Effects Of Misuse Research Articles

Antibiotic Effluence in the Atmosphere

Amoxicillin' ability to cure infectious diseases has since been one fundamental building block therapy. Nonetheless, rampant antimicrobial overuse that overuse often resulted in unintended consequences, necessitating sizable policy decisions to mitigate. Throughout this study, we look at two key types of bacterial resistance and misuse consequences. To begin, we look at how resistant bacteria spreads beyond centers of resistant strains toward the environment, paying special emphasis to probable conveyance channels. Finally, we discuss the effects of antibiotic poisoning on natural microbiomes, along with crustaceans and humans, irrespective of resistant strains. We close with a review of current geographical laws aimed at decreasing microbiological pollution's effects, as well as a list of areas where these regulations are now being developed.

Dual-Use Quickscan: A Web-Based Tool to Assess the Dual-Use Potential of Life Science Research.

Research on pathogenic organisms is crucial for medical, biological and agricultural developments. However, biological agents as well as associated knowledge and techniques, can also be misused, for example for the development of biological weapons. Potential malicious use of well-intended research, referred to as “dual-use research”, poses a threat to public health and the environment. There are various international resources providing frameworks to assess dual-use potential of the research concerned. However, concrete instructions for researchers on how to perform a dual-use risk assessment is largely lacking. The international need for practical dual-use monitoring and risk assessment instructions, in addition to the need to raise awareness among scientists about potential dual-use aspects of their research has been identified over the last years by the Netherlands Biosecurity Office, through consulting national and international biorisk stakeholders. We identified that Biorisk Management Advisors and researchers need a practical tool to facilitate a dual-use assessment on their specific research. Therefore, the Netherlands Biosecurity Office developed a web-based Dual-Use Quickscan (www.dualusequickscan.com), that can be used periodically by researchers working with microorganisms to assess potential dual-use risks of their research by answering a set of fifteen yes/no questions. The questions for the tool were extracted from existing international open resources, and categorized into three themes: characteristics of the biological agent, knowledge and technology about the biological agent, and consequences of misuse. The results of the Quickscan provide the researcher with an indication of the dual-use potential of the research and can be used as a basis for further discussions with a Biorisk Management Advisor. The Dual-Use Quickscan can be embedded in a broader system of biosafety and biosecurity that includes dual-use monitoring and awareness within organizations. Increased international attention to examine pathogens with pandemic potential has been enhanced by the current COVID-19 pandemic, hence monitoring of dual-use potential urgently needs to be encouraged.

Stimulant Usage by Medical Students for Cognitive Enhancement: A Systematic Review.

Stimulants have been used throughout human history for a variety of reasons. High levels of stress and the demanding nature of medical school make their usage among medical students particularly common. The most prevalent stimulant used by students is coffee, followed by tea and other forms of caffeine like sugary energy drinks. In addition, amphetamine-based medications for treating attention deficit hyperactivity disorder (ADHD) have been increasing in popularity, which many students take illicitly. Students report taking various forms of stimulants to promote cognitive enhancement, prolong wakefulness and retain focus for long periods of time. Moderate doses of caffeine and amphetamines would lead to enhanced alertness and concentration. However, large increases in dosage or frequency would lead to an increased risk of toxicity and adverse effects. The positive outcomes from stimulant consumption are often overshadowed by the negative side effects and incorrect dosage. Thus, it appears that usage of stimulants should be limited, in favor of a more sustainable approach to cognitive enhancement.This review analyzes the use of stimulants among the medical student community, consequences of misuse and discussed the healthy and organic approaches to lessen the stress and improve academic performance. This article also discusses the mechanisms of action, acceptable doses, additives, ingredients of stimulants commonly used by medical students for cognitive enhancement and the implications of long-term use as the stress of practicing medicine extends well beyond the medical school years.

Adolescents’ awareness about prescription opioid misuse and preferences for educational interventions

ObjectivesThis study explored adolescents’ awareness about prescription opioid misuse, sources of medication information, and educational preferences. DesignAn online survey explored adolescents’ understanding and perceptions of prescription opioids and opioid misuse and safety, medication information sources, and educational preferences. Setting and ParticipantsEligible participants included students from 3 Wisconsin high schools who could speak and understand English. Participants were recruited through “backpack mail” and completed surveys online at school. Outcome MeasursSurvey responses were compared across demographic information of the study participants. Binary response items were compared across demographic strata by Fisher exact tests, and Likert responses were analyzed by Kruskal-Wallis tests. ResultsA total of 190 students (53% female, 53% white, 32% Hispanic) were surveyed. Most (83.5%) considered using someone else’s opioid medication to be misuse, 85.2% identified using opioids at a higher dose or frequency than prescribed as misuse, and 67.6% considered using an opioid prescription after its expiration date to be misuse. Approximately 90% of students perceived that opioid misuse causes some, quite a bit, or a great deal of harm to a person’s physical and mental health and school ability. Many students were able to correctly identify examples and consequences of misuse, however 24.7% believed that flushing opioids down the drain was dangerous. The most common source for finding information about opioids was Google or other search engines (67.6%), followed by talking with parents (56.7%), talking with a doctor or nurse (54.9%), and online videos (42.3%). ConclusionAdolescents have some opioid safety knowledge, but there is a clear opportunity to increase knowledge and understanding of risks. Adolescents could benefit from opioid safety education, particularly on safe storage and disposal, harms of misuse, and strategies for discouraging peer opioid misuse.

Risk and Protective Factors of Tramadol Abuse in the Gaza Strip: The Perspective of Tramadol Abusers and Psychiatrists

We sought to identify the perceptions of users and medical providers regarding the recreational use of tramadol in the Gaza Strip, a society that is affected by severe political and military violence. We conducted qualitative interviews with psychiatrists and tramadol users to identify their perceptions of the individual, community, and socio-political determinants of tramadol use, its effect on quality of life, and the challenges experienced in the recovery process. Thematic analysis was applied to the narratives of 26 interviewees; 13 psychiatrists (12 males, one female; age range = 32–58, mean age = 44.5, SD,=6.9; years of experience = 6–29, mean = 16.6, SD = 6.3), and 13 tramadol users (13 males; age range = 24–52, mean = 35.1, SD = 8.98). Three main themes emerged, namely, conditions contributing to the misuse of tramadol, challenges in recovering from tramadol misuse, and consequences of misuse on individuals and social networks. Participants stated that critical environmental and living conditions, such as unemployment, poverty, stress, health, and mental health-related determinants have led to the use of the opioid. Also, disrupted and weak social services that are unprepared to manage widespread substance use cannot safeguard and assist tramadol users. We conceptualize the data in terms of a socio-ecological model drawing on individual, social and cultural determinants of tramadol use, and discuss the clinical and research implications of the findings.

Feasibility study of prospective audit, intervention and feedback as an antimicrobial stewardship strategy at the Lagos University Teaching Hospital

Antimicrobial resistance, a global problem, is mostly a consequence of misuse or overuse of antimicrobials. This study sought to audit the compliance to hospital antimicrobial policy and determine the ability of medical students to carry out audits. This was a retrospective study to determine compliance with departmental policies in the preceding 2 months in the Children's Emergency Room (ChER) using a checklist. The primary outcome was to determine the rational use of antibiotics. The secondary outcomes were to determine whether the de-escalation of antibiotic, change from intravenous to oral or change in prescriptions were performed in line with culture results based on the departmental policy. The records of 450 children who attended ChER of Lagos University Teaching Hospital in January and February 2018 were retrieved for this study, of which 279 (62.0%) were prescribed antimicrobials. A suspected or confirmed diagnosis of infection was made in 214 (76.6%) of the patients, significantly highest in the infant age group (P = 0.03). Cultures were taken from 94 patients (33.7%), and although not statistically significant, cultures were mostly taken from neonatal patients aged <28 days (20/49, 40.8%). Applying the criteria, compliance with departmental guidelines was found in 111 (39.8%) of the cases. We found that the use of antimicrobials was judged unnecessary in 17.2% of the patients seen in ChER. There was a poor practice of collecting samples for culture before prescribing antibiotics. Prospective audit and feedback is feasible and it can be done with medical students who will report their findings to consultants and other doctors knowledgeable in principles of antimicrobial therapy.

Government Legislation in Response to the Opioid Epidemic.

Opioid misuse and abuse in the USA has evolved into an epidemic of tragic pain and suffering, resulting in the estimated death of over 64,000 people in 2016. Governmental regulation has escalated alongside growing awareness of the epidemic's severity, both on the state and federal levels. This article reviews the timeline of government interventions from the late 1990s to today, including the declaration of the opioid crisis as a national public health emergency and the resultant changes in funding and policy across myriad agencies. Aspects of the cultural climate that fuel the epidemic, and foundational change that may promote sustained success against it, are detailed within as well. As a consequence of misuse and abuse of opioids, governmental regulation has attempted to safeguard society, and clinicians should appreciate changes and expectations of prescribers.

A Single Amino Acid Residue at Transmembrane Domain 4 of the α Subunit Influences Carisoprodol Direct Gating Efficacy at GABAA Receptors.

The muscle relaxant carisoprodol has recently been controlled at the federal level as a Schedule IV drug due to its high abuse potential and consequences of misuse, such as withdrawal syndrome, delusions, seizures, and even death. Recent work has shown that carisoprodol can directly gate and allosterically modulate the type A GABA (GABAA) receptor. These actions are subunit-dependent; compared with other GABAA receptors, carisoprodol has nominal direct gating effects in α3β2γ2 receptors. Here, using site-directed mutagenesis and whole-cell patch-clamp electrophysiology in transiently transfected human embryonic kidney 293 cells, we examined the role of GABAA receptor α subunit transmembrane domain 4 (TM4) amino acids in direct gating and allosteric modulatory actions of carisoprodol. Mutation of α3 valine at position 440 to leucine (present in the equivalent position in the α1 subunit) significantly increased the direct gating effects of carisoprodol without affecting its allosteric modulatory effects. The corresponding reverse mutation, α1(L415V), decreased carisoprodol direct gating potency and efficacy. Analysis of a series of amino acid mutations at the 415 position demonstrated that amino acid volume correlated positively with carisoprodol efficacy, whereas polarity inversely correlated with carisoprodol efficacy. We conclude that α1(415) of TM4 is involved in the direct gating, but not allosteric modulatory, actions of carisoprodol. In addition, the orientation of alkyl or hydroxyl groups at this position influences direct gating effects. These findings support the likelihood that the direct gating and allosteric modulatory effects of carisoprodol are mediated via distinct binding sites.

Safety Concerns Surrounding Quinolone Use in Children

Fluoroquinolones are highly effective antibiotics with many desirable pharmacokinetic and pharmacodynamic properties including high bioavailability, large volume of distribution, and a broad spectrum of antimicrobial activity. Despite their attractive profile as anti-infective agents, their use in children is limited, primarily due to safety concerns. In this review we highlight the pharmacological properties of fluoroquinolones and describe their current use in pediatrics. In addition, we provide a comprehensive assessment of the safety data associated with fluoroquinolone use in children. Although permanent or destructive arthropathy remains a significant concern, currently available data demonstrate that arthralgia and arthropathy are relatively uncommon in children and resolve following cessation of fluoroquinolone exposure without resulting in long-term sequelae. The concern for safety and risk of adverse events associated with pediatric fluoroquinolone use is likely driving the limited prescribing of this drug class in pediatrics. However, in adults, fluoroquinolones are the most commonly prescribed broad-spectrum antibiotics, resulting in the development of drug-resistant bacteria that can be challenging to treat effectively. The consequence of misuse and overuse of fluoroquinolones leading to drug resistance is a greater, but frequently overlooked, safety concern that applies to both children and adults and one that should be considered at the point of prescribing.

Analysis of lifestyle and physical culture and sports of students

ARTICLE RETRACTED The article reviewed the importance and necessity of sport and physical education at the present stage. The article describes the trend of health deterioration of young people as the consequence of a wrong lifestyle, alcohol, tobacco products, narcotic drugs‘use. The reasons of disregard for the healthy lifestyle and the consequences of misuse of the daily routine are presented. The reasons of the emergence and sport development and its history, the analysis of sport nature and physical education in the modern society were also considered in this article. It is shown the necessity and importance of sports and physical education at the present stage of the society development. Some factors that prevent globalization and widespread dissemination of sport and physical culture were introduced. Possible ways of solving these problems were put forward, motivational sphere for the formation of the active position in the field of healthy lifestyle was proposed in the research.

The Pattern of Antibiotic Prescribing by Dental Practitioners in Zagreb, Croatia.

Bacterial resistance is considered a consequence of misuse or overuse of antibiotics. Dentistry significantly contributes to this increasing public health problem. The aim of this cross-sectional study was to examine the pattern of antibiotics prescribed by Croatian dentists in Zagreb area. Out of 220 Doctors of Dental Medicine (DMDs) from Zagreb 110 responded to survey. Prior to the research an ethical approval was obtained. Participants were directly contacted. The questionnaire consisted of two parts: general data on DMDs and the part concerning indications, duration, type and dosage of antibiotic therapy. Data were processed using MS Excel and SPSS for Windows, Version 17.0. Statistical significance was tested by Fisher's exact test, chi-square test, Mann-Whitney U test and Spearman's rank correlation at the level of statistical significance p<0.05. During the period of two months, the doctors prescribed antibiotics to 1,500 patients, 690 (46%) were men and 810 (54%) women. The most often prescribed antibiotics were penicillin (72.5% of patients), represented mostly by amoxicillin in combination with clavulanic acid (57.6%). The most common indication for the prescribed antibiotics was periapical or periodontal abscess (44%). Definite clinical indication (71.2%) was stated as the most common reason for antibiotic prescription. Antibiotic therapy usually lasted 7 days (62.9%). The doctors prescribed daily doses of antibiotics according to the instructions for the use of specific drugs. The examined subjects prescribe antibiotics according to the curriculum taught at the School of Dental Medicine for majority of types, doses and duration of the treatments, although antibiotics over-prescription in cases without medical indication was observed. The national guidelines on antibiotic regimens are required in order to reduce unnecessary antibiotic use.

Abstract 4260: Standardized decision support in next-generation sequencing (NGS) reports of somatic cancer variants

Abstract Introduction: Of hundreds to thousands of somatic mutations that exist in each cancer genome, a large number are unique and non-recurrent variants. Many such variants occur in tumor genes that have well-established biological and clinical relevance and are putative targets of molecular therapy, however, most variants are still of unknown significance. Prioritizing and reporting genetic variants identified via NGS technologies remains a major challenge. Methods: Based on a systematic framework for cancer variant annotation/prioritization, we propose a structured molecular pathology report using standardized terminology in order to best inform oncology clinical practice. In parallel with the variant interpretation pipeline, we developed a comprehensive knowledge database (Kdb) that integrates tumor types, genes, variants, response/resistance patterns to approved and experimental agents and PubMed identifiers. Results: As physicians rely heavily on limited subsets of data and frequently apply rules based on strength of evidence in the decision-making process, NGS results are presented in a very discrete manner, avoiding detailed descriptions of each genomic aberration. Reportable variants are grouped in three categories: (i) actionable, which support treatment recommendation, enrollment in clinical trials and/or have prognostic or diagnostic implications; (ii) biologically relevant but not clearly actionable, including novel variants lacking functional preclinical validation in known cancer genes; and (iii) variants of unknown significance. Predictive associations are reported according to tumor type and classified in a hierarchical way based on the strength of evidence: (i) late trials; (ii) early trials; (iii) case reports; and (iv) preclinical data being explored in clinical trials. In our internal Kdb, tumor types with the largest number of emerging predictive associations are acute leukemias, non-small cell lung cancer, brain tumors, melanoma, colorectal, ovarian and breast cancers, comprising more than 100 unique gene - drug interactions. Further interpretation of gene variants requires a team with strong background in cancer biology, careful evaluation of the published literature and ability to match a patient's tumor genotype to clinical trials in the context of multiple aberrations. Conclusions: With large amounts of data being generated as high throughput sequencing assays enter the clinical realm, there is a growing need to better communicate relevant findings in a timely manner while remaining cognizant of the potential consequences of misuse or overinterpretation of genomic information. The scientific knowledge on actionable events should be presented the report, so that physicians can make evidence-based decisions and patients may benefit from treatment with matched targeted agents. We hope that our experience in this process will help other institutions implement similar programs. Citation Format: Rodrigo Dienstmann, Fei Dong, Darrell Borger, Dora Dias Santagata, Leif W. Ellisen, Long P. Le, A. John Iafrate. Standardized decision support in next-generation sequencing (NGS) reports of somatic cancer variants. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4260. doi:10.1158/1538-7445.AM2014-4260

Substance Use, Misuse, and Abuse Among Older Adults: Implications for Clinical Mental Health Counselors

Researchers project a threefold increase in substance abuse, inclusive of alcohol, prescription, and illicit drugs, for adults aged 50 or older by 2020, when an estimated 5 million older adults will need treatment for substance abuse problems (Gfroerer, Penne, Pemberton, &amp; Folsom, 2003). This suggests a need for heightened awareness among clinical mental health counselors as they treat this population. This article (a) discusses the prevalence, vulnerabilities, and consequences of misuse and abuse of alcohol, prescription drugs, and illicit substances; (b) reviews age-specific counseling considerations and approaches to assessment, diagnosis, and intervention; and (c) calls for more attention to the subject in training and research.

Have you met your organization's computer usage policy?

PurposeThis paper aims to examine the effectiveness of computer usage policies in university settings.Design/methodology/approachStudents enrolled in business courses at three midwestern universities were divided, by class, into control and experimental groups. All subjects were asked to complete a survey regarding their awareness of university computer usage policies, consequences of misuse, and methods of policy distribution. The experimental group was exposed to sample computer usage policies. Two weeks later, all subjects were asked to complete the same survey again.FindingsResults suggest that most students have not read their university computer usage policies. However, the presence of a computer usage policy does influence students who have read those policies, but a single exposure is insufficient to influence all subjects.Research limitations/implicationsThe sample is limited to students from three universities.Practical implicationsWritten policy statements alone cannot serve as a cornerstone of security; multiple factors must be used to communicate the content of the deterrents.Originality/valueThis study notes that the existence of computer usage policies within a university (or organization) does not ensure that all users are familiar with the content of those policies and the penalties imposed for their violation. Providing a copy of computer usage policies to students (or employees) and verbally highlighting major points are not sufficient exposure to eliminate indifference about computer misuse.

Assessing the Megatons to Megawatts Program

Assessing the Megatons to Megawatts Program

Dealing with alcohol: indigenous usage in Australia, New Zealand and Canada

1. Introduction 2. What's the harm? 3. The broader context of alcohol use 4. Patterns of indigenous alcohol use 5. Explanations of indigenous alcohol use 6. The supply and promotion of alcohol to indigenous Australian communities 7. The consequences of misuse 8. What's being done? 9. Determining what works: program evaluation 10. Where to from here?

Early modeling of drinking behavior by Native American elementary school children playing drunk.

A report of games played by elementary school children on a Native American reservation in the United States illustrates how intoxicated adult behavior is perceived as funny. Only later does one develop an awareness that the consequences of misuse can be injury, illness, and death. Prevention messages targeted at elementary school children need to provide positive alternatives to the humor in drunkenness and may need to be culturally adapted. Examples of some culturally specific approaches are discussed.

Organizational Change and Development: The Consequences of Misuse

A major house‐building corporation in the United States employed an organizational change and development (OCD) strategy during the early 1970s to assist its transformation to a mega‐corporation. The outcome was the development of an autocratic, machiavellian, coercive management style. Initial financial success during a growth phase in the construction industry masked the deficiencies of the approach, which only became apparent during an economic slump. Provides a lesson for managers who ignore the participant needs of employees.

Reply to the Commentary by Dr. John C. Reed

The Commentary by Reed in Arctic 15:1 expresses opinions not shared by many of those who are interested in the future of the North. The quotation from Robertson, with which Reed agrees, is virtually a touch-stone for those engaged in the exploitative and extractive industries, whether in the arctic, temperate, or tropical zones. It is also, in my opinion, quite outdated. For example, it was formerly believed that the extractive industries were the mainstay of the non-military Alaskan economy, yet Buckley clearly showed that the financial return from fisheries and wildlife is greater. ... Perhaps the greatest obstacle to a balanced program of research on northern resources are inappropriate temperate zone concepts. All permanent human occupancy of land (as Dr. Bader points out) is based on local use of renewable resources. In the temperate zone man can get away with such misuse of the land as strip-mining and burning forests so as to expose the country rock because vegetational succession is relatively rapid and the land can recover. In the Arctic and Subarctic all schemes for exploitation and use must be rigidly controlled because the consequences of misuse (through faulty application of traditional temperate zone procedures) are extreme and long-lasting. The temperate zone concept of laissez-faire in regard to everyday use of renewable resources is a dangerous concept for the Arctic and Subarctic. ...