Measured Concentrations Research Articles

Feasibility of sparse large Lotka-Volterra ecosystems.

Consider a large ecosystem (foodweb) with n species, where the abundances follow a Lotka-Volterra system of coupled differential equations. We assume that each species interacts with [Formula: see text] other species and that their interaction coefficients are independent random variables. This parameter d reflects the connectance of the foodweb and the sparsity of its interactions especially if d is much smaller that n. We address the question of feasibility of the foodweb, that is the existence of an equilibrium solution of the Lotka-Volterra system with no vanishing species. We establish that for a given range of d, namely [Formula: see text] or [Formula: see text] with an extra condition on the sparsity structure, there exists an explicit threshold depending on n and d and reflecting the strength of the interactions, which guarantees the existence of a positive equilibrium as the number of species n gets large. From a mathematical point of view, the study of feasibility is equivalent to the existence of a positive solution [Formula: see text] (component-wise) to the equilibrium linear equation: [Formula: see text]where [Formula: see text] is the [Formula: see text] vector with components 1 and [Formula: see text] is a large sparse random matrix, accounting for the interactions between species. The analysis of such positive solutions essentially relies on large random matrix theory for sparse matrices and Gaussian concentration of measure. The stability of the equilibrium is established. The results in this article extend to a sparse setting the results obtained by Bizeul and Najim in Bizeul and Najim (2021).

Pressmud overcome lead toxicity by improving spinach biomass in lead-contaminated soils.

Lead (Pb) pollution is a severe problem that primarily affects food chain indeveloping countries. Continuous use of Pb containing effluent for growing food crops builds up measurable concentration of Pb in soils; and adversely affects the soil properties and crop produce quality. To reduce the Pb metal toxicity in contaminated soil, a pot experiment was conducted with graded doses of pressmud (PM) (0, 2.5, 5.0, and 10.0g/kg) and Pb (0, 100, 150, and 300mg/kg soil). Various metal dynamics parameters were computed after spinach crop was harvested. Result showed that higher doses of Pb (300mg/kg) diminished the spinach root and shoot biomass during the study; whereas, application of PM improved the spinach biomass. However, increasing the pressmud reduced the Pb concentration in shoot from 6.16, 5.99, 4.94, and 3.39µg/g. Maximum reduction was measured in highest PM applied treatment in shoot (44.92%) and root (57.33%). In this experiment, increasing level of Pb significantly uptake was recorded with higher application rate of Pb (150 and 300mg/kg). However, elevated doses of PM from control initially enhanced the small chunk of Pb and drastically reduced the shoot Pb uptake(0.060 to 0.049mg/pot) in maximum level of PM applied treatment. This study is very useful to improve the soil health by immobilizing the labile fraction of Pb by addition of PM in Pb-contaminated soils.

Correlation analysis and application investigation of multi-angle simultaneous polarization measurement data and concentration of suspended particulate matter in the atmosphere

Determining the composition, particle size distribution and concentration changes of suspended particulate matter in the atmosphere is important for evaluating the quality of air and its impact on public health. The scattering and absorption of light by suspended particulate matter can change the polarization state of light, which can be used to extract characteristic information of measured particles. Firstly, we use our previously developed multi-angle simultaneous polarization measurement device to monitor the particulate matter around Dianshan Lake, Shanghai, and obtain high-throughput, high-dimensional Stokes data for nearly 1 month. The correlation between the Stokes data measured and the reference concentrations of five suspended particulate matter (Si, K, Fe, Ca, and Zn) was analyzed using the Periodical canonical correlation analysis (PCCA) method. The study shows a strong correlation between the three Stokes vectors and the concentrations of two types of suspended particulate matter in the atmosphere. Moreover, a prediction model for the concentration change of suspended particles was proposed by combining the locally weighted linear regression (LWLR) and the auto regressive moving average (ARMA) model. The prediction results on the concentration change of K and Fe in the atmosphere verified the validity of our method. The research in this work offers the possibility of continuous analysis and prediction of atmospheric suspended particulate matter in real environments.

Basic Study on Measurement of Return Loss and Smith Chart Change Using Microstrip Patch Antenna with Concentration Transition for Non-invasive Blood Glucose Measurement.

This paper describes a basic study on the measurement of return loss and change in Smith chart using a microstrip patch antenna (MPA) with concentration transition to perform non-invasive blood glucose measurements. To evaluate blood glucose level changes in the human body, the concentration of measurements was changed 10 times to an equivalent of 100mg/dL in a range of 0-1000mg/dL to reflect a concentration of 400mg/dL, which is the fatal level of diabetes. Five types of MPAs were fabricated that formed resonant frequencies in the 1, 2, 3, 4, and 5GHz bands, and were used in the experiment. Each MPA constituted a sharp narrow band characteristic and induced a large change in return loss. By measuring the return loss and Smith chart to evaluate the concentration change at resonant frequencies, the return loss was observed to change by an average of 0.058 dB for every 100mg/dL change, and the impedance magnitudes and phase angles analyzed through the Smith chart were observed to have a certain tendency, which confirmed that they were changed. This study shows that for performing non-invasive measurements of blood sugar level, measuring the change in return loss can provide a more stable and reliable measurement compared to the two methods that are simultaneously used to view the samples.

High-sensitivity troponin I is associated with cardiovascular outcomes but not with breast arterial calcification among postmenopausal women

BackgroundPrior studies support the utility of high sensitivity troponin I (hsTnI) for cardiovascular disease (CVD) risk stratification among asymptomatic populations; however, only two prior studies examined women separately. The association between hsTnI and breast arterial calcification is unknown. MethodsCohort study of 2896 women aged 60–79 years recruited after attending mammography screening between 10/2012 and 2/2015. BAC status (presence versus absence) and quantity (calcium mass mg) was determined using digital mammograms. Pre-specified endpoints were incident coronary heart disease (CHD), ischemic stroke, heart failure and its subtypes and all CVD. ResultsAfter 7.4 (SD = 1.7) years of follow-up, 51 CHD, 30 ischemic stroke and 46 heart failure events were ascertained. At a limit of detection of 1.6 ng/L, 98.3 of the cohort had measurable hsTnI concentration. HsTnI in the 4–10 ng/L range were independently associated of CHD (adjusted hazard ratio[aHR] = 2.78; 95% CI, 1.48–5.22; p = 0.002) and all CVD (aHR = 2.06; 95% CI, 1.37–3.09; p = 0.0005) and hsTnI over 10 ng/L was independently associated with CHD (aHR = 4.75; 95% CI, 1.83–12.3; p = 0.001), ischemic stroke (aHR = 3.81; 95% CI, 1.22–11.9; p = 0.02), heart failure (aHR = 3.29; 95% CI, 1.33–8.13; p = 0.01) and all CVD (aHR = 4.78; 95% CI, 2.66–8.59; p < 0.0001). No significant association was found between hsTnI and BAC. Adding hsTnI to a model containing the Pooled Cohorts Equation resulted in significant and clinical important improved calibration, discrimination (Δ Cindex = 6.5; p = 0.02) and reclassification (bias-corrected clinical NRI = 0.18; 95% CI, −0.13-0.49 after adding hsTnI categories). ConclusionsOur results support the consideration of hsTnI as a risk enhancing factor for CVD in asymptomatic women that could drive preventive or therapeutic decisions.

Comparison of pharmacokinetics, pharmacodynamics, safety, and immunogenicity of teriparatide biosimilar with EU- and US-approved teriparatide reference products in healthy men and postmenopausal women

SummaryBiosimilar teriparatide (INTG-8) was tested in a healthy population of males and postmenopausal females to assess pharmacokinetic bioequivalence to originator teriparatide comparator products. Primary pharmacokinetic comparison confirmed bioequivalence. Pharmacodynamics, safety, and tolerability were comparable to the originator products. INTG-8 was therefore confirmed to be biosimilar to originator products.IntroductionThe purpose of this present study was to demonstrate pharmacokinetic (PK) equivalence of a biosimilar teriparatide (INTG8) to EU- and US-approved teriparatide reference products in healthy men and postmenopausal women. Secondary objectives included comparison of the pharmacodynamics (PD), safety, and tolerability.MethodsOne hundred and five subjects randomly (1:1:1) received single subcutaneous 20 μg injection of teriparatide biosimilar, EU- and US-teriparatide on 3 consecutive days in this assessor-blind, three-period, single-dose, crossover study. Maximum serum concentration (Cmax), area under the curve (AUC) from time zero to t (AUC0-t), and AUC from time zero extrapolated to infinity (AUC0-∞) were primary PK parameters, analyzed by non-compartmental methods. The secondary PD endpoints were maximum observed effect (Emax), area under the effect curve (AUE) from time zero to the last measurable concentration (AUE0–t), and time to maximum observed effect (Tmax) for total serum calcium levels. Safety, tolerability, and immunogenicity were also evaluated. This study was registered with ctri.nic.in/ (CTRI/2020/10/028627) on 26 October 2020.ResultsBaseline demographics were similar across the three-treatment sequence groups. The 90% confidence intervals (CI) for the geometric mean ratios (test:reference) of Cmax, AUC0-t, and AUC0-∞ were within the predefined bioequivalence criterion of 80.00% to 125.00%, which demonstrated PK equivalence of teriparatide biosimilar to EU- and US-teriparatide for all primary endpoints. The PD comparability was demonstrated by similar serum calcium levels. Study treatments were generally well tolerated and showed no meaningful differences in safety or immunogenicity profiles. There were no deaths, or serious AEs were reported during this study.ConclusionThe study demonstrated PK bioequivalence of teriparatide biosimilar to the EU- and US-teriparatide reference products with comparable PD, safety, and immunogenicity profiles.

Prognostic Value of High-Sensitivity Cardiac Troponin in Women.

High-sensitivity cardiac troponin assays have become the gold standard for diagnosing acute and chronic myocardial injury. The detection of troponin levels beyond the 99th percentile is included in the fourth universal definition of myocardial infarction, specifically recommending the use of sex-specific thresholds. Measurable concentrations below the proposed diagnostic thresholds have been shown to inform prognosis in different categories of inpatients and outpatients. However, clinical investigations from the last twenty years have yielded conflicting results regarding the incremental value of using different cut-offs for men and women. While advocates of a sex-specific approach claim it may help reduce gender bias in cardiovascular medicine, particularly in acute coronary syndromes, other groups question the alleged incremental diagnostic and prognostic value of sex-specific thresholds, ultimately asserting that less is more. In the present review, we aimed to synthesize our current understanding of sex-based differences in cardiac troponin levels and to reappraise the available evidence with regard to (i) the prognostic significance of sex-specific diagnostic thresholds of high-sensitivity cardiac troponin assays compared to common cut-offs in both men and women undergoing cardiovascular disease risk assessment, and (ii) the clinical utility of high-sensitivity cardiac troponin assays for cardiovascular disease prevention in women.

Effects of Salicylic Acid Concentration and Post-Treatment Time on the Direct and Systemic Chemical Defense Responses in Maize (Zea mays L.) Following Exogenous Foliar Application.

Salicylic acid (SA) plays a critical role in allergic reactions of plants to pathogens and acquired systemic resistance. Thus far, although some research has been conducted on the direct effects of different concentrations of SA on the chemical defense response of treated plant parts (leaves) after at multiple post-treatments times, few research has reported on the systematic effects of non-treated parts (roots). Therefore, we examined direct and systemic effects of SA concentration and time following foliar application on chemical defense responses in maize variety 5422 with two fully expanded leaves. In the experiments, maize leaves were treated with different SA concentrations of 0.1, 0.5, 1.0, 2.5, 5.0 mM, and then, the presence of defense chemicals and enzymes in treated leaves and non-treated roots was measured at different time points of 3, 12, 24, 48, 72 h following SA foliar application. The results showed that direct and systemic effects of SA treatment to the leaf on chemical defense responses were related to SA concentration and time of measurement after spraying SA. In treated leaves, total phenolics content increased directly by 28.65% at the time point of 12 h following foliar application of 0.5 mM SA. DIMBOA (2,4-dihydroxy-7-methoxy-2H, 1, 4-benzoxazin-3 (4H)-one) content was directly enhanced by 80.56~551.05% after 3~72 h following 0.5~5.0 mM SA treatments. Polyphenol oxidase and superoxide dismutase activities were directly enhanced after 12~72 h following 0.5~5.0 mM SA treatments, whereas peroxidase and catalase activities were increased after 3~24 h following application of 1.0~5.0 mM SA. In non-treated roots, DIMBOA content and polyphenol oxidase activity were enhanced systematically after 3~48 h following 1.0~5.0 mM SA foliar treatments. Superoxide dismutase activities were enhanced after 3~24 h following 0.5~2.5 mM SA applications, but total phenolics content, peroxidase and catalase activity decreased in some particular concentrations or at the different times of measurement in the SA treatment. It can be concluded that SA foliar application at 1.0 and 2.5 mM produces strong chemical defense responses in maize, with the optimal induction time being 24 h following the foliar application.

Development of a Contactless Conductivity Sensor in Flowing Micro Systems for Cerium Nitrate

Impedance spectroscopy has a high potential to detect chemical reactions in flowing systems. In this work, the approach using impedance spectroscopy as a possible analytical tool for a continuous hydrothermal syntheses (CHTS) is presented. With the CHTS-process, it is possible to produce metalloxide nanoparticles with a close particle size distribution and specific surface properties. For this, it is necessary to evaluate the electrode geometry, frequency and other factors influencing the impedance with respect to concentration measurements. In case of frequency-sweep measurements possible electrode geometries for C4D-Sensors (capacitively coupled contactless conductivity detection) are evaluated. Then distinguishability and reproducibility are tested applying titration measurements to show the ability for concentration detection in constant flow systems. The possibility to measure concentration changes in flowing systems in a reproducible and fast manner as well as with high distinguishability for the test solution cerium nitrate will be presented. Furthermore, the major influencing-factors like electrode geometry, frequency etc. could be determined. It has been shown that with increasing electrode spacing and electrode width, the distinguishability of the concentrations increases and shifts them to lower frequencies.

Comparative clinical pharmacology of mometasone furoate, fluticasone propionate and fluticasone furoate

AimsTo investigate the pharmacokinetics and effects on the hypothalamic-pituitary-adrenal (HPA) axis of mometasone furoate (MF), fluticasone propionate (FP) and fluticasone furoate (FF). MethodsStudy 1: Fourteen healthy participants received inhaled and intravenous MF (inhaled dose via Twisthaler) and FP (inhaled dose via Diskus), both given at 400 μg, using a randomised, single-dose, four-way crossover design. Study 2: Twenty-seven participants with mild to moderate asthma, who discontinued their corticosteroid medication for 5 days to obtain a baseline 24 h serum cortisol, received inhaled MF Twisthaler and FP Diskus, both given at 400 μg twice daily (BID), using a randomised, 14-day repeat dose, two-way crossover design. Study 3: Forty-four healthy participants were randomised to a double-blind, placebo-controlled, five-period crossover study where the following treatments were administered via the inhaled route for 7 days: FP Diskus (250, 500, 1000 μg BID), FF Diskus (100, 200, 400, 800, 1600 μg once daily [QD]) or placebo Diskus. In each study, 24-h serial blood samples were collected and assayed to assess concentrations of MF, 6β-hydroxy mometasone, mometasone, FP, FF and cortisol. Pharmacokinetic and serum cortisol parameters were estimated as geometric means and 95% confidence intervals (CI). ResultsStudy 1: For intravenous MF and FP, respectively: absolute bioavailability was 11.4% (95% CI: 7.5, 17.6) and 7.8% (6.3, 9.6); plasma clearance was 47 L/h (41, 52) and 60 L/h (52, 69); half-life was 7.4 h (6.9, 8.0) and 7.2 h (6.5, 8.0); and volume of distribution was 499 L (439, 567) and 623 L (557, 698). Inhalation of single dose MF or FP did not significantly affect serum cortisol (<10% reduction from baseline), whereas intravenous administration of MF or FP each changed serum cortisol by approximately −50% from baseline. Study 2: For MF and FP, respectively: area under the curve up to the last measurable concentration on Day 1 was 421 pg h/mL (270, 659) and 248 pg h/mL (154, 400), and on Day 14 was 1092 pg h/mL (939, 1269) and 591 pg h/mL (501, 696); absolute bioavailability was 12.8% (11.2, 14.2) and 8.9% (7.7, 10.2). On Day 14, 24-h serum cortisol change from baseline was −35% (−44%, −26%) and −18% (−28%, −5%) for MF and FP, respectively; the reduction was significantly greater for MF than FP (ratio for geometric adjusted mean serum cortisol concentration: 1.28 [1.04, 1.56]). Low plasma concentrations of 6β-hydroxy mometasone were detected after intravenous dosing (Study 1) and after multiple inhaled dosing (Study 2); mometasone was not detected in any samples. Study 3: Inhaled FP and FF had similar systemic bioavailability estimates (12.0% [11.0, 13.2] and 15.0% [12.0, 17.3], respectively), but a differential effect on the HPA axis which was in agreement with the known 1.7-fold higher glucocorticoid receptor-binding affinity of FF versus FP. However, for FP 250 μg BID and FF 100, 200 and 400 μg QD, reduction in serum cortisol was not significantly different from placebo. For higher doses, FP 500 and 1000 μg BID, and FF 800 and 1600 μg QD, changes in serum cortisol concentration relative to placebo were −30%, −70%, −41% and −90%, respectively. Repeat inhaled dosing of FP 1000 μg/day (within the therapeutic dose range) resulted in comparable cortisol suppression to MF in the therapeutic range (30% reduction); whereas for FF this occurred at more than 3-fold above the therapeutic dose range (644 μg/day). ConclusionsSingle inhaled and intravenous doses of MF and FP (400 μg) resulted in similar bioavailability and reductions in serum cortisol. Repeat dosing of inhaled MF and FP in the therapeutic range (800 μg/day) resulted in greater systemic exposure for MF, and a 35% reduction in serum cortisol that was 2-fold greater than for FP. The higher glucocorticoid receptor-binding affinity and bioavailability, lower clearance and the presence of active metabolites may contribute to the greater systemic exposure and effect on cortisol for MF. Repeat dosing of inhaled FP and FF resulted in similar systemic bioavailability but differed in terms of the dose required for comparable cortisol suppression to MF in the therapeutic range. Unlike FP and FF, MF has active metabolites that may contribute to its systemic effects, while device/formulation performance differences also exist between MF-containing products.

Sticky Brownian Rounding and its Applications to Constraint Satisfaction Problems

Semidefinite programming is a powerful tool in the design and analysis of approximation algorithms for combinatorial optimization problems. In particular, the random hyperplane rounding method of Goemans and Williamson [ 31 ] has been extensively studied for more than two decades, resulting in various extensions to the original technique and beautiful algorithms for a wide range of applications. Despite the fact that this approach yields tight approximation guarantees for some problems, e.g., Max-Cut , for many others, e.g., Max-SAT and Max-DiCut , the tight approximation ratio is still unknown. One of the main reasons for this is the fact that very few techniques for rounding semi-definite relaxations are known. In this work, we present a new general and simple method for rounding semi-definite programs, based on Brownian motion. Our approach is inspired by recent results in algorithmic discrepancy theory. We develop and present tools for analyzing our new rounding algorithms, utilizing mathematical machinery from the theory of Brownian motion, complex analysis, and partial differential equations. Focusing on constraint satisfaction problems, we apply our method to several classical problems, including Max-Cut , Max-2SAT , and Max-DiCut , and derive new algorithms that are competitive with the best known results. To illustrate the versatility and general applicability of our approach, we give new approximation algorithms for the Max-Cut problem with side constraints that crucially utilizes measure concentration results for the Sticky Brownian Motion, a feature missing from hyperplane rounding and its generalizations.

Prediction of worsening heart failure in patients with hypertrophic cardiomyopathy using plasma proteomics profiling

Abstract Background While hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease affecting 1 in 200–500 people, it is a heterogeneous disease. Only a subset of patients with HCM develop heart failure (HF; prevalence 35–50%). Prediction of worsening HF using clinical measures alone (e.g., cardiac imaging, genetic testing) remains limited. Furthermore, the underlying mechanism by which patients with HCM develop worsening HF has not been fully investigated. Proteomics profiling measures concentrations of thousands of proteins simultaneously and has been used to predict worsening of HF and to highlight which signaling pathways mediate worsening HF in non-HCM populations. Purpose In patients with HCM, we aimed to develop a plasma proteomics-based model to predict which patients with HCM would develop worsening HF and to identify signaling pathways that are differentially regulated in those who subsequently develop worsening HF. Methods We conducted a prospective cohort study in our multi-center biorepository of patients with HCM. We performed plasma proteomics profiling of 5032 proteins. We then developed a random forest model to predict worsening HF using proteomics profiling data from patients enrolled through one institution (training set). The outcome of worsening HF was defined as an increase in New York Heart Association functional class by at least 1 class. We externally validated this model in independent samples from patients enrolled through a different institution (test set). Further, we executed pathway analysis of proteins significantly dysregulated (i.e., univariable p&amp;lt;0.05) in patients who developed worsening HF compared to those who did not. Pathways with false discovery rate [FDR]&amp;lt;0.05 were considered to be dysregulated. Results There were 398 patients included in the study, with 278 in the training set and 120 in the test set. During a median follow-up of 1.8 years [interquartile range, 1.2–2.6], 60 (15%) patients developed worsening HF symptoms (45 patients in the training set and 15 patients in the test set). Using the proteomics-based model derived from the training set, the area under the receiver-operating-characteristic curve to predict worsening HF was 0.85 (95% confidence interval: 0.75–0.95) in the test set (Figure 1). Pathway analysis revealed that the Ras-MAPK pathway (FDR&amp;lt;0.00001) and its upstream PI3K-Akt pathway (FDR&amp;lt;0.00001) were dysregulated in patients who subsequently developed worsening HF (Figure 2). Conclusions Our study is the first to apply proteomics profiling to the prediction of worsening HF symptoms in patients with HCM, identifying patients who are at high risk of worsening HF and elucidating that the Ras-MAPK and related signaling pathways as potential underlying mechanisms. These findings support the potential application of proteomics profiling to clinical risk stratification and the investigation of signaling pathways underlying disease progression in HCM. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): NIH/NHLBI R01 grant

Evaluating the impact of COVID-19 countermeasures on alcohol consumption through wastewater-based epidemiology: A case study in Belgium

Wastewater-based epidemiology (WBE) is a complementary approach to monitor alcohol consumption in the general population. This method measures concentrations of xenobiotic biomarkers (e.g., ethyl sulphate) in influent wastewater (IWW) and converts these to population-normalized mass loads (PNML, in g/day/1000 inhabitants) by multiplying with the flow rate and dividing by the catchment population. The aims of this case study were to: (i) investigate temporal trends in alcohol use during the COVID-19 pandemic; and (ii) measure the effect of policy measures on alcohol consumption. Daily 24-h composite IWW samples (n = 735) were collected in the wastewater treatment plant of the university city of Leuven (Belgium) starting from September 2019 to September 2021. This is the first study that investigates alcohol use through WBE for a continuous period of two years on a daily basis. Mobile phone data was used to accurately capture population fluxes in the catchment area. Data was evaluated using a time series based statistical framework to graphically and quantitatively assess temporal differences in the measured PNML. Different WBE studies observed temporal changes in alcohol use during the COVID-19 pandemic. In this study, the PNML of ethyl sulphate decreased during the first lockdown phase, potentially indicating that less alcohol was consumed at the Leuven area during home confinement. Contrastingly, alcohol use increased after the re-opening of the catering industry. Additionally, a decrease in alcohol use was observed during the exam periods at the University of Leuven and an increase during the holiday periods. The present study shows the potential of WBE to rapidly assess the impact of some policy measures on alcohol consumption in Belgium. This study also indicates that WBE could be employed as a complementary data source to fill in some of the current knowledge gaps linked to lifestyle behavior.

S918 Pharmacokinetic Equivalence of Biosimilar Adalimumab-aqvh and Adalimumab in Healthy Subjects

Introduction: This study assessed the pharmacokinetic (PK) bioequivalence between adalimumab-aqvh, an FDA-approved biosimilar, and the reference product adalimumab after a single dose administered to healthy subjects. Adalimumab is indicated for many inflammatory conditions such as psoriasis as well as inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease. Biosimilars are biologic drugs that are highly similar in purity, potency, efficacy, and safety to the reference biologic and are available at lower costs. Methods: This double-blind, single-dose, parallel-group study randomized healthy subjects (N = 210) 1:1 to receive one 40-mg dose of adalimumab-aqvh or adalimumab. The primary PK endpoints were maximum serum concentrations (Cmax) and the area under the serum concentration versus time curve extrapolated from 0 to infinity (AUC0-inf) of adalimumab-aqvh versus adalimumab. Other PK endpoints included the time to reach Cmax, terminal elimination half-life, AUC calculated from 0 to the last measurable concentration, and apparent volume of serum cleared of drug per unit time. Safety and immunogenicity were also assessed. Results: The Cmax geometric mean ratio (GMR) was 98.6% (90% CI 90.7–107.3) and the AUC0-inf GMR was 102.7% (90% CI 92.2–114.3); PK bioequivalence was demonstrated, as both endpoints were contained within the predefined 90% CI GMR range (80%–125%). The other PK endpoints were similar between adalimumab-aqvh and adalimumab. Treatment-emergent adverse events (TEAEs) and study drug–related TEAEs were similar for each treatment, and most were mild or moderate in severity; no new safety signals were identified. Immunogenicity was similar after treatment with adalimumab-aqvh and adalimumab. Conclusion: The study demonstrated PK bioequivalence between adalimumab-aqvh and adalimumab following a single dose in healthy subjects. The safety profile, including immunogenicity, of adalimumab-aqvh was also similar to that of adalimumab.

Data and statistical evaluation of the protection effect of essential oil extracts on plain carbon steel in dilute acid media

Optimal performance of corrosion inhibiting compounds significantly depends on specific range of inhibitor concentration and measurement time. Data on the protection effect of laurus cassia and rosmarinus angustifolius essential oil extracts on plain carbon steel in 0.5 M H2SO4 and HCl electrolyte was researched into by weight loss analysis. The data showed the admixed extracts were highly potent at the concentrations studied with protection effect typically above 95%. The protection effect increased progressively with measurement time at 1% to 2% extracts concentration beyond which (2.5% to 3% concentration) the results were generally constant. The extracts exhibited inhibition performance independent of concentration. Data on standard deviation showed the degree of deviation of protection effect with measurement time and concentration is minimal. The fraction of protection effect data above 90% protection in H2SO4 is 98% and 100% in HCl solution at limit of errors of 3.24% and 0%. Statistical data by analysis of variance shows both inhibitor concentration and measurement time remarkedly altered the protection effect of the extracts with statistical relevance values of 47.17% and 53.02 for concentration and 26.51% and 29.52% in H2SO4 and HCl solution.

Concentration estimates for random subspaces of a tensor product and application to quantum information theory

Given a random subspace Hn chosen uniformly in a tensor product of Hilbert spaces Vn ⊗ W, we consider the collection Kn of all singular values of all norm one elements of Hn with respect to the tensor structure. A law of large numbers has been obtained for this random set in the context of W fixed and the dimension of Hn, Vn tending to infinity at the same speed by Belinschi, Collins, and Nechita [Commun. Math. Phys. 341(3), 885–909 (2016)]. In this paper, we provide measure concentration estimates in this context. The probabilistic study of Kn was motivated by important questions in quantum information theory and allowed us to provide the smallest known dimension for the dimension of an ancilla space, allowing for Minimum Output Entropy (MOE) violation. With our estimates, we are able, as an application, to provide actual bounds for the dimension of spaces where the violation of MOE occurs.

Zeytinyağında Radyoaktivite Konsantrasyonun İncelenmesi

It is obvious that healthy eating will only be with healthy foodstuffs, and the foods consumed can affect social life and religious life in addition to physical and mental health. The concentration of radioactivity that may be in basic foodstuffs such as oil can increase the dose rate taken with food. In the study, no measurable U-238, Ra-226, Th-232, K-40, Cs-137 and Cs-134 concentrations were found in olive oils obtained from olives grown in Osmaniye, Düziçi and Erzin regions. The absence of measurable radionuclide concentrations in olive oils is a positive result. It is a desirable property that the olive oil that people consume as food is clean and does not contain radioactivity.

Impact of Boundary Condition and Kinetic Parameter Uncertainties on NOx Predictions in Methane–Air Stagnation Flame Experiments

Abstract A comprehensive understanding of uncertainty sources in experimental measurements is required to develop robust thermochemical models for use in industrial applications. Due to the complexity of the combustion process in gas turbine engines, simpler flames are generally used to study fundamental combustion properties and measure concentrations of important species to validate and improve modeling. Stable, laminar flames have increasingly been used to study nitrogen oxide (NOx) formation in lean-to-rich compositions in low-to-high pressures to assess model predictions and improve accuracy to help develop future low-emissions systems. They allow for nonintrusive diagnostics to measure sub-ppm concentrations of pollutant molecules, as well as important precursors, and provide well-defined boundary conditions to directly compare experiments with simulations. The uncertainties of experimentally measured boundary conditions and the inherent kinetic uncertainties in the nitrogen chemistry are propagated through one-dimensional stagnation flame simulations to quantify the relative importance of the two sources and estimate their impact on predictions. Measurements in lean, stoichiometric, and rich methane–air flames are used to investigate the production pathways active in those conditions. Various spectral expansions are used to develop surrogate models with different levels of accuracy to perform the uncertainty analysis for 15 important reactions in the nitrogen chemistry and the six boundary conditions (ϕ, Tin, uin, du/dzin, Tsurf, P) simultaneously. After estimating the individual parametric contributions, the uncertainty of the boundary conditions are shown to have a relatively small impact on the prediction of NOx compared to kinetic uncertainties in these laboratory experiments. These results show that properly calibrated laminar flame experiments can, not only, provide validation targets for modeling, but also accurate indirect measurements that can later be used to infer individual kinetic rates to improve thermochemical models.

Detection of Particle Concentration and Particle Size Based on Aerodynamic Particle Size Spectrometer

In order to solve the problem of the continuous online monitoring of the fixed pollution source emission particles, on the basis of the advantages and disadvantages of the comprehensive analysis of the extinction method, the β-ray absorption method, the micro-oscillating balance method, the charge transfer method, and the light scattering method, the particle size distribution and concentration optical detection system based on aerodynamic particle size spectrometer is designed according to the Mie light scattering principle. A high-performance aerodynamic particle size spectrometer is designed using a single-wavelength method to measure the concentration of particulate matter, and the equipment and the detection system are used in the continuous monitoring of particulate matter emitted by thermal power plants and compared with the ES632 equipment. Through the system test, the results show that compared with the ES632 equipment performance, the lowest concentration measured by the design of aerodynamic particle size spectrometer equipment can reach 0.1 mg/m3 with a measurement accuracy of 0.01 mg/m3. Compared with the ES632 equipment, the measurement concentration value is 8% higher, which meets the test requirements.

Rates of convergence in the two-island and isolation-with-migration models

A number of powerful demographic inference methods have been developed in recent years, with the goal of fitting rich evolutionary models to genetic data obtained from many populations. In this paper we investigate the statistical performance of these methods in the specific case where there is continuous migration between populations. Compared with earlier work, migration significantly complicates the theoretical analysis and requires new techniques. We employ the theories of phase-type distributions and concentration of measure in order to study the two-island and isolation-with-migration models, resulting in both upper and lower bounds on rates of convergence for parametric estimators in migration models. For the upper bounds, we consider inferring rates of coalescent and migration on the basis of directly observing pairwise coalescent times, and, more realistically, when (conditionally) Poisson-distributed mutations dropped on latent trees are observed. We complement these upper bounds with information-theoretic lower bounds which establish a limit, in terms of sample size, below which inference is effectively impossible.