Frames and orthonormal bases are important concepts in functional analysis and linear algebra. They are naturally linked to bounded operators. To describe unbounded operators those sequences might not be well suited. This has already been noted by von Neumann in the 1920ies. But modern frame theory also investigates other sequences, including those that are not naturally linked to bounded operators. The focus of this manuscript will be two such kind of sequences: lower frame and Riesz-Fischer sequences. We will discuss the inter-relation of those sequences. We will fill a hole existing in the literature regarding the classification of these sequences by their synthesis operator. We will use the idea of generalized frame operator and Gram matrix and extend it. We will use that to show properties for canonical duals for lower frame sequences, such as a minimality condition regarding its coefficients. We will also show that other results that are known for frames can be generalized to lower frame sequences. Finally, we show that the converse of a well-known result is true, i.e. that minimal lower frame sequences are equivalent to complete Riesz-Fischer sequences, without any further assumptions.To be able to tackle these tasks, we had to revisit the concept of invertibility (in particular for non-closed operators). In addition, we are able to define a particular adjoint, which is uniquely defined for any operator.