The flow of six kinds of fresh concrete under different flow rates and lubrication layer thickness (TLL) values in the horizontal pipe was numerically simulated. The influence of the TLL on the pressure per unit length (PL) was analyzed. It was determined that the formation of the lubrication layer (LL) significantly reduces the PL in concrete pumping. As the TLL increased, the PL decreased. However, the degree of reduction in the PL gradually decreased as the TLL increased. Relating the simulated PL with the experimental PL, the size of the TLL was obtained, which was between 1 and 3 mm. The minimum and maximum were 1.23 and 2.58 mm, respectively, and the average value was 1.97 mm. The strength (S24, S50), the size of the aggregate (A10, A20, A25), and the flow rate of pumping all affected the TLL. The type of fresh concrete and the flow rate of pumping significantly affected the PL, which impacted the TLL. However, the TLL also impacted the PL. Finally, this made the TLL change within a certain range. When PL > 14,000 Pa/m, 2 mm < TLL< 3 mm; on the other hand, 1 mm < TLL< 2 mm. Therefore, we can use CFD to simulate the flow of all types of concrete in the actual pumping pipeline with a TLL of 2 mm to obtain their pumping pressure and guide the actual construction.