Event Abstract Back to Event Sleep Induced Mu-Beta Rhythm Modulations in Motor Sequence Memory Consolidation Genevieve Albouy1*, Francoise Lecaignard2, Jeremie Mattout1, Claude Delpuech3, Pierre-Emmanuel Aguera1, Pierre-Herve Luppi4, Alain Nicolas4, Pierre Maquet5 and Olivier Bertrand1 1 University of Lyon, INSERM U821, France 2 CERMEP, Imagerie du Vivant, MEG Dept, France 3 CERMEP/INSERM U821, France 4 University of Lyon, CNRS UMR 5167, France 5 University of Liège, Cyclotron Research Centre, Belgium The neural correlates of motor sequence memory consolidation have already been studied but its electrophysiological correlates remain scarcely described. The aim of the present study was to determine the influence of sleep on the electrophysiological correlates of motor sequence memory consolidation, using magnetoencephalography (275-channel MEG). Subjects were scanned during training on a sequential finger tapping task (FTT). After training, they were divided in two groups whether they slept (N=15) or were totally sleep-deprived (N=16) on the following night. Three days after training, a second MEG session consisted in the retest on the FTT for the two groups. Using ELAN software package (INSERM U821, Lyon), both sessions were analysed in the time frequency (TF) domain, during practice and inter-tapping rest periods. Subsequent group source reconstruction analyses of significant effects during training were performed using SPM8 (Wellcome Department of Imaging Neuroscience, London, UK). TF analyses on the training session show a progressive desynchronization, i.e. a power decrease, of mu (10-15 Hz) and beta (20-25 Hz) oscillations over bilateral and medial central areas during practice of the learned sequence. The anatomical sources of this effect in the beta band were localised in bilateral sensorimotor cortices (pre- and post-central gyri). An overall sleep-dependent increase in the amplitude of mu-beta oscillations was observed over controlateral and medial central areas during both practice periods and inter-tapping rest periods following practice of the learned sequence. Interestingly, in sleepers, a beta power increase was observed specifically for the learned sequence during inter-tapping rest periods. In contrast, no changes in mu-beta oscillatory activity were observed after sleep deprivation. These results provide the first electrophysiological evidence of sleep-dependent reorganisation of motor cortex activity during procedural sequence memory consolidation. Conference: Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010. Presentation Type: Poster Presentation Topic: Neurocognition and Functional Connectivity Citation: Albouy G, Lecaignard F, Mattout J, Delpuech C, Aguera P, Luppi P, Nicolas A, Maquet P and Bertrand O (2010). Sleep Induced Mu-Beta Rhythm Modulations in Motor Sequence Memory Consolidation. Front. Neurosci. Conference Abstract: Biomag 2010 - 17th International Conference on Biomagnetism . doi: 10.3389/conf.fnins.2010.06.00393 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 08 Apr 2010; Published Online: 08 Apr 2010. * Correspondence: Genevieve Albouy, University of Lyon, INSERM U821, Bron, France, gmalbouy@club-internet.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Genevieve Albouy Francoise Lecaignard Jeremie Mattout Claude Delpuech Pierre-Emmanuel Aguera Pierre-Herve Luppi Alain Nicolas Pierre Maquet Olivier Bertrand Google Genevieve Albouy Francoise Lecaignard Jeremie Mattout Claude Delpuech Pierre-Emmanuel Aguera Pierre-Herve Luppi Alain Nicolas Pierre Maquet Olivier Bertrand Google Scholar Genevieve Albouy Francoise Lecaignard Jeremie Mattout Claude Delpuech Pierre-Emmanuel Aguera Pierre-Herve Luppi Alain Nicolas Pierre Maquet Olivier Bertrand PubMed Genevieve Albouy Francoise Lecaignard Jeremie Mattout Claude Delpuech Pierre-Emmanuel Aguera Pierre-Herve Luppi Alain Nicolas Pierre Maquet Olivier Bertrand Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.