The Patristic period stands as a pivotal era in the development of Christian doctrine, marked by profound theological and philosophical debates. Amidst these discussions, the Shema in Deuteronomy 6:4-5 retains its central importance for both Jewish and Christian faith traditions, offering insights into the nature of God. This paper explored the Patristic interpretation of the Shema, highlighting the perspectives of the Alexandrian and Antiochene Schools of thought. Key theological issues addressed include the monotheistic concept of God, the symbolic significance of Israel, the unity of God, and the Trinitarian debate. A historical approach was used where the views of selected theologians were explored within their socio-cultural and political settings. Drawing from African perspectives, the study reflected on the enduring relevance of these theological inquiries for contemporary society. Ultimately, the theological insights garnered from Patristic interpretations continue to inform and enrich modern theological discourse, bridging the gap between ancient wisdom and contemporary understanding. Keywords: God, Patristic Era, Shema, Trinity