In this study, we investigated the intrinsic correlation between the crystal configuration and persistent mechanical stability of semi-crystalline polymers. The creep resistances of microstructures with different grain sizes and the same crystallinity were evaluated using coarse-grained molecular dynamics simulations. It was demonstrated that under tensile loading at constant pressure, microstructures with larger grains have more pronounced resistance to molecular rearrangement and significantly delay creep deformation. The improved creep resistance can be attributed to two factors. First, larger crystal sizes result in an increased moment of inertia, reducing the angular velocity required for the rotational rearrangement of the crystalline phase. Second, the elongated crystalline stems enhance the resistance to intermolecular slippage, elevating the strain energy necessary to disrupt the crystalline structure. These findings reveal the molecular basis of creep resistance at the nanoscale and highlight the pivotal role of crystal morphology in enhancing the long-term mechanical integrity of polymers.