ABSTRACTSince the concept of Smart Specialization was launched, an effort has been made to clarify and establish criteria for its implementation. Part of the difficulties in implementing Research and Innovation Smart Specialization Strategies (RIS3) is their emphasis on bottom-up approaches, which are required because there are public and private stakeholders that are better positioned than governments to find the domains in which the region is likely to excel. Regions must shift towards a new generation of industrial policy and the difficulties for advancing in this direction are already visible. Designing and implementing a smart specialisation strategy at regional level: Some open questions. The centrality of entrepreneurial discovery in building and implementing a smart specialisation strategy. Efforts to implement smart specialization in practice – leading unlike horses to the water. The paper is based on four cases related to governance and learning for smart specialization in the Basque Country (Spain) and presents three main lessons learnt. The first has to do with connections between regional and sub-regional governments in order to construct networks of territorial actors that can act as the senses of governments in the territory. The second is about the challenge of handling complexity and conflict and the third is about the integration of social researchers in RIS3 processes.
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