Concept Of Complete Mesocolic Excision Research Articles

Laparoscopic right hemicolectomy: a SICE (Società Italiana di Chirurgia Endoscopica e Nuove tecnologie) network prospective study on the approach to right colon lymphadenectomy in Italy: is there a standard?—CoDIG 2 (ColonDx Italian Group)

BackgroundColon cancer is a disease with a worldwide spread. Surgery is the best option for the treatment of advanced colon cancer, but some aspects are still debated, such as the extent of lymphadenectomy. In Japanese guidelines, the gold standard was D3 dissection to remove the central lymph nodes (203, 213, and 223), but in 2009, Hoenberger et al. introduced the concept of complete mesocolic excision, in which surgical dissection follows the embryological planes to remove the mesentery entirely to prevent leakage of cancer cells and collect more lymph nodes. Our study describes how lymphadenectomy is currently performed in major Italian centers with an unclear indication on the type of lymphadenectomy that should be performed during right hemicolectomy (RH).MethodsCoDIG 2 is an observational multicenter national study that involves 76 Italian general surgery wards highly specialized in colorectal surgery. Each center was asked not to modify their usual surgical and clinical practices. The aim of the study was to assess the preference of Italian surgeons on the type of lymphadenectomy to perform during RH and the rise of any new trends or modifications in habits compared to the findings of the CoDIG 1 study conducted 4 years ago.ResultsA total of 788 patients were enrolled. The most commonly used surgical technique was laparoscopic (82.1%) with intracorporeal (73.4%), side-to-side (98.7%), or isoperistaltic (96.0%) anastomosis. The lymph nodes at the origin of the vessels were harvested in an inferior number of cases (203, 213, and 223: 42.4%, 31.1%, and 20.3%, respectively). A comparison between CoDIG 1 and CoDIG 2 showed a stable trend in surgical techniques and complications, with an increase in the robotic approach (7.7% vs. 12.3%).ConclusionsThis analysis shows how lymphadenectomy is performed in Italy to achieve oncological outcomes in RH, although the technique to achieve a higher lymph node count has not yet been standardized.Trial registration (ClinicalTrials.gov) ID: NCT05943951.

Robotic versus laparoscopic right hemicolectomy with complete mesocolic excision: a retrospective multicenter study with propensity score matching.

During the past decade, the concept of complete mesocolic excision (CME) has been developed in an attempt to minimize recurrence for right-sided colon cancer. This study aims to compare outcomes of robotic versus laparoscopic right hemicolectomy with CME for right-sided colon cancer. We performed a retrospective multicenter propensity score matching study. From July 2016 to July 2021, 382 consecutive patients from different Chinese surgical departments were available for inclusion out of an initial cohort of 412, who underwent robotic or laparoscopic right hemicolectomy with CME. Data of all patients were retrospectively collected and reviewed. Of these, 149 cases were performed by a robotic approach, while the other 233 cases were done by laparoscopy. Propensity score matching was applied at a ratio of 1:1 to compare perioperative, pathologic, and oncologic outcomes between the robotic and the laparoscopic groups (n = 142). Before propensity score matching, there were no statistical differences regarding the sex, history of abdominal surgery, body mass index (BMI), American Joint Committee on Cancer (AJCC) staging system, tumor location, and center between groups (p > 0.05), while a significant difference was observed regarding age (p = 0.029). After matching, two comparable groups of 142 cases were obtained with equivalent patient characteristics (p > 0.05). Blood loss, time to oral intake, return of bowel function, length of stay, and complications were not different between groups (p > 0.05). The robotic group showed a significantly lower conversion rate (0% vs. 4.2%, p = 0.03), but a longer operative time (200.9min vs. 182.3min, p < 0.001) and a higher total hospital cost (85,016 RMB vs. 58,266 RMB, p < 0.001) compared with the laparoscopic group. The number of harvested lymph nodes was comparable (20.4 vs. 20.5, p = 0.861). Incidence of complications, mortality, and pathologic outcomes were similar between groups (p > 0.05). The 2-year disease-free survival rates were 84.9% and 87.1% (p = 0.679), and the overall survival rates between groups were 83.8% and 80.7% (p = 0.943). Despite the limitations of a retrospective analysis, the outcomes of robotic right hemicolectomy with CME were comparable to the laparoscopic procedures with fewer conversions to open surgery. More clinical advantages of the robotic surgery system need to be further confirmed by well-conducted randomized clinical trials with large cohorts of patients.

Role of preoperative CT angiography with multimodality imaging reconstruction to perform laparoscopic Complete Mesocolic Excision (CME) and Central Vascular Ligation (CVL) in right-sided colon cancer: Is it really useful? A prospective clinical study.

The concept of complete mesocolic excision (CME) and central vascular ligation (CVL) in right colonic resections appears to improve the oncological outcomes. The highest rate of complications reported in the literature in patients undergoing CME is related to difficult surgical manuevers and intraoperative bleeding due to the central vascular dissection. We used preoperative findings obtained with the CT angiography, multiplanar reformation (MPR), maximum intesity projection (MIP) and 3D volume rendering (VR) technique to verify if this preoperative radiological assessment had significant benefits regarding the difficulty of dissection of the embryological planes, the identification of vascular structures and central lymph nodes with reduction in mean operative time, intraoperative complications and better short-term outcomes versus standard contrast enhanced CT scan. We also have administered a questionnaire to investigate the subjective responses on the degree of difficulty of the surgical procedure both by the surgical team expert in CME and by a group of young surgeons. Statistical analysis showed that overall operative time was significant shorter in patients underwent to radiological assessment (224,5min; range 160-300 versus 252,6min; range 200-340; p-value 0.023) with a significant lower rate of intraoperative complication (2.7% versus 4.2%; p-value 0.043). No differences were reported with respect to blood loss, conversion rate, anastomotic leakage or other surgical results. Analysis of the questionnaire underlined a progressive awareness of the correspondence between the radiological imaging and the surgical field. The possibility of identifying the characteristics and course of the vascular structures along the axis of the superior mesenteric vessels certainly increases the surgeon's knowledge of the operating field, making him more confident with surgical maneuvers and significantly reducing the duration of the operating time and intraoperative complications.

The Concept of Complete Mesocolic Excision

The Concept of Complete Mesocolic Excision

Comparison of right hemicolectomies with and without complete mesocolic excision (CME)

Abstract Objective Since the concept of complete mesocolic excision (CME) in right hemicolectomies was introduced, it is still under debate if all patients require this radical technique. Methods Patients with adenocarcinoma of the colon undergoing right hemicolectomies at our hospital were retrospectively analyzed and stratified in a non-CME group (08/2014-04/2018) and a CME group (05/2018-11/2021). Patients were compared in regard to clinical, histopathological and prognostic parameters. CME were classified according to Benz et al. Results A total of 130 right hemicolectomies were performed, 33 (25.4%) patients were excluded due to other pathologies or emergency patients. Finally, 97 patients were included (53 in the CME group, 39 in the non-CME group). No difference in patient's characteristics were found except more male patients in the CME group (20 vs. 6; p=0.02). Tumors in the CME group were mainly located in the colon ascendens (66.0%), in the non-CME group in the coecum (48.7%; n.s.). In the CME group, 26 of 53 (49.1%) patients were operated laparoscopically compared to 10 of 39 (25.6%) patients in the non-CME group. Da Vinci system were used exclusively in the CME group (5 of 53 (9.4%); p=0.003). TNM classification, histology and UICC stadium showed no significant difference. In total, 50 (94.3%) surgical specimen were classification either as CME 0 or 1. In average, 35.2 lymph nodes (8.2% positive) were found in the CME group compared to 32.7 (16.2% positive) lymph nodes in the non-CME group (p=0.9). No relevant intraoperative complications occurred in both groups. Distance of the mesocolon were available in 39 (73.6%) patients in the CME group and 34 (37.1%) in the non-CME group; the distance tended to be longer in the CME group (mean 116.0 mm in CME group vs. 96.6 mm in non-CME group; p=0.09). Follow-up were 336.4 days in CME-group and 1210.4 days in the non-CME group. In the follow-up, 2 (5.1%) patients in the non-CME group developed a local recurrence in the smaller pelvis. No local recurrence occurred in the CME group (p=0.18). Distant metastasis occurred in 5 of 53 (9.4%) patients in the CME group and in 2 of 39 (5.4%) patients in the non-CME group (p=0.7). Conclusion This study shows that the benefit for CME in all performed right hemicolectomies is marginal and that the surgical standards was already high in the pre-CME era.

Is Laparoscopic Complete Mesocolic Excision and Central Vascular Ligation Really Necessary for All Patients With Right-Sided Colon Cancer?

Colon cancer treatment is on the way to evolution over several decades. The minimally invasive surgery has improved postoperative short-term outcomes. Adjuvant chemotherapy has prolonged the survival of advanced colon cancer patients. Hohenberger proposed the noble concept of complete mesocolic excision (CME) which consists of 3 components: plane surgery, sufficient longitudinal bowel resection, and central vascular ligation (CVL). Mesocolic plane surgery shares the same surgical principle of total mesorectal excision, which is maintaining the intact mesothelial envelope. However, there remain debates about the extent of bowel resection and the level of CVL for maximizing lymph node dissection. There is no solid clinical evidence for the oncological necessity and benefit of extended radical dissection in right hemicolectomy. CME with CVL based on open surgery has been adopted in laparoscopic surgery. So, it is also necessary to look at how the CME could be transformed and successfully implanted in the laparoscopic era. Recent rapid advances in surgical technology and cancer biology are preparing for fundamental changes in cancer surgery. In this study, we reviewed the history, oncological necessity, and compatibility of CME for the right hemicolectomy in the laparoscopic era and outline the new perspectives on the evolution of cancer surgery.

Reduced port versus open right hemicolectomy for colorectal cancer: a retrospective comparison study of two centers.

The concept of complete mesocolic excision (CME) in right-sided colorectal cancer is well known for open and laparoscopic surgery. The aim of this study was to evaluate and compare perioperative and oncological outcomes of reduced port and open surgery for right-sided colorectal cancer. One hundred forty-one patients received elective surgery for right-sided colonic cancer between January 2015 and December 2019 and were included in a retrospective database. We observed longer operation time in the RP-CME group (145 min vs. 119.43 min, p<0.01). Hospital stay (8 days vs. 14 days, p<0.01) and time to first intestinal passage (42 h. vs. 59 h, p<0.01) were significantly shorter in the reduced port group. Postoperative complications were more likely to be observed in the O-CME group (7.2% vs. 14.1%, p=0.28); anastomotic leakage rate was low in both groups (1.8% vs. 2.4%, p=1.00). Specimen scores (score 1= good: 93.8% vs. 91.7%, p=1.00) and average number of retrieved lymph nodes were comparable (24 vs. 23 p=0.69). In O-CME patients, we observed more advanced tumor stages (UICC III: 21.4% vs. 45.9%, p<0.01). To our knowledge, this is the first study comparing reduced port to open surgery for right-sided colorectal cancer. We could demonstrate that this technique is feasible for oncological right hemicolectomy with observation of shorter hospital stay and lower morbidity rates compared to open surgery. The oncological outcome did not differ in the present study.

Concept of Complete Mesocolic Excision and the Role of Computed Tomography Imaging

Abstract Complete mesocolic excision (CME) with central vascular ligation (CVL) has gained traction in recent years as an effective advanced surgical technique for surgical treatment of colon cancer. In this review, the concept of CME is described, along with relevant variant vascular anatomy and local staging implications for radiologists. Future directions in research are also explored, with a focus on correlation between radiology and pathology.

Complete mesocolic excision for right sided colonic carcinoma - Our Experience in tertiary care hospital

Background: The concept of Complete Mesocolic Excision(CME) as a surgical techniquefor colonic carcinoma.was first introduced in the west in 2008. CME follows the sameprinciple as Total MesorectalExcision(TME) in rectal carcinoma. We have adopted this newtechnique since 2014.&#x0D; Objective: Here we describe the CME technique in open and laparoscopic right hemicolectomy,and our initial experience of the surgery.&#x0D; Methods: This is a prospective observational study. Data collected from 24 patientsadmitted under our care in BIR DEM General Hospital from January 2015 to January 2017with carcinoma caecum or ascending colon.&#x0D; Results: Out of 24 patients 14 patients opted for laparoscopic right hemicolectomy and 10patients choose open right hemicolectomy. In laparoscopic right hemicolectomy with CMEthe mean operating time was 152 minutes, amount of blood loss ranges 70-100ml.Number of lymphnodes removed enbloc with specimen 25-30(mean27). Distance oftumor from mesenteric margins at the point of vascular tie 11-15 cm. In open righthemicolectomy with CME mean operating time was 142 minutes, estimated blood loss120-300 ml, harvested lymph nodes within mesocolic envelop 24-31(mean27), anddistance of tumor from vascular tie is 9-15 cm. there is one major complication of uretericinjury. Histopathology shows resection margin are free of tumor in all except 2 cases.&#x0D; Conclusion: Right hemicolectomy with CME in both open and laparoscopic approach canbe easily adopted by general surgeons and colorectal surgeons who are performing'standard technique' or 'conventional technique' routinely for right hemicolectomy. Withthe encouraging results available from centers who are routinely performing CME incolonic surgery it is now considered as the new bench mark of quality of standard colonicsurgery.&#x0D; Journal of Surgical Sciences (2017) Vol. 21 (1) :15-18

Complete mesocolic excision for colon cancer: a surgical dilemma

In the recent years the concept of complete mesocolic excision (CME) with central vascular ligation (CVL) in colon cancer surgery was put beside that of total mesorectal excision in rectal cancer (1,2). However, it is not widely accepted since a little of confusion exists regarding the definition of CME, there are many technical aspects that vary among the reported series, and there are no solid data regarding its benefit on overall survival and local recurrence rates. The first thing we should determine is the end point for measuring the usefulness of CME.

Complete mesocolic excision for colonic cancer: Society for Translational Medicine expert consensus statement

Total mesorectal excision (TME), a revolutionary change and a milestone in the history of surgical treatment for rectal cancer, has been widely recognized as the gold standard and is now a routine procedure. The concept of complete mesocolic excision (CME) was proposed based on the similar philosophy as TME, aimed to achieve better surgical quality and improve the oncological outcomes of colon cancer. In recent years, many surgeons have increasingly adopted the principle and conducted clinical trials to verify the effect of CME; however, whether CME should be used as the standard surgical technique is still controversial. In this article, we reviewed and updated the literature. Experts in this field from nine countries were invited to complete a questionnaire concerning CME, with the aim to illustrate the embryological and anatomical basis and reach a consensus of the current situation and future of CME.

The choice of optimal lymph node dissection extent in surgical treatment for colon cancer: protocol the clinical trial

Background. The choice of the best surgical approach to colon cancer treatment remains a complicated and controversial problem of modern coloproctology. Current data shows better long-term outcomes after procedures performed in accordance with embryological layers and concept of complete mesocolic excision, while level of vessel ligation remains debatable. In the US and Europe D3 lymph node dissection is not routinely performed for colon cancer, while in eastern countries it is considered to be a standard. Up-to-date there is no published data from randomized trials comparing long-term outcomes of D2 and D3 dissection. Materials and methods. A literature review was performed to evaluate current data on colon cancer lymph node dissection. A design of ran-domized trial was proposed to obtain the evidence on the superiority of D3 over D2 lymph node dissection. Discussion. As evidence regarding long-term outcomes of D3 lymph node dissection is lacking the choice of lymph node dissection is made according to surgeon’s or clinic preferences. Conclusion. To objectify the preferred lymph node dissection extent randomized controlled studies are needed.

Investigate the radical extent of lymphadenectomy of right colon cancer

Considering radical surgeries of right colon cancer, the reasonable extent of lymphadenectomy has always been argued. The concept of complete mesocolic excision (CME) has recently been established and optimized, which follows similar oncological principles as total mesorectal excision (TME) does for rectal cancer and is recommended by more and more surgeons. Studies published so far in the literature have been comprehensively reviewed, they do not, however, provide convincing evidence that demonstrate the standardized operation indications. Moreover, the existence of potential surgical risk and discernible oncological benefit has not been determined. Thus future studies are needed to further investigate the safety and efficacy of CME surgery, as has been demonstrated with TME such that it should become the procedure of choice in surgical practice.

Optimal Colonic Cancer Surgery- the Concept of Complete Mesocolic Excision

Although colorectal cancer is one of the most common malignancies worldwide, the colon cancer related mortality significantly decreased in the last decades due to the wide implementation of screening programs and due to a better therapeutic approach. Once Heald introduced the concept of total mesorectal excision and demonstrated its’ benefits in terms of oncologicaloutcomes, attention was focused on the possibility of implementation of a similar technique for patients with colon cancer. This is how the concept of complete mesocolic excision appeared. This is a literature review regarding the surgical technique and oncologic outcomes of complete mesocolic excision.

Single-port plus an additional port robotic complete mesocolic excision and intracorporeal anastomosis using a robotic stapler for right-sided colon cancer.

The concept of complete mesocolic excision and central vascular ligation for colonic cancer has been recently introduced. The paper describes a technique of right-sided complete mesocolic excision and intracorporeal anastomosis by using a single-port robotic approach with an additional conventional robotic port. We performed a single-port plus an additional port robotic surgery using the Da Vinci Single-Site platform via the Pfannenstiel incision and the wristed robotic instruments via an additional robotic port in the left lower quadrant. The total operative and docking times were 280 and 25 minutes, respectively. The total number of lymph nodes harvested was 36 and the proximal and distal resection margins were 31 and 50 cm, respectively. Single-port plus an additional port robotic surgery for right-sided complete mesocolic excision and intracorporeal anastomosis appears to be feasible and safe. This system can overcome certain limitations of the previous robotic systems and conventional single-port laparoscopic surgery.

Surgery for colon cancer – complete mesocolic excision

This review presents the concept of complete mesocolic excision (CME) for colon carcinomas. It focuses on an anatomical preparation in embryological preformed planes. Different tumour locations require individual operative strategies. In contrast to other malignancies, lymphatic metastasis in colon cancer is initially based on fixed rules. The extent of lymph node dissection and mesocolic resection for each tumour depends on the location of potential tumour deposits in lymph nodes along supplying arteries and aberrant lymph node stations.

Initial retrocolic endoscopic tunnel approach (IRETA) for complete mesocolic excision (CME) with central vascular ligation (CVL) for right colonic cancers: technique and pathological radicality.

The concept of complete mesocolic excision (CME) with central vascular ligation (CVL) for treatment of right colon cancer evolved over last one decade. It decreases local recurrences and improves the survival rates. We describe our novel technique which involves first posterior sharp dissection between planes of parietal and visceral fascia of mesocolon followed by ligation of ileocolic, right colic and middle colic pedicles at their origin. We highlight the technical variations with various techniques and advantages over conventional medial to lateral approach in current study. The outcomes were measured in terms of technical feasibility, short-term outcomes and pathological radicality of current laparoscopic technique (IRETA) for CME with CVL. Two hundred twelve patients (163 males) who underwent laparoscopic CME for right colon cancer over the period of January 2009 to December 2013 were analysed via prospectively maintained database. 97.16 % of patients (n = 206) underwent laparoscopic CME while six patients required open conversion. Mean operative time was 142 ± 28.4 min with median hospital stay of 5 days (range 4-11). The median count of lymph node harvested were 24 (range 10-42). The complete mesocolic excision plane was achieved in 93.8 % patients. 84.4 % (n = 179) of our patients were having (T3, N+) disease on pathological examination. The overall morbidity (<30 days) was 9.9 %. Laparoscopic initial retrocolic endoscopic tunnel approach (IRETA) for CME with CVL in right colonic cancers is safe, simpler and feasible laparoscopic approach with minimal complications. Creation of retro colic tunnel is key highlight of IRETA approach. This approach becomes especially useful in patients with late presentations where complete mesocolic excision remains essential to enhance oncological radicality as per evidence available.

Extent of surgery in cancer of the colon: is more better?

Since the introduction of total mesorectal excision as the standard approach in mid and low rectal cancer, the incidence of local recurrence has sharply declined. Similar attention to surgical technique in colon cancer (CC) has resulted in the concept of complete mesocolic excision (CME), which consists of complete removal of the intact mesentery and high ligation of the vascular supply at its origin. Although renewed attention to meticulous surgical technique certainly has its merits, routine implementation of CME is currently unfounded. Firstly, in contrast to rectal cancer, local recurrence originating from an incompletely removed mesentery is rare in CC and usually a manifestation of systemic disease. Secondly, although CME may increase nodal counts and therefore staging accuracy, this is unlikely to affect survival since the observed relationship between nodal counts and outcome in CC is most probably not causal but confounded by a range of clinical variables. Thirdly, several lines of evidence suggest that metastasis to locoregional nodes occurs early and is a stochastic rather than a stepwise phenomenon in CC, in essence reflecting the tumor-host-metastasis relationship. Unsurprisingly, therefore, comparative studies in CC as well as in other digestive cancers have failed to demonstrate any survival benefit associated with extensive, additional or extra-mesenteric lymphadenectomy. Finally, routine implementation of CME may cause patient harm by longer operating times, major vascular damage and autonomic nerve injury. Therefore, data from randomized trials reporting relevant endpoints are required before CME can be recommended as a standard approach in CC surgery.

Laparoscopic-Assisted Versus Open Complete Mesocolic Excision and Central Vascular Ligation for Right-Sided Colon Cancer

A concept of complete mesocolic excision (CME) and central vascular ligation for colonic cancer has been recently introduced. The aim of this study was to evaluate and compare perioperative and oncologic outcomes after laparoscopic-assisted CME (LCME) and open CME (OCME) for right-sided colon cancers. The study group included 128 patients who underwent an LCME and 137 patients who underwent an OCME for right-sided colon cancer between June 2006 and December 2008. The propensity scoring matching for sex, body mass index, tumor location, and pathologic T and TNM stage produced 85 matched pairs. The median time to soft diet (LCME 6 days vs. OCME 7 days, p < 0.001) and the possible length of stay (7 vs. 13 days, p < 0.001) were significantly shorter in the laparoscopic group. The median operation time (179 vs. 194 minutes, p = 0.862) and number of harvested lymph nodes (27 vs. 28, p = 0.337) were comparable between groups. The morbidity within 30 days after surgery was comparable between the groups (12.9 vs. 24.7 %, p = 0.050). The 5-year overall survival rates of the OCME and LCME groups were 77.8 and 90.3 % (p = 0.028), and the 5-year disease-free survival rates were 71.8 and 83.3 % (p = 0.578), respectively. Herein, we demonstrated the feasibility and safety of LCME for right-sided colon cancer, and in terms of better short-term outcomes, LCME was more advantageous than OCME. Although LCME for right-sided colon cancer was associated with better 5-year overall survival, compared with an open approach, the long-term oncologic outcomes between the groups were comparable.

The rationale behind complete mesocolic excision (CME) and a central vascular ligation for colon cancer in open and laparoscopic surgery

It has been evident for a while that the result after resection for colon cancer may not have been optimal. Several years ago, this was showed by some leading surgeons in the USA but a concept of improving results was not consistently pursued. Later, surgeons in Europe and Japan have increasingly adopted the more radical principle of complete mesocolic excision (CME) as the optimal approach for colon cancer. The concept of CME is a similar philosophy to that of total mesorectal excision for rectal cancer and precise terminology and optimal surgery are key factors. There are three essential components to CME. The main component involves a dissection between the mesenteric plane and the parietal fascia and removal of the mesentery within a complete envelope of mesenteric fascia and visceral peritoneum that contains all lymph nodes draining the tumour area (Hohenberger et al., Colorectal Disease 11:354-365, 2009; West et al., J Clin Oncol 28:272-278, 2009). The second component is a central vascular tie to completely remove all lymph nodes in the central (vertical) direction. The third component is resection of an adequate length of bowel to remove involved pericolic lymph nodes in the longitudinal direction. The oncological rationale for CME and various technical aspects of the surgical management will be explored. The consensus conference agreed that there are sound oncological hypotheses for a more radical approach than has been common up to now. However, this may not necessarily apply in early stages of the tumour stage. Laparoscopic resection appears to be equally well suited for resection as open surgery.