This study introduces a machine learning-based methodology designed to rapidly predict the seismic responses of reinforced concrete (RC) frame structures. The research focuses on three types of RC frame structures: low-rise, multi-story, and small high-rise buildings. Ground shaking records are selected according to the conditional mean spectrum (CMS). A sample database, constructed via Incremental Dynamic Analysis (IDA), facilitates the prediction of structural responses using ground shaking intensity and structural details as inputs. Concurrently, the study performs a feature importance analysis of the model. Machine learning algorithms, including integrated learning and neural networks, are utilized to predict the seismic responses of the RC frame structures. This methodology also assists in evaluating the seismic fragility of these structures. The results show that the discrepancy between the neural network-based seismic fragility assessments and the IDA results is minimal, indicating a high degree of accuracy in the proposed methodology. Among the characteristic parameters, Average Spectral Acceleration (AvgSa) is identified as the most significant. This methodology serves as a valuable tool for the rapid prediction of seismic responses in RC frame structures, demonstrating substantial practical value.