The purpose of this article was to analyze the work-related biography of a group of journalists working across the border between Tijuana, Mexico, and San Diego, United States. The discussion focuses on the influence of the nature of journalism on the configuration of the professional identities of ten journalists interviewed during the second half of 2015. Based on an analysis of work-related trajectories and forms of identification, we found that multiple activities and independent work are two strategies used by cross-border journalists to stay active in the field, but also as areas of rupture with the profession. This exploratory study brings new questions to the analysis of professions, and particularly journalism, in complex contexts such as the Mexico-U.S. border.