The Sepik-Ramu River system (SRRs) is a principal contributor of terrestrial materials to the pelagic waters of the tropical Western Pacific, boasting the highest sediment discharge in New Guinea. However, this system's sediment outflow and dispersal patterns are not well-documented. This study seeks to address this gap by analyzing the estuarine sediment plumes, which are the key indicators of the marine dispersion of terrestrial materials. Utilizing Moderate Resolution Imaging Spectroradiometer (MODIS) images from 2010 to 2020 and applying the Novoa17 algorithm, we examined the distribution and temporal evolution of the sediment plume of the SRRs estuary. The sediment plume was categorized into two distinct zones: core and diffuse, based on suspended sediment concentration (SSC) levels. Our findings reveal significant seasonal variations of these sediment plumes in the nearshore. The plume area expands during the wet season and contracts during the dry season, respectively, with core and diffuse plumes sharing similar change characteristics. The diffuse plume primarily extends northeast in the wet season and subsequently shifts northwest in the dry season, and the core plume consistently points to the northeast. The study further explores the driving factors and mechanisms behind these patterns, identifying river discharge as the primary influence on the core plume and sea surface winds and coastal currents as determinants of the diffuse plume's behavior. Interannual variations in the plume characteristics were found to be influenced by the El Niño-Southern Oscillation (ENSO), which indirectly affects plume dynamics through its impact on regional precipitation. During El Niño events, characterized by drier conditions and reduced discharge, the plume SSC and area typically decrease. During La Niña events, the plume's SSC and area typically increase, except for the 2011 super La Niña's negative anomaly, caused by the rain belt's excessive westward shift.