Machine learning has proved an efficient tool, but the systems need tools to mitigate risks during runtime. One approach is fault tolerance: detecting and handling errors before they cause harm. This paper investigates whether rare co-activations – pairs of usually segregated nodes activating together – are indicative of problems in neural networks (NN). These could be used to detect concept drift and flagging untrustworthy predictions. We trained four NNs. For each, we studied how often each pair of nodes activates together. In a separate test set, we counted how many rare co-activations occurred with each input, and grouped the inputs based on whether its classification was correct, incorrect, or whether its class was absent during training. Rare co-activations are much more common in inputs from a class that was absent during training. Incorrectly classified inputs averaged a larger number of rare co-activations than correctly classified inputs, but the difference was smaller. As rare co-activations are more common in unprecedented inputs, they show potential for detecting concept drift. There is also some potential in detecting single inputs from untrained classes. The small difference between correctly and incorrectly predicted inputs is less promising and needs further research.