In a previous communication by Penniston et al.l in these PROCEEDINGS, the multiple configurational states of the inner membrane of the mitochondrion were shown to be determined both by the conformation of the repeating units (nonenergized, energized, or energized-twisted) and also by the mode of the cristae (orthodox, aggregated, or comminuted). The conformational changes in the repeating units were constant and independent of the mode of the cristae, but the electron microscopic expression of these conformational changes at the membrane level was profoundly affected by the mode of the cristae. Table 1 summarizes