Aiming at the problems of many types of abnormal states in industrial defective sorting stations, long time consuming analysis of abnormal causes, and untimely equipment monitoring, the control system of industrial defective sorting stations based on IOT2050 is designed. With Siemens PLC-1200 as the main body, combined with TIA Portal and IOT2050, it realizes the design of software and hardware configuration, programming, WinCC screen and industrial cloud platform of industrial defective sorting station control system. The simulation results show that the system runs stably, realizes automatic production operation and data monitoring, and is of great significance to ensure the reliable operation of equipment.