The manuscript introduces a new structural system called the reinforced concrete (RC) space grid cassette multi-tube structure for high-rise buildings. A case study building is analyzed using this system and compared to a conventional RC frame-core tube structure. Through modal analysis in the software “Midas Gen”, the torsional effect and control indices like inter-story displacement ratio, maximum displacement, etc. are compared between the two structural systems. The results show that the space grid cassette system has smaller displacement ratios, displacements, inter-story torsion angles, and thus better torsional resistance compared to the conventional frame-core tube system. Based on these analyses, the manuscript concludes that the RC space grid cassette multi-tube structural system has superior seismic performance and is more suitable for irregularly shaped high-rise residential buildings.