Concurrent Applications Research Articles

Auditory Proprioceptive Integration: Effects of Real-Time Kinematic Auditory Feedback on Knee Proprioception.

The purpose of the study was to assess the influence of real-time auditory feedback on knee proprioception. Thirty healthy participants were randomly allocated to control (n = 15), and experimental group I (15). The participants performed an active knee-repositioning task using their dominant leg, with/without additional real-time auditory feedback where the frequency was mapped in a convergent manner to two different target angles (40 and 75°). Statistical analysis revealed significant enhancement in knee re-positioning accuracy for the constant and absolute error with real-time auditory feedback, within and across the groups. Besides this convergent condition, we established a second divergent condition. Here, a step-wise transposition of frequency was performed to explore whether a systematic tuning between auditory-proprioceptive repositioning exists. No significant effects were identified in this divergent auditory feedback condition. An additional experimental group II (n = 20) was further included. Here, we investigated the influence of a larger magnitude and directional change of step-wise transposition of the frequency. In a first step, results confirm the findings of experiment I. Moreover, significant effects on knee auditory-proprioception repositioning were evident when divergent auditory feedback was applied. During the step-wise transposition participants showed systematic modulation of knee movements in the opposite direction of transposition. We confirm that knee re-positioning accuracy can be enhanced with concurrent application of real-time auditory feedback and that knee re-positioning can modulated in a goal-directed manner with step-wise transposition of frequency. Clinical implications are discussed with respect to joint position sense in rehabilitation settings.

Cache-Aware Query Optimization in Multiapplication Sharing Wireless Sensor Networks

Hosting multiple applications in a shared infrastructure of wireless sensor networks is a trend nowadays, and sharing sensory data for answering concurrent applications is a promising and energy-efficient strategy. To address this challenge, this paper proposes an energy-efficient query optimization mechanism for supporting multiple concurrent applications leveraging our two-tier cooperative caching mechanism. Specifically, query requests for concurrent applications are represented as binary strings, which are reduced to a single one for avoiding the reprocessing of shared subquery requests. This reduced query request is answered through our cooperative caching mechanism, where sensory data, which are highly possible to be reused for answering forthcoming query requests, are cached at the sink node (SN). Besides, the gray model GM(1, 1) is adopted for forecasting sensory data units which may be interested mostly by forthcoming query requests. These units of sensory data may be prefetched from the network and cached at the SN. Experimental evaluation shows that this approach can reduce the energy consumption significantly, and improve the network capacity to an extent, especially when the number of concurrent query requests is relatively large.

Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson’s disease? A pilot study

Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can boost motor performance in Parkinson’s disease (PD) when it is applied at rest. However, the potential supplementary therapeutic effect of the concurrent application of tDCS during the training of motor tasks is largely unknown. The present study examined the effects of tDCS on upper limb motor blocks during a freezing-provoking writing task (the funnel task) requiring up- and down-stroke movements at alternating amplitudes. Ten PD patients and 10 age-matched controls underwent two sessions of writing combined with 20 min of anodal or sham tDCS on the left M1 in a randomized cross-over design. The primary outcome was the number of upper limb freezing episodes during five trials of the funnel task on a touch-sensitive tablet. PD patients showed a significant reduction in freezing episodes during tDCS compared to sham. No effects of tDCS were found for the amplitude, variability and speed of the strokes outside the freezing episodes. However, patients who reported freezing episodes in daily life (N = 6) showed a beneficial effect of tDCS on stroke characteristics. These results indicate a subgroup-dependent variability in response to non-invasive brain stimulation applied during the performance of motor tasks in PD. This warrants future studies to examine tDCS as an adjuvant tool for training programs aimed to reduce motor deficits related to freezing.

Involving users in energy conservation: a case study in scientific clouds

Services offered by cloud computing are convenient to users for reasons such as their ease of use, flexibility, and financial model. Yet data centres used for their execution are known to consume massive amounts of energy. The growing resource utilisation following the cloud success highlights the importance of the reduction of its energy consumption. This paper investigates a way to reduce the footprint of HPC cloud users by varying the size of the virtual resources they request. We analyse the influence of concurrent applications with different resources sizes on the system energy consumption. Simulation results show that resources with larger size are more energy consuming regardless of faster completion of applications. Although smaller-sized resources offer energy savings, it is not always favourable in terms of energy to reduce too much the size. High energy savings depend on the user profiles' distribution.

Safe privatization in transactional memory

Transactional memory (TM) facilitates the development of concurrent applications by letting the programmer designate certain code blocks as atomic. Programmers using a TM often would like to access the same data both inside and outside transactions, e.g., to improve performance or to support legacy code. In this case, programmers would ideally like the TM to guarantee strong atomicity , where transactions can be viewed as executing atomically also with respect to non-transactional accesses. Since guaranteeing strong atomicity for arbitrary programs is prohibitively expensive, researchers have suggested guaranteeing it only for certain data-race free (DRF) programs, particularly those that follow the privatization idiom: from some point on, threads agree that a given object can be accessed non-transactionally. Supporting privatization safely in a TM is nontrivial, because this often requires correctly inserting transactional fences , which wait until all active transactions complete. Unfortunately, there is currently no consensus on a single definition of transactional DRF, in particular, because no existing notion of DRF takes into account transactional fences. In this paper we propose such a notion and prove that, if a TM satisfies a certain condition generalizing opacity and a program using it is DRF assuming strong atomicity, then the program indeed has strongly atomic semantics. We show that our DRF notion allows the programmer to use privatization idioms. We also propose a method for proving our generalization of opacity and apply it to the TL2 TM.

Application of Biochar and Compost for Enhancement of Rice (Oryza Sativa L.) Grain Yield in Calcareous Sandy Soil

ABSTRACTThe application of compost to calcareous soils by farmers is a well-established practice and has been shown to improve yields. However, incorporation of biochar and mixture of biochar and compost into calcareous soils is a relatively novel concept for improving soil quality and yield since calcareous soils comprise a large scale of soils worldwide. The objective of this study was to determine the effects of the co-application of biochar and compost on the soil properties, nutrient status and grain yield of rice in calcareous sandy soil. The experiment was conducted in a factorial arrangement based on randomized complete block design with three replications. The compost application rates were 1% and 3% (w/w; compost/soil) and the applied rates of biochars (rice straw biochar, RSB; sugarcane bagasse biochar, SBB) were 0.3% and 0.9% (w/w; biochar/soil). The results showed that soil pH decreased with increasing application rates of either compost or biochars. However, soil EC was enhanced through increasing the application rates of compost and biochars. The co-application of biochar and compost improved soil total N and available P concentrations. The soil available K increased with increasing the rate of incorporated biochars and compost. An increase of soil available K was more predominate with the application of RSB than SBB. The RSB, also, added a considerable amount of silicon (Si) to the soil. The co-incorporation of biochars and compost enhanced soil available concentrations of Fe, Zn, Cu, and Mn as well. The RSB was more effective than the SBB in grain yield enhancement almost certainly due to a higher Si content in RSB. Furthermore, the concurrent application of biochars and compost increased grain yield more than applying them individually. A higher application rate of biochar and compost induced a higher grain yield. The co-application of highest rates of RSB (0.9%) and compost (3%) induced the highest grain yield (26.1 g/pot) among the treatments. The increase in yield compare to the control were 321% and 260% for 0.9% RSB + 3% compost and 0.9% SBB + 3% compost, respectively. The increase in the grain yield was due to an improvement in the soil chemical properties and nutrients enhancement. Finally, the co-application of the highest rate of RSB (0.9%) and compost (3%) is recommended to obtain the appropriate rate of rice grain yield in calcareous sandy soil.

A feasibility study of neo-adjuvant low-dose fractionated radiotherapy with two different concurrent anthracycline-docetaxel schedules in stage IIA/B-IIIA breast cancer.

The aim of the study was to evaluate the feasibility of neoadjuvant low-dose fractionated radiotherapy, in combination with two anthracycline-docetaxel regimens, in breast cancer treatment. Women with stage IIA/B-IIIA breast cancer were assigned to receive the treatment of low-dose fractionated radiotherapy (0.4 Gy/per fraction, 2 fractions per day, for 2 days, every 21 days for 8-6 cycles) with concomitant neoadjuvant chemotherapy with non-pegylated liposomal doxorubicin and docetaxel. Two chemotherapy schedules were planned to be combined with low-dose fractionated radiotherapy. The first schedule consisted of four cycles of non-pegylated liposomal doxorubicin sequentially followed by four cycles of docetaxel, and the second schedule consisted of six cycles of non-pegylated liposomal doxorubicin plus concomitant docetaxel. Acute toxicity was evaluated according to the Radiation Therapy Oncology Group score system. Pathological response was evaluated by the Mandard score and expressed as tumor regression grade. Between March 2008 and February 2009, 10 patients underwent low-dose fractionated radiotherapy and concomitant chemotherapy. No grade 3-4 breast toxicity was observed. Five patients had a clinical complete response. Seven patients underwent conservative surgery. Overall, tumor regression grade 1 (absence of residual cancer) was achieved in one patient (10%) and grade 2 (residual isolated cells scattered through the fibrosis) in 4 patients (40%). The pathologic major response rate (tumor regression grade 1 + 2) was 20% in patients receiving low-dose fractionated radiotherapy and sequential non-pegylated liposomal doxorubicin and docetaxel and 80% in the group receiving low-dose fractionated radiotherapy and concurrent non-pegylated liposomal doxorubicin and docetaxel treatment. Concomitant low-dose fractionated radiotherapy combined with anthracycline and docetaxel is feasible. The toxicity profile of radio-chemotherapy was similar to that of chemotherapy alone: there was no acute skin or cardiac toxicity. The concurrent application of liposomal doxorubicin and docetaxel with low-dose fractionated radiation led to higher histological response rates compared to the sequential application of the same two drugs.

Enhancing proliferation and optimizing the culture condition for human bone marrow stromal cells using hypoxia and fibroblast growth factor-2

This study aimed to determine the cellular characteristics and behaviors of human bone marrow stromal cells (hBMSCs) expanded in media in a hypoxic or normoxic condition and with or without fibroblast growth factor-2 (FGF-2) treatment. hBMSCs isolated from the vertebral body and expanded in these four groups were evaluated for cellular proliferation/migration, colony-forming units, cell-surface characterization, in vitro differentiation, in vivo transplantation, and gene expression. Culturing hBMSCs using a particular environmental factor (hypoxia) and with the addition of FGF-2 increased the cellular proliferation rate while enhancing the regenerative potential, modulated the multipotency-related processes (enhanced chondrogenesis-related processes/osteogenesis, but reduced adipogenesis), and increased cellular migration and collagen formation. The gene expression levels in the experimental samples showed activation of the hypoxia-inducible factor-1 pathway and glycolysis in the hypoxic condition, with this not being affected by the addition of FGF-2. The concurrent application of hypoxia and FGF-2 could provide a favorable condition for culturing hBMSCs to be used in clinical applications associated with bone tissue engineering, due to the enhancement of cellular proliferation and regenerative potential.

Effect of Out-of-Band Blockers on the Required Linearity, Phase Noise, and Harmonic Rejection of SDR Receivers Without Input SAW Filter

The required linearity of wideband receivers for applications, such as software-defined radio in the absence of input surface-acoustic wave (SAW) filters, is studied. It is shown that the required linearity of wideband SAW-less receivers is surprisingly higher than what has been commonly assumed. For these receivers, although the out-of-band blockers can reduce the compression point of the receiver, they can also potentially generate interferers that appear in the desired frequency band, resulting in higher noise floor and signal corruption. The required out-of-band IIP2 and IIP3 of low-noise amplifier (LNA) and mixer for single and concurrent applications are analytically derived. The required wideband SAW-less receiver phase noise is also studied, and it is shown that blockers located at the frequencies of the local oscillator harmonics can significantly increase the noise floor of the receiver. The effects of input and intermediate filters on the above applications along with the conditions under which they help to alleviate the limitations of LNA and mixer are defined. The validity of the models and subsequent derivations is verified by actual measurements using a wideband SAW-less receiver.

Performance Assessment of Emerging Memories through FPGA Emulation

Emerging memory technologies offer the prospect of large capacity, high bandwidth, and a range of access latencies ranging from DRAM-like to SSD-like. In this paper, we evaluate the performance of parallel applications on CPUs whose main memories sweep a wide range of latencies within a bandwidth cap. We use an FPGA emulator, the logic in memory emulator (LiME) to accelerate evaluation. The LiME framework uses a multiprocessor system on chip (MPSoC) combining multicore CPU, integrated memory controller, and FPGA fabric, and enables emulation orders of magnitude faster than software simulation. Our paper highlights the performance impact of higher latency on concurrent applications and identifies conditions under which future high latency memories can effectively be used as main memory.

Sustainability-based Optimization Criteria for Industrial Symbiosis: The Symbioptima Case

The United Nations’ Sustainable Development Goals require industrial infrastructures to provide a positive impact on society by reducing waste generation and resource consumption. The enhancement and optimization of symbiotic aspects in industry clusters can support the achievement of such goals. The present paper illustrates a new quantification methodology to foster the implementation of industrial symbiosis within existing industry clusters. A Java tool has been developed to track and optimize material and energy flows within different symbiosis scenarios. The quantitative assessment is focused on identifying environmental, social and cost gains for specific Key Performance Indicators, considering a comprehensive Life Cycle Sustainability Assessment (LCSA) perspective. Furthermore, multi-criteria optimization allows to identify heuristic solutions for symbiosis scenarios. The tool has been implemented with reference to a symbiosis case from the Steel Sector. Preliminary results evidence that industrial symbiosis and industrial sustainability are complementary but different areas. Moreover, concurrent applications of such paradigms introduce a number of new challenges and operational managerial issues to be addressed.

Characterizing Transactional Memory Consistency Conditions Using Observational Refinement

Transactional memory (TM) facilitates the development of concurrent applications by letting a programmer designate certain code blocks as atomic. The common approach to stating TM correctness is through a consistency condition that restricts the possible TM executions. Unfortunately, existing consistency conditions fall short of formalizing the intuitive semantics of atomic blocks through which programmers use a TM. To close this gap, we formalize programmer expectations as observational refinement between TM implementations. This states that properties of a program using a concrete TM implementation can be established by analyzing its behavior with an abstract TM, serving as a specification of the concrete one. We show that a variant of Transactional Memory Specification (TMS), a TM consistency condition, is equivalent to observational refinement for a programming language where local variables are rolled back upon a transaction abort. We thereby establish that TMS is the weakest acceptable condition for this case. We then propose a new consistency condition, called Strong Transactional Memory Specification (STMS) , and show that it is equivalent to observational refinement for a language where local variables are not rolled back upon aborts. Finally, we show that under certain natural assumptions on TM implementations, STMS is equivalent to a variant of a well-known condition of opacity. Our results suggest a new approach to evaluating TM consistency conditions and enable TM implementors and language designers to make better-informed decisions.

SCALO

Shared memory machines continue to increase in scale by adding more parallelism through additional cores and complex memory hierarchies. Often, executing multiple applications concurrently, dividing among them hardware threads, provides greater efficiency rather than executing a single application with large thread counts. However, contention for shared resources can limit the improvement of concurrent application execution: orchestrating the number of threads used by each application and is essential. In this article, we contribute SCALO, a solution to orchestrate concurrent application execution to increase throughput. SCALO monitors co-executing applications at runtime to evaluate their scalability. Its optimizing thread allocator analyzes these scalability estimates to adapt the parallelism of each program. Unlike previous approaches, SCALO differs by including dynamic contention effects on scalability and by controlling the parallelism during the execution of parallel regions. Thus, it improves throughput when other state-of-the-art approaches fail and outperforms them by up to 40% when they succeed.

Learning curve in concurrent application of laparoscopic and robotic-assisted hysterectomy with lymphadenectomy in endometrial cancer

ObjectiveTo evaluate the concurrent interaction of laparoscopic and robotic-assisted surgery in the initial learning period of endometrial cancer staging. Materials and methodsA retrospective cohort study was performed for the first 44 consecutive patients with endometrial cancer underwent laparoscopic (LSS) or robotic-assisted staging surgery (RSS) from February 2012 to October 2015 by a single surgeon in a tertiary care referral hospital. Demographics, diagnosis, perioperative variables, and complications were recorded. Quality of surgery was determined by the number of lymph nodes dissected and learning curve was estimated by operative time with respect to chronologic order of operation. ResultsTwenty-four patients received LSS and 20 patients received RSS. RSS required longer operative time, but obtained more total number of lymph nodes compared with LSS (286.9 vs. 201.9 min (p < 0.001); 26.2 vs. 20.7 (p < 0.05), respectively. There were no difference in blood loss, number of para-aortic nodes removed, complications and hospital stay between the two types of surgery. An additive model based on tumor grade, body mass index, estimated blood loss and chronological order of operation was constructed to fit operative time of these two types of surgery. Proficiency of achievement was not observed for LSS and was 6 for RSS. ConclusionsOperative time was longer but Lymph node dissection was easier in RSS. Learning curve for LSS to maintain similar surgical quality as RSS was not observed. The concurrent use of robotic platform in the initial practice of minimally invasive staging surgery could optimize surgical technique for LSS.

Analysis, Classification and Comparison of Scheduling Techniques for Software Transactional Memories

Transactional Memory (TM) is a practical programming paradigm for developing concurrent applications. Performance is a critical factor for TM implementations, and various studies demonstrated that specialised transaction/thread scheduling support is essential for implementing performance-effective TM systems. After one decade of research, this article reviews the wide variety of scheduling techniques proposed for Software Transactional Memories. Based on peculiarities and differences of the adopted scheduling strategies, we propose a classification of the existing techniques, and we discuss the specific characteristics of each technique. Also, we analyse the results of previous evaluation and comparison studies, and we present the results of a new experimental study encompassing techniques based on different scheduling strategies. Finally, we identify potential strengths and weaknesses of the different techniques, as well as the issues that require to be further investigated.

Symbiotic Sensing for Energy-Intensive Tasks in Large-Scale Mobile Sensing Applications.

Energy consumption is a critical performance and user experience metric when developing mobile sensing applications, especially with the significantly growing number of sensing applications in recent years. As proposed a decade ago when mobile applications were still not popular and most mobile operating systems were single-tasking, conventional sensing paradigms such as opportunistic sensing and participatory sensing do not explore the relationship among concurrent applications for energy-intensive tasks. In this paper, inspired by social relationships among living creatures in nature, we propose a symbiotic sensing paradigm that can conserve energy, while maintaining equivalent performance to existing paradigms. The key idea is that sensing applications should cooperatively perform common tasks to avoid acquiring the same resources multiple times. By doing so, this sensing paradigm executes sensing tasks with very little extra resource consumption and, consequently, extends battery life. To evaluate and compare the symbiotic sensing paradigm with the existing ones, we develop mathematical models in terms of the completion probability and estimated energy consumption. The quantitative evaluation results using various parameters obtained from real datasets indicate that symbiotic sensing performs better than opportunistic sensing and participatory sensing in large-scale sensing applications, such as road condition monitoring, air pollution monitoring, and city noise monitoring.

Concurrent application of ethyl formate and 1‐methylcyclopropene to control Tetranychus urticae on exported sweet persimmons (Diospyros kaki Thunb. ‘Fuyu’)

AbstractExtending the shelf life of fruits during post‐harvest storage and eradicating pests associated with quarantine issues could together comprise the key steps toward expanding the exportation of sweet persimmon in South Korea. Here we firstly investigated the concurrent application of ethyl formate (EF), a methyl bromide alternative fumigant, which is currently considered a beneficial and safe fumigant in quarantine use, and 1‐methylcyclopropene (1‐MCP), an anti‐ethylene compound that is broadly used in post‐harvest systems, on sweet persimmon. We also suggest the proper fumigation methods to be follow when using these compounds. Tetranychus urticae, an important quarantine pest, was inoculated under the calyx of sweet persimmon, and the fruits were then fumigated using 35.0 mg L−1 of EF for 6 h before and after treating with 1.0 μL L−1 of 1‐methylcyclopropene for 24 h under storage conditions of 5°C. Our results showed that concurrent treatments with 1‐MCP and EF could be suitable for commercial purposes by extending shelf life, delaying color changes and softening, and offering complete control of the target pest, Tetranychus urticae.

IMMU-59. ALTERNATING ELECTRIC FIELDS (TTFIELDs) INDUCE IMMUNOGENIC CELL DEATH RESULTING IN ENHANCED ANTITUMOR EFFICACY WHEN COMBINED WITH ANTI-PD-1 THERAPY

AbstractTumor Treating Fields (TTFields) are an effective anti-neoplastic treatment modality delivered via noninvasive application of low intensity, intermediate frequency, alternating electric fields. TTFields are employed as a local treatment modality with the intent to kill tumor cells and reduce local recurrence. This therapy is approved for the treatment of patients with glioblastoma. Previous investigations have shown that TTFields disrupt formation of the mitotic spindle, leading to abnormal chromosome segregation and various modes of cell death. In this study we evaluated whether TTFields-induced cell death can be perceived as immunogenic by the immune system. We demonstrate that cancer cells that die under TTFields application exhibit release of the chromatin-binding protein high mobility group B1(HMGB-1), endoplasmic reticulum (ER) stress leading to Calreticulin translocation to the cell surface, and autophagy leading to decreased intracellular levels of adenosine triphosphate (ATP), all of which are cardinal signs of immunogenic cell death. In vivo, the combined treatment of lung tumor-bearing mice with TTFields plus the immune checkpoint inhibitor anti-programmed death 1 (PD-1) led to a significant decrease in tumor volume compared to anti-PD-1 alone or to the control group. Significant increases in CD45+ tumor infiltrating cells were observed in the TTFields plus anti-PD-1 group. These infiltrating cells, specifically macrophages (F4/80+CD11b+) and dendritic (CD11c+) cells, demonstrated a significant upregulation of surface PD-L1 expression as compared to infiltrating immune cells in the control group. Our results demonstrate the potential of TTFields therapy to induce immunogenic cell death in vitro which may lead enhanced immune response against cancer cells. We also demonstrate significant efficacy of concurrent application of TTFields and anti PD-1 therapy in vivo. These data suggest that combining TTFields with anti-PD-1 might achieve tumor control by further enhancing antitumor immunity.

Development of novel adjustable focus head mount display for concurrent image-guided treatment applications

Purpose: A conventional see-through head mount display contains many optical lenses, which can be problematic in image-guided treatment applications due to its size, weight, structure, and focus limitation. Therefore, we have designed a new type of see-through head mount display with a reduced number of optical lenses and an adequate optical resolution that can be utilized for image-guided treatment applications.Materials and methods: A new type of adjustable focus head mount display with expanded virtual images and an external treatment space that can be provided to the eyes of a user by enlarging the images of a small display is designed and investigated in this study. This type of head mount display can be used in image-guided treatment applications because of the dual paths of imaging and treatment from the optical systems. Therefore, this system with an adjustable focus function can aid doctors in obtaining images for the treatment of the eyes of patients because every patient has a unique pupil size.Results: The results of the adjustable focus see-through head mount display showed distortion values of +0.36% in the +1 diopter location and −0.55% in the −4 diopter location, and there are less significant modulation transfer function differences within the ±5 diopter locations.Conclusions: Low optical distortions within ±0.5 diopters can help doctors image the eye conditions of patients through fewer image processing techniques. Therefore, the designed adjustable focus head mount display can provide low optical aberrations and high optical modulation transfer function resolutions for image-guided treatment applications.

Large Deviations for Increasing Subsequences of Permutations and a Concurrency Application

The study of concurrent processes with conflict points is connected with the geometry of increasing subsequences of permutations -- a permutation encodes the transactions of two processes that conflict (i.e., must be executed serially), and a given increasing subsequence encodes one particular serialization of the executions of two processes. This motivates the study of random increasing subsequences of random permutations. Here, we give a large deviation principle which implies that such a subsequence never deviates too far from the identity permutation: a random serialization of two concurrent processes will not favor either process too much at any given time. We then give an efficient exact algorithm for uniform random sampling of an increasing subsequence from a given permutation.