The nuclear oxide fuels are submitted ‘in-pile’ to strong structural and chemical modifications due to the fissions and temperature. The diffusion of species is notably the result of a thermal activation and of radiation induced diffusion. This study proposes to estimate to what extent the radiation induced diffusion contributes to the diffusion of lattice atoms in UO2. Irradiations are simulated using molecular dynamics simulation by displacement cascades induced by uranium primary knock-on atoms between 1 and 80keV. As atoms are easier to displace when their vibration amplitude increases, the temperature range which have been investigated is 300–1400K. Cascade overlaps were also simulated. The material is shown to melt at the end of cascades, yielding a reduced threshold energy displacement. The nuclear contribution to the radiation induced diffusion is compared to thermally activated diffusion under in-reactor and long-term storage conditions.