Conditions In Pigs Research Articles

Preliminary research on tailored fluid therapy in pigs: comparing customized ionic solutions with Hartmann’s solution

BackgroundFluid therapy in veterinary medicine is pivotal for treating various conditions in pigs; however, standard solutions, such as Hartmann’s solution, may not optimally align with pig physiology. This study explored the development and efficacy of a customized fluid therapy tailored to the ionic concentrations of pig blood, aiming to enhance treatment outcomes and safety in both healthy and diseased pigs.ResultsThe study involved two experiments: the first to assess the safety and stability of customized fluids in healthy pigs, and the second to evaluate the efficacy in pigs with clinical symptoms of dehydration. In healthy pigs, the administration of customized fluids showed no adverse effects, with slight alterations observed in pO2, hematocrit, and glucose levels in some groups. In symptomatic pigs, the customized fluid group did not show any improvement in clinical symptoms, with no significant changes in blood chemistry or metabolite levels compared to controls. The customized fluid group showed a mild increase in some values after administration, yet within normal physiological ranges. The study reported no significant improvements in clinical or dehydration status, attributing the observed variations in blood test results to the limited sample size and anaesthesia effects rather than fluid characteristics.ConclusionsCustomized fluid therapy, tailored to mimic the ionic concentrations of pig blood, appears to be a safe and potentially more effective alternative to conventional solutions such as Hartmann’s solution for treating pigs under various health conditions. Further research with larger sample sizes and controlled conditions is recommended to validate these findings and to explore the full potential of customized fluid therapy in veterinary practice.

Kajian Studi Sistem Pemeliharaan Ternak Babi Yang Terdampak Asian Swine Fever (ASF) di Kota Palangka Raya

This study aims to determine the effect of raising pigs in the city of Palangka Raya on the incidence of African Swine Fever (ASF). This research is field research using a survey method and the selection of pig pens was carried out using purposive sampling. Correspondents drawn from 15 pig farmers, and pig farming business actors were interviewed and observed about cases of ASF incidents on their farms. The research variables used were the pen system, expert system, health system, and handling system for pigs affected by ASF and not affected by ASF. Data analysis is presented in tabular form and described in the discussion. The research results showed that 14 farmers in the city of Palangka Raya were affected by ASF (93.33%). 11 correspondents (73.33%) had knowledge of ASF cases and immediately reported them to the relevant agencies and 10 correspondent (66.6%) reported them to the nearest veterinarian and 11 correspondent (73.3%) of breeders did not have cages quarantine separating pigs affected by ASF from those not affected by ASF. It was concluded that the rearing system for pigs in the city of Palangka Raya has an influence on the condition of pigs through prevention and a good rearing system.

Changes in cortisol and cortisone in hair of pigs reared under heat stress conditions.

Heat stress accounts for millions of dollars in losses for swine producers worldwide. The aim of the present study was to determine and evaluate cortisol and cortisone in hair as indicators of thermal stress in growing pigs reared under high environmental temperatures. The study was carried out in two independent batches of commercial crosses of Lean Duroc and Pietrain in trials 1 and 2, respectively, during the growing period (from 40 to 100 kg; 81 days in trial 1 and 77 days in trial 2) in the same commercial farm in Spain during the summers of 2020 and 2021. In both cases, four rooms were used. In Trial 1, Room 1 had cooling and 11 pigs per pen; Room 2 had no cooling and 13 pigs per pen; Room 3 had no cooling and 11 pigs per pen, and Room 4 had cooling and 13 pigs per pen. In Trial 2, Rooms 2 and 3 had cooling and rooms 1 and 4 had no cooling, and all of them had 13 pigs per pen. Mean THI value was higher (p < 0.0001) in rooms without cooling systems (75.0 trial 1; 74.9 trial 2) than with them (71.3 trial 1; 71.7 trial 2). A total of four pens per room (16 in total) was selected for analysis of hair corticoids and all pigs inside were sampled at the end of the study. Fifty percent of the pigs were males (castrated and intact in trial 1 and 2, respectively) and 50% females. In total, 44, 52, 44, and 52 pigs, respectively, were sampled in four rooms from the first trial and 52 for each of four rooms in Trial 2. Cortisol concentrations in hair did not show any significant change in relation to cooling-non-cooling in any trial. However, hair cortisone concentration was 172.3 pg./mg and 105.8 pg./mg less (p < 0.001) in pigs housed with cooling systems compared to those without them in Trial 1 and 2, respectively. In addition, the cortisone/cortisol ratio, which is an estimator of the activity of 11β-hydroxysteroid dehydrogenase (11β-HSD) type 2, was also greater in rooms without cooling than in rooms with cooling in both trials (p < 0.0001 and p = 0.0105 for Trials 1 and 2, respectively). In relation to the sex effect, the results showed greater levels in females than in castrated males both in cortisone and the cortisol/cortisone ratio while cortisol hair levels were greater in intact males than in females. Therefore, the use of cortisone and the estimation of 11β-HSD type 2 activity in hair is recommended to evaluate the chronic stress produced by high environmental conditions in pigs instead of using hair cortisol concentrations alone.

Influence of deoxynivalenol and zearalenone on the immunohistochemical expression of oestrogen receptors and liver enzyme genes in vivo in prepubertal gilts

Deoxynivalenol (DON) and zearalenone (ZEN) are often detected in plant materials used to produce feed for pre-pubertal gilts. Daily exposure to small amounts of these mycotoxins causes subclinical conditions in pigs and affects various biological processes (e.g. mycotoxin biotransformation). The aim of this preclinical study was to evaluate the effect of low monotonic doses of DON and ZEN (12 µg/kg body weight—BW—and 40 µg/kg BW, respectively), administered alone or in combination to 36 prepubertal gilts for 42 days, on the degree of immunohistochemical expression of oestrogen receptors (ERs) in the liver and the mRNA expression of genes encoding selected liver enzymes during biotransformation processes. The level of expression of the analysed genes proves that the tested mycotoxins exhibit variable biological activity at different stages of biotransformation. The biological activity of low doses of mycotoxins determines their metabolic activity. Therefore, taking into account the impact of low doses of mycotoxins on energy-intensive processes and their endogenous metabolism, it seems that the observed situation may lead to the activation of adaptation mechanisms.

Influence of nitrogen fertilization on the energy value of maize grain in non-ruminants

Abstract. Maize is the most widely spread energy source used in rations for farm animals and poultry, especially in countries in America, Southern Europe and Asia, where maize grain is the main cereal used for feed. The quality of maize grain is formed under the influence of several interrelated factors. The aim of the study is to determine the effect of different rates of nitrogen fertilization on the chemical composition and energy value of maize grain grown under irrigation conditions in non-ruminants. The study was conducted in the experimental field of the Agricultural Institute – Stara Zagora under irrigation conditions on cinnamon-meadow soil with maize for grain, medium late hybrid LG 35.36 with density of crops – 70000 plants per hectare. The study includes the following four treatments of fertilization: 1 experimental variant N0P80K60 – non-fertilizer control, 2 experimental variant N100P80K60 – fertilization with 100 kg N.ha-1, 3 experimental variant N150P80K60 – fertilization with 150 kg N.ha-1 and 4 experimental variant N200P80K60 – fertilization with 200 kg N.ha-1. Nitrogen fertilizer was applied during the vegetation of the crop in phase 3-5 leaf, and phosphorus and potassium fertilizers in rates 80 kg P2O5.ha-1 and 60 kg K2O.ha-1 in the main tillage. During the vegetation of the maize, pre-irrigation humidity of 80-85% of field capacity (FC) was maintained by 3 waterings. As the fertilization rate increases, the crude protein content in the maize grain also grows up. During the treatment with the highest fertilizer rate of 200 kg N.ha-1, 9.5% per 1 kg of dry matter (DM) was obtained, followed by the treatment with 150 kg N.ha-1 – with a value of 9.1% per 1 kg of dry matter. The content of crude fiber in the grain of maize with increasing fertilization rate decreases, being the smallest in the treatment with rate 100 kg N.ha-1 – 0.8% per 1 kg of dry matter. The fertilization rate does not have a significant effect on the content of digestible and metabolite energy in corn grain grown under irrigated conditions in pigs and poultry.

Experience in the introduction of scientific, information, technological innovations in the production process of the pig breeding complex

Purpose: assessment of the introduction of innovations in the conditions of a pig -breeding complex.A special role in increasing the profitability of agricultural production is given to the use of digital technologies. The authors organized a local network that provides the collection of information about animals throughout the entire period of their use, as a result of which the database is constantly updated with new information. The problem of the correct organization of the in-line process of reproduction of the herd and the uniform production of young animals of the desired condition was solved by scientists of the Don State Agrarian University using the system of index evaluation of young animals, which is implemented in the ACC program package. The complex of ACC programs allows you to keep records of the presence and condition of breeding and commercial pigs; compile reports on the movement of the herd for a day, month, quarter, year; promptly and comprehensively analyze the productivity of animals, timely detect and eliminate deviations in technological indicators; optimize the reproduction process to reduce the number of sow failures; timely identification of sows not coming to hunt; accounting for abortions, causes of death, production rhythm disturbances; accounting for the quantity and quality of sperm production of boars-producers. All this makes it possible to reduce unproductive technological downtime and reduce losses in the production of final products, identify the causes of rejection, conduct a reliable assessment of the quality of work of insemination technicians, animal care operators, as well as analyze veterinary measures. The use of new methods for assessing the breeding value of animals, index selection based on the use of computer technology creates ample opportunities for further improvement of breeding management systems. The positive experience of step-by–step introduction of breeding methods and comprehensive work on a closed circuit "production - science – IT solutions - production" allows you to increase not only the quantity of products, but also its quality.

Cystic hygroma in a female suckling pig: a case report

BackgroundCystic hygromas (lymphangiomas) are rarely reported in various animal species, humans included. A hygroma is a benign congenital malformation of the lymphatic drainage system, presenting itself as a mass consisting of multiple cysts of various sizes with a watery content.Case presentationThis report describes clinical, ultrasonographic, and post-mortem findings of a cystic hygroma in a suckling pig. The mass was characterized by a few thin-walled cysts, containing clear yellow serous fluid. Histologically, the central cavity was lined by a single layer of squamous cells, supported by a thick fibrous stroma. On immunohistochemistry, scattered lining cells were weakly positive for Factor-VIII, suggesting their possible endothelial origin.ConclusionsThis case report contributes to raising awareness on this condition in pigs allowing early identification in life so that appropriate care can be provided. The case report attributes to science on hygromas in general, as better understanding of pathologic features, the aetiology and appropriate treatment are needed.

Poor hygiene of housing conditions influences energy metabolism in a muscle type-dependent manner in growing pigs differing in feed efficiency

The ability of pigs to cope with inflammatory challenges may by modified by selection for residual feed intake (RFI), a measure of feed efficiency. In the current study, we evaluated skeletal muscle metabolic responses to degraded hygiene conditions in pigs divergently selected for RFI. At 82 d of age, low RFI and high RFI pigs were housed in either poor or good hygiene conditions. After a 6-week challenge, the poor hygiene conditions induced a decrease in growth performance (P < 0.001) and in plasma IGF-I concentrations (P < 0.003) in both lines. In the slow-twitch oxidative semispinalis muscle, poor hygiene conditions induced a shift towards a more oxidative metabolism and an activation of the AMPK pathway in pigs of both RFI lines. In the fast-twitch glycolytic longississimus muscle, poor hygiene conditions were associated to a less glycolytic metabolism in the HRFI line only. Poor hygiene conditions also increased the protein level of lipidation of microtubule-associated protein 1 light-chain 3β (LC3-II) in both RFI lines, suggesting an activation of the autophagy pathway. Altogether, the data revealed muscle-type specific metabolic adaptations to poor hygiene conditions, which may be related to different strategies to fuel the activated immune system.

Stress induced by pre-slaughter farm conditions in pigs

ABSTRACT Cortisol is a steroid hormone, one of the glucocorticoids, made in the cortex of the adrenal glands and then released into the blood, which transports it in the entire body. Almost every cell contains receptors for cortisol and so cortisol can have lots of different actions depending on which sort of cells it is acting upon. These effects include controlling the body’s blood sugar levels and thus regulating metabolism, acting as an anti-inflammatory product, controlling salt and water balance and influencing blood pressure. The study was conducted over a period of 3 months, between March-August 2020, in 2 swine farms in Iasi county, Romania, on a total of 46 pigs, 3 to 4 months old, both males and females, in order to investigate stress levels in finishing facilities. The study revealed higher levels of cortisol while eosinophil counts severely decreased, changes which are associated with a strong reaction to stress for individuals that were housed in finishing facilities.

Identification of porcine circovirus-3 in Mozambique

Porcine circovirus 3 (PCV-3) has been associated with an assortment of clinical conditions in pigs and has been reported in many countries worldwide. In Africa there is no data on the presence of PCV-3. In this study, DNA samples collected from 91 pigs between 2011 and 2019 in nine of the ten provinces of Mozambique in the context of African swine fever (ASF) monitoring were further screened for the presence of PCV-3. Of these samples, 7 (7.5%) animals were positive for PCV-3. Sequence and phylogenetic analysis of the capsid protein gene (ORF2) of the PCV-3s provided evidence of epidemiological links with PCV-3s identified in North and South America, Asia, and Europe. This is the first identification of PCV-3 in Mozambique (and Africa) and the first evidence of co-infection of PCV-3 and ASF virus. It should provide a starting point for further investigations into the presence and impact of PCV-3 in Africa.

Some skin conditions in pigs: types, control and prevention

Skin conditions in pigs are common problems presented to the veterinary surgeon. A careful clinical examination, especially considering the age of the pig and the distribution of the lesions, all aids making an accurate diagnosis and treatment plan. Pain management is essential in clinical management. Sarcoptic mange is a condition that can be eliminated from pigs and should be considered a welfare problem. Ear necrosis and trauma injuries can be particularly problematic and must be treated aggressively. African swine fever (ASF) presents with a range of clinical signs including skin lesions, and all veterinary surgeons must be able to put ASF as a differential where appropriate.

Health concerns with backyard pigs

The care of pet pigs and pigs in small holdings can be challenging, as pigs are less commonly seen in general veterinary practice. Although, the majority of health problems in pigs require only basic veterinary care. This article discusses the most likely clinical presentations and outlines several of the more serious conditions in pigs, such as the threat posed by infectious diseases such as African swine fever. Effective communication between vets and owners is very important in the care of pigs and this article also highlights how this can be maintained. It is also important to note that members of the Pig Vet Society are always willing to help colleagues through the more difficult cases

Increased air velocity in the lying area improves pen hygiene and reduces ammonia emissions from houses with partly slatted pens for growing/finishing pigs

Partly slatted pens can offer growing/finishing pigs a better house environment than pens with fully slatted floors. Under thermoneutral conditions, pigs prefer to rest on a solid area and some litter can be provided as enrichment. Ammonia emissions are lower in systems with partly slatted pens, provided the pens are kept clean. However, under high-temperature conditions, pigs in partly slatted pens may begin lying on the slatted area and fouling on the solid floor area, resulting in increased ammonia emissions. This study examined the effects of increasing the air velocity (IAV) in the lying area from max 0.5 m s−1 to max 1.0 m s−1 on conditions for pigs in partly slatted pens during warm periods. Air velocity was increased by redirecting the inlet air from the ceiling inlets down into the animal zone.The study was performed in a commercial growing/finishing house with 10 identical rooms, each containing 16 pens for 9-14 pigs growing from 25-30 kg to 115-120 kg live weight. Pigs were introduced simultaneously into two parallel rooms, one with IAV in the lying area and one without (control treatment). During two summers with six batches, concentrations of carbon dioxide (CO2) and ammonia (NH3), pig activity and choice of lying area in the pen, pen fouling and NH3 emissions were recorded in both rooms on four measuring occasions (M1-M4) during the growing period. Gas concentrations were measured by photoacoustic analyser, pig activity and pig choice of lying area by machine vision techniques, and pen fouling by visual inspection. Climate parameters (air temperature, relative humidity) were logged continuously during the growing period. Ammonia emissions were calculated from the ventilation rate (determined by the indirect CO2 tracer gas method) and the difference in ammonia concentration between outlet and inlet air.Under high ambient temperatures, pigs in the IAV treatment were observed lying significantly more often (p<0.05) in the part of the lying area with the highest air velocity. Pigs tended to lie less in the slatted area (p=0.052) in the IAV treatment than in the control. Problems with pen fouling were significantly reduced with increased air velocity in the lying area and NH3 emissions were reduced by 21% (p=0.009), from 8.4 to 6.6 g pig−1 day−1, during the late growing period (M4).In conclusion, increasing air velocity in the lying area of partly slatted pens from max 0.5 to max 1.0 m s−1 influenced pigs´ choice of lying area, improved pen hygiene and reduced ammonia emissions.

Porcine circoviruses

Porcine circoviruses have become an integral part of the pig production landscape. They are an evolving pathogen whose impact spans non-pathogenic to association with some of the most serious and far-reaching pathological conditions of pigs.

Bionic measurement of defecation in a swine model

Objective. Fecobionics was used to assess pressures, orientation, bending, shape, and cross-sectional area (CSA) changes during defecation. This study aimed to evaluate the device feasibility and performance in swine. Approach. Twelve pigs had wired or wireless Fecobionics devices inserted in the rectum. The bag was distended to simulate feces in the rectum. Fecobionics data were acquired simultaneously during the whole experiment. Six pigs were euthanized immediately after the procedure for evaluation of acute injury to anorectum (acute group). The remaining pigs lived two weeks before euthanasia for evaluation of long-term tissue damage and inflammation (chronic group). Signs of discomfort were monitored. Main results. All animals tolerated the experiment well. The chronic animals showed normal behavior after the procedure. Mucosal damage, bleeding, or inflammation was not found in either group. Fecobionics was defecated 1 min 35 s–61 min 0 s (median 8 min 58 s) after insertion. The defecation lasted 0 min 20 s–4 min 25 s (median 1 min 52 s). The device was almost straight inside rectum (160°–180°) but usually bended 5°–20° during contractions. The three pressure sensors showed simultaneous and identical increase during rectal or abdominal muscle contractions, indicating the location inside rectum. During defecation, the maximum rear pressure was 114.1 ± 14.3 cmH2O whereas the front pressure gradually decreased to 0 cmH2O, indicating the front passed anus. CSA decreased from 1017.1 ± 191.0 mm2 to 530.7 ± 46.5 mm2 when the probe passed from the rectum through the anal canal. Significance. Fecobionics provides defecatory measurements under physiological conditions in pigs without inducing tissue damage.

Effects of tissue-specific biomolecules on piglets after-weaning period.

Background and Aim:Now-a-days antibiotics are the main tool for correcting the pathological conditions of pigs; unfortunately, antibiotics are a potential threat to the environment, as they lead to the spread of antibiotic-resistant infections. This study aimed to study the immunomodulatory encapsulated biomolecules on piglets in the post-weaning period.Materials and Methods:An immunomodulator based on biomolecules obtained from animal raw materials included in alginate capsules to improve absorption has been developed. The study presents the results of a study on 25 weaned piglets (25-30 days old) which received biomolecules at a dose of 200 mg/piglet for 14 days, followed by 400 mg/piglet from days 15 to 28. Blood was taken from animals for analysis (biochemical, hematological, cytometric, and enzyme immunoassay) and the integral index of blood serum antimicrobial activity was determined.Results:Experimental animals, whose initial weight was 1.6 times less than that of the control animals, were able to bridge this gap and, on the 28th day, there were no differences in weight. Stimulation of the production of cytokines interleukin (IL)-2 and IL-4 was observed and the antimicrobial resistance of blood serum to Escherichia coli also increased. A positive effect on the metabolism of piglets was noted, which helped them adapt to a change in diet (from colostrum to solid food).Conclusion:The results show that the immunomodulation at the dose of 150 mg/kg body weight has a great potential for improving weaned pigs.

Swine influenza: Newer data on diagnosis, interpretation of the results, and control

Influenza viruses are among the major causes of acute respiratory disease outbreaks in pigs. In most cases, infections are subclinical. Until 2009, three subtypes of IAV-S circulated in the pig population in Europe, with some geographical restrictions regarding their prevalence: avian-like (av) H1N1, reassortant (r) H3N2, and human (hu) H1N2. Viruses of the H1N1av lineage appeared to be responsible for the majority of swine infections in Europe. In 2009, a fourth subtype entered the pig population: the human pandemic H1N1 2009 influenza A virus (H1N1pdm). Due to the expression of receptors with α-2-6 or α-2-3-linked terminal sialic acids in the porcine upper respiratory tract, swine appear to be susceptible to influenza A viruses of both avian and human origin. A clinical diagnosis of swine influenza is not easy, since there are no observable pathognomonic clinical signs, and the disease must be distinguished from a variety of other respiratory conditions in pigs. A final diagnosis can be made by the following methods: detection of viral proteins or nucleic acid, isolation of virus, or demonstration of virus-specific antibodies. IAV-S is most likely to be found in nasal and pharyngeal secretions during the fever period of illness. Serological tests are used to demonstrate the presence of influenza-specific antibodies. Serology is the most useful technique to determine the immune status of the herd, to assess the levels of maternally derived antibodies in young piglets and their profile, as well as post-vaccination antibody titers, and to perform pre-movement testing of pigs. The interpretation of serological data is often complex and may be further confounded by concurrent circulation of different virus subtypes and gene lineages. In control of IAV-S, vaccination appears to be the primary tool for preventing influenza. The efficacy of vaccination may be various and is correlated with homology between vaccine and field IAV-S strains. There is no treatment available for IAV-S. The administration of aspirin via the water system or of paracetamol in feed may play a role as a support therapy. To avoid subsequent bacterial infections, treatment with an antibiotic is essential.

Characterization of gastrointestinal transit and luminal conditions in pigs using a telemetric motility capsule

Within preclinical research, the pig has become an important model in regulatory toxicology and pharmacokinetics, to assess oral dosage forms and to compare different formulation strategies. In addition, there are emerging application of the pig model to asses clinical dosing conditions in the fasted and fed state. In this study, the gastrointestinal transit conditions in male landrace pigs were studied with a telemetric motility capsule under fasted and postprandial conditions. The whole gut transit time (WGTT) was determined by administering a SmartPill® capsule to four landrace pigs, under both fasted and fed state conditions in a cross-over study design. Overall, this study found that small intestinal transit in landrace pigs ranged from 2.3 – 4.0 h, and was broadly similar to reported human estimates and was not affected by the intake conditions. Gastric emptying was highly variable and prolonged in landrace pigs ranging from 20 – 233 h and up to 264 h in one specific case. Under dynamic conditions pigs have a low gastric pH comparable to humans, however a high variability under fasted conditions could be observed. The comparison of the data from this study with a recent similar study in beagle dogs revealed major differences between gastric maximum pressures observed in landrace pigs and dogs. In the porcine stomach maximum pressures of up to 402 mbar were observed, which are comparable to reported human data. Intestinal maximum pressures in landrace pigs were in the same range as in humans. Overall, the study provides new insights of gastrointestinal conditions in landrace pigs, which can lead to more accurate interpretation of in vivo results obtained of pharmacokinetic studies in preclinical models. While small intestinal transit conditions, GI pH and pressures were similar to humans, the prolonged gastric emptying observed in pigs need to be considered in assessing the suitability of the pig model for assessing in vivo performance of large non-disintegrated oral drug products.

Generation of reference serum proteome map for monitoring swine health

To the best of our knowledge, it is the first report on pig serum proteome map generated with LAPs enriched serum using nano ESI LC-MS/MS method. A total of 224 proteins were identified including several proteins not yet reported in earlier pig serum proteome maps. Moreover, identification of many intracellular proteins indicates their usefulness in determination of altered cell functionality. Altogether, the identified proteins in our study can serve as baseline prerequisite for future analytical studies to understand different patho-physiological conditions in pigs.

A Novel Therapeutic Reagent, KA-1002 for Alleviating Lysophosphatidic Acid-Mediated Inflammation Related Gene Expression in Swine Macrophages.

Simple SummaryInflammatory diseases are a key factor reducing the productivity of animals in a livestock industrial environment. We have identified a novel lysophosphatidic acid signaling antagonist, KA-1002, which alleviates lysophosphatidic acid-mediated a broad range of inflammation related gene expression in swine macrophages. Specifically, we found that KA-1002 significantly alleviated LPA-induced genes related with inflammation such as a role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis and STAT3 signal pathway. Taken together, KA-1002 could be considered a novel therapeutic reagent candidate for swine inflammatory diseases.Stresses and various infectious reagents caused multiple inflammatory diseases in swine in a livestock industrial environment. Therefore, there is a need for an effective therapeutic or preventive agent that could alleviate chronic and acute inflammation. We found that lysophosphatidic acid (LPA), a stress-induced potent endogenous inflammatory molecule, causes a broad range-regulation of inflammation related genes inflammation in swine macrophages. We further investigated the genome scaled transcriptional regulatory effect of a novel LPA-signaling antagonist, KA-1002 on swine macrophages, inducing the alleviated LPA-mediated inflammation related gene expression. Therefore, KA-1002 could potentially serve as a novel therapeutic or preventive agent to maintain physiologically healthy and balanced conditions of pigs.