BackgroundWe examined the associations and interactions of hearing impairment (HI) and vision impairment (VI) with frailty. MethodsWe performed a 3-year longitudinal analysis of the Japan Gerontological Evaluation Study (JAGES), a nationwide prospective cohort study of functionally independent Japanese older people (age ≥ 65 years). Frailty status at baseline and follow-up was defined according to the Kihon Checklist. HI and VI at baseline were self-reported. Logistic regression models were used to examine the main and interaction effects of HI and VI on incident frailty during a 3-year follow-up period. ResultsOf the 7,852 participants (mean age 73.2 years, standard deviation 5.6; 50.7% women), 9.7%, 5.3%, and 1.9% reported HI, VI, and concurrent HI and VI, respectively. After adjusting for possible confounders and the other sensory impairment, VI (odds ratio [OR] 2.50, 95% confidence interval [CI] 1.62–3.85, p < 0.001), but not HI (OR 1.29, 95% CI 0.97–1.72, p = 0.081), was significantly associated with incident combined pre-frailty and frailty from a robust baseline. No interaction was observed between HI and VI (OR 0.83, 95% CI 0.38–1.81, p = 0.636). We observed no significant associations between sensory impairments and incident frailty from a pre-frail baseline (HI: OR 1.26, 95% CI 0.88–1.80, p = 0.205; VI: OR 1.44, 95% CI 0.90–2.31, p = 0.127; interaction between HI and VI: OR 1.16, 95% CI 0.53–2.53, p = 0.718). ConclusionsVI, rather than HI, may be an independent risk factor for frailty, without any interaction between the two.
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