Social-ecological systems (SESs) in Iran face escalating challenges and pressures due to a multitude of environmental and social factors, such as global warming, population growth, and unsustainable resources management practices. This paper presents a comprehensive review of the historical context and evolution of SESs in Iran and examines the current challenges and pressures confronting these systems. The methods utilized include literature review, case studies, framework development, analysis and synthesis, comparative analysis, integration of feedback, and Driver-Pressure-State-Impact-Response (DPSIR) framework analysis. We also discuss opportunities for enhancing resilience and sustainability in the country’s SESs, including case studies of successful management approaches. This analysis highlights the urgent need for integrated and interdisciplinary approaches to manage SES in Iran, including with community engagement and inclusive participation. Our findings develop and recommend a holistic management approach that can effectively respond to changing social and ecological conditions over time. The suggested holistic management approach involves various processes and aspects, such as stakeholder engagement, baseline data collection and monitoring, scenario planning, adaptive management strategies, and evaluation. Overall, this paper provides a valuable resource for different stakeholders, especially researchers and policymakers interested in the management of SESs in Iran and offers insights to other neighboring nations encountering similar challenges in their SESs.