The article considers the possibility of using protein supplements obtained by microbiological synthesis in the nutrition of pigs instead of traditional protein supplements. According to the principle of analogues, two groups of pigs were formed after weaning. Pigs of the control group received full-fledged compound feed, the experimental group received a grain mixture with the inclusion of 10% high-protein concentrate. The introduction of a protein feed additive obtained by microbiological synthesis into the diet of pigs had a positive effect on the metabolism, resistance, safety and productivity of experimental animals. In the blood of pigs of the experimental group, the content of lysis and lysozyme was 13.6% and 18.8% higher than in the control group. The bactericidal activity of blood serum in the experimental group was 19.5% higher than in the control. When assessing the effect of feed products and biologically active substances on the body, special importance is attached to the formation of nonspecific resistance of the body. The number of hemolytic microorganisms in the intestinal contents of pigs of the experimental group is an order of magnitude lower than in the control. The ratio of lactose-positive representatives of the Escherichia coli group responsible for the fermentation of carbohydrates, in particular, lactose, was significantly higher (by more than 2.73 times) in the experimental group that received a high-protein concentrate to the main diet. The inclusion in the diet of young pigs, consisting of grain components with the inclusion of 10% high-protein concentrate, had a positive effect on the growth rate of pigs and allowed to increase the average daily gain in live weight by 19.0%. The safety of young animals in the control group was 93%, in the experimental group 100%.