In the new era of leapfrog development and popularization of higher education, applied undergraduate universities play a vital role in the higher education system in China, becoming an indispensable force in building a powerful higher education country. Compared with the cultivation of academic talents, the cultivation of applied talents pays more attention to the traing of professional knowledge, abilities, and qualities, and pays more attention to the practicality and adaptability of talent cultivation. However, applied talents are not only technical specialists, but must also have goodcomprehensive quality, including citizenship, professional ethics, humanistic accomplishment, scientific literacy, etc., in order to better adapt to the needs of future development and change. Applied universities pay more attention to cultivating students’ practical application ability and entrepreneurial ability. General education in applied undergraduate universities has a significant impact on the process of talent cultivation. Based on the analysis of the current situation of general education in applied undergraduate universities, this article proposes ways to improve the quality of general education in applied undergraduate universities from updating the concept of general education, optimizing the setting of general education courses, reforming the teaching mode of general education, strengthening the construction of teacher teams, improving the evaluation system of general education, and expanding international exchanges and cooperation.