Currently, there is intense interdisciplinary interest and a significant amount of literature on the prevention and treatment of postoperative scars, but international treatment recommendations and regimens have not yet caught up with current knowledge and practice in many medical institutions.
 The aim of our study was to establish how the biological rhythm can affect the reparative functions of the human body, namely wound healing and scar formation when combining the intraoperative injection of placenta cryoextract and the postoperative electrophoresis on the 90th to 180th day.
 The research was conducted in the Department of Maxillofacial Surgery on the basis of the Poltava Regional Clinical Hospital. M.V. Sklifosivskyi of the Poltava Regional Council". In total, 40 people took part in the study.
 On the 90th day of the clinical study, the average score of postoperative scars was as follows: subgroup 1a was 49.3% lower compared to subgroup 2a. A difference of 25.5% could be observed between subgroups 1a and 1b, and 18.5% between subgroups 2a and 2b. From the data of clinical studies, the best results were obtained in subgroup 1a, which indicates the maximum impact of the author's prevention method on the condition of the postoperative scar in patients with a morning chronotype. In this group, a significant decrease in P1, P2, and P7 indicators was established on the 90th day and zero values on the 180th day, respectively; Indicators P3, P4, and P5 recorded the lowest values on the 90th day and a uniform decrease on the 180th and 360th days.
 Thus, it can be argued that the most optimal results are in patients with the morning type of chronotype, who were injected with placenta cryoextract; the clinical difference was especially noticeable in the earlier period of the postoperative period.