At the current stage of transformational transformations, the problems of transformation of the national economy are extremely relevant. And these questions are especially relevant in the conditions of rapid development of the digital economy. According to estimates by Forbes experts, 67% of the leaders of companies from the Global 2000 list chose digital transformation as a priority goal of their corporate strategy in 2018. According to a study by analysts International Data Corporation, the total global spending on digital technologies will grow by 16.8% annually and amounted to 2.1 trillion dollars in 2019. Research by Huawei and Oxford Economics has shown that intelligent network interaction will trigger the growth of the digital economy, which will reach 23 trillion dollars by 2025. This increase will be 78.3% compared to 2017 (12.9 trillion dollars). By 2025, the share of the digital economy is planned to increase by 7.2 percentage points, or from 17.1 to 24.3% of global GDP. According to the calculations of The Boston Consulting Group experts, the volume of the digital economy by 2035 will amount to 16 trillion dollars USA. In view of this, the purpose of this study is to determine the trends and key directions of digital transformation research in the era of Industry 5.0 based on bibliometric analysis using the VOSviewer software. The article carries out a bibliometric analysis of the relationship between the terms “digital transformation”, “digitalization”,”Industry 4.0”, “Industry 5.0”. It has been established that currently the problems of the digital transformation of the economy in the context of the implementation of the digital strategy of the European Union are gaining special relevance. Digital transformation is a key component of the overall strategy to transform the global economy. Correctly selected digital technologies combined with employee competencies, processes and operations will allow companies to quickly adapt to crisis situations, use promising opportunities to modernize work processes, meet new and constantly changing customer needs, stimulate growth and implement innovative and management solutions. The concept of digital transformation of the national economy in the context of Industry 5.0 should involve the use of digital tools and platforms to transform traditional business processes, improve interaction with customers, introduce innovative technologies and form a digital ecosystem. The main components of the digital transformation of critical infrastructure include: digital technologies (cloud computing, artificial intelligence, big data analytics and the Internet of Things (IoT); organizational changes (restructuring of processes to increase their flexibility, introduction of new methodologies (DevOps, Agile), formation of a digital culture); customer orientation and integration of digital channels. For effective digital transformation of the economy on a practical level, it is advisable to pay attention to such main aspects as: having a clear vision and strategy that meets business goals; involving different groups of stakeholders and ensuring the interest of the entire organization; constant monitoring and evaluation of the implementation of digital transformation initiatives; an adaptive and iterative approach that allows you to navigate the changing digital landscape. It has been proven that the priority direction of research in the future should be the substantiation of the theoretical and methodological provisions of the formation of the digital ecosystem.