Objective: This study was conducted to investigate the effect of depression levels on the quality of life of pregnant women with probable and confirmed coronavirus disease 2019 (COVID-19) diagnosis. Methods: This is a cross-sectional study. The sample of the study was composed of thirty pregnant women who were defined as probable and confirmed cases in the COVID-19 Case Tracking module of the Public Health Software System. Results: The average age of pregnant women participating in the study was 32.53 ± 3.71 (min: 24, max: 40). The mean Beck Depression Inventory for Primary Care score of the pregnant women participating in the study was 2.2 ± 2.8 (min: 7, max: 20). Only five of the pregnant women had a high probability of depression. Considering the participants' average scores from the Short Form-36 Health Survey subdimensions, it is seen that the highest score of pregnant women is in the mental health category (x: 71.37 ± 2 8.8 6). The COVID-19 test result and the parameters of quality of life subscale were compared, and a statistically significant relationship was found between the social life quality of not only pregnant women with positive COVID-19 test results but also that of the women with negative test results (t: −2,627, P: 0.014). Conclusion: It is obvious that people's mental health is negatively affected during the COVID-19 pandemic. For this reason, midwifery care, which will be given to ensure that pregnant women are least affected by the COVID-19 pandemic, to protect their mental health, and to increase their quality of life, is even more important.