Escape Conditioning Research Articles

Experimental Study to Determine the Leakage Area of Single-Leaf Smoke Control Doors in the Design of Pressure Differential Systems

On the occasion of building fires, the risk of smoke, which adversely influences escape conditions, must be minimised. One way to reduce the risk is, for example, to pressurise the escape route in order to limit the infiltration of smoke. Careful determination of the design parameters of the pressurisation system is of great importance. This study will propose a new leakage area for single-leaf smoke control doors based on the analysis of the leakage area of the doors in the EN 12101-13 standard, estimating the leakage rate through closed doors. This value is half the currently recommended value, regardless of the opening direction. The determination of the leakage area is supported by measurements in pressurised smoke-free lobbies with single-leaf smoke control doors opening into and outwards from a pressurised space. The measurements are performed using the fans of the lobbies’ pressurisation systems to provide the required air volume. The suitability of this method has also been tested using blower door assembly measurements. The newly proposed leakage area takes into account the increased air tightness of the smoke control doors, thereby ensuring that the optimum air volume to be supplied by the pressurisation system can be determined. The results of this research suggest an appropriate leakage area value for designers when using the calculation method proposed by the applicability of the investigated standard.

The Definition of ‘Covered Entities’ under the GPA: The General Scope and Escape Conditions

AbstractThe WTO Government Procurement Agreement (GPA) does not legally define what entities should be covered by the Agreement. However, its member Parties list their ‘covered entities’ in a series of schedules. The list approach has complicated accession negotiations and discourages Parties from providing a ‘wider’ range of entity coverage. Moreover, the list approach raises some tensions and a lack of legal certainty, especially concerning those that are not strictly ‘government entities’, such as State-owned enterprises (SOEs). This problem is exacerbated in the case of modern SOEs in developing countries, many of which can bear both public and private features. Given these conditions, the author proposes a definition of ‘covered entities’ to facilitate accession negotiations and the future expansion of the GPA. The proposal is based on a comparative study of the GPA and the EU public procurement regulations. It develops a framework by which all publicly controlled entities are presumably covered by the GPA. Nevertheless, Parties can rebut GPA obligations by proving that an entity competes with other commercial entities under normal market conditions.

Modulating glucose metabolism and relieving hypoxia for enhanced Chemo/Photoimmunotherapy with photosensitizing enzymatic nanodrugs

Photoimmunotherapy by photodynamic therapy (PDT) induces immunogenic cell death (ICD), providing anti-tumor treatment in a safe, precise, minimally invasive way. However, PDT-demanded massive oxygen consumption exacerbates the hypoxia and creates an acidic tumor microenvironment (TME), leading to an anaerobic glycolysis and immune escape condition. In this study, a natural anti-tumor resveratrol (RSV) nanodrug was introduced via Fe3+ coordination flash nanoprecipitation (cFNP) for enhanced aqueous solubility to specifically downregulate the expression of Pyruvate kinase M2 (PKM2) and lactate dehydrogenase A (LDHA), reduce the glucose resorption and lactate production, tipping the cellular balance from anaerobic glycolysis to oxidative phosphorylation (OXPHOS). RSV enhances the immunotherapy by suppressing tumor cell glycolysis and active the apoptotic cell death as well. Meanwhile, structural linker Fe3+ could also effectively catalyze the endogenous H2O2 in the tumor cells to generate oxygen in situ and relieve the hypoxic microenvironment, enhancing the PDT efficacy. This strategy can effectively modulate glucose metabolism and relieve hypoxia by Fe/RSV/ZnPc nanodrugs to greatly promote the synergistic chemo/photoimmunotherapy, providing a promising strategy to tackle the formulation of multi-therapeutic nanodrugs for clinical cancer therapy.

The interface of gravity and dark energy

At sufficiently large radii dark energy modifies the behavior of (a) bound orbits around a galaxy and (b) virialized gas in a cluster of galaxies. Dark energy also provides a natural cutoff to a cluster’s dark matter halo. In (a) there exists a maximum circular orbit beyond which periodic motion is no longer possible, and orbital evolution near critical binding is analytically calculable using an adiabatic invariant integral. The finding implicates the study of wide galaxy pairs. In (b), dark energy necessitates the use of a generalized Virial Theorem to describe gas at the outskirts of a cluster. When coupled to the baryonic escape condition, aided by dark energy, the results is a radius beyond which the continued establishment of a hydrostatic halo of thermalized baryons is untenable. This leads to a theoretically motivated virial radius. We use this theory to probe the structure of a cluster’s baryonic halo and apply it to X-ray and weak-lensing data collected on cluster Abell 1835. We find that gas in its outskirts deviates significantly from hydrostatic equilibrium beginning at ∼1.3 Mpc , the ‘inner’ virial radius. We also define a model dependent dark matter halo cutoff radius to A1835. The dark matter cutoff gives an upper limit to the cluster’s total mass of ∼7×1015M⊙ . Moreover, it is possible to derive an ‘outer’ hydrostatic equilibrium cutoff radius given a dark matter cutoff radius. A region of cluster gas transport and turbulence occurs between the inner and outer cutoff radii.

Productivity evaluation of 10 Hevea brasiliensis clones in Ecuador under escape conditions for South American leaf blight

Productivity evaluation of 10 Hevea brasiliensis clones in Ecuador under escape conditions for South American leaf blight

RISK ASSESSMENT OF SUBWAY STATION FIRE BY USING A BAYESIAN NETWORK-BASED SCENARIO EVOLUTION MODEL

Subway station fires frequently result in massive casualties, economic losses and even social panic due to the massive passenger flow, semiconfined space and limited conditions for escape and smoke emissions. The combination of different states of fire hazard factors increases the uncertainty and complexity of the evolution path of subway station fires and causes difficulty in assessing fire risk. Traditional methods cannot describe the development process of subway station fires, and thus, cannot assess fire risk under different fire scenarios. To realise scenario-based fire risk assessment, the elements that correspond to each scenario state during fire development in subway stations are identified in this study to explore the intrinsic driving force of fire evolution. Accordingly, a fire scenario evolution model of subway stations is constructed. Then, a Bayesian network is adopted to construct a scenario evolution probability calculation model for calculating the occurrence probability of each scenario state during subway station fire development and identifying critical scenario elements that promote fire evolution. Xi’an subway station system is used as a case to illustrate the application of Bayesian network-based scenario evolution model, providing a practical management tool for fire safety managers. The method adopted in this study enables managers to predict fire risk in each scenario and understand the evolution path of subway station fire, supporting the establishment of fire response strategies based on “scenario–response” planning.

Examining patterns suggestive of acquisition during functional analyses: A consecutive controlled series of 116 cases.

The functional analysis approach described by Iwata et al. (1982/1994) has been used widely to determine the variables evoking and maintaining challenging behavior. However, one potential concern with conducting functional analyses is that repeated exposure to contingencies may induce a novel functional relation. To examine the likelihood of these potential iatrogenic effects, we evaluated social test conditions of the functional analysis for 116 participants and searched for patterns of responding indicative of acquisition. Patterns suggestive of acquisition occurred in 13.70% of tangible reinforcement conditions; however, the prevalence was only slightly lower in the attention condition (8.75%). Much lower prevalence was observed for the escape condition (2.13%). When grouped by quotient score, a pattern of acquisition was just as likely to be observed in the attention condition as in the tangible condition. Additionally, patterns indicative of acquisition were no more likely to be observed with participants who emitted automatically reinforced challenging behavior.

Particle Dynamics and Matter Accretion onto Non‐linear Charged AdS Black Holes in Massive Gravity

AbstractThis article investigates the dynamics of charged particles and accretion process around nonlinear charged AdS black holes (BHs). the impact of key factors such as angular momentum, specific energy, and magnetic field on the behavior of particles are focused. Firstly, the concept of the effective potential is examined, which provides insights into the forces acting on particles and the escape velocity they must overcome. The innermost stable circular orbit (ISCO) is also discussed, which is the closest distance a particle can orbit a BH without being pulled in and explore the conditions for particle escape. Next, the energy efficiency and epicyclic frequency of test particles are studied, which measure the amount of energy particle loses due to friction and the frequency of its oscillations, respectively. The accretion processes is analyzed by examining the radial velocity, energy density, and accretion mass of matter falling into the BH. Using the equation of state, how different types of fluid, such as stiff, dust, quintessence and phantom‐like dark energy fluid, affect the accretion process near a BH is investigated. Throughout this study, the parameter plays a key role in shaping the dynamics of particles and accretion systems is found. This parameter is a measure of the strength of the nonlinear electrodynamics field, and it can have a significant impact on the radius of the ISCO, the energy efficiency of accretion, and other properties. These findings provide new insights into the physics of particle dynamics around nonlinear charged AdS BHs. They could have implications for understanding the behavior of matter in extreme gravitational environments, such as those found near the center of galaxies.

Avoidance and escape conditioning adjust adult neurogenesis to conserve a fit hippocampus in adult male rodents.

In this study, the connection between cognitive behaviors and the adult rodent hippocampus was investigated. Recording field potentials at performant pathway (PP)-hippocampal dentate gyrus (DG) synapses in transverse slices from the dorsal (d), intermediate (i), and ventral (v) hippocampus showed differences in paired-pulse responses and long-term potentiation in rats. The Barnes maze (BM) and passive avoidance (PA) tests indicated a decrease in escape latency and step-through latency in both rats and mice over training days. A decrease in the use of random or sequential strategy while an increase in the use of direct strategy to search for an escape box occurred in both groups. Evaluation of the levels of neurogenesis markers (Ki67 and BrdU/NeuN) by immunofluorescence assay in the dDG, iDG, and vDG revealed a long-axis disparity in the hippocampal dentate baseline cell proliferation and exposure to the BM and PA task changed the profile of baseline cell proliferation along the DG in both rats and mice. Also, these learning experiences changed the profile of BrdU+ /NeuN+ cells along the DG of rats. Quantitation of hippocampal BDNF protein levels using ELISA exhibited no changes in BDNF levels due to learning experiences in rats. We demonstrate that PP-DG synaptic efficacy and neurogenesis are organized along a gradient. Avoidance and escape conditioning themselves are sufficient to change and calibrate adult neurogenesis along the hippocampal long axis in rodents. Further research will be required to determine the precise mechanisms underlying the role of experience-derived neuroplasticity in cognitive function and decline.

Pediatric anxiety disorders: Basic concepts for primary care.

Anxiety disorders in children and adolescents often present in primary care, and many clinicians will need to guide families on treatment. The purpose of this article is to give a brief overview of assessment and treatment principles for clinicians in primary care. Anxiety and its expression are heavily influenced by children's developmental progression and capabilities. Anxiety disorders have multiple underlying etiologies including temperament, environmental exposure to stressors, and childhood trauma. All anxiety disorders are strengthened by an operant process known as escape conditioning. The most effective treatments for child and adolescent anxiety begin with behavioral-based interventions including exposure with response prevention (ERP) and cognitive behavioral therapy (CBT). Medication can be effective in combination with CBT and ERP, or as a standalone treatment when behavioral interventions are not available. Selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors have been evaluated by randomized clinical trials for the treatment of childhood anxiety, but most are not approved by the Food and Drug Administration. When anxiety is severe and functional impairment is high, referral for psychiatric care and multimodal treatment reduces the likelihood of poor outcomes.

Assessment of air quality using AERMOD modeling: a case study in the Middle East.

Emissions of greenhouse gases from industrial facilities, such as refineries, are one of the most significant environmental problems in many countries. This study aimed to assess the present status of emission sources near a gas refinery region, and the contribution of sources to air pollution was estimated by monitoring CO for a year at a fixed station. This descriptive-analytical study was conducted between January and December 2020. A simulation of CO gas distribution and pollutant concentration prediction was carried out. The results show that the maximum concentration of CO in the 1-h period was 2260 µg/m3, which corresponds to the peak concentration in spring, and in the 8-h period, it was 573 µg/m3, which corresponds to the peak concentration in winter. The studied area's maximum pollutant concentration was also compared to national and international standards for clean air. In all four seasons, the maximum simulated CO concentrations were lower than the Iranian and EPA standards for clean air. Maximum concentrations have occurred in the southern slopes of the study area's heights, and, due to the appropriate wind speed, maximum concentrations in the northeastern mountain peaks occurred at a more considerable distance due to the high altitude of the mountains and the lack of suitable conditions for pollutant escape. Furthermore, because of the height of smokestacks and flares from the ground and the effect of wind on the release height, the concentration of pollutants at the foot of the stacks is low and decreases gradually over a certain distance. Finally, the distribution and deposition of pollutants in the pathway of the smoke were influenced by the type of topography.

Radiation hydrodynamical self-similar accretion disc winds

ABSTRACT Self-similar supersonic winds from an accretion disc around a central object are examined with/without radiation fields under the fully self-similar treatment of two-dimensional outflows. The thermal pressure and viscosity are ignored for simplicity. In the case without radiation fields, many solutions are not outflowing winds, but bound flows, except for limited cases which satisfy the escape condition with sufficiently large initial launch speed and rotational one. In the case with radiation fields, the radiation force acts as a driving force, and therefore, the winds blow easier. However, several solutions are unphysical, since the radiative energy density becomes negative. As a result, depending on the rotational motion and boundary conditions, the radiatively driven self-similar cold disc winds are divided into three types; bound solutions lacking launch speed or radiative acceleration, unphysical ones with a negative energy density, and escaping winds confined in the conical region or extending in the whole space as a special type.

Convergence Properties of the (μ/μI, λ)-ES on the Rastrigin Function.

The highly multimodal Rastrigin test function is analyzed by deriving a new aggregated progress rate measure. It is derived as a function of the residual distance to the optimizer by assuming normally distributed positional coordinates around the global optimizer. This assumption is justified for successful ES-runs operating with sufficiently slow step-size adaptation. The measure enables the investigation of further convergence properties. For moderately large mutation strengths a characteristic distance-dependent Rastrigin noise floor is derived. For small mutation strengths local attraction is analyzed and an escape condition is established. Both mutation strength regimes combined pose a major challenge optimizing the Rastrigin function, which can be counteracted by increasing the population size. Hence, a population scaling relation to achieve high global convergence rates is derived which shows good agreement with experimental data.

Energy analysis of the single impulsive Earth–Moon transfer with the temporary lunar capture

The single impulsive planar Earth–Moon transfer strategy is investigated by analyzing the energy change of the lunar capture. A planar bicircular model of the restricted four-body problem is applied to define the single impulsive trajectory to the Moon from the Earth. Then analytical expressions are derived to describe the energy changes of the lunar capture in the Sun–Earth rotating frame. Accordingly, the eccentricity at the perilune of the single impulsive transfer trajectory can be calculated analytically to explore the lunar escape and capture conditions. The error analysis shows that the theoretical solutions serve as good approximations of the energy changes of the single impulsive transfer. Furthermore, it has been found that the perilune angle and the perilune radius are the critical factors for lunar capture. Finally, the theoretical results are successfully employed to find a series of single impulsive planar Earth–Moon transfers.

The principle of clarity in the study of ways to make escapes from custody.

The subject of the study is the peculiarity of the use of the principle of visibility in the study of methods of escape from custody by suspects (accused) by employees of the security and convoy units of the police. The author draws attention to the fact that for criminal-legal characteristics at different times, including today, not all methods of escape from custody are important, however, it is necessary to know and recognize them for each police officer, since favorable conditions for escape from custody are more often created by themselves employees of security and convoy units. Using the acquired knowledge, a police officer will be able to reproduce the situation in practice and prevent the escape from custody. The article notes the professional qualities that an employee of the security and convoy service must possess in order to successfully solve the tasks assigned to him and the orientation of training that can contribute to the development of these qualities. The author considers the importance of applying the principle of visibility in teaching, justifies the use of specific means of ensuring visibility that can be illustrated to students, and provides examples. The article examines the violations that contribute to the escape from custody, the methods of its commission, in the study of which examples are used in the form of tables, graphs, photographs, video clips, extracts from court decisions. The position is substantiated that using the principle of visibility improves the perception and memorization of information

Bispecific antibody Armed activated T cells exhibit time-dependent co-expression patterns of inhibitory ligands and gene expression programs

Abstract Immunotherapy success has been limited in treating solid tumors. Bispecific antibody Armed activated T cell (BATs) therapy activates, expands, and arms patient T cells ex vivowith bispecific antibodies (BiAb) to produce a “drug” that combines non-MHC restricted cytotoxicity of T cells and specificity of BiAb. BATs therapy promises to improve survival in patients with metastatic breast, prostate, and pancreatic cancer without dose limiting toxicities. However, the anti-tumor potency of BATs varies between patients and decreases with time. Understanding the mechanisms behind this decrease of potency will help identify therapeutic combinations and dosing strategies to maximize patient response. Low effector:target coculture conditions allowing target cell escape from BAT killing were identified. BAT function was measured by anti-tumor cytotoxicity, flow cytometry, and RNA sequencing. Samples were taken at set timepoints to produce a dynamic representation of BAT functional changes in target escape conditions. We observed time-dependent co-expression of inhibitory ligands in BATs, including increased co-expression of PD-1 and LAG3 during the first 24h of coculture, followed by increased co-expression of TIGIT and LAG3 at later timepoints. RNA-seq revealed upregulation of genes associated with T cell dysfunction, including NR4A and checkpoint proteins TIGIT, LAG3, and PD-1, as early as 1 hr in coculture. These findings were integrated into a mechanistic model of BAT-target cell interactions. Our model demonstrated time-dependent emergence of therapeutically targetable inhibitory receptors, suggesting optimizing dosing targets and administration times may improve synergistic immunotherapy combination outcomes.

Is physical pain causally related to suicidal behavior: An experimental test

Existing evidence suggests a link between physical pain and suicide, but the nature of this relationship remains unknown. To address this critical gap in knowledge, the present study leveraged a validated virtual reality (VR) suicide paradigm to experimentally examine the causal effects of physical pain on subsequent virtual suicidal behaviors. Based on previous findings, we hypothesized that physical pain would causally drive virtual suicidal behavior only if suicide was conceptualized as having desirable anticipated consequences (e.g., a means of escaping from current pain; an opportunity to avoid future pain). We tested this by randomizing 326 participants across four different conditions: a physical pain condition, an anticipated escape condition, an anticipated avoidance condition, and a control condition. As predicted, physical pain alone did not result in statistically significant increases in VR suicide rates; however, the anticipation that virtual suicidal behavior would result in the avoidance of future physical pain had a large causal effect on VR suicide rates (B = 1.61, p < .001, IRR = 5.01). We failed to find evidence that anticipating that VR suicide would provide an escape from currently experienced physical pain increases the likelihood of VR suicide. Our findings add to a growing body of evidence suggesting that the anticipated consequences of suicide (e.g., avoidance of future physical pain) may serve as primary causes of suicidal behavior.

Perturbation of relativistic effect in the dynamics of test particle

In this work, the dynamical system of two–body problem under the relativistic effect as a perturbation is considered. The escape conditions and scattering angle are studied, appropriate formulae of scattering angle and escape velocity are found. Furthermore, within the frame of semi–analytical ansatz, two different solutions are found and analyzed: approximation solutions and extended version of Kepler solution. We have demonstrated that the dynamical behaviour of the test particle will drastically be changed according to the initial conditions and the proposed particular assumptions for the particular class of solutions.

Multi-Player Linear-Quadratic Exponential Stochastic Differential Games on Directed Graphs

To solve the problem caused by limited communication and ubiquitous noise, we formulate the multi-player stochastic differential pursuit-evasion games based on directed graphs. This paper proposes a novel Riccati equation concerning multi-player stochastic differential games based on the linear-quadratic exponential cost function. We define capture and escape conditions for pursuers and evaders, respectively. Subsequently, the optimal strategies for pursuers and evaders are obtained based on the communication topologies and a direct method using completion square and Radon-Nikodym derivative. Under the constraints of directed topology, the strategy presented in this article is distributed, and players do not require any global information. Besides, we provide sufficient theoretical evidence that the proposed strategy is a Nash equilibrium. Numerical simulations verify the effectiveness of the strategy in capture scenarios and escape scenarios.

Structural Dynamics and Activity of B19V VP1u during the pHs of Cell Entry and Endosomal Trafficking.

Parvovirus B19 (B19V) is a human pathogen that is the causative agent of fifth disease in children. It is also known to cause hydrops in fetuses, anemia in AIDS patients, and transient aplastic crisis in patients with sickle cell disease. The unique N-terminus of Viral Protein 1 (VP1u) of parvoviruses, including B19V, exhibits phospholipase A2 (PLA2) activity, which is required for endosomal escape. Presented is the structural dynamics of B19V VP1u under conditions that mimic the pHs of cell entry and endosomal trafficking to the nucleus. Using circular dichroism spectroscopy, the receptor-binding domain of B19V VP1u is shown to exhibit an α-helical fold, whereas the PLA2 domain exhibits a probable molten globule state, both of which are pH invariant. Differential scanning calorimetry performed at endosomal pHs shows that the melting temperature (Tm) of VP1u PLA2 domain is tuned to body temperature (37 °C) at pH 7.4. In addition, PLA2 assays performed at temperatures ranging from 25–45 °C show both a temperature and pH-dependent change in activity. We hypothesize that VP1u PLA2 domain differences in Tm at differing pHs have enabled the virus to “switch on/off” the phospholipase activity during capsid trafficking. Furthermore, we propose the environment of the early endosome as the optimal condition for endosomal escape leading to B19V infection.