The purpose of this study is to develop an effective method for increasing the filtration characteristics of ores during borehole uranium mining, depending on the geological characteristics of ores and host rocks. At the same time, it is planned to increase the productivity of production and the pick-up rate of injection wells, increase the period of uninterrupted operation of equipment and reduce operating costs for production. The geotechnological parameters of borehole uranium mining on technological blocks of various mining and geological conditions are investigated and evaluated. Core material samples were taken and the structures and compositions of the host rocks of the Santonian, Maastrichtian and Campanian ore intervals were determined by microscopic method. Based on a comparative analysis of the methods used to intensify borehole production, a combined method for restoring the permeability of the productive horizon was developed. The effective parameters of the combined well regeneration method combining fluctuations of compressed air pulses with chemical reagents – solvents are calculated and justified. The possibility of reducing the processing time of wells by a new method and increasing the productivity of wells is discussed. The method of calculation and application of the combined method of intensification of borehole production of uranium in ores with low filtration characteristics has been developed.