Transitioning away from fossil-fuel-based chemical manufacturing is critical in advancing towards a carbon-neutral society. Chemical manufacturing processes that can be driven by renewable energy and use renewable feeds or waste products from other processes are of particular interest. This talk focuses on utilization of glycerol, a byproduct of biodiesel production and other processes, as a platform chemical for electro-organic synthesis of a number of value-added intermediates.Oxidation of glycerol can result in ten or more different products. Processes are needed to synthesize specific products of interest selectively. Based on market size and value, the four most promising oxidation products of glycerol are lactic acid, glycolic acid, oxalic acid, and dihydroxyacetone. Electrochemical reduction and oxidation processes can, in principle, be directed to produce different products by tuning reactor and reaction conditions such as catalyst identity, electrolyte/analyte concentration, flow/stir rates, electrolyte composition, etc. While a significant body of work has studied glycerol electrooxidation (GEOR) in electrochemical cells with the goals of unraveling mechanisms and identifying better catalysts (higher rates/selectivities), transitioning some of the most promising GEOR approaches to larger scales has received limited attention.In our work, we pursue glycerol electrooxidation in flow reactor configurations that could be scaled to industrial levels. Flow electrolysis approaches, in addition to providing a scalable chemical manufacturing platform, enhance mass transfer and kinetics while retaining the ability to tune key operational parameters that determine rates and selectivities. In this talk, we will report on two aspects: (i) Product speciation: what parameters can be used to optimize product selectivity towards key desired products (e.g., lactic acid, glycolic acid), and (ii) Feedstock composition: how to utilize raw glycerol (so-called ‘crude’ glycerol, containing varying amounts of water, NaOH, and methanol), available as a byproduct from a wide variety of plants, as the feedstock. For the former, we employ a systematic design approach that seeks to optimize the interplay between the different parameters that determine current density (conversion rate) and Faradaic efficiency (selectivity). For the latter, we explore which of the other ingredients (methanol, NaOH, water) of crude glycerol needs to be controlled or adjusted for reproducible, desired outcomes of flow glycerol electrolysis.