Currently, reinforced thin-walled irregular steel tube concrete frame structures have been applied in engineering, but there are few researches on the seismic performance of this type of structures after fire. The seismic performance of structures after fire is generally carried out based on rigid foundation conditions. Therefore, it is of certain engineering and theoretical value to study the seismic performance considering the SSI (soil–structure interaction) in this paper. ABAQUS is employed to establish the finite element models of the reinforced thin-walled irregular steel tube concrete frame structure considering the SSI after a fire. The paper analyzes the impact of different site conditions and fire durations on the structural natural vibration period, maximum acceleration, inter-story shear force, and maximum inter-story displacement angle. The results show that the consideration of the SSI increases the basic natural vibration period of the structure by 10–30%. The softer the soil and the longer the fire duration, the more significant the increase. For harder soil, lower seismic intensity, and shorter fire duration, the acceleration assigned to the structure and foundation after considering the SSI is smaller than the results assuming a rigid foundation. The change in inter-story shear force is mainly determined by the acceleration of the structure and foundation. The inter-story displacement angle increases when considering the SSI, and the increase is more significant with softer soil, larger seismic wave acceleration amplitude, and longer fire duration.
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