Different cowpea genotypes respond differently to water regimes and to different climatic conditions. The aim of this study was to evaluate the response of cowpea to different irrigation depths in the Submedium São Francisco River Valley, Brazil. The experiment was conducted at the experimental field of DTCS/UNEB, in Juazeiro, BA, Brazil, from November/2016 to January/2017, in a 2 x 5 factorial scheme randomized block design (cowpea genotypes x irrigation depths), with three replicates. The genotypes used were BRS Acauã and Canapu and irrigation depths, obtained based on 50, 75, 100, 125, and 150% of ETo. Physiological characteristics, production components and water use efficiency were analyzed. Increased irrigation depths only caused a significant effect on mass of one 100 grains. With water availability and climatic conditions observed during the experiment, BRS Acauã outperformed Canapu, with a better yield performance. BRS Acauã genotype had a better response in water use efficiency for grain yield, exceeding Canapu by 47.21%.