Concentration Of Microparticles Research Articles

Amorphous ribbons for GMI detection of stray fields FeOx magnetic filler of epoxicomposites

Magnetoimpedance (MI) effect in stress-annealed Co-based amorphous ribbon was studied in the states without and in presence of the magnetic epoxy composite of cylindrical shape. Iron oxide FeOx magnetic microparticles of different concentrations (0–70 wt%) were used as a magnetic filler. The condition of stress annealing (350 °C, 1 h and 250 MPa specific load) were selected in order to insure the high MI sensitivity with respect to external magnetic field in the field of a few Oersted. The MI responses were modified in the presence of the magnetic epoxy composites due to the contribution of the stray fields of embedded microparticles. It was experimentally found that degree of the MI curves modification depended on the microparticles concentration. The MI characteristics were also dependent on the length-to-width ratio of the MI element. The most sensitive MI element under study showed a linear dependence with a 1 %/weightpercent microparticle concentration slope. Mathematical modeling using finite elements (FEM) protocol for the properties of short MI elements confirmed the results and highlighted the non-monotonic contribution of high-concentration composites to the MI responses

Periprocedural Intravascular Hemolysis During Atrial Fibrillation Ablation: A Comparison of Pulsed Field With Radiofrequency Ablation

BackgroundHemolysis-related renal failure has been described after pulmonary vein isolation (PVI) with pulsed field ablation (PFA). ObjectivesThis study sought to compare the potential for hemolysis during PVI with PFA vs radiofrequency ablation (RFA). MethodsIn consecutive patients, PVI was performed with PFA or RFA. Blood samples were drawn at baseline, immediately postablation, and 24 hours postablation. Using flow cytometry, the concentration of red blood cell microparticles (RBCμ) (fragments of damaged erythrocytes) in blood was also assessed. Lactate dehydrogenase (LDH), haptoglobin, and indirect bilirubin were measured at baseline and 24 hours. ResultsSeventy patients (age: 64.7 ± 10.2 years; 47% women; 36 [51.4%] paroxysmal atrial fibrillation) were enrolled: 47 patients were in the PFA group (22 PVI-only and 36.4 ± 5.5 pulsed field energy applications; 25 PVI-plus, 67.3 ± 12.4 pulsed field energy applications), and 23 patients underwent RFA. Compared to baseline, the RBCμ concentration increased ∼12-fold postablation and returned to baseline by 24 hours in the PFA group (median: 70.8 [Q1-Q3: 51.8-102.5] vs 846.6 [Q1-Q3: 639.2-1,215.5] vs 59.3 [Q1-Q3: 42.9-86.5] RBCμ/μL, respectively; P < 0.001); this increase was greater with PVI-plus compared to PVI-only (P = 0.007). There was also a significant, albeit substantially smaller, periprocedural increase in RBCμ with RFA (77.7 [Q1-Q3: 39.2-92.0] vs 149.6 [Q1-Q3: 106.6-180.8] vs 89.0 [Q1-Q3: 61.2-123.4] RBCμ/μL, respectively; P < 0.001). At 24 hours with PFA, the concentration of LDH and indirect bilirubin increased, whereas haptoglobin decreased significantly (all P < 0.001). In contrast, with RFA, there were only smaller changes in LDH and haptoglobin concentrations (P = 0.03) and no change in bilirubin. ConclusionsPFA was associated with significant periprocedural hemolysis. With a number of 70 PFA lesions, the likelihood of significant renal injury is uncommon.

Spallation and particles infusion into the extracorporeal circuit during CRRT: a preventable phenomenon

Patients in intensive care are exposed to the risk of microparticle infusion via extracorporeal lines and the resulting complications. A possible source of microparticle release could be the extracorporeal circuit used in blood purification techniques, such as continuous renal replacement therapy (CRRT). Disposable components of CRRT circuits, such as replacement bags and circuit tubing, might release microparticles such as salt crystals produced by precipitation in replacement bags and plastic microparticles produced by spallation. In-line filtration has proven effective in retaining microparticles both in in-vitro and in-vivo studies. In our study, we performed an in-vitro model of CRRT-treatment with the aim of detecting the microparticles produced and released into the circuit by means of a qualitative and quantitative analysis, after sampling the replacement and patient lines straddling a series of in-line filters. Working pressures and flows were monitored during the experiment. This study showed that microparticles are indeed produced and released into the CRRT circuit. The inclusion of in-line filters in the replacement lines allows to reduce the burden of microparticles infused into the bloodstream during extracorporeal treatments, reducing the concentration of microparticles from 14 mg/mL pre in-line filter to 11 mg/mL post in-line filter. Particle infusion and related damage must be counted among the pathophysiological mechanisms supporting iatrogenic damage due to artificial cross-talk between organs during CRRT applied to critically ill patients. This damage can be reduced by using in-line filters in the extracorporeal circuit.

Effect of micro-particles on cavitation erosion behavior of 2Cr3WMoV steel

Purpose This paper aims to study the influence of microparticles on the surface cavitation behavior of 2Cr3WMoV steel; microparticle suspensions of different concentration, particle size, material and shape were prepared based on ultrasonic vibration cavitation experimental device. Design/methodology/approach 2Cr3WMoV steel was taken as the research object for ultrasonic cavitation experiment. The morphology, quantity and distribution of cavitation pits were observed and analyzed by metallographic microscope and scanning electron microscope. Findings The study findings showed that the surface cavitation process produced pinhole cavitation pits on the surface of 2Cr3WMoV steel. High temperature in the process led to oxidation and carbon precipitation on the material surface, resulting in the “rainbow ring” cavitation morphology. Both the concentration and size of microparticles affected the number of pits on the material surface. When the concentration of microparticles was 1 g/L, the number of pits reached the maximum, and when the size of microparticles was 20 µm, the number of pits reached the minimum. The microparticles of Fe3O4, Al2O3, SiC and SiO2 all increased the number of pits on the surface of 2Cr3WMoV steel. In addition, the distribution of pits of spherical microparticles was more concentrated than that of irregularly shaped microparticles in turbidity. Originality/value Most of the current studies have not systematically focused on the effect of each factor of microparticles on the cavitation behavior when they act separately, and the results of the studies are more scattered and varied. At the same time, it has not been found to carry out the study of microparticle cavitation with 2Cr3WMoV steel as the research material, and there is a lack of relevant cavitation morphology and experimental data.

UV Light-Mediated Hydrolytic Reaction to Develop Magnetic Hydrogel Actuators with Spatially Distributed Ferriferous Oxide Microparticles.

Magnetic hydrogel actuators are developed by incorporating magnetic fillers into the hydrogel matrix. Regulating the distribution of these fillers is key to the exhibited functionalities but is still challenging. Here a facile way to spatially synthesize ferrosoferric oxide(Fe3 O4 ) microparticles in situ in a thermal-responsive hydrogel is reported. This method involves the photo-reduction of Fe3+ ions coordinated with carboxylate groups in polymer chains, and the hydrolytic reaction of the reduced Fe2+ ions with residual Fe3+ ions. By controlling the irradiation time and position, the concentration of Fe3 O4 microparticles can be spatially controlled, and the resulting Fe3 O4 pattern enables the hydrogel to exhibit complex locomotion driven by magnet, temperature, and NIR light. This method is convenient and extendable to other hydrogel systems to realize more complicated magneto-responsive functionalities.

ANALISIS KONSENTRASI PARTIKEL MIKRO AMBIENT PADA FUNGSI PARU POPULASI URBAN JAKARTA

Introduction: The potential impact on lung function due to high exposure to ambient microparticles in cities such as Jakarta has not been comprehensively studied. The background of this research is based on the lack of studies regarding the impact of high micro-particle exposure in major cities like Jakarta on lung function. Research Objective: The purpose of this study is to investigate the relationship between the dominant levels of ambient micro-particle concentration in urban areas of Jakarta and changes in spirometry indices among its residents. Method: A cross-sectional approach was used to determine the relationship between ambient micro-particle concentration and irregularities in spirometry indices among the urban population of Jakarta. This study involved 187 adults, aged between 20 to 65 years, mostly from the busy urban sectors of Jakarta. Statistical techniques of association and logistic regression were used for the assessment of the collected data. Results: The average exposure to ambient micro-particles was 315 µg/m³. Aberrations in spirometry indices were detected in 41.2% of participants. A significant relationship was found between high micro-particle concentrations and anomalies in spirometry readings among urban residents of Jakarta. This correlation remained significant after considering confounding factors such as gender, duration of exposure, local ventilation quality, smoking habits, and prevailing humidity. Conclusion: The results of this analysis suggest that the dominant levels of ambient micro-particles in the urban areas of Jakarta may play an important role in causing variations in spirometry results among its inhabitants..

تقييم النفايات الصناعية في قطاع صناعة الدهانات - بمنطقة الخرطوم بحري الصناعية

The study focused on the management of industrial waste in the paints industry in the Khartoum North industrial area. The research material was collected through laboratory analysis of wastewater samples resulting from factories and subsequently compared with the instructions of the Sudanese standard board for wastewater. Through measuring the concentration of suspended microparticles in the production units and comparing them with occupational health instructions in addition to direct observation and a questionnaire-based exercise for factory departments. The results showed that the wastewater was discharged into the sewage network without adhering to the standards of the Sudanese standards board. Solid waste was disposed of in a landfill without treating of the hazardous waste, also factories do not treat the polluted air by the suspended particles. The paper recommended that there is a need to implement integrated environmental management of Sudan’s industry and keep pace with the global development in the field for combating industrial pollution from its sources and to encourage further research and studies in this area.

Variations in the Concentration of Microparticles in the Atmospheric Surface Layer in the Summer Periods of 2021 and 2022 According to the Mikhnevo Observatory

Variations in the Concentration of Microparticles in the Atmospheric Surface Layer in the Summer Periods of 2021 and 2022 According to the Mikhnevo Observatory

Presurgical circulating platelet-derived microparticles level as a risk factor of blood transfusion in patients with valve heart disease undergoing cardiac surgery

BackgroundCell-derived microparticles (MPs) are membrane vesicles that have emerged as a potential biomarker for various diseases and their clinical complications. This study investigates the role of MPs as a risk factor for blood transfusion in patients with valve heart disease undergoing cardiac surgery. MethodsForty adult patients undergoing heart valve surgery with cardiopulmonary bypass (CPB) were enrolled, and venous blood samples were collected prior to surgical incision. Plasma rich in MPs was prepared by double centrifugation, and the concentration of MPs was determined using the Bradford method. Flow cytometry analysis was performed to determine MPs count and phenotype. Patients were divided into “with transfusion” (n = 18) and “without transfusion” (n = 22) groups based on red blood cell (RBC) transfusion. ResultsThere was no significant difference in MPs concentration between the “with transfusion” and “without transfusion” groups. Although the count of preoperative platelet-derived MPs (PMPs), monocyte-derived MPs (MMPs), and red cell-derived MPs (RMPs) was higher in “without transfusion” group, these differences were not statistically significant. The preoperative PMPs count was negatively correlated with RBC transfusion (P = 0.005, r = -0.65). Multivariate logistic regression analysis revealed that the count of CD41+ PMPs, Hemoglobin (Hb), and RBC count were risk factors for RBC transfusion. ConclusionThis study suggests that the presurgical levels of PMPs, Hb, and RBC count can serve as risk factors of RBC transfusion in patients with valve heart disease undergoing cardiac surgery. The findings provide insights into the potential use of MPs as biomarkers for blood transfusion prediction in cardiac surgery.

Effect of Thrombolysis on Circulating Microparticles in Patients with ST-Segment Elevation Myocardial Infarction.

We demonstrated that circulating microparticles (MPs) are increased in patients with coronary heart disease (both chronic coronary syndrome (CCS) and acute coronary syndrome). Whether thrombolysis affects MPs in patients with ST-segment elevation myocardial infarction (STEMI) with or without percutaneous coronary intervention (PCI) is unknown. This study was divided into three groups: STEMI patients with thrombolysis (n = 18) were group T, patients with chronic coronary syndrome (n = 20) were group CCS, and healthy volunteers (n = 20) were the control group. Fasting venous blood was extracted from patients in the CCS and control groups, and venous blood was extracted from patients in the T group before (pre-T) and 2 hours after (post-T) thrombolysis. MPs from each group were obtained by centrifugation. After determining the concentration, the effects of MPs on endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) in rat myocardial tissue in vitro were detected by immunohistochemistry and western blotting. Changes in nitric oxide (NO) and oxygen free radicals (O2•-) were also detected. The effect of MPs on vasodilation in isolated rat thoracic aortae was detected. Compared with that in the control group (2.60 ± 0.38 mg/ml), the concentration of MPs was increased in patients with CCS (3.49 ± 0.72 mg/ml) and in STEMI patients before thrombolysis (4.17 ± 0.58 mg/ml). However, thrombolysis did not further increase MP levels (post-T, 4.23 ± 1.01 mg/ml) compared with those in STEMI patients before thrombolysis. Compared with those in the control group, MPs in both CCS and STEMI patients before thrombolysis inhibited the expression of eNOS (both immunohistochemistry and western blot analysis of phosphorylation at Ser1177), NO production in the isolated myocardium and vasodilation in vitro and stimulated the expression of iNOS (immunohistochemistry and western blot analysis of phosphorylation at Thr495), and the generation of O2•- in the isolated myocardium. The effects of MPs were further enhanced by MPs from STEMI patients 2 hours after thrombolysis. Changes in MP function after thrombolysis may be one of the mechanisms leading to ischemia-reperfusion after thrombolysis.

Lead-free silver niobate microparticles-loaded PDMS composite films for high-performance clip-like hybrid mechanical energy harvesters

A triboelectric nanogenerator (TENG) is a highly potential green energy harvesting technology to power small-scale electronic devices. Enhancing the overall electricity production capacity of TENGs is a primary concern for their utilization as an electricity generator in day-to-day life. Herein, we proposed a lead-free silver niobate (AgNbO3 (ANb)) microparticles (MPs)-embedded polydimethylsiloxane (PDMS) composite film-based clip-like hybrid nanogenerator (HNG) device, producing an enhanced electrical output from the applied mechanical movements. The ANb MPs with a high dielectric constant were initially synthesized and embedded inside the PDMS polymer matrix. Various HNGs were fabricated utilizing ANb MPs/PDMS composite films/aluminum tape as negative/positive triboelectric films, respectively and operated in contact-separation mode. The electrical output from them was comparatively analyzed to investigate an optimum concentration of the ANb MPs inside the PDMS film. The robust HNG with 5 wt % ANb MPs/PDMS composite film produced the highest electrical output with promising stability. Thereafter, three similar optimized HNGs were fabricated and integrated within a 3D-printed clip-like structure and the electrical output was thoroughly evaluated while combining multiple HNGs as well as from each independent HNG. The clip-like HNG device exhibited an electrical output of 340 V and 20 µA that can be further utilized to charge various capacitors and power portable electronics. Owing to the high resilience structure of the clip-like HNG device, it was also demonstrated to harvest biomechanical energy produced by human movements into electricity. The mechanical energy harvesting when the clip-like HNG device was attached to the accelerator pedal of the car and the pedal of a musical piano was successfully demonstrated.

Impact of splenectomy on circulating microparticles in patients with sickle cell anemia.

Circulating microparticles (MP) are being described as potential biomarkers for disease activity in a variety of conditions including sickle cell anemia (SCA). However, relatively little is known about the influence of spleen status on MP levels in patients with SCA. Using a prospective study design we characterize circulating MP in 144 patients with SCA in steady state by assessing their cellular origin and their relationships to spleen status defined by clinical and imaging findings. In addition, MP levels were studied according to demographic characteristics, clinical status, treatment modalities, and other hematological and biochemical parameters. Absolute plasma concentrations of MP were determined by flow cytometry. Patients with SCA displayed a 10-fold increase in levels of MP derived from red blood cell (RBC) and platelets (PLT) when compared to their healthy counterparts (p < 0.0001). Splenectomized patients with SCA have more pronounced levels of MPRBC and MPPLT, and remained elevated after several weeks of follow-up. Levels of MP were not significantly associated with spleen removal procedures, age, gender, clinical severity score, hydroxyurea therapy, hemoglobin F, and co-existence of glucose-6-phosphate dehydrogenase deficiency. Collectively, these results suggest that splenectomy affects circulating levels of MP regardless of the known SCA modifiers and correlates.

Poly(sebacic acid) microparticles loaded with azithromycin as potential pulmonary drug delivery system: Physicochemical properties, antibacterial behavior, and cytocompatibility studies

Recurrent bacterial infections are a common cause of death for patients with cystic fibrosis and chronic obstructive pulmonary disease. Herein, we present the development of the degradable poly(sebacic acid) (PSA) microparticles loaded with different concentrations of azithromycin (AZ) as a potential powder formulation to deliver AZ locally to the lungs. We characterized microparticle size, morphology, zeta potential, encapsulation efficiency, interaction PSA with AZ and degradation profile in phosphate buffered saline (PBS). The antibacterial properties were evaluated using the Kirby-Bauer method against Staphylococcus aureus. Potential cytotoxicity was evaluated in BEAS-2B and A549 lung epithelial cells by the resazurin reduction assay and live/dead staining. The results show that microparticles are spherical and their size, being in the range of 1–5 μm, should be optimal for pulmonary delivery. The AZ encapsulation efficiency is nearly 100 % for all types of microparticles. The microparticles degradation rate is relatively fast – after 24 h their mass decreased by around 50 %. The antibacterial test showed that released AZ was able to successfully inhibit bacteria growth. The cytotoxicity test showed that the safe concentration of both unloaded and AZ-loaded microparticles was equal to 50 μg/ml. Thus, appropriate physicochemical properties, controlled degradation and drug release, cytocompatibility, and antibacterial behavior showed that our microparticles may be promising for the local treatment of lung infections.

Open cultivation of microorganisms in water‐in‐oil Pickering emulsions stabilized by stearate microparticles

AbstractWe report a long‐term open cultivation of model microorganisms in water‐in‐oil (W/O) Pickering emulsions stabilized by food‐grade calcium stearate microparticles without contamination. W/O Pickering emulsions were successfully prepared using calcium stearate microparticles in tetradecane. Effect of microparticle concentration on the emulsion's Sauter mean diameter was investigated at various hold‐ups. As a result, the smaller the hold‐up, the smaller was the change in Sauter mean diameter due to the microparticle concentration. It was found that Sauter mean diameter of the emulsions was almost constant for 2 months. Model microorganisms Escherichia coli and Bacillus subtilis solubilized in the emulsion were stationary cultivated in the air‐exposed state. The viable cell ratio temporarily decreased at the beginning of cultivation but then increased continuously with cultivation time after 28 days. Furthermore, there were no contamination for 28 days in the air‐exposed state of the emulsion solution containing a culture medium without microorganisms. It was also shown that the growth rate of the microorganisms in the emulsion system is significantly lower than those in conventional cultivation systems. Thus, the calcium stearate Pickering W/O emulsion system is suitable for a long‐term “open” cultivation of microorganisms without the use of any special equipment such as a jar‐fermenter.

Floods enhance the abundance and diversity of anthropogenic microparticles (including microplastics and treated cellulose) transported through karst systems

Microplastics (plastics <5 mm) are emerging contaminants that have been detected in virtually all environments. While microplastic research in terrestrial surface waters has been proliferating, microplastic contamination in subsurface environments remains understudied. Karst terrains may be particularly susceptible to microplastic pollution because the presence of large dissolution openings allows fast transport of water through these systems, facilitating the introduction of surface contaminants into subsurface habitats. Furthermore, few studies address the prevalence and movement of microparticles composed of semisynthetic and modified natural materials, despite their known ecotoxicity. Our study therefore aims to identify anthropogenic (i.e., synthetic, semisynthetic, and treated natural) microparticle extent, sourcing, and transport in subsurface karst environments. To do so, we examined a cave spring under variable flow conditions, finding that anthropogenic microparticles were present in all samples and were most frequently fibrous and clear. The mean anthropogenic microparticle concentration during baseflow was 9.2 counts/L but increased up to 81.3 counts/L during floods, indicating their enhanced mobilization when relatively dilute, acidic, and sediment-rich event water entered the cave. These results suggest that anthropogenic microparticles may originate from surface recharge or sediment resuspension within the cave. When we analyzed a subset of microparticles with Fourier transform infrared spectroscopy (FTIR), we found that cellulose of known (i.e., dyed) and suspected (i.e., clear) anthropogenic origin was the most abundant material type. We nevertheless confirmed the presence of microplastics in the cave stream under all flow conditions, with the most common polymer being polyethylene. Both the concentrations and relative fractions of microplastics were higher during floods compared to baseflow, indicating their increased transport during high flow events. We also observed that microplastic polymer types diversified as discharge increased. Our study gives new insight into how anthropogenic microparticle contamination is transported through karst landscapes that can help inform debris mitigation strategies to protect ecosystems and water resources.

ქ. რუსთავის და მიმდებარე ტერიტორიის ატმოსფეროში PM2.5-ის გავრცელების გამოკვლევა

The distribution of PM2.5 in the atmosphere of the city of Rustavi and its environs was studied under eastern background light air, gentle and fresh breeze. It has been established that the maximum concentrations of PM2.5 in the atmosphere of Rustavi are almost always higher than the corresponding maximum allowable concentrations. The trend of hourly changes in concentrations showed that during the day the concentration of microparticles reaches its maximum in the various period of the day. Numerical modeling of the local distribution of microparticles carried out in the city of Rustavi during background easterly light air, gentle and fresh breeze showed us that the change in the daily regime of relief and temperature with eastern light air in Rustavi for 12 hours leads to a complex and significant change in the wind speed directed to land. It forms on the territory of Kvemo Kartli the opposite current of the background wind, which corresponds to the horizontal circular wind circulation. The value of circulation gradually decreases with increasing height and in the boundary layer of the atmosphere (600 m above the earth's surface) has the form of a wave disturbance. the picture obtained with an average background east wind is qualitatively similar to the field obtained with a background light air, and with a fresh breeze, in contrast to the case of a light air and gentle breeze, the pollution zone covers most of the simulation zone.

The effect of liquid bound by microparticles (ions) on the membrane selectivity

Notion “critical concentration” was introduced for membrane processes, and a formula was proposed to calculate it. A mathematical problem of steady-state convective-diffusive mass transfer within the layer of concentration polarization was formulated and exactly solved, taking into account the hydration of microparticles (ions). For numerous examples, analyses were performed to estimate the effect of hydration and mass transfer parameters on the concentration of suspended microparticles at the membrane surface and its selectivity for uniform impurity.

Magnetizable Membranes Based on Cotton Microfibers, Honey, Carbonyl Iron, and Silver Nanoparticles: Effects of Static Magnetic Fields and Medium-Frequency Electric Fields on Electrical Properties

In this work, we present the manufacturing process of magnetizable membranes based on cotton microfibers, honey, carbonyl iron, and three different concentrations of silver microparticles. Each membrane is used as a dielectric material for the fabrication of electrical devices. By using the plane capacitor method, the electrical capacitance and dielectric loss tangent are measured in a medium-frequency alternating field superimposed on a static magnetic field. From the obtained data, the time constants of the devices, the components of complex dielectric permittivity, and the electrical conductivity of the membranes as a function of the electric field frequency and magnetic flux density can be extracted. The results show that the obtained membranes can be useful for the fabrication of low-cost and environmentally friendly magneto-active membranes that are required for various technical and biomedical applications.

MPs-ACT, an Assay to Evaluate the Procoagulant Activity of Microparticles.

The procoagulant effect of microparticles (MPs) contributes to hypercoagulability-induced thrombosis. We provide preliminary findings of the MPs-Activated Clotting Time (MPs-ACT) assay to determine the procoagulant activity of MPs. MPs-rich plasma was obtained and recalcified. Changes in plasma viscoelasticity were evaluated and the time to the peak viscoelastic changes was defined as the MPs-ACT. MPs concentration was measured by flow cytometry. Coagulation products produced during plasma clotting were identified by fibrin and fibrinopeptide A. MPs were prepared in vitro and added to standard plasma to simulate pathological samples. In addition, reproducibility and sensitivity were evaluated. We confirmed the linear relationship between MPs-ACT and MP concentrations. Dynamic changes in fibrin production were depicted. We simulated the correlation between MPs-ACT and standard plasma containing MPs prepared in vitro. The reproducibility of high-value and low-value samples was 6.0% and 10.8%, respectively. MPs-ACT sensitively detected hypercoagulable samples from patients with pre-eclampsia, hip fractures, and lung tumors. MPs-ACT largely reflects the procoagulant effect of MPs. MPs-ACT sensitively and rapidly detects hypercoagulability with MPs-rich plasma. It may be promising for the diagnosis of hypercoagulable states induced by MPs.

Correlations between the Circulating Level of Cell-Derived Microparticles and Surgical Variables in Heart Valve Surgery with Cardiopulmonary Bypass.

Cell-derived microparticles (MPs) as membrane vesicles are procoagulant. They play a role in surgical hemostasis. In this study, the correlations between the circulating level of cell-derived MPs and surgical variables in heart valve surgery were investigated. The present prospective case-series study was conducted in Rajaie Cardiovascular Medical and Research Center from January through March 2021. Forty patients undergoing heart valve surgery with cardiopulmonary bypass (CPB) were enrolled. Before the induction of anesthesia and 30 minutes after the administration of protamine sulfate, venous blood samples were collected. After MP isolation, the concentration of MPs was determined via the Bradford method. Flow cytometry analysis was performed to determine the MP count and phenotype. Intraoperative variables and postoperative routine coagulation tests were defined as surgical variables. Postoperative coagulopathy was defined as an activated partial thromboplastin time (aPTT) ≥48 seconds or an international normalized ratio (INR) >1.5. The total concentration of MPs and the MP count increased significantly after surgery compared with before surgery. The postoperative concentration of MPs was positively correlated with the CPB time (P=0.030, ρ=0.40). The preoperative concentration of MPs was significantly lower in patients with higher postoperative aPTT and INR (P=0.003, P= -0.50 and P=0.020, P= -0.40, respectively). In multivariate logistic regression analysis, the preoperative MP concentration (OR, 1.00; 95% CI, 1.00 to 1.01; P=0.017) was considered a risk factor for postoperative coagulopathy. The levels of MPs, especially platelet-derived MPs, rose after surgery, in correlation with the CPB time. Given the role of MPs in the induction of coagulation and inflammation, they can be considered therapeutic goals for preventing postoperative complications. In addition, the preoperative levels of MPs are a risk factor for predicting the occurrence of postoperative coagulopathy in heart valve surgery.