Sodium Concentration Research Articles

تقدير المعادن الثقيلة في بعض أنواع مختلفة الكعك المجمعة من أسواق مدينة البيضاء – ليبيا

Heavy metals are chemical elements with high density and atomic weight. Despite their widespread use in various industries and applications, they pose significant risks to the environment and public health if not handled properly. This study was conducted to estimate the concentration of some different elements in different types of cakes, where cake samples were collected from different shops from Al-Bayda city, the study dealt with six types of cakes. Flame photometer was used to estimate sodium and potassium salts and spectrophotometer to estimate heavy elements. The samples were digested using the digestion method using HNO1 and HCl and heating until the brown oxides evaporate and we get half the amount. The results showed that the concentration of sodium, chromium, iron and copper is below the permissible limits and the concentration of potassium is higher than the permissible limits and the results also showed that the collected cake samples do not contain lead and a discrepancy was observed .The potassium concentration ranged from (541. 50 to 763.25), sodium concentration ranges from (1.34 to 3.52), iron concentration ranges from (1.72 to 7.16), copper concentration ranges from (44.36 to 67.62), and chromium concentration ranges from (0 to 0.25). The study could be expanded to include other types of cakes, such as filled cakes to provide a more comprehensive picture of heavy metal contamination in these products. More heavy metals, such as mercury, arsenic, and cadmium, could be analyzed to more accurately assess health risks. Keywords: Heavy metals, Cakes types, market and Al-Bayda – Libya.

Investigation on release and migration characteristics of sodium during the combustion of high-sodium coal with phosphorite

To mitigate slagging, fouling, and corrosion from burning high-sodium coal, phosphorite was introduced during combustion. The migration and release characteristics of Na were analyzed at different temperatures and phosphorite ratios. Results show that Na in Shaerhu coal mainly exists in water-soluble (68.75 %) and insoluble forms (22.35 %). As the temperature increases from 700 °C to 1100°C, the water-soluble sodium in the coal ash decreases by 1151 μg∙g−1, and the insoluble sodium increases by 98 μg∙g−1. Phosphorite can react with water-soluble sodium at high temperatures. Adding 15 % phosphorite at 900°C will reduce the water-soluble sodium content by 455 μg∙g−1, increase the insoluble sodium content by 1408 μg∙g−1, and reduce the sodium release ratio by 12.99 %. The softening temperature of Shaerhu coal is 1158°C. After adding phosphorite, the softening temperature of coal ash can be increased to more than 1200°C. Compared with SiO2 used in traditional processes, phosphorite as an additive can improve anti-scaling performance and facilitate ash discharge in solid form. Meanwhile, recycling phosphorite co-combustion with coal for using in thermal phosphoric acid process can increase the conversion ratio of phosphorite by 10 %–20 %.

Evaluating Groundwater Quality for Drinking and Irrigation Purposes and Health Risk Assessment in West Midnapore District of West Bengal, India

Groundwater quality in the West Midnapore district of West Bengal, India is affected by anthropogenic activities as well as by water quality of Subarnarekha and Kangsabati rivers. This study aims to assess quality of groundwater and river water for drinking and irrigation usage, and assess the health risks of the people consuming the water across the rivers. The study also explores the groundwater-river water interaction. The river water and groundwater samples were collected three times during monsoon season from 14 sites across the rivers. The samples were analyzed for 11 water quality parameters, i.e., pH, total dissolved solids (TDS), total hardness (TH), major anions and cations, and iron (Fe). The groundwater was found slightly acidic (mean pH ~ 6.71) and correlated with nitrate concentrations. Most of the water quality parameters were found within their permissible limits of drinking water. However, elevated concentrations of potassium (K), ammonium (NH4), magnesium (Mg), phosphate (PO4), sodium (Na), and Fe were detected at some places, which were likely due to use of fertilizers. Water quality index (WQI), sodium absorption ratio (SAR), and percentage Na values were computed to evaluate the groundwater quality. The mean WQI value of 37.07 showed that the majority of groundwater samples met drinking water standards. Groundwater was also found suitable for irrigation (SAR ~ 0.26 to 1.62 meq L-1 and percentage Na ~ 13.10% to 78.12%). Health risk assessments suggested minimal immediate risks, though high Na levels in certain areas raised concerns. Piper plot showed that increased calcium concentrations in groundwater were mainly due to interactions between river water and groundwater. Overall, groundwater quality did not present any harmful health hazards to the community. The findings of this study can be instrumental for groundwater managers in identifying potential areas for treating groundwater quality.

Green Hydrogen Production From Non-Traditional Water Sources: A Sustainable Energy Solution With Hydrogen Storage and Distribution.

Green hydrogen development plays an essential role in creating a sustainable and environmentally conscious society while reducing reliance on traditional fossil fuels. Proton Exchange Membrane Water Electrolysers (PEMWEs), are sensitive to water quality, with various impurities impacting their efficiency, the quality of the hydrogen produced, and the device's lifespan. High-purity water is required for PEM electrolyzers; Type II water, which is required for commercial electrolyzers, must have a resistivity greater than 1 MΩ cm, sodium, and chloride concentrations less than 5 μg/L, and total organic carbon (TOC) content less than 50 parts per billion. The majority of electrolyzers operate on freshwater, or total dissolved solids (TDS) <0.5 g/kg, whereas brackish, rainwater, wastewater, and seawater have TDSs of 1-35 g/kg, 0.01-0.15 g/kg, 0.5-2 g/kg, and 35-45 g/kg, respectively. This critical review offers, for the first time, a comprehensive overview of relevant impurities in operating electrolyzers and their impact. The findings of this study indicate that electrolysis-based H2 processes are promising options that contribute to the H2 production capacity but require improvements to produce larger competitive volumes. In addition, the main challenges and opportunities for generating, storing, transporting, and distributing hydrogen, as well as large-scale adoption are discussed.

Optimizing Intracranial Pressure Management in AKI: A Novel Approach Using Enhanced Sodium Concentration in Continuous Kidney Replacement Therapy

Optimizing Intracranial Pressure Management in AKI: A Novel Approach Using Enhanced Sodium Concentration in Continuous Kidney Replacement Therapy

Thirst and the influence of ionic concentration; an investigation into the effect on salivary lubrication and the role of MUC5B

Saliva plays a crucial role in lubricating the oral cavity and maintaining a normal hydrated mouthfeel, with the main macromolecule in saliva, MUC5B, playing a significant role in its lubricating properties. Mucins form a hydrated biogel that covers the oral epithelium and forms part of the mucosal pellicle, maintaining proper hydration. This study investigates the relationship between ionic concentration, saliva lubrication, and the perception of oral dryness. At baseline, sodium was found to be ten times more concentrated in the mucosal pellicle compared to bulk saliva, in contrast to potassium which was only 1.5 times more concentrated in the pellicle. Increasing concentrations of mouthwashes containing sodium or potassium indicated a preferential sequestering of sodium in the mucosal pellicle with sodium chloride rinses being associated with an increased thirst perception. We therefore propose that sodium binds to MUC5B, reducing the electrostatic repulsions between its negatively charged moieties. This interaction subsequently leads to a compaction of the mucin structure, which decreases the hydration of MUC5B and reduces its lubricating properties. We determined that increased sodium concentrations compact the mucin structure as indicated by transmission electron microscopy. However, we found that increased sodium concentrations were associated with improved the lubrication of salivary and MUC5B films in an oral tribology mimic, decreasing the coefficient of friction from 0.044 to 0.018, and 0.416 to 0.100 with the addition of 200 mM sodium chloride for saliva and MUC5B, respectively. MUC5B was also demonstrated to become more hydrated with increasing ionic concentrations, as indicated by Quartz Crystal Microbalance with Dissipation. We therefore propose that increased hydration shells surrounding the sodium counterions are responsible for this improved lubrication via the hydration lubrication mechanism. Lastly, it was observed that the spinnbarkeit of saliva decreased with increasing ionic concentrations, indicating a reduced stretchiness in its rheological properties. However, the concentration of MUC5B alone did not appear to affect spinnbarkeit, highlighting that many factors influence the biophysical properties of saliva.

Urea to Treat Hyponatremia Due to Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Systematic Review and Meta-Analysis

Rationale & ObjectiveThe use of urea to treat hyponatremia related to the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) has not been universally adopted due to questions about effectiveness, safety, and tolerability. This systematic review and meta-analysis of observational studies aimed to address these questions. Study DesignThis PRISMA-guided study examined published research across four electronic databases. Study PopulationsPatients with SIADH-related hyponatremia. Selection CriteriaClinical trials and observational studies reporting at least one outcome related to serum sodium concentration, symptom resolution, or adverse effects after oral or nasogastric urea administration. Data ExtractionData extraction was performed independently by two reviewers using a standardized form recording study characteristics, participant demographics, intervention details, and treatment outcomes. Analytical ApproachA meta-analysis was conducted using the restricted maximum likelihood method for the random-effects model to assess the effect of urea treatment on serum sodium and serum urea compared to other treatment modalities. Subgroup analyses were conducted based on treatment duration and SIADH severity. ResultsUrea treatment significantly increased serum sodium [mean difference (MD) = 9.08 (95%CI 7.64-10.52), p < 0.01] and urea [MD = 31.66 (95%CI 16.05-47.26), p < 0.01] in patients with SIADH albeit with significantly high heterogeneity. Subgroup analysis based on the treatment duration showed a significant rise in the serum sodium level after 24 hours, two, five, seven, and fourteen days, as well as after one year of treatment. Greater increases in serum sodium levels after treatment with urea occurred in patients with severe (<120 mEq/L) [MD = 18.04 (95%CI 13.68-22.39)] than with moderate (120-129 mEq/L [MD = 7.86 (95%CI 6.78-8.94)] or mild (130-135 mEq/L) [MD = 8.00 (95%CI 7.31-8.69)] SIADH induced hyponatremia. Urea treatment was comparable to fluid restriction [MD = 0.81 (95%CI: -0.93-2.55), p = 0.36) and vaptans [MD = -1.96 (95%CI: -4.59-0.66, p = 0.14) but superior to no treatment [MD = 7.99 (95%CI 6.25-9.72), p < 0.01]. Urea was associated with minor adverse events, with poor palatability being most common. LimitationsAs no RCTs investigating urea as a treatment for hyponatremia were identified for inclusion, these analyses were based on observational studies. ConclusionsUrea is safe and effective for managing SIADH-induced hyponatremia. These finding suggest that urea may be a useful treatment modality in resource-limited settings or when other treatments are contraindicated or poorly tolerated.

Critical Appraisal of Volume Status, Urine Sodium Concentration, and Urine Osmolality in the Differential Diagnosis of Hypotonic Hyponatremia

Critical Appraisal of Volume Status, Urine Sodium Concentration, and Urine Osmolality in the Differential Diagnosis of Hypotonic Hyponatremia

Higher Spot Urinary Sodium Concentration Is Associated with Better Decongestion and Lower Risk of AKI in Acute Heart Failure

Higher Spot Urinary Sodium Concentration Is Associated with Better Decongestion and Lower Risk of AKI in Acute Heart Failure

Sweat Sodium Concentration Accuracy For A Wearable Fabric Sensor And Two Hydration Monitors During Running

Sweat Sodium Concentration Accuracy For A Wearable Fabric Sensor And Two Hydration Monitors During Running

Monoammonium Glutamate: What Is Its Potential in the Reduction of Sodium Content in Different Food Matrices?

ABSTRACTThe objective of the study was to assess the efficacy of monoammonium glutamate (MAG) in reducing the sodium chloride (NaCl) content (CCRD) of food matrices, including shoestring potatoes, requeijão cheese, and beef burgers. To this end, a time intensity (TI) analysis, temporal dominance of sensations (TDSs), and acceptance tests were employed to evaluate the NaCl reduction in various food items. The TI analysis showed that all experimental units had a mean salty taste intensity that equaled or exceeded the control. The TDS profiles of shoestring potatoes and requeijão cheese and the control were similar. However, the requeijão cheese exhibited significantly lower acceptance than the controls. The food matrices influenced the potential use of MAG and the CCRD. The addition of 2% MAG to the formulation reduced the NaCl content by up to 50% in shoestring potatoes and 65% in beef burgers without compromising the temporal perception of a salty taste and sensory acceptance.

Understanding the Structural and Electrochemical Properties of Anion‐Redox O3‐Na[Li1/3Mn2/3]O2 Cathode for Sodium‐Ion Batteries

AbstractActivating anionic redox is an effective strategy for enhancing the capacity of cathode materials in both lithium‐ion and sodium‐ion batteries. However, the fundamental mechanisms of O3‐type sodium anionic redox cathodes remain poorly understood due to the limited availability of such materials, despite their inherent advantages such as high initial sodium content and high reversible capacity. Herein, we employ multiple characterization methods to elucidate the structural and electrochemical properties of O3‐Na[Li1/3Mn2/3]O2, a promising sodium anionic redox cathode developed recently, with a particular focus on the effect of cutoff voltages during electrochemical aging. Our synchrotron powder X‐ray diffraction results indicate that charging the material to voltages above 4.1 V induces substantial structural changes, which compromise the structural and electrochemical reversibility of the material. This is corroborated by more rapid capacity decay and increased impedance, attributed to severe degradation on both the surface and in the bulk, as evidenced by the formation of lower valence manganese compounds. Furthermore, increasing the lower cutoff voltage for the discharge process effectively suppresses surface degradation, thereby improving cycling stability. This work offers a comprehensive understanding of a pivotal sodium anionic redox cathode material, providing valuable insights that can drive the development of advanced materials for sodium‐ion batteries.

Survey on the salt usage among Fish Cracker (Keropok lekor) manufacturers in several districts of Kuala Terengganu, Malaysia

Fish crackers (keropok lekor) are known for their tastiness. Although rich in protein and iodine, it contains a high amount of salt or sodium. Therefore, this study aimed to determine the manufacturers’ practice in the preparation of keropok lekor, perception and challenges concerning salt usage, and motivation to reduce salt content. This study also aimed to estimate the sodium content in keropok lekor. Seven manufacturers of keropok lekor in Terengganu were interviewed either face-to-face or online to obtain relevant information. All interviews were recorded, transcribed, and analyzed based on a thematic analysis framework. The recipes of keropok lekor were analyzed using the Nutritionist Pro software to determine the nutritional and sodium content, calculated based on the Malaysian and ASEAN Food Composition Tables. Based on the interviews, most manufacturers (90%) supported the effort to reduce salt in keropok lekor. However, the effort was met with several challenges, such as customer acceptance and negative perception of the taste, decreased sales, and increased material costs. The enabling factors include maintaining the original flavor of keropok lekor, customer requests, marketing opportunities, and the availability of salt substitutes. Support for marketing and financial technology know-how is also necessary. An estimate of 606.43 mg/100g of sodium content in keropok lekor was obtained in this study, which was mainly derived from the usage of sodium chloride and monosodium glutamate (MSG) during the preparation. This study revealed the high salt content in keropok lekor due to the addition of salt and seasonings. There is a potential to reduce salt content in keropok lekor with appropriate support provided to the manufacturers. Nevertheless, further research is needed to produce keropok lekor with reduced salt content, improved sensory, and enhanced microbial and physicochemical characteristics, which can improve customer perception.

Different Sodium Concentrations of Noncancerous and Cancerous Prostate Tissue Seen on MRI Using an External Coil

Abstract Background Sodium (23Na) MRI of prostate cancer (PCa) is a novel but under-documented technique conventionally acquired using an endorectal coil. These endorectal coils are associated with challenges (e.g., a non-uniform sensitivity profile, limited prostate coverage, patient discomfort) that could be mitigated with an external 23Na MRI coil. Purpose To quantify tissue sodium concentration (TSC) differences within the prostate of participants with PCa and healthy volunteers using an external 23Na MRI radiofrequency coil at 3 Tesla. Materials and Methods A prospective study was conducted from January 2022 to June 2024 in healthy volunteers and participants with biopsy-proven PCa. Prostate 23Na MRI was acquired on a 3 Tesla PET/MRI scanner using a custom-built two-loop (diameter, 18 cm) butterfly surface coil tuned for the 23Na frequency (32.6 MHz). The percent difference in TSC (ΔTSC) between prostate cancer lesions and surrounding noncancerous prostate tissue of the peripheral zone (PZ) and transition zone (TZ) was evaluated using a one-sample t-test. TSC was compared to apparent diffusion coefficient (ADC) measurements as a clinical reference. Results 6 healthy volunteers (mean age, 54.5 years ± 12.7) and 20 participants with PCa (mean age, 70.7 years ± 8.3) were evaluated. A total of 31 lesions were detected (21 PZ, 10 TZ) across PCa participants. Compared to noncancerous prostate tissue, prostate cancer lesions had significantly lower TSC (ΔTSC, -14.1% ± 18.2, p = 0.0002) and ADC (ΔADC, -26.6% ± 18.7, p &amp;lt; 0.0001). Conclusion We used an external 23Na MRI coil for whole-gland comparison of TSC in PCa and noncancerous prostate tissue at 3 Tesla. PCa lesions presented with lower TSC compared to surrounding noncancerous PZ and TZ tissue. These findings demonstrate the feasibility of an external 23Na MRI coil to quantify TSC in the prostate and offer a promising, non-invasive approach to prostate cancer diagnosis and management.

Ion-exchange enhancement of borosilicate glass vials for pharmaceutical packaging

Pharmaceutical containers for parenteral use, including vials, ampoules, prefilled syringes, and cartridges, are traditionally made of glass. However, the most commonly used type, borosilicate glass, is susceptible to issues such as breakage, corrosion, and delamination, which can jeopardize the safety and efficacy of the enclosed drugs. To address these concerns without compromising the visual or qualitative aspects of borosilicate medical glass vials, this study aimed at the enhancement of their mechanical, chemical, and corrosion resistance. A single ion exchange treatment (IET) in a salt bath of molten KNO3 at temperatures of 400, 450, and 500 °C for 2, 12, and 24 h was applied. The effects of the ion exchange process performed under different conditions were assessed by measuring Vickers hardness, crushing load, and chemical durability. The mechanical load required to crush full-body vials after the ion exchange process at 500 °C for 2, 12, and 24 h showed an increase in the applied force values (1650 ± 80, 2340 ± 80, and 2325 ± 40 N) compared to untreated vials (1157 ± 20 N).No radial cracks were observed on the surface of treated glass vials after indentation, indicating the presence of compressive stresses that prevented the initiation and propagation of cracks. The EDS analysis confirmed an increase in potassium concentration and a decrease in sodium content near the surface of samples modified by ion exchange treatment. The treated samples showed appropriate chemical stability in different acidic, basic, and neutral solutions. Conspicuous changes are noticed in the Raman spectra after IET, specifically in the Qn species region. The results indicate the potential of the ion exchange treatment in enhancing the properties of borosilicate glass vials by relatively simple and easily scalable techniques.

Sustainable agriculture through qanat systems in Karabakh: Water and soil characteristics in the context of climate change

This study investigates the water quality and soil characteristics associated with qanat systems in the Cebrail district of the Karabakh region, Azerbaijan. Qanat systems, traditional underground channels designed for water transport, play a crucial role in providing reliable water sources for drinking and irrigation. Water and soil samples were collected from seven qanat systems and analyzed for various physicochemical properties. Water quality parameters included pH, electrical conductivity, hardness, mineralization, and concentrations of calcium, magnesium, sodium, and other ions. Soil analyses focused on pH, electrical conductivity, organic matter content, salinization degree, and the presence of key ions like sulfate and nitrate. The results indicated that qanat water is generally of high quality, with pH levels suitable for both drinking and irrigation. However, some qanat systems exhibited high electrical conductivity and mineralization levels, suggesting potential salinity issues for sensitive crops. Soil samples showed favorable conditions for agriculture, with good pH levels, low salinity, and high organic matter content. The analysis revealed a significant interaction between water quality and soil characteristics, emphasizing the importance of integrated management practices. In the context of climate change, the sustainability of qanat systems is critical. Recommendations include regular monitoring of water and soil quality, soil amendments to mitigate salinity, efficient irrigation techniques, and the use of climate-resilient infrastructure. This study underscores the importance of qanat systems in arid and semi-arid regions and provides practical recommendations for sustainable land and water resource management, enhancing the socio-economic well-being of local communities.

Adaptive capability of slow-growing backyard poultry as indicated by physiological and molecular responses in a hot and humid coastal climate

Assessing the adaptability of slow-growing rural chickens for improving thermotolerance to suit the global climate change is a major research need. This work was aimed to evaluate the adaptability of CARI-Debendra chickens and to identify the polymorphism as well as expression profiling of thermotolerant genes (HSP70 and GRP78) under prevailing temperature-humidity indices and thermal stress in a coastal environment. One hundred sixty straight run chicks were reared at THI≥75 (control) and THI>80 under coastal climate till 12 weeks. Polymorphism of HSP70 and GRP78 candidate genes were explored using restriction enzymes TaqI and HaeIII to identify possible thermotolerance markers. Expression profiling of both the genes in liver, intestine and pectoralis muscle was determined through quantitative real-time PCR. Rectal and body surface temperature recorded in the neck and back showed significant differences (P < 0.01) with higher temperature in THI>80 group. Comparatively lower live weights (P < 0.05) and poor FCR were recorded in THI>80 group. The villi height in all intestinal segments was significantly lower (P < 0.01), but deeper crypt depth was observed in THI>80 than control group. A lowest thymus weight (P < 0.05) was noted with no significant differences in immune response in treatment group. Serum levels of cholesterol, activities of lactate dehydrogenase, creatinine kinase and concentration of potassium, sodium and thyroxine hormone were not different between the 2 groups. The concentration of triiodothyronine and chloride ion was lower in THI>80 group indicating adaptive changes for thermoregulation. HSP70 gene expressions in the three tissues were differentially increased (P < 0.01) by temperature-humidity indices, but the expression of GRP78 was not different between the 2 groups. The results concluded that the environmental factors interact with genetics on adaptability towards thermotolerance in slow-growing chickens.

Почвенные водоросли и цианопрокариоты степных сообществ Байкальской котловины

The article presents the results of studies of herbaceous plant communities in the Baikal basin, with the significant participation of the diazotrophic cyanoprokaryota Nostoc commune. The territory of the investigation is located at the foot of the Primorskiy range. There are developed mountain, typical steppe, and meadow communities on chestnut soils. A high content of carbonates was found in the soils, and the pH of the upper horizons varied from slightly acidic to alkaline. The composition of algae and cyanoprokaryota species living in and on soils has been revealed. In total, in steppe and meadow communities we identified 71 species from five divisions: Cyanoprokaryota – 27, Bacillariophyta – 4, Ochrophyta – 3, Chlorophyta – 34, and Charophyta – 3. 58 species have been found in steppe communities, 40 in meadow. A predominance of cyanoprokaryota and green algae was noted. The composition of the studied phototrophic species in steppe communities differed significantly from that of the meadow. In steppe communities Nostoc commune formed macroscopic colonies, and its biomass production was low (about 2 g/m2) comparable to that of a number of Asia arid territories. The N. commune biomass formation was higher on the mountain slope and at its foot, where higher density of soil composition, lower field humidity, as well as an increased content of calcium, magnesium, and sodium was found in soils. The N. commune biomass was reduced in the site at a distance from the mountain slope where the content of the above elements was lower. The regular sampling of macrocolonies had a negative impact on their renewal.

Diversidad y distribución de los helechos y licófitos de un bosque subandino del norte de los Andes

Background and aims: Ferns and lycophytes are highly diverse in Neotropical forests, and their distribution is influenced by various biotic and abiotic factors, including disturbance. This study analyzes the effect of some of these factors on the diversity of these plants in a sub-Andean forest. M&amp;M: Four transects of 400 m2 (80×5 m) were established, two in highly disturbed sites, grassland, and stream edge, and two in the forest. Each transect was divided into 16 plots where all terrestrial and epiphytic individuals were recorded. Clustering analyses were performed to recognize the presence of floristic groups, and a canonical correlation analysis was performed to identify how soil chemistry and vegetation structure affect the composition and diversity of these plants. Results: A total of 4935 individuals were found, representing 42 species. Amauropelta rudis (Kunze) Pic. Serm. (2485 individuals) and Asplenium flabellulatum Kunze (1190 individuals) were the dominant terrestrial species. The clustering and ordination analyses revealed that the plots of open sites are more related to each other than to those of the forest. Species of open sites are more correlated with a lower layer of litter, a lower height and coverage of trees or saplings, a higher concentration of aluminum and a lower concentration of sodium. Conclusions: Ferns and lycophytes are influenced by the environmental, structural and disturbance conditions of the site where they grow. Key words Disturbance, diversity, edaphic factors, multivariate analysis, pteridophytes, richness, structural factors.

A recent ongoing effect: Hyponatremia in neurologically ill patients

Different variables altering the volume of extracellular fluid might result in hyponatremia, which is defined as a serum sodium content below 136 millimoles per liter. Depending on the volume status, it can be classified as hypovolemic, euvolemic, or hypervolemic. Hyponatremia is caused by a number of risk factors and drugs, such as diuretics, NSAIDs, and antidepressants. Hyponatremia is more common in patients with neurological conditions, especially those with head trauma, subarachnoid hemorrhage, or acute meningitis. Recent advancements in analysis for disorder of antidiuretic hormone syndrome (SIADH), a prevalent cause, include vasopressin-2 receptor antagonists. The intricate regulation of sodium and water balance by humoral, neurological, and renal mechanisms is a part of normal physiology. Hyponatremia may result from medications such as tramadol, sacubitril/valsartan, antidepressants, and anticonvulsants interfering with these mechanisms. Drug-induced hyponatremia is managed by stopping the offending agent, limiting fluid intake, and occasionally administering hypertonic saline. For chronic hyponatremia, the use of vaptans, like tolvaptan, in conjunction with urea therapy is growing. A risky complication of hyponatremia is osmotic demyelination syndrome, which can occur when the condition is treated too quickly. To avoid negative consequences, close observation and the right amount of fluids must be administered during treatment. To summarize, treating hyponatremia effectively entails determining the underlying causes, treating them, and making sure that serum sodium levels are carefully corrected to avoid consequences such as osmotic demyelination syndrome.