Purpose. The purpose of the article is to improve the theoretical-methodical and applied foundations of human factor research within the framework of anti-crisis management. Design/methodology/approach. The informational and theoretical-methodological base of the conducted research was the works of scientists who are dedicated to the study of anti-crisis management, emergency management, social and humanitarian upheavals, stressful factors, and remote management. Empirical results have been obtained based on official sources of statistical data. To achieve the goal, the article uses a set of scientific methods that ensured the conceptual integrity of the research, in particular: methods of theoretical generalization and abstraction, dynamic modeling, analysis of tables of mutual conjugation, cluster analysis, and regression analysis, tabular method, graphic method, etc. Findings. The article aims at improving the theoretical-methodical and applied foundations of human factor research within the framework of anti-crisis management. It has been noted that the priority of sustainable development takes into account not only the expediency of ensuring progress in all spheres of life but also the need to assess its impact on the security of human civilization, where a person appears not only as the main object but also as a subject of the system of anti-crisis measures. Taking into account the defined goal, several tasks have been set and fulfilled in the work: the scientific basis of the place of the human factor in anti-crisis management was summarized, highlighting its socially positive role; the impact of the pandemic crisis on the labor market and the activation of remote management was analyzed; an evaluation of the impact of the level of innovative development of human potential (LP) on the prevention of economic crisis was carried out. The research hypothesis has been defined: a person can destimulate and stimulate crises; the pandemic crisis caused the activation of stressful conditions in the carriers of LP and the spread of remote management; the innovation of LPs reduces the chances of an economic crisis. Practical implications. The materials presented in the article may be useful for representatives of institutions and scientists whose activities relate to the study of the human factor in the framework of the development of measures in the anti-crisis management system. Originality/value. In the article the authors have summarized the scientific basis of the place of the human factor in anti-crisis management. The socially positive role and place of man in anti-crisis management as an object of protection in crisis conditions have been singled out and have been characterized; destimulator of crises in tactical and strategic dimensions; generator, implementer, and controller of management decisions in crisis situations. The influence of the pandemic crisis on the labor market and on the activation of remote management has been studied. It has been noted that the pandemic crisis caused modern problems related to the methods and tools of remote management. The specifics of remote management have been disclosed; the influence of the level of innovative development of human potential on the prevention of the economic crisis is proven.