Chromium contamination in groundwater is becoming a significant concern due to its potential contribution to the global cancer burden. Membrane distillation (MD) is a promising method known for producing high-quality water, yet issues namely temperature and concentration polarizations should be addressed. To overcome these issues, adsorption (ADS) is proposed to reduce Chromium concentration in the concentrated feed and enhance water production and resource recovery. This study assesses the performance optimization considered parameter effects of the process individually and subsequently executes it into a combined process. Slow sand filtration (SSF) is performed to eliminate particles and thus mitigate fouling. A novel Fe3O4@C-SiO2 is introduced in the ADS process. The technical and economic performances of single MD, hybrid systems (ADS-MD and SSF-MD), and an integrated SSF-ADS-MD system are compared. The results showed the integrated process outperformed various scenarios, achieving significant water recovery almost a 2-fold increase in a single process, and notable reductions in Chromium mass (485.3 gr) and abatement (31.4 mg/h). The economic analysis indicated that the benefit-cost ratio of the integrated process is slightly higher compared to hybrid ADS-MD primarily because of the lower costs in SSF. Ultimately, the results underscored the process of SSF and ADS in boosting MD performance, particularly in water production and Chromium reduction, with prudent economic considerations.