Consistent Effect Research Articles

Trends in waking salivary alpha-amylase levels following healing lucid dreams.

Salivary alpha-amylase (sAA) is considered a marker of autonomic nervous system activity in stress research, and atypical waking sAA responses have been reported for traumatized individuals. Lucid dreams, characterized by a dreamer's awareness of their dream state while remaining asleep, have shown promising preliminary evidence of their potential to enhance mental health. This study's objective was to evaluate sAA in relation to healing lucid dreams. Participants experiencing PTSD symptoms attended a six-day workshop delivered via live video designed to teach techniques for transforming trauma through dreamwork and dream lucidity. Participants (n = 20) collected saliva samples each morning, immediately upon awakening (Time 1) and 30 min afterward (Time 2). sAA levels were determined by enzymatic assay, and the waking sAA slope was calculated as the difference of Time 2 minus Time 1. Participants completed dream reports each morning, with a dream classified as a 'healing lucid dream' when they reported attaining lucidity and remembered their intention to manifest a healing experience within the dreamscape. Of eight participants experiencing healing lucid dreams, four were able to provide usable saliva samples. Statistical tests on these four participants were not significant because of low power. However, nonsignificant positive associations were observed between experiencing more healing lucid dreams and increased waking sAA slope. The results did not reveal a consistent effect of healing lucid dreams on waking sAA slope. Identifying meaningful patterns in this relationship will require larger samples and more stringent control over saliva collection procedures in future studies.

An Age Study on Adopting Adult Hypertension Standards in Chinese Mature Children and Adolescents

Abstract OBJECTIVE To determine age cutoff values for the use of adult hypertension diagnostic criteria in children and adolescents, and to evaluate the consistency and screening effect of the adult criteria with the sex-, age-, and height-specific blood pressure reference (gold standard). METHODS A literature review and expert consultation were used to determine age cutoff value. In children above the cutoff age, the China Child and Adolescent Cardiovascular Health Survey was used to compare the consistency and screening effect between the adult criteria and the gold standard, and Beijing Blood Pressure Study was used to evaluate the predictive value of childhood hypertension diagnosed by adult criteria and gold criteria for hypertension and subclinical cardiovascular damage in adulthood. RESULTS (i) Adult criteria can be used to evaluate hypertension for children aged 16 and above. (ii) Among adolescents aged 16 and above, the adult standard has lower sensitivity (21.1%) but higher specificity (100.0%) compared with the gold standard, with a consensus rate of over 80.0%. And the predictive ability of the adult standard for subclinical cardiovascular health damage in adulthood is also similar to that of the gold standard. CONCLUSIONS Sixteen years can be used as a cutoff point for the adoption of adult hypertension diagnostic criteria in children, and it has a certain degree of simplicity and accuracy.

Consistent effects of independent domestication events on the plant microbiota

The effect of plant domestication on plant-microbe interactions remains difficult to prove. In this study, we provide evidence of a domestication effect on the composition and abundance of the plant microbiota. We focused on the genus Phaseolus, which underwent four independent domestication events within two species (P.vulgaris and P.lunatus), providing multiple replicates of a process spanning thousands of years.We targeted Phaseolus seeds to identify a link between domesticated traits and bacterial community composition as Phaseolus seeds have been subject to large and consistent phenotypic changes during these independent domestication events. The seed bacterial communities of representative plant accessions from subpopulations descended from each domestication event were analyzed under controlled and field conditions. The results showed that independent domestication events led to similar seed bacterial community signatures in independently domesticated plant populations, which could be partially explained by selection for common domesticated plant phenotypes. Our results therefore provide evidence of a consistent effect of plant domestication on seed microbial community composition and abundance and offer avenues for applying knowledge of the impact of plant domestication on the plant microbiota to improve microbial applications in agriculture.

Suspension of Sonchus arvensis L Leaves Ethanolic Extract Affects Blood Creatinine and Urea Levels in Streptozotocin-Induced Wistar Male Rats

The study focused on analyzing the secondary metabolites present in the ethanol extract of Sonchus arvensis L. leaves (SALEE) and their impact on creatinine and urea levels when administered in suspension form at different doses. Phytochemical screening of SALEE identified alkaloids, flavonoids, phenols, saponins, and tannins. In the experiment, twenty-five white male rats were divided into five groups: a healthy control group (Group I), a negative control group (Group II), and three test groups (Groups III, IV, and V) receiving SALEE at doses of 200, 300, and 400 mg/kg BW, respectively. After inducing diabetes with streptozotocin and a 21-day follow-up period, creatinine and urea levels were assessed. The results demonstrated that SALEE administration significantly reduced creatinine levels and increased urea levels. Notably, the 200 mg/kg BW dose of SALEE exhibited a consistent and long-term effect. It was observed that blood urea levels fluctuated even in healthy and negative control groups during the 21-day observation period. In the group receiving the highest dose of SALEE (400 mg/kg BW), blood urea levels increased significantly on days 14 and 21, indicating a potential increase in the rats' appetite rather than renal function failure. Overall, the findings suggest that SALEE has promising potential to regulate creatinine and urea levels in the blood of individuals with diabetes, highlighting its potential for therapeutic and supplemental use.

Methane uptake responses to extreme droughts regulated by seasonal timing and plant composition

Increasingly frequent and severe droughts are occurring in multiple seasons of a year in many dryland ecosystems, with unknown impacts on the role of drylands in cycling of methane (CH4), a potent greenhouse gas. In particular, there is limited understanding of how drought occurring at different times within the growing season regulates biological CH4 uptake, and how these responses are mediated by plant community composition. Here, we quantify how drought timing and plant community composition regulate CH4 uptake in a semiarid grassland. We employ a field experiment in which droughts were imposed in early, middle, or late growing season in three different communities (two graminoids, two shrubs and their mixture), respectively. All three droughts increased CH4 uptake, but the effect size and pathway varied with seasonal timing. Early and middle drought increased CH4 uptake through increasing both soil pomA abundance and diffusivity resulting from reduced soil water content (SWC), while late drought increased CH4 uptake only by reducing SWC. Overall, early drought had the least positive effects on CH4 uptake because it excluded the least precipitation and therefore had smaller impacts on SWC. Besides, plant composition did not affect CH4 uptake under normal environment but regulated CH4 uptake in response to droughts due to different response of plant composition to droughts. Early and middle drought had larger positive effects on CH4 uptake in shrub communities than the other two communities, consistent with larger reductions in SWC and larger increases in pomA abundance, respectively. In contrast, late drought had consistent effects on CH4 uptake across three communities. Our results suggest that the magnitude and pathways of extreme drought effects on CH4 uptake are strongly co-regulated by seasonal timing and plant composition.

The Effect of Diet Consistency on the Craniofacial Morphology: A review Article.

Mastication is a chewing route, that implicates a group of muscles that are responsible for moving the mandible condyle in the temporomandibular joint (TMJ) to chore food between the teeth in the maxillary and mandibular arches (1) .Regarding the growth of the craniofacial system (CFS),there are an agreement which is strongminded via genetic and ecological aspects (2) . Masticatory forces considered as one of the chief environmental incentives that produce craniofacial difference amongst modern humans. New researeches on a broad variety of creatures, counting those having retro-gnathic post canine teeth, expect that retorts to the force of mastication that determined the superior in the occlusal plane (3) . The effect of masticatory stroke induced by the muscles of the mastication on the development of the morphology of craniofacial portion, has established significant attention in the recent oral invistigations (4) . Meanwhile the skeletal of the CFS adapts to the applied loads by bone remodeling in order to get the optimum formula to resist loads according to Wollf ’s law (5) . CFS has been assumed that it formula is mainly resolute by loading induced by mucsles of mastication. This has been reinforced by numerous clinical and experimental readings (6-9) . Investigational studies displayed that the reduced stresses induced by function on the animals mandibles, whose nourished a lenient diet outcomes in organizational variations in their masticatory systems (10) , in addition to morphological modifications of the lower jaw, like diminished of the alveolar bone size (11, 12) .Diet could be considered as a element of masticatory magnitude. Recent humans in developed countries eat an additional treated and softer diet rather than old humans. The change from hard to soft nourishment has been join by reduce in mandibular dimension and the growth of the alveolar bone, along with enlarged occurrence of malocclusion (1,5,7).

Effect of Acute Vasodilator Testing Using Oxygen in Pulmonary Hypertension Due to Left Heart Disease.

Pulmonary vasodilators, including oxygen, have not shown consistent beneficial effects on pulmonary hypertension due to valvular heart disease (PH-VHD). Therefore, the study aimed to assess the effect of 100% fractional inspiration of oxygen (FiO2) on pulmonary and systemic hemodynamics in patients with combined pre- and post-capillary pulmonary hypertension (CpcPH) and isolated post-capillary pulmonary hypertension (IpcPH) due to PH-VHD. This prospective study was conducted among patients with PH-VHD undergoing mitral or aortic valve replacement or repair. The study was conducted after induction of anesthesia and pulmonary artery catheterization. Cardiac output was obtained using thermodilution and all direct, and derived hemodynamic variables were obtained at 30% and 100% FiO2. The patients were stratified a priori into responders {(≥10mmHg fall in mean pulmonary artery pressure (MPAP)} and non-responders. Fifty-seven patients completed the acute vasodilator test. The mean age and body mass index of the study population was 41.8 ± 14.1years and 21.4 ± 4.6kg/m2, respectively. There was a significant decrease in MPAP (40.77 ± 12.07mmHg vs 36.74 ± 13.3mmHg; P < .001) and pulmonary vascular resistance (PVR) {(median; Interquartile range (IQR); 388; 371 vs 323; 362dynes sec.cm-5; P < .001) at 100% FiO2. Transpulmonary gradient (TPG) and diastolic pulmonary gradient (DPG) also decreased significantly (P < .001 and P < .001). Cardiac output did not change significantly. The magnitude of decrease in MPAP, PVR, TPG, DPG, and pulmonary artery compliance (PAC) between CpcPH and IpcPH was comparable. Responders did not show a significantly greater fall in MPAP, PVR, TPG, DPG, and PAC after surgery. Hyperoxia may lead to reduction in MPAP and PVR in both hemodynamic phenotypes of PH-VHD. A larger sample size is required to support or refute the findings of this study.

Ayahuasca and its major component harmine promote antinociceptive effects in mouse models of acute and chronic pain

Ethnopharmacological relevanceAyahuasca (AYA) is a psychedelic brew used in religious ceremonies. It is broadly used as a sacred medicine for treating several ailments, including pain of various origins. Aim of the studyTo investigate the antinociceptive effects of AYA and its mechanisms in preclinical models of acute and chronic pain in mice, in particular during experimental neuropathy. Materials and methodsThe antinociceptive effects of AYA administered orally were assessed in the following models of pain: formalin test, Complete Freund's Adjuvant (CFA)-induced inflammation, tail flick test, and partial sciatic nerve ligation model of neuropathic pain. Antagonism assays and Fos immunohistochemistry in the brain were performed. AYA-induced toxicity was investigated. AYA was chemically characterized. The antinociceptive effect of harmine, the major component present in AYA, was investigated. ResultsAYA (24–3000 μL/kg) dose-dependently reduced formalin-induced pain-like behaviors and CFA-induced mechanical allodynia but did not affect CFA-induced paw edema or tail flick latency. During experimental neuropathy, single treatments with AYA (24–3000 μL/kg) reduced mechanical allodynia; daily treatments once or twice a day for 14 days promoted consistent and sustained antinociception. The antinociceptive effect of AYA (600 μL/kg) was reverted by bicuculline (1 mg/kg) and methysergide (5 mg/kg), but not by naloxone (5 mg/kg), phaclofen (2 mg/kg), and rimonabant (10 mg/kg), suggesting the roles of GABAA and serotonergic receptors. AYA increased Fos expression in the ventrolateral periaqueductal gray and nucleus raphe magnus after 1 h, but not after 6 h or 14 days of daily treatments. AYA (600 μL/kg) twice a day for 14 days did not alter mice's motor function, spontaneous locomotion, body weight, food and water intake, hematological, biochemical, and histopathological parameters. Harmine (3.5 mg/kg) promoted consistent antinociception during experimental neuropathy. ConclusionsAYA promotes consistent antinociceptive effects in different mouse models of pain without inducing detectable toxic effects. Harmine is at least partially accountable for the antinociceptive properties of AYA.

QTL epistasis plays a role of homeostasis on heading date in rice

If there was no gene interaction, the gene aggregation effect would increase infinitely with the increase of gene number. Epistasis avoids the endless accumulation of gene effects, playing a role of homeostasis. To confirm the role, QTL epistases were analyzed by four single-segment substitution lines with heading date QTLs in this paper. We found that QTLs of three positive effects and one negative effect generated 62.5% negative dual QTL epistatic effects and 57.7% positive triple QTL epistatic effects, forming the relationship “positive QTLs-negative one order interactions-positive two order interactions”. In this way, the aggregation effect of QTLs was partially neutralized by the opposite epistatic effect sum. There also were two exceptions, QTL OsMADS50 and gene Hd3a-2 were always with consistent effect directions with their epistases, implying they could be employed in pyramiding breeding with different objectives. This study elucidated the mechanism of epistatic interactions among four QTLs and provided valuable genetic resources for improving heading date in rice.

Acute and persistent effects of oral glutamine supplementation on growth, cellular proliferation, and tight junction protein transcript abundance in jejunal tissue of low and normal birthweight pre-weaning piglets.

Breeding for higher fertility has resulted in a higher number of low birthweight (LBW) piglets. It has been shown that LBW piglets grow slower than normal birthweight (NBW) littermates. Differences in growth performance have been associated with impaired small intestinal development. In suckling and weaning piglets, glutamine (Gln) supplementation has been associated with improved growth and intestinal development. This study was designed to examine the effects of oral Gln supplementation on growth and small intestinal parameters in LBW and NBW suckling piglets. At birth (day 0), a total of 72 LBW (1.10 ± 0.06 kg) and 72 NBW (1.51 ± 0.06) male piglets were selected. At day 1, litters were standardized to 12 piglets, and experimental piglets supplemented daily with either Gln (1 g/kg BW) or isonitrogenous amounts of Alanine (Ala) as control (1.22 g/kg BW) until day 12. Creep feed was offered from day 14 onward. Subgroups of piglets were euthanized at days 5, 12, and 26 for the analyses of jejunal morphometry, cellular proliferation, glutathione concentration and transcript abundance of tight junction proteins. From age day 11 to 21, Gln supplemented LBW (LBW-Gln) piglets were heavier than Ala supplemented LBW (LBW-Ala) littermates (P = 0.034), while NBW piglets were heavier until age day 26 compared to LBW littermates. Villus height was higher in LBW-Gln compared to LBW-Ala on age day 12 (P = 0.031). Sporadic differences among supplementation and birthweight groups were detected for jejunal cellular proliferation, cellular population and glutathione concentration, whereas age was the most dominant factor. These results show that Gln supplementation improved the growth of LBW piglets compared to LBW-Ala beyond the termination of Gln supplementation, but this was not associated with consistent effects on selected parameters of jejunal development.

Mitotane-Driven Apoptosis in Adrenocortical Carcinoma: A Molecular Insight

Objective: This study aimed to investigate the responses of antiapoptotic BCL-2 and proapoptotic BID genes to Mitotane and other chemotherapy drugs in Adrenocortical Carcinoma (ACC) cells. The objective was to understand the impact of these drugs on apoptosis-related genes in ACC, shedding light on potential treatment pathways. Materials and Methods: The study involved the use of ACC cells to assess gene expressions in response to Mitotane, Etoposide, and Cisplatin treatment. Gene expression levels of BCL-2 and BID were measured after drug exposure, providing insights into the modulation of apoptosis pathways by Rt-qPCR. Results: The results demonstrated that Mitotane notably affected the expression of the proapoptotic BID gene in ACC cells, promoting apoptosis. In contrast, Etoposide and Cisplatin exhibited less consistent effects, with Cisplatin increasing the antiapoptotic BCL-2 gene and decreasing the proapoptotic BID gene compared to Mitotane. Conclusion: This study revealed that Mitotane, as well as other chemotherapy drugs, influences the expression of key apoptosis-related genes in ACC cells. Mitotane showed a significant effect on the proapoptotic BID gene, indicating its potential as a treatment option for ACC. The findings suggest that Mitotane impacts ACC cells through multiple apoptosis pathways, highlighting its significance in ACC therapy.

Pharmacological interventions for reducing the incidence of myoclonus in patients receiving etomidate for induction of general anesthesia: an umbrella review.

The objective of this umbrella review was to examine various pharmacologic interventions for their potential to reduce etomidate-induced myoclonus. A secondary objective was to compare the relative effectiveness of those medications in reducing the incidence of myoclonus when etomidate is utilized for the induction of general anesthesia. Etomidate is the drug of choice when inducing general anesthesia in hemodynamically unstable patients. However, its use is limited among the general surgical population due to its ability to cause adrenal suppression, vomiting, and myoclonus. Myoclonus can lead to damage of muscle fibers, myalgias, and patient discomfort, and can also be detrimental in patients with low cardiac reserve. Several systematic reviews have reported on the effectiveness of various intravenous medications in reducing mild, moderate, and severe myoclonus; however, a more thorough examination of their influence was lacking. This review included systematic reviews and meta-analyses of randomized controlled trials involving the use of pharmacologic interventions to reduce etomidate-induced myoclonus. Reviews in English and conducted after 1965 were considered for inclusion. A comprehensive search of 11 databases was conducted to identify published and unpublished reviews up to March 2022. Critical appraisal was conducted by 2 independent reviewers using the standardized JBI appraisal tool. Quantitative findings were summarized according to the dose, timing of administration, and relative risk using a data matrix, and were synthesized in tabular format with supporting narrative text. Results were organized by severity of myoclonus (overall, mild, moderate, and severe) and by type of intervention. Eight systematic reviews were included in this umbrella review, which included 48 relevant studies, after removal of duplicates (3909 participants included in the primary studies). Five of the systematic reviews examined the effectiveness of various types of opioids in the prevention of myoclonus, and 3 systematic reviews examined the effectiveness of non-opioid interventions, such as lidocaine, midazolam, and dexmedetomidine. Seven reviews searched at least 4 databases for pertinent studies and specifically indicated that blinded reviewers appraised the articles. All reviews used a published and validated appraisal instrument. The overall quality of all included reviews was judged to be moderate to high. The absolute risk reduction indicating the effectiveness of the prophylactic medications ranged from 47% to 81% for mild, 52% to 92% for moderate, and 61% to 96% for severe myoclonus. Opioids demonstrated the most consistent and substantial effect on the reduction in myoclonus. All pharmacologic interventions identified in this review demonstrated a statistically significant reduction in the incidence of myoclonus. Future studies and reviews should focus on elucidating the particular dose range and timing that is most effective. Anesthesia providers should consider a pre-treatment dose of one of the medications described in this umbrella review as a means to reduce myoclonus and the untoward effects of that condition.

Comparison of the inward leakage rate between N95 filtering facepiece respirators and modified surgical masks during the COVID-19 pandemic.

Owing to shortage of surgical and N95 filtering facepiece respirators (FFRs) during the COVID-2019 pandemic, various masks were developed to prevent infection. This study aimed to examine the inward leakage rate (ILR) of sealed face masks and modified surgical masks using a quantitative fit test and compared it with the ILR of unmodified N95 FFRs. We conducted paired comparisons of ILRs of bent nose-fit wire masks, double masks, and N95 FFRs from October to December 2021. To measure the protective effectiveness of masks, participants wore masks, and the number of particles outside and inside the mask were measured. The ILR was based on the percentage of particles entering the mask using a fit tester. We enrolled 54 participants (20 men and 34 women) in this study. The median ILR for surgical masks without and with a W-shaped bend in the nose-fit wire were 96.44% and 50.82%, respectively. The nose-fit wire adjustment reduced the ILR of surgical masks by a mean of 28.57%, which was significantly lower than the ILR without adjustment (P < 0.001). For double masks, with surgical or polyurethane masks on top of the W-shaped mask, the ILR did not differ significantly from that of N95. Although the filtration performance of double surgical masks matched that of N95 masks, their ILR was notably higher, indicating that double masks do not provide equivalent protection. Wearing N95 masks alone is effective in many cases. However, surgical mask modifications do not guarantee consistent effectiveness. Properly selected, sealed masks with a good fit overcome leakage, emphasizing their crucial role. Without evidence, mask-wearing may lead to unexpected infections. Education based on quantitative data is crucial for preventing adverse outcomes.

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Semantic search is the process of retrieving relevant information from a large corpus of texts based on the meaning and context of the query. This paper is introduced in order to explore the use of large language models for semantic search of Quranic texts. The Quran, which is the central religious text of Islam, contains rich and complex linguistic and semantic features that pose challenges for traditional keyword-based search methods. This study investigates a semantic search approach utilizing. Large Language Models (LLM) embedding and assess the performance of LLM embedding in comparison to a baseline embedding-based search method using a set of queries that represent different semantic search levels. In addition, this study will also discuss the limitations and implications of using large language models for semantic search of Quranic texts and suggest directions for future research. A significant finding in this study is the consistent effectiveness of the LLM embedding across varying semantic complexities. This suggests that embedding using LLMs can capture deep semantic connections effectively. On the other hand, as a second finding, the state-of-the-art transformer, AraT5, outperforms LLM embeddings in low-level semantic searches, indicating potential for further LLM fine-tuning on Arabic text corpora

Latitudinal richness patterns in a temperate forest region: disentangling the effects of evenness, density and aggregation

It is well known that species diversity declines with increasing latitude. However, the underlying causes and mechanisms remain ambiguous due to effects of scale, the shape of the species abundance distributions (SAD), the total number of individuals (N) and the spatial aggregation of individuals (AGG). In this study, we examine how SAD, N and AGG contribute to the latitudinal richness gradient. Our study is based on a dataset that includes tree, shrub, and herbaceous plants collected from 445 permanent forest plots scattered across an expansive temperate forest region, covering latitudes from 39.71°N to 53.37°N. We compared multiple diversity patterns along the latitude between three life forms (trees, shrubs and herbs) and analyzed the effects of SAD, N and AGG on the latitudinal richness gradient. Our results reveal a general decline in most diversity measures along the latitudinal gradient, with the exception of herbaceous plants. Furthermore, we observed consistent effects of AGG and SAD on the latitudinal richness gradient across all three life forms. Specifically, a decreasing species evenness with increasing latitude led to a reduction in richness, while the simultaneous decrease in spatial aggregation, along with the effects of total number of individuals, collectively contributed to the decline in species richness with increasing latitude. However, the effect of total abundance varies among life forms, with a negligible effect on tree richness, a negative effect on shrub richness, and a significantly positive effect on herbaceous richness. These findings highlight the dependency of the “more-individuals hypothesis” on specific life forms. Our study shows that decomposing species richness into community structure components provides an opportunity for linking specific processes to latitudinal diversity gradients.

Field-of-View IoU for Object Detection in 360° Images.

360° cameras have gained popularity over the last few years. In this paper, we propose two fundamental techniques-Field-of-View IoU (FoV-IoU) and 360Augmentation for object detection in 360° images. Although most object detection neural networks designed for perspective images are applicable to 360° images in equirectangular projection (ERP) format, their performance deteriorates owing to the distortion in ERP images. Our method can be readily integrated with existing perspective object detectors and significantly improves the performance. The FoV-IoU computes the intersection-over-union of two Field-of-View bounding boxes in a spherical image which could be used for training, inference, and evaluation while 360Augmentation is a data augmentation technique specific to 360° object detection task which randomly rotates a spherical image and solves the bias due to the sphere-to-plane projection. We conduct extensive experiments on the 360° indoor dataset with different types of perspective object detectors and show the consistent effectiveness of our method.

THE ROLE OF MICRONIZED PROGESTERONE IN THE PREVENTION OF PRETERM BIRTH IN WOMEN WITH CERVICAL LENGTH GREATER THAN 2.5 CM

Preterm birth, defined as the delivery of a baby before 37 weeks of gestation, remains a significant public health concern globally due to its association with adverse neonatal outcomes and long-term health implications. The study's main objective is to find the role of Micronized progesterone in preventing preterm birth in women with cervical length greater than 2.5 cm. This prospective study was conducted in DHQ Teaching Hospital Gujranwala in 2023. Data was collected from 120 female patients. The study population comprises pregnant women with a singleton gestation, cervical length greater than 2.5 cm, and no history of preterm birth. Informed consent is obtained from all participants, and ethical approval is secured from relevant institutional review boards. Micronized progesterone demonstrated a 5% preterm birth rate compared to 10% in the control group (p=0.03). Adherence was high (92%), and adverse events were mild. Birth weight increased in the intervention group. Subgroup analysis revealed consistent preventive effects across various cervical length strata. It is concluded that micronized progesterone supplementation among women with cervical length &gt; 2.5 cm shows promise in reducing preterm birth rates. The safety profile and adherence support its feasibility in routine prenatal care.

Multi-dimensional unobserved heterogeneities: Modeling likelihood of speeding behaviors in different patterns for taxi speeders with mixed distributions, multivariate errors, and jointly correlated random parameters

Speeding behaviors can be classified into different patterns according to both speeding-range and speeding-distance. Among the speeding patterns, some are more frequently observed in specific traffic scenarios, implying that the likelihood of speeding behaviors may vary across the speeding patterns due to the inconsistent impact of temporal, road, environmental, and other traffic factors. Additionally, the trigger of speeding is a complex process so the researchers may not have access to all the critical information associated with the speeding behaviors. This issue may bring about not only independent heterogeneity but also multi-dimensional heterogeneities that are mutually correlated when modeling speeding behaviors by patterns. However, the joint solution to the above challenges is rarely seen in past studies. To fill the knowledge gaps, this study uses taxi GPS trajectories to extract speeding behaviors and classify them into four patterns. The speeder’s percent of speeding distance for each speeding pattern is respectively measured to represent the likelihood of speeding behaviors by patterns. Afterwards, we compare the data-fitting between the models combined with different beta-gamma mixture distributions and a multivariate Gaussian error in modeling the four patterns of speeding likelihood. The combination with the best fitness is used to incorporate jointly correlated random parameters. The results show that the model with beta-gamma-gamma-gamma mixed distributions performs better than other combinations. The model with jointly correlated random parameters outperforms models with other random parameters. The factor analysis reveals that percent of driving at night, percent of driving on roads with a low-speed limit (≤30 km/h), average delays in junctions along the trips, and hourly income have consistent effects on the likelihood of speeding behaviors in all patterns, while the effects of the remaining factors are inconsistent across the speeding patterns. Furthermore, the heterogeneity unveiled by the model parameters is discussed. The study highlights the necessity of considering mixed distributions and multi-dimensional heterogeneities in modeling speeding likelihood by different patterns.

The Punisher's Dilemma: Domestic Opposition and Foreign Policy Crises

Abstract Existing work on the democratic accountability of foreign policy suggests that when an incumbent incurs foreign policy losses, including but not limited to standing down in a crisis, making costly compromises, or accepting defeat abroad, opposition politicians at home weigh criticizing the government with the national interest. But this work has largely been developed with a view to explaining oppositional behavior in consolidated democracies. I argue that while electorally competitive oppositions in weakly institutionalized regimes can and frequently do criticize elected incumbents for costly foreign policy reversals, they are less likely to do so if they believe this criticism may negatively affect democratic stability and potentially invite irregular leadership turnover, as this would prevent the opposition from coming into office. I find support for this hypothesis, which I term oppositional pragmatism, in a survey experiment on 430 political party workers affiliated with Pakistan's biggest political party and directionally consistent effects on a smaller but highly elite sample of 202 Pakistani legislators.

Carnosic Acid Shows Higher Neuroprotective Efficiency than Edaravone or Ebselen in In Vitro Models of Neuronal Cell Damage.

This study compared the neuroprotective efficacy of three antioxidants-the plant-derived carnosic acid (CA), and two synthetic free radical scavengers: edaravone (ED) and ebselen (EB)-in in vitro models of neuronal cell damage. Results showed that CA protected mouse primary neuronal cell cultures against hydrogen peroxide-induced damage more efficiently than ED or EB. The neuroprotective effects of CA were associated with attenuation of reactive oxygen species level and increased mitochondrial membrane potential but not with a reduction in caspase-3 activity. None of the tested substances was protective against glutamate or oxygen-glucose deprivation-evoked neuronal cell damage, and EB even increased the detrimental effects of these insults. Further experiments using the human neuroblastoma SH-SY5Y cells showed that CA but not ED or EB attenuated the cell damage induced by hydrogen peroxide and that the composition of culture medium is the critical factor in evaluating neuroprotective effects in this model. Our data indicate that the neuroprotective potential of CA, ED, and EB may be revealed in vitro only under specific conditions, with their rather narrow micromolar concentrations, relevant cellular model, type of toxic agent, and exposure time. Nevertheless, of the three compounds tested, CA displayed the most consistent neuroprotective effects.