ABSTRACT This research aims to experimentally investigate the thermal performance of iron oxide nanofluids having different particle shapes for multiple impinging jet flow. The heat transfer performance of nanofluids with spherical like, faced nanocube and nanowires shapes prepared by hydrothermal synthesis was investigated experimentally. The weight percentage of the nanofluids examined in this study is 0.2 wt%, and different jet-to-jet spacing (B) and jet-to-plate distance (H) values were tested for each nanofluid. The experiments were carried out for laminar flow conditions, the temperature distribution was obtained through thermocouples, and the Nu number was calculated for each case. In experiments using nanowires, it was observed that the highest Nu numbers were obtained for jet-target/diameter ratio 2 for all cases (jet spaces and Reynolds numbers). Maximum Nu number enhancement was approximately 27.3% compared to pure water for the specified conditions. This value is quite significant since it was obtained with a relatively low concentration of nanofluids. It was observed that the particle size and morphology shape significantly impact nanofluids’ performance in heat transfer.