In this research paper, we delve into the analysis of a generalized discrete reaction-diffusion system. Our study begins with the discretization of a generalized reaction-diffusion model, achieved through second-order and L1-difference approximations. We explore the local stability of its unique solution, both in the absence and presence of the diffusion term. To determine the conditions for global asymptotic stability of the steady-state solution, we employ suitable techniques including the direct Lyapunov method. To illustrate the practical application of this theoretical framework, we provide several numerical simulations that examine both the Lengyel-Epstein reaction-diffusion model and the discrete Degn-Harrison reaction-diffusion model. These simulations serve to validate the predictions of asymptotic stability.