For civil high-speed rotorcraft designed to operate at specific cruising altitudes, this study proposes nine structural design schemes for pressurized cabins. These schemes integrate commonly used materials and processing technologies in the aviation industry with advanced PRSEUS (Pultruded Rod Stitched Efficient Unitized Structure) technology. An analysis of the structural composition reveals that frames constitute 8–19% of the total structural weight, while stringers and beams make up 15–50%, and skins account for 11–25%, with thicknesses ranging from 1.0 mm to 2.0 mm. The separating interface of the pressurized cabin contributes 4–29% of the total structural weight. The weight distribution of each component in the pressurized cabin structure varies significantly depending on the chosen materials and processing technologies. Utilizing the Analytic Hierarchy Process (AHP), along with Gray Relational Analysis (GRA) and Dempster–Shafer (D-S) evidence theory, this study compares the simulation results of the nine schemes across multiple dimensions. The findings indicate that the configuration combining 7075 aluminum alloy and T300 composite material has the greatest advantages in terms of the high structural reliability of the configuration, light weight, mature processing technology, and low production cost. This comprehensive evaluation method quantitatively analyzes the factors influencing the structural configuration design of the pressurized cabin for civil high-speed rotorcraft, offering a valuable reference for the design of similar structures in related fields.