Equal Conditions Research Articles

Interactive design of discrete Voss nets and simulation of their rigid foldings

Voss nets are surface parametrizations whose parameter lines follow a conjugate network of geodesics. Their discrete counterparts, so called V-hedra, are flexible quadrilateral meshes with planar faces such that opposite angles at every vertex are equal; by replacing this equality condition with the closely related constraint that opposite angles are supplementary, we get so-called anti-V-hedra. In this paper, we study the problem of constructing and manipulating (anti-)V-hedra. First, we present a V-hedra generator that constructs a modifiable (anti-)V-hedron in a geometrically exact way, from a set of simple conditions already proposed by Sauer in 1970; our generator can compute and visualize the flexion of the (anti-)V-hedron in real time. Second, we present an algorithm for the design and interactive exploration of V-hedra using a handle-based deformation approach; this tool is capable of simulating the one-parametric isometric deformation of an imperfect V-hedron via a quad soup approach. Moreover, we evaluate the performance and accuracy of our tools by applying the V-hedra generator to constraints obtained by numerical optimization. In particular, we use example surfaces that originate from one-dimensional families of smooth Voss surfaces – each spanned by two isothermal conjugate nets – for which an explicit parametrization is given. This allows us to compare the isometric deformation of the smooth target surface with the rigid folding of the optimized (imperfect) V-hedron.

Regularities of particle motion on vibrating conveyor

Vibratory conveying equipment is widely used in industry and agriculture. The choice of operating parameters has a significant influence on the conveying velocity. Herein, the velocity of a particle under equal vibration intensity conditions is investigated using a frequency-adjustable vibratory feeder. The discrete element method was used to study the motion regularities of a particle on a vibrating conveyor. The effects of the amplitude, vibration direction angle, inclination angle, and vibration intensity on the transport velocity of the vibrating conveyor were investigated using the response surface method. The experimental and calculate results demonstrate that the simulation method and the model is reliable. When the vibration intensity is greater than Kc and remains constant, increasing the amplitude increases the velocity of particle motion. A large vibration direction angle enhances the throwing motion of the particle. A large inclination angle enhances the sliding motion. The inclination angle is used to increase transport velocity by enhancing forward sliding and attenuating backward sliding. The response surface analysis shows that the particle motion velocity is more evidently influenced by the amplitude, followed by the installation inclination and vibration direction angles. The results of the study are important for optimizing the design and operating parameters of vibratory conveying equipment.

The effect of the COVID-19 pandemic on pediatric emergency department utilization in three regions in Switzerland.

The COVID-19 pandemic was associated with a decrease in emergency department (ED) visits. However, contradictory, and sparse data regarding children could not yet answer the question, how pediatric ED utilization evolved throughout the pandemic. Our objectives were to investigate the impact of the pandemic in three language regions of Switzerland by analyzing trends over time, describe regional differences, and address implications for future healthcare. We conducted a retrospective, longitudinal cohort study at three Swiss tertiary pediatric EDs (March 1st, 2018-February 28th, 2022), analyzing the numbers of ED visits (including patients` age, triage categories, and urgent vs. non-urgent cases). The impact of COVID-19 related non-pharmaceutical interventions (NPIs) on pediatric ED utilization was assessed by interrupted time series (ITS) modelling. Based on 304'438 ED visits, we found a drop of nearly 50% at the onset of NPIs, followed by a gradual recovery. This primarily affected children 0-4years, and both non-urgent and urgent cases. However, the decline in urgent visits appeared to be more pronounced in two centers compared to a third, where also hospitalization rates did not decrease significantly during the pandemic. A subgroup analysis showed a significant decrease in respiratory and gastrointestinal diseases, and an increase in the proportion of trauma patients during the pandemic. The COVID-19 pandemic had substantial effects on number and reasons for pediatric ED visits, particularly among children 0-4years. Despite equal regulatory conditions, the utilization dynamics varied markedly between the three regions, highlighting the multifactorial modification of pediatric ED utilization during the pandemic. Furthermore, future policy decisions should take regional differences into account.

Rehabilitation Service in the Hospitality Industry

Topicality. The hospitality industry development in Ukraine takes place in crisis conditions of the post-pandemic environment and escalating military threats. In the context of the mentioned above, accommodation facilities reformate business concepts and customer-oriented approaches, supplementing them with certain security compliance, and the creation of relevant wartime rehabilitation services. Psycho-emotional exhaustion, physical injuries, hidden and definite stressors cause a necessity in forming rehabilitative hospitality. The rehabilitation services need for war victims and military personnel is acutely actualised, taking into account global tendencies: ensuring inclusive and barrier-free services; growing requirements for sustainable and environmental responsibility in the hotel business; increasing demands for health and medical services. Thus, rehabilitation hospitality can become an efficient means of ensuring equal conditions of access to hotel services for all population groups, as well as promoting social inclusion and tourism development (including medical and sanative ones), which means improvement of the economy and well-being of society in total. The aim of the article is to ground approaches to the development of rehabilitation hospitality as a concept for promoting human mental health and societal inclusion. The focus of the research methodology is the hypothesis that the rehabilitation service integration into the hospitality sphere can help in increasing the competitiveness of business entities, attract the target audience to the newly created ground, and ensure the sustainable development of society. Research methods. Presented for review research topic acquires the use of certain general economic methods of studying literary sources and scientific publications; statistical methods in the study of tendencies; empirical studies. This contributed to elaborating theoretical approaches and tools of scientific study, as well as logical interpreting the prospects for the rehabilitation hospitality development in Ukraine. Results. The definition of “rehabilitation hospitality” is offered for use in the scientific operational field; its objectives, systemic components and functions in sustainable societal development are defined. The types of hospitality establishments that integrate rehabilitation services into the system of additional services are characterised. Preconditions for the rehabilitation services development in the hospitality subjects’ activity are evaluated. Based on empirical research results, the state of the development of the rehabilitation services system in Ukraine is determined. The checklist on forming the system of marketing management rehabilitation services is elaborated. The directions for developing rehabilitation hospitality are offered, basing on digital tools and partnership programmes in the rehabilitation sphere. Prospects for further research include finding and implementing innovative approaches and technologies in the rehabilitation hospitality sphere in order to enhance its effectiveness and service quality. Conclusions and discussion. The conducted study demonstrates the relevance of rehabilitation hospitality as a factor in restoring human potential in sustainable state’s development, as it allows to research and scientifically ground directions for health restoration, and integration into society for those ones who suffered because of war, military personnel; to create barrier-free and inclusive environment in the hospitality industry, which ensures increasing accessibility and admission to services for people with disabilities and special needs, their social integration and improving the quality of life. In addition, this contributes to expanding the customer audience, and improving the reputation and competitiveness of hospitality establishments, as well as increasing their income. The sources of information and empirical research results used in this study confirm the offered hypothesis, the formulated conclusions and research perspectives, also creating a discussion platform for the study of rehabilitation hospitality, and its qualitative integration into the system of the state’s rehabilitation services.

Machinability performance of different fiber orientations of roll wrapped CFRP pipes

AbstractIntegrating fiber reinforcement plastics (FRP) materials into the industry plays a key role especially for pipes. However, due to the production methods of CFRP pipes, surface finishing processes are inevitable at the end of production. Despite the widespread use of CFRP materials, the predominant focus in the literature has been on their mechanical performance. This study aims to contribute to the limited research on the machinability of CFRP materials. In this context, the turning machining process for CFRP pipes was experimentally investigated in the present study. For this purpose, carbon fiber pipes with an inner diameter of 30 mm and an outer diameter of 60 mm were produced and subjected to computer numerical control (CNC) turning. First, a cylindrical aluminum pipe is used as a mold to manufacture CFRP pipes. Unidirectional (UD) carbon fabrics were wrapped on these aluminum molds. Shrink tape was used to enhance the surface smoothness and required pressure to prevent delaminating of the end product during the process. UD carbon fabrics are wrapped on to the mold at the selected angles (0°, 45°, and 90°) and the CFRP pipe specimens were manufactured using epoxy matrix. Pipes were processed on CNC lathe at 120, 160, 200 rev/min speeds and f 0.4 mm/rev feed rate. The surfaces of the machined specimens were measured with a microscope and a surface roughness device. On the other hand, wear on the tools was observed after the process.Highlights CFRP pipes were produced with different fibre orientations, i.e., 0°, 45°, and 90°. All CFRP pipes are made under equal conditions and cured at 80°. Turning of CFRP pipes was examined under dry environments. Performance criteria: surface roughness, temperature, tool wear, and chip formation were explored. 45° fibre angles CFRP pipes showed the best machinability performance.

A novel balance index for preliminary assessment of proprioception based on a balance-cognitive study

Finding a quick and accurate method for evaluating proprioception is useful for improving performance which is the main objective of the current research. This paper presents a novel index, called the Synergy Balance Index (SBI), that leverages lower limb electromyography signals for the evaluation of proprioception. The concept has been tested on a set of balance tasks performed by 23 healthy subjects on a ∞-shape path. The capability of the SBI has been investigated using two ways, classification and monitoring. Also, the relationship between the features extracted from the recorded signals was investigated by calculating the correlation coefficient. The findings suggest that in the absence of sufficient and accurate information on individuals, this index can only differentiate groups if there is a significant difference in their proprioception. All of the evaluated criteria were obtained above 95 percent. This index was effective when used with equal conditions and comparisons of each individual with himself over multiple stages of proprioception training that included two tasks (balance, and cognitive). The index showed increased proprioception performance after just one training session, showing its possible sensitivity and speed. The SBI is a quick, low-cost, and easy-to-use index for assessing a person’s proprioception. It has potential applications in rehabilitation, neurology, and sports biology. Enhanced research in this area could result in better patient care. The small sample size and the lack of a diverse population group limit the study. This can be fixed by gathering more data from a larger and more diverse set of participants.

The comparative analysis of health care systems based on rating definition.

The article describes system of compulsory medical insurance and voluntary medical insurance in the Kyrgyz Republic nowadays. The becoming of medical insurance as system of access for citizens to preferential medical services and medications is considered. The State Guarantees Program offers equal conditions for entire population to access free medical services and particular medications, especially for certain category of citizens with chronic, age-related or individual physical characteristics.

근로자대표 관련 근로기준법 일부개정법률(안)에 대한 소고

The worker representative system has been expanded as the subject of written agreement and hearing opinions in labor laws, including the Labor Standards Act. Workers' representatives are recognized as important in determining working conditions at workplaces in a situation where the limitations of the traditional working condition determination system are faced due to the low labor union organization rate and diversification of employment types. However, in fact, there are no legal protection regulations for the selection procedure, method, status and activity guarantee of worker representatives, so they are not functioning properly. On October 16, 2020, the Economic, Social & Labor Council announced the results of the Labor-Management Agreement on the Improvement of the Workers' Representation System, and on March 6, 2023, the government announced the legislation of a partial amendment to the Labor Standards Act related to the Workers' Representation System based on the Economic, Social & Labor Council. However, it cannot be said that the government's legislative amendment bill has sought legislative measures in line with the principle of equal working conditions, and legislative reorganization should be prepared to enable equal decisions by labor and management, including when there is no labor union in the workplace based on Article 32 (3) of the Constitution or in light of the basic ideology of equal working conditions in labor contracts. Considering the relationship with the labor union, it is not easy to achieve its legal intention properly without an agreement between labor and management and constant efforts by labor and management to realize the system as originally intended. It will be necessary to seek an institutional search to realize the principle of equal working conditions even under realistic constraints, and giving workers' representatives a role in writing and changing employment rules is also positive in that sense.

CREATIVE THINKING AS AN ELEMENT OF SOFT􀍳SKILLS OF SPECIALISTS IN THE SOCIO􀍳CULTURAL AND ART FIELDS

In the article, the author considers the problem of the formation of soft skills of specialists in the socio-cultural and artistic fields. Modern requirements for higher education, changes in information technologies and the increase in the availability of information, together with changes in social life, which require the presence of a wide range of knowledge and competences in modern specialists, as well as the ability to quickly adapt to changing conditions, require modern institutions of higher education of education, ensuring a high-quality educational process, with its focus on the combination of traditions and innovations in education and the formation of a high-quality specialist for the modern labor market. For professional implementation, development and success in personal and social life, a modern specialist in the socio-cultural and artistic fields must be able to quickly adapt to changing conditions, make balanced and informed decisions in conditions of uncertainty and lack of information, establish effective interpersonal communications with colleagues, management,, representatives of authorities, the scientific community, the public, resolve conflict situations, show empathy, organize one’s own life, professional activity and development in the existing conditions, leadership qualities and the ability to take responsibility, etc. The author proves that today precisely such qualities and skills, which are united by the concept of soft skills, along with other equal conditions (in particular, the same level of professionalism, professional qualification) determine the success of a specialist in the labor market, and an individual in life. The question of the formation of soft skills during the acquisition of higher education by students has become relevant in the last few decades. However, considering the experience and trends in the development of higher education in our country in the last few years, the importance of these issues is constantly increasing. High-quality training of students of art and pedagogical education in modern conditions must necessarily involve the formation of soft skills in them through the use in the educational process of a wide range of innovative pedagogical technologies, modern interactive teaching methods and the involvement of students in various social, public, communication activities based on understanding of the essence, meaning and methods of soft skills formation by all representatives of the educational process. Keywords: socio-cultural activity, artistic and pedagogical education, competence, soft-skills, education seekers

Недопустимость ограничения или устранения конкуренции как принцип государственной политики и правового регулирования отношений в сфере высшего образования

The principle of inadmissibility of restricting or eliminating competition in the field of education in relation to public policy implies either the creation of equal conditions for competition, or non-interference of authorities in the processes of competition in the field of education, and the establishment of rules of conduct and legal mechanisms to ensure their compliance with legal regulation. The field of educational services is segmented by types of educational services (education levels, specialties, etc.), each of which represents a separate commodity market. Competition exists between educational organizations, and between educational programs, faculties, departments, scientific schools and other structural elements of the educational process as an activity. The application of the term “competition” to the educational sphere is conditionally permissible, in the field of education it is important to ensure not so much the development of competition as an independent activity of educational organizations, as to create a mechanism for determining the leadership of educational institutions and their structural elements, ensuring fair and non-discriminatory access to those educational services in which a particular consumer is interested.

VERTICAL MOBILITY, THE “GLASS CEILING”, AND GENDER DISCRIMINATION: PERCEPTION OF FEMALE POLICE OFFICERS

In Serbia women are still discriminated against in all aspects of their public and private lives. The security system, especially police, bears the consequences of structural inequalities. Our research deals with the position of women working in police units. The aim of the research was to define the identities of policewomen in Serbia through their perception of vertical advancement and exposure to gender discrimination. The research will be based on qualitative approach ‒ interviews with women police officers. The sample will consist of 40 respondents from different police units, selected using the snowball method. Qualitative results indicated the presence certain doses of gender stereotypes in women, but also their impression that they are not completely professionally accepted by colleagues. The results indicate a structural gender segregation and marginalization, which is reflected in the imprisonment of women in narrow circle of administrative and auxiliary police work. The findings of this study will represent an important argument in the development and improvement of gender-sensitive regulation in the police, protection against discrimination and in the projection of its personnel structure and career advancement of employees under equal conditions.

AOSMA-MLP: A Novel Method for Hybrid Metaheuristics Artificial Neural Networks and a New Approach for Prediction of Geothermal Reservoir Temperature

To ascertain the optimal and most efficient reservoir temperature of a geothermal source, long-term field studies and analyses utilizing specialized devices are essential. Although these requirements increase project costs and induce delays, utilizing machine learning techniques based on hydrogeochemical data can minimize losses by accurately predicting reservoir temperatures. In recent years, applying hybrid methods to real-world challenges has become increasingly prevalent over traditional machine learning methodologies. This study introduces a novel machine learning approach, named AOSMA-MLP, integrating the adaptive opposition slime mould algorithm (AOSMA) and multilayer perceptron (MLP) techniques, specifically designed for predicting the reservoir temperature of geothermal resources. Additionally, this work compares the basic artificial neural network and widely recognized algorithms in the literature, such as the whale optimization algorithm, ant lion algorithm, and SMA, under equal conditions using various evaluation regression metrics. The results demonstrated that AOSMA-MLP outperforms basic MLP and other metaheuristic-based MLPs, with the AOSMA-trained MLP achieving the highest performance, indicated by an R2 value of 0.8514. The proposed AOSMA-MLP approach shows significant potential for yielding effective outcomes in various regression problems.

Exploring the Landscape of Smart Cities: A Comprehensive Review of IoT and Cyber-Physical Systems

They focus on housing, well-being, equality, clean energy and fair conditions. The cyber-physical approach involves the development of IoT and Cyber-Things. Smart cities have a variety of use cases, including electricity and transportation. Automating is used for efficiency in industrial manufacturing. An integrated supply and demand side management system is required for the reliability, security and ability to manage the power grid. This paper introduces an integrated energy approach, enhances existing standards, and establishes a shared basis for multidisciplinary planning. It also introduces new semantic network ontologies to provide a comprehensive framework for solving resource-related challenges. This new approach aims to fill the gaps in current standards and create an integrated environment for multi-stakeholder collaboration, using a semantic web ontology for communication and improved decision making in energy systems Provides information integrated, including various forms of smart cities With flexibility for flexibility and inclusion in the energy industry, can accommodate the specific characteristics and needs of various smart city applications In this study, computing -physical system (CPS), software-defined network (SDN), internet (IoT). ), and analyze how smart cities are connected. CPS combines physical channels with electronic systems to provide increased network management efficiency and flexibility. SDN improves dynamic capacity and flexibility, while IoT is more connected for real-time data exchange and decision-making.

Relevance of Lev Karsavin’s Ideas on State Cultural Policy

The article substantiates the expediency of using domestic philosophical heritage in the development of concepts and other normative documents of Russia’s cultural policy in the current situation. At present, Russian society has gained an understanding of the need to abandon the strategy of catch-up modernization and to implement socio-cultural development on the ways of deepening the country’s traditional spiritual values and its own historical vision of the multipolarity of the world. The ideas of the Russian religious philosopher L.P. Karsavin concerning such fundamental aspects of cultural policy as the peculiarities of the development of state ideology, the design of culture and state cultural programmes, the vocabulary and language of cultural studies are considered. Special attention is paid to Karsavin’s understanding of Russian culture as having Orthodox origins and developing on the basis of Orthodoxy. Attention is drawn to the importance of ensuring the unifying and living, creative character of Russian culture, the conditions of equality of different cultures and, at the same time, the presence of a hierarchy of interpenetrating cultural spheres. The development of some of L.P. Karsavin’s ideas by his followers is outlined, including the need to clarify the Christian meaning of atheism and to overcome the “irreconcilable” antagonism between religious and atheistic worldviews. The study outlines a line of enrichment of cultural theory with little-known works by L.P. Karsavin and A.A. Vaneev, which, according to the authors of the article, opens prospects for further development of new approaches to understanding the essence of cultural policy.

Bail as a preventive measure in criminal proceedings: procedural- legal aspects and issues

The article examines the role and significance of bail as a preventive measure in criminal proceedings. Procedural and legal aspects of applying this preventive measure are explored, along with the problems arising from its use. Procedural and legal aspects of bail, including its designation, application mechanisms, and limitations, are analyzed in detail.
 The study focuses on exploring the mechanisms for determining bail, its role in preventing crimes, and its impact on criminal proceedings. The procedures for bail assignment are analyzed, taking into account the risks arising from possible careless or unfair application of this preventive measure. Risks associated with potential improper or unjustified use of this measure are considered. Identified flaws in assigning bail could lead to violations of the rights of individuals suspected of crimes.
 The necessity to refine legislation for determining procedures to establish the legality of pledged funds is highlighted, which is an important issue in criminal proceedings. Specifically, attention is drawn to the European Court of Human Rights decision in the case «V. v. Switzerland» regarding the refusal to apply bail if the individual providing funds fails to provide adequate evidence of their legality. To ensure transparency and effectiveness of preventive measures, it is essential to establish mechanisms to verify the origin of funds used as bail. This would prevent situations where the source of funds remains unknown or when the individual offering bail has a questionable reputation that could compromise the legality of the funds.
 Issues in bail application, such as the potential for discrimination, lack of a uniform assignment standard, and the possibility of using bail to pressure suspects or defendants, are discussed.
 Emphasis is placed on the importance of a balanced approach to bail application in criminal proceedings, considering the individual circumstances of each case and maintaining a balance between the interests of justice and the protection of the rights of suspects or defendants.
 Conclusions and recommendations are made to improve legislation and practices related to bail application, aiming to enhance judicial efficiency and ensure equal conditions for all participants in criminal proceedings. The analysis could serve as a basis for further research and improvements in this field.

Difference between endocardial and epicardial application of pulsed fields for targeting Epicardial Ganglia: An in-silico modelling study

BackgroundPulsed Field Ablation (PFA) has recently been proposed as a non-thermal energy to treat atrial fibrillation by selective ablation of ganglionated plexi (GP) embedded in epicardial fat. While some of PFA-technologies use an endocardial approach, others use epicardial access with promising pre-clinical results. However, as each technology uses a different and sometimes proprietary pulse application protocol, the comparation between endocardial vs. epicardial approach is almost impossible in experimental terms. For this reason, our study, based on a computational model, allows a direct comparison of electric field distribution and thermal-side effects of both approaches under equal conditions in terms of electrode design, pulse protocol and anatomical characteristics of the tissues involved. Methods2D computational models with axial symmetry were built for endocardial and epicardial approaches. Atrial (1.5−2.5 mm) and fat (1−5 mm) thicknesses were varied to simulate a representative sample of what happens during PFA ablation for different applied voltage values (1000, 1500 and 2000 V) and number of pulses (30 and 50). ResultsThe epicardial approach was superior for capturing greater volumes of fat when the applied voltage was increased: 231 mm3/kV with the epicardial approach vs. 182 mm3/kV with the endocardial approach. In relation to collateral damage to the myocardium, the epicardial approach considerably spares the myocardium, unlike what happens with the endocardial approach. Although the epicardial approach caused much more thermal damage in the fat, there is not a significant difference between the approaches in terms of size of thermal damage in the myocardium. ConclusionsOur results suggest that epicardial PFA ablation of GPs is more effective than an endocardial approach. The proximity and directionality of the electric field deposited using an epicardial approach are key to ensuring that higher electric field strengths and increased temperatures are obtained within the epicardial fat, thus contributing to selective ablation of the GPs with minimal myocardial damage.

Effects of chronic social equality and inequality conditions on passive avoidance memory and PTSD-like behaviors in rats under chronic empathic stress

Introduction: Social inequality conditions induce aversion and affect brain functions and mood. This study investigated the effects of chronic social equality and inequality (CSE and CSI, respectively) conditions on passive avoidance memory and post-traumatic stress disorder (PTSD)-like behaviors in rats under chronic empathic stress. Methods: Rats were divided into different groups, including control, sham-observer, sham-demonstrator, observer, demonstrator, and co-demonstrator groups. Chronic stress (2 hours/day) was administered to all stressed groups for 21 days. Fear learning, fear memory, memory consolidation, locomotor activity, and PTSD-like behaviors were evaluated using the passive avoidance test. Apart from the hippocampal weight, the correlations of memory and right hippocampal weight with serum corticosterone (CORT) levels were separately assessed for all experimental groups. Results: Latency was significantly higher in the demonstrator and sham-demonstrator groups compared to the control group. It was decreased significantly in other groups compared to the control group. Latency was also decreased in the observer and co-demonstrator groups compared to the demonstrator group. Moreover, the right hippocampal weight was significantly decreased in the demonstrator and sham-demonstrator groups compared to the control group. Pearson’s correlation of memory and hippocampal weight with serum CORT levels supported the present findings. Conclusion: Maladaptive fear responses occurred in demonstrators and sham-demonstrators. Also, extremely high levels of psychological stress, especially under CSI conditions (causing abnormal fear learning) led to heightened fear memory and PTSD-like behaviors. Right hippocampal atrophy confirmed the potential role of CSI conditions in promoting PTSD-like behaviors. Compared to inequality conditions, the abnormal fear memory was reduced under equality conditions.

How does women’s health matter? A qualitative study on women’s health issues in relation to work participation. Experiences and perspectives from nurses and managers in a Norwegian hospital

In this article, we explore associations between women’s health and participation in working life, work ability and sickness absence. Through interviews with nurses and hospital managers, we identified three main occupational barriers connected to biological and physiological sex differences: considerations on women’s health, work organization and work environment as conditions for health, and equality and expectations in society. We find that individual experiences, job systems, and societal attitudes affect each other negatively, and that systemic problems tend to be individualized. The lack of recognition of women’s health affects work participation, work ability and sickness absence in women, representing a challenge to female occupational health, as well as to gender equality and public health in general.

Study of Tildox AVZ effect on rat blood parameters in a subchronic experiment

The purpose of our research was to study the effect of Tildox AVZ on rat blood counts in a subchronic experiment. Tildox is a complex antibiotic in powder form. One gram of drug contains doxycycline hyclate – 100 mg and tylosin tartrate - 100 mg as active ingredients, sodium benzoate and sucrose as auxiliary substances. The experiment lasted 90 days. The study was conducted on 150 Wistar rats (75 males and 75 females). The body weight of the animals was 190-230 g. During the experiment 5 groups of 30 animals (15 males and 15 females) were formed, three of them were experimental groups, one - control and one – intact. Of the 150 rats involved in the experiment after its completion 100 individuals (50 males and 50 females) were killed for pathomorphological studies of internal organs.To identify the ability to recover and the appearance of resistance to toxic effects the remaining 50 animals (5 males and 5 females from each group) were monitored for 28 days after the experiment.An aqueous solution of the test sample of the drug was administered daily intragastrically using an atraumatic metal probe. The drug was administered to the first experimental group at a dose of 70 mg / kg, the second group - 265 mg / kg, the third group - at a dose of 1000 mg / kg of animal body weight. The control group was in equal conditions and received intragastric saline solution. Intact animals served as a reference. It was found that Tildox AVZ administered intragastrically at doses of 265 and 1000 mg / kg 1 time per day for 90 days has an effect on clinical and biochemical blood parameters. The drug administered at a dose of 70 mg / kg does not cause changes in blood parameters. However when examining the blood of rats 28 days after the recovery period there were no significant changes in clinical and biochemical parameters compared with the control and intact groups.From this it can be concluded that all blood changes had a dose-dependent effect and after stopping the use of the drug the body recovered which indicates the reversibility of the caused shifts in the blood picture.

Equality or Equity? E-CARGO Perspectives on the Fairness of Education

The educational equality or equity problem (EEEP) has a long-term debate in civilization. This problem is often discussed by sociologists, philosophers, educationists, and so on for various phenomena or decisions. However, there is hardly any absolutely convincing answer to this question. We believe that a series of quantitative methods may provide decision-makers with a clearer orientation in their discussions and help them make decisions. Therefore, this article depicts a common scenario to discuss the EEEP. It uses quantitative methods to conduct computational social simulations and obtain the results under equal or equitable conditions via role-base collaboration (RBC), environments-classes, agents, roles, groups, and objects (E-CARGO), and group role assignment (GRA). The simulation results show that educational equality or equity can be significantly improved by making a reasonable and optimized allocation plan through GRA. Finding the optimal allocation plan, which validates the reliability of the results by changing the experimental parameters of equality and equity, is helpful and interesting to relevant decision-makers.