Increase In Concentration Research Articles

ROS as Signaling Molecules to Initiate the Process of Plant Acclimatization to Abiotic Stress.

During their life cycle, plants constantly respond to environmental changes. Abiotic stressors affect the photosynthetic and respiratory processes of plants. Reactive oxygen species (ROS) are produced during aerobic metabolism and play an important role as regulatory mediators in signaling processes, activating the plant's protective response to abiotic stress and restoring "oxidation-reduction homeostasis". Cells develop normally if the rates of ROS production and the ability to neutralize them are balanced. To implement oxidation-reduction signaling, this balance must be disrupted either by an increase in ROS concentration or a decrease in the activity of one or more antioxidant systems. Under abiotic stress, plants accumulate excessive amounts of ROS, and if the ROS content exceeds the threshold amount dangerous for living organisms, it can lead to damage to all major cellular components. Adaptive resistance of plants to abiotic stressors depends on a set of mechanisms of adaptation to them. The accumulation of ROS in the cell depends on the type of abiotic stress, the strength of its impact on the plant, the duration of its impact, and the recovery period. The aim of this review is to provide a general understanding of the processes occurring during ROS homeostasis in plants, oxidation-reduction processes in cellular compartments in response to abiotic stress, and the participation of ROS in signaling processes activating adaptation processes to abiotic stress.

Investigating the hypothermic effects of fluoroquinolone antimicrobials on non-bacterial fever model mice

BackgroundFluoroquinolone (FQ) antimicrobials have antipyretic effects during the treatment of bacterial infections; however, it is not clear whether these are due to their antimicrobial activities or their hypothermic effects. In this study, we investigated the hypothermic effects of FQ antimicrobials (ciprofloxacin [CPFX], gatifloxacin [GFLX], and levofloxacin [LVFX]) on fever by evaluating rectal body temperature changes in a mouse model of non-bacterial fever.MethodsCPFX, GFLX, and LVFX were administered intraperitoneally to non-bacterial fever model mice induced by yeast. Rectal body temperature was measured up to 180 min after administration.ResultsA decrease in rectal body temperature of up to 1.2 °C for CPFX, 3.4 °C for GFLX, and 1.0 °C for LVFX was observed. The decrease in temperature was induced by an increase in the plasma concentration of FQ antimicrobials, suggesting that they are responsible for the temperature reduction. Focusing on glucocorticoids, one thermoregulation mechanism, we investigated the substances responsible for the reduction in rectal body temperature induced by FQ antimicrobials. Aminoglutethimide (an inhibitor of glucocorticoid production) were premedicated, followed by intraperitoneal administration of GFLX in the yeast-induced fever mouse model, resulting in attenuated GFLX-induced hypothermic effects.ConclusionsThese results suggest that certain antipyretic effects of CPFX, GFPX, and LVFX during fever may contribute to their hypothermic effects; certain mechanisms are glucocorticoid-mediated.

A Pharmacokinetic and Bioavailability Study of Ecklonia cava Phlorotannins Following Intravenous and Oral Administration in Sprague–Dawley Rats

This study examines the pharmacokinetics and bioavailability of phlorotannins from Ecklonia cava in rats following intravenous and oral administration. Known for their potent antioxidant, anti-inflammatory and many other bioactivities, these phlorotannins, particularly dieckol, 8,8′-bieckol, and phlorofucofuroeckol-A (PFF-A), were analyzed using high-performance liquid chromatography coupled with tandem mass spectrometry. Intravenous administration at 10 mg/kg allowed detectability in plasma for up to 36 h for dieckol and 8,8′-bieckol, but only 2 h for PFF-A. Oral administration at doses of 100 mg/kg and 1000 mg/kg showed limited detectability, indicating low bioavailability and rapid clearance, particularly for PFF-A. The pharmacokinetic data suggest non-linear increases in the maximum plasma concentration (Cmax) and area under the curve (AUC) with increasing doses, pointing to significant challenges in achieving systemic availability of these eckols through oral administration. This study underscores the necessity for advanced formulation strategies and alternative routes of administration to enhance systemic bioavailability. At the same time, this result also suggests their effects may be through non-systemic pathways such as gut microbiome modulation or lipid-rich tissue targeting. The findings lay a crucial foundation for the further development of Ecklonia cava phlorotannins as therapeutic agents, offering insights into their pharmacokinetic behavior and informing enhancements in future clinical utility.

Particle transport and turbulence modification in unstably stratified mixed convection within a horizontal channel

Particle transport and turbulence modification in an unstably stratified, particle-laden turbulent flow within a horizontal channel is studied via direct numerical simulations combined with Lagrangian point‒particle tracking techniques. Two-way coupling in momentum and energy is considered in dilute gas‒solid flows under mixed convection (synergistic effects of shear and buoyancy). For comparison, simulations of neutral turbulence are also conducted with equivalent parameters. The study reveals that large-scale longitudinal vortical structures induce significant spatial heterogeneity in the spanwise distribution of inertial particles. This heterogeneity is characterized by an increase in the particle concentration on the side of the cold plume and a corresponding decrease on the side of the hot plume. In the context of unstably stratified turbulence, particles reduce the fluid streamwise velocity and promote its profile toward symmetry. This phenomenon contrasts with that observed in neutral flows, where particles induce velocity asymmetry by dragging the upper flow and accelerating the lower flow. A quantitative analysis of the heat flux indicates that particles absorb heat as they settle, thereby reducing the average temperature of the flow. Buoyancy effects slow the settling and reinjection of particles, which in turn diminishes thermal energy absorption. Particles with higher inertia preferentially settle on the cooler plume side, minimizing their participation in heat exchange due to prolonged durations of repeated wall collisions.

Vegetation traits and biogeomorphic complexity shape the resilience of salt marshes to sea-level rise

The adaptive capacity of ecosystems, or their ability to function despite altered environmental conditions, is crucial for resilience to climate change. However, the role of landscape complexity or species traits on adaptive capacity remains unclear. Here, we combine field experiments and morphodynamic modelling to investigate how ecosystem complexity shapes the adaptive capacity of intertidal salt marshes. We focus on the importance of tidal channel network complexity for sediment accumulation, allowing vertical accretion to keep pace with sea-level rise. The model showed that landscape-scale ecosystem complexity, more than species traits, explained higher sediment accumulation rates, despite complexity arising from these traits. Landscape complexity, reflected in creek network morphology, also improved resilience to rising water levels. Comparing model outcomes with real-world tidal networks confirmed that flow concentration, sediment transport and deposition increase with drainage complexity. These findings emphasize that natural pattern development and persistence are crucial to preserve resilience to climate change.

Molecular dynamics simulations unveil the aggregation patterns and salting out of polyarginines at zwitterionic POPC bilayers in solutions of various ionic strengths

This study employs molecular dynamics (MD) simulations to investigate the adsorption and aggregation behavior of simple polyarginine cell-penetrating peptides (CPPs), specifically modeled as R9 peptides, at zwitterionic phosphocholine POPC membranes under varying ionic strengths of two peptide concentrations and two concentrations of NaCl and CaCl2. The results reveal an intriguing phenomenon of R9 aggregation at the membrane, which is dependent on the ionic strength, indicating a salting-out effect. As the peptide concentration and ionic strength increase, peptide aggregation also increases, with aggregate lifetimes and sizes showing a corresponding rise, accompanied by the total decrease of adsorbed peptides at the membrane surface. Notably, in high ionic strength environments, large R9 aggregates, such as octamers, are also observed occasionally. The salting-out, typically uncommon for short positively charged peptides, is attributed to the unique properties of arginine amino acid, specifically by its side chain containing amphiphilic guanidinium (Gdm+) ion which makes both intermolecular hydrophobic like-charge Gdm+ – Gdm+ and salt-bridge Gdm+ – C-terminus interactions, where the former are increased with the ionic strength, and the latter decreased due to electrostatic screening. The aggregation behavior of R9 peptides at membranes can also be linked to their CPP translocation properties, suggesting that aggregation may aid in translocation across cellular membranes.

Soluplus-Stabilized Nimodipine-Entrapped Spanlastic Formulations Prepared with Edge Activator (Tween20): Comparative Physicochemical Evaluation.

Nimodipine (ND) is a vasodilator drug that is used for acute subarachnoid hemorrhage. It has a predominant hydrophobic property, causing low solubility and low bioavailability. Spanlastics are elastic nanovesicular systems based on non-ionic surfactants and edge activators as major components. The goal of this work is to formulate ND as spanlastic nanovesicles to improve the drug's bioavailability. Spanlastic formulations containing ND were prepared by using the ethanol injection method. The composition of the ND formulation includes Span60 as a nonionic surfactant and Tween 20 as edge activators in different ratios. Stabilizers like Soluplus are used in some formulations and then compared with other formulations without that stabilizer. The evaluation study involved Vesicle Size (VS), PolyDispersity Index (PDI), and Entrapment Efficiency (%EE). Then, the optimized formula was subjected to an in vitro release study and zeta potential, additionally comparing the optimized formula with the formula without soluplus in the same concentration in Scanning Electron Microscopy (SEM), solubility study, Deformability Index (DI), and stability study. The results indicated a significant shift in some evaluation criteria and a non-significant change in other characterizations, including the difference in polymer ratio, sonication time, and the existence of a stabilizer. The best formula, F27, was found to have VS, PDI, %EE, and zeta potential of 125.7±0.29 nm, 0.4744±0.002, and 85.43±0.17% and -20.01 ± 0.89 mV, respectively. The photomicrographs of the prepared spanlastic revealed a more uniform and spherical spanlastic, indicating a greater capacity for continuous release. With the addition of Soluplus, the formula became more stable in one month and had a higher deformability index. A significant shift was observed in both VS and PDI. As the stabilizer concentration increases, VS and PDI will decrease. The non-significant shift was noted in the %EE with the presence of a stabilizer. Soluplus has the ability to spontaneously self-assemble into spherical particles. Additionally, PEG 6000, as a component of Soluplus's structure, has a tendency to form strong or tightly bound bilayers and prevent aggregation and formulation of large vesicles. This study explains the accessibility of the formulation of ND as spanlastic nanovesicles by using the ethanol injection method. This spanlastic formulation contains non-ionic surfactants and edge activators (Span 40 and Tween 20) in varying ratios. To get a stable formula, Soluplus is added to prevent the development of crystals and agglomeration.

A Numerical Simulation of the Effect of Drilling Fluid Rheology on Cutting Migration in Horizontal Wells at Different Drilling Fluid Temperatures

In recent years, significant breakthroughs have been made in the exploration of deep to ultra-deep oil and gas reserves onshore in China. These conventional deep to ultra-deep reservoirs are typically buried at depths exceeding 4500 m, with bottom-hole temperatures surpassing 150 °C. The high temperatures at the bottom of the well are more likely to cause deterioration in drilling fluid properties, altering its rheological properties and reducing cutting transport efficiency, which can lead to wellbore cleaning issues. In this paper, the numerical simulation method is used to analyze the influence of cutting particle size, drilling fluid flow rate, drill pipe rotation speed, and drill pipe eccentricity on the annular cutting concentration under different wellbore drilling fluid temperature conditions. The results show that at the same cutting particle size, as the drilling fluid temperature increases, the cutting concentration in the annulus increases sharply. The increase is the largest when the particle size is 3 mm, and when the drilling fluid temperature is 220 °C, the cutting concentration increases by 79.7% compared to at 200 °C and by 279% compared to at 180 °C. When the flow rate increases from 0.5 m/s to 1.0 m/s, the annular cutting concentration at drilling fluid temperatures of 220 °C and 200 °C decreases by 70.5% and 50.4%, respectively. The higher the drilling fluid temperature, the better the cutting removal effect when increasing the drill pipe rotation speed. However, when the rotation speed exceeds 120 rpm, the change in cutting concentration with increasing rotation speed becomes insignificant. When the drill pipe eccentricity is small, an increase in drilling fluid temperature leads to a significant rise in annular cutting concentration. However, when the drill pipe eccentricity is large, changes in drilling fluid temperature have a smaller impact on cutting concentration. The research findings can provide engineering guidance and theoretical support for the design of drilling fluid hydraulic parameters for cutting transport and rheological parameters in high-temperature wellbores.

Fermented Gold Kiwi Improves Gastrointestinal Motility and Functional Constipation: An Animal Study and Human Randomized Clinical Test.

Constipation is a functional disorder of the gastrointestinal system characterized by difficult bowel movements, infrequent defecation, reduced water content, and hard stools. This study aims to evaluate the preventive effects of fermented gold kiwis (FGK) on loperamide-induced constipation in rats and investigate its efficacy in improving constipation symptoms in human patients through a randomized clinical trial. In the animal study, FGK was administered orally at doses of 50, 125, and 250 mg/kg to constipated rats for two weeks, resulting in significant improvements in constipation parameters. FGK increased serum serotonin and acetylcholine levels and suppressed increases in serum dopamine concentration. FGK also upregulated mRNA expression of the serotonin-synthesizing receptors 5-HT3R and 5-HT4R and suppressed the expression of the dopamine 2-receptor (D2R) in the duodenum. Furthermore, FGK inhibited inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. In the clinical trials, the improvement in constipation symptoms was evaluated using the gastrointestinal symptom rating scale (GSRS). Clinical trial participants reported significant improvements in constipation symptoms after receiving FGK. These findings suggest that FGK effectively relieves constipation in both animals and humans, indicating its potential as an effective dietary supplement.

Synergistic Suppression of Bipolar Effect and Lattice Thermal Conductivity Leading to High Average Figure of Merit in Bi0.4Sb1.6Te3 Materials through Alloying with AgSbTe2.

Bismuth telluride-based materials have been widely used in commercial thermoelectric applications due to their excellent thermoelectric performance in the near-room-temperature range, yet further improvement of their thermoelectric properties is still necessary. Moreover, the narrow band gap of these materials results in a bipolar effect at elevated temperatures, which causes severe degradation of the thermoelectric performance. In this work, the commercial Bi0.4Sb1.6Te3 was alloyed with AgSbTe2 by using high-energy ball milling method combined with spark plasma sintering. It was found that ball milling can effectively reduce the lattice thermal conductivity of the samples. The alloying of AgSbTe2 leads to a gradual increase in hole carrier concentration, resulting in an enhanced electrical conductivity and optimized power factor. Additionally, the bipolar effect is also weakened due to the increased hole carrier concentration. Furthermore, the substitution of Ag in the Bi/Sb sublattice causes further reduction in the lattice thermal conductivity. Ultimately, the sample alloyed with 0.15 wt % AgSbTe2 demonstrates its best thermoelectric performance with a maximum zT of 1.35 at 393 K, showing a 20.5% improvement compared to the commercial sample. Besides, its average zT reaches a high value of 1.25 between 303 and 483 K, with a 27.6% improvement compared to that of the commercial sample.

Gambaran Kadar Hematokrit pada Penderita Demam Berdarah Dengue di RSUD Al – Ihsan

Early signs of dengue virus infection are often nonspecific, which can result in delays in assessment. This disease can develop quickly, even in a matter of days or hours, and can result in serious conditions. The primary pathophysiology of dengue hemorrhagic fever (DHF) involves increased vascular permeability and impaired hemostasis. Increased blood vessel permeability can result in plasma leakage, hypovolemia, and even severe stress. Disturbances in hemostasis can result in thrombocytopenia and bleeding manifestations. In dengue fever sufferers, thrombocytopenia occurs due to antibodies attacking platelets, which make antigen-antibody complexes. Hematocrit levels can increase due to an increase in the number of blood cells or a decrease in the amount of plasma, which often occurs in cases of dengue fever. conversely, hematocrit levels can decrease due to an increase in plasma concentration, similar to the case of a decrease in the number of blood cells or anemia. Blood tests are very crucial in monitoring the patient's condition and determining the prognosis. Based on WHO testing guidelines, thrombocytopenia and plasma extravasation, which are reflected in blood concentrations, are crucial indicators in the assessment of dengue fever. The research method used in this research is narrative, carried out from March to May 2024 at Al-Ihsan Regional Hospital. The study population included 30 patients, and the sample was representative of the entire population. Research findings show that 24 out of 30 patients (80%) experienced an increase in hematocrit levels. Key terms: Dengue Hemorrhagic Fever, Hematocrit.

Triple-Layered Noncombustible PEO-Based Solid Electrolyte for Highly Safe Lithium-Metal Batteries.

Lithium-metal batteries are currently recognized as promising next-generation technologies owing to their high energy density. Solid polymer electrolytes, particularly those based on polyethylene oxide (PEO), are lauded for their leakage resistance, safety, and flexible design. Despite the ongoing fire safety- and ionic conductivity-related concerns, a novel noncombustible solid polymer electrolytes with superior ionic conductivities are introduced here with additive decabromodiphenyl ethane and zeolite. To enhance the mechanical strength and ensure soft interactions at the electrode interface, a triple-layer structure with self-extinguishing properties and robust ionic conductivity is proposed. Notably, the softness at the electrode interface intensifies as the LiTFSI concentration increases; this higher concentration negatively impacts PEO crystallinity, enhancing the ionic conductivity owing to the presence of free Li+ and TFSI- ions. This novel electrolyte can achieve a conductivity of 1.5 mS cm-1 at 60°C, maintain anodic stability up to 4.8V, and exhibit flame retardancy. Furthermore, adding LiTFSI at 60% relative to PEO is shown to reduce LiF formation on the surface, enhancing anode stability. The [LiFePO4/triple-layered electrolyte/Li] lithium-metal batteries are capable of an initial capacity of 153 mAh g-1, sustained superior capacity retention of 87.9%, and high Coulombic efficiency (99.6%) over 1000 cycles at a 1C rate.

Gel Cleaning in Heritage: Comparison of the Water Release among Gels and Traditional Pads

Water release is a crucial aspect when considering cleaning effects on water-sensitive materials. In conservation practice, a water-based cleaning method which limits water release is very often needed. Unfortunately, this is not accompanied by an appropriate measure of the effectively released water. In this paper, water release has been measured by comparing traditional cleaning formulations, such as paper pulp and sepiolite, with several gar gel formulations, used by both Italian and European conservators. The assessment has been carried out by the gravimetric method, using three different stone material specimens as reference: Noto calcarenite, Manciano sandstone and Black Bergamo limestone, whose porosity values and distributions are known. Moreover, water distribution has been evaluated by portable NMR tests. Different commercial agar gel products (Bresciani, CTS, Sigma), having different concentrations (3, 4, and 5%), application modes (rigid at room T or fluid warm gels, with and without inserting Japanese tissue paper), and geometry (horizontal in gravity force direction or vertical), have been compared to obtain a full scenario among different water release mechanisms present in real conservation works. The paper faces the important issue of preparing reproducible chemical or water pads as well, useful for further research aimed at comparing cleaning effects in heritage conservation. The most interesting quantitative results can be summarized as follows. The water release measured from paper pulp and sepiolite was found to be 2 to 4 times higher than from any tested agar gel. Water release decreases by increasing agar concentration; an increase in the agar concentration by 1% induces a decrease in water release in the range 16.98–66.88 g depending on the stone; the increase from 4% to 5% is more obvious with respect to that from 3% to 4%. It is possible to assess the effect of the presence of Japanese paper, which is able to reduce the water release from 18 to 76%, depending on the stone and on the agar used. The gravimetric results were also used in the preliminary calibration tests of a contact probe named System Unit Salinity Index (SUSI), recently patented and useful in providing humidity and salinity indexes in a given porous material.

Intravenous iron sucrose when administered to moderately anemic pregnant women raises the hemoglobin concentration and replenishes body iron at 6 months

ABSTRACT Introduction: Intravenous iron sucrose (IVIS) is a rapidly acting, safe, and effective treatment for moderate anemia among pregnant women. The effectiveness of IVIS at 6 months post IVIS infusion was unknown. We, therefore, assessed the mean increase in hemoglobin concentration and body iron replenishment status at 6 months after the last dose of IVIS infusion. Methods: The study was conducted in 28 villages served by two primary health centers in district Faridabad, Haryana. The participants (n = 129), when originally recruited in 2020, were all moderately anemic (hemoglobin level 7.0 to 9.9 g/dL) pregnant women in either the second or third trimester of pregnancy. Their iron deficiency was calculated by Ganzoni’s formula with additional allowance of 500 mg of depot iron. The calculated deficit was rounded off to the nearest 100 mg. The dose of IVIS was 300 mg of iron diluted in 300 ml of normal saline administered intravenously every third day till the full calculated dose was administered. In this study, we collected the follow-up blood specimen 6 months after the last dose of IVIS and measured the hemoglobin concentration, C-Reactive protein (CRP), and serum ferritin level. Hemoglobin concentration was measured using an automated hematology analyzer (Sysmex XS-1000i). Serum ferritin and CRP were measured by enhanced chemiluminescence immunoassay and the enzymatic heterogeneous, sandwich immunoassay method, respectively (VITROS ECiQ, Ortho Clinical Diagnostics, New Jersey, USA). Results: The mean [standard deviation (SD)] duration of time elapsed since the administration of the last dose of IVIS infusion was 6.4 (0.9) months. The mean (SD) hemoglobin level at the time of original recruitment (baseline) was 8.7 ± 0.8 g/dL. The mean (SD) increase in the hemoglobin concentration at 6 months follow-up was 3.2 [95% confidence interval (CI): 3.0–3.4)] g/dL. The median [interquartile range (IQR)] serum ferritin level (ng/mL) at follow-up was 28.1 (12.7, 61.5). A total of 10.2% of the participants had a raised (>10 mg/L) CRP level. Adjusting for CRP level and based on serum ferritin level, the proportion of participants who were iron-deficient was 35.3%. The proportion of participants who had any degree of anemia was 70.5%. Conclusion: Administration of IVIS infusion was effective in raising the mean hemoglobin concentration and in replenishing the body iron reserve at 6 months post infusion.

Transfer and biological effects of cadmium along a tomato – thrip – predatory bug food chain

The heavy metal, cadmium (Cd) is an increasingly serious issue in agricultural ecosystems, mediating bottom-up effects on plants, herbivores and natural enemies. We measured how Cd modifies interactions between tomato Solanum lycopersicum, western flower thrips Frankliniella occidentalis, and the predatory bug Orius sauteri by examining Cd effects on the growth of tomato, the fitness of western flower thrips, and the survival and behavior of predators. The photosynthetic parameters of Pn (net photosynthetic rate), Gs (stomatal conductance), Ci (intercellular CO2 concentration), and Tr (transpiration rate) of tomato plants significantly decreased with the increase of Cd concentration. The total survival number of western flower thrips fed on tomato plants treated with different concentrations of Cd was significantly lower than that of the control, and sex ratios (female/male) gradually increased with the increase of Cd concentration. The numbers of thrips predated by O. sauteri on tomato plants treated with high concentrations of Cd (2.0 or 4.0mg/L) were significantly reduced by the second day. Cadmium was accumulated and bioconcentrated in the roots, stems, leaves of tomato plants, and transferred to F. occidentalis, and O. sauteri. Cadmium translocated in significant quantities from roots to the stems and leaves of tomato plants, and from the tomato leaf to F. occidentalis. However, there was minimal (non-significant) transfer of Cd from F. occidentalis to O. sauteri. The presence of Cd significantly reduced the growth of tomato plants, the fitness of F. occidentalis, and the predation efficiency of O. sauteri. Collectively, Cd can mediate bottom-up effects on tomato, thrip, and predatory bug along food chain, potentially interrupting pest biological control in tomato in heavy metal-contaminated ecosystems.

Dynamic impact analysis of solution droplets in frost-free air-source heat pumps: Transition from droplets to liquid film

This study investigates the dynamic propagation of solution droplets in frost-free air source heat pump systems, focusing on calcium chloride and ethylene glycol solutions. The research examines three key stages: droplet impact on a surface, collision with stationary droplets, and impact on a stabilized liquid film. Key findings include that increased surface contact angle and solution concentration inhibit droplet spreading, while higher impact velocity enhances it. Droplet retraction is influenced by surface tension and adhesion, with calcium chloride droplets showing variable retraction and ethylene glycol droplets consistently retracting less as concentration increases. Collisions with stationary droplets lead to behaviors such as merging, spreading, and rebound, with higher velocity accelerating these processes. In the final impact stage, a stable liquid film formation results in crown sputtering and oscillation, where sputtering height is inversely related to concentration but increases with impact velocity. These insights contribute to optimizing droplet management in air treatment systems.

Experimental study on the unsteady evolution mechanism of centrifugal pump impeller wake under solid–liquid two-phase conditions: Impact of particle concentration

To study the spatiotemporal evolution process of particle wakes behind the impeller in the centrifugal pump, this paper utilized high-speed photography to capture the particle motion characteristics under different solid-phase particle concentrations (1%, 1.5%, and 2%). First, this paper studies the changes in hydraulic performance of the centrifugal pump under solid–liquid two-phase flow conditions. It then introduces the evolution process of the impeller particle wake, comparing the differences in particle wake evolution under varying solid-phase concentrations. Finally, the impact of the solid-phase concentration on the wear of the volute's partitions is investigated. This study found that as the solid-phase particle concentration increases, the hydraulic performance of the pump gradually declines. Under the design conditions, when the solid-phase concentration increases by 0.5%, the efficiency of the centrifugal pump decreases by 0.56% and 0.35%. There is mutual transport of particles between adjacent wakes, and the movement of particle wakes within the volute passage is not equidistant over time. As the solid-phase particle concentration increases, wake cutting occurs at the volute partitions, and there is a significant solid–liquid separation between the particle wakes. The spatial evolution of the particle wakes is significantly influenced by the solid-phase concentration. Wear at the volute partitions intensifies with increasing solid-phase concentration and is also affected by changes in the particle wakes. The research results provide a basis for further exploration of the solid–liquid two-phase flow dynamics within centrifugal pumps.

Transient Photocurrent Responses of Sr1-xCexTiO3 Perovskites Under Visible Light Illumination for Photovoltaic Applications.

The objective of this study was to synthesize strontium titanate (Sr1-xCexTiO3) doped with Ce3+ by solid state method.Its crystalline structure is Sr1-xCexTiO3, and its bandgap ranges from ~3.3 to ~2.7 eV. In the photoluminescence of samples excited at 288 nm, the maximum emission of blue light was observed at 380 and 390 nm. Photocatalytic results show that dye molecules have a high absorbance, whereas their surface area is large. According to a line sweep voltammetric plot (LSV), illumination increases the current density by 0.4 μA cm-2 compared with dark conditions. It was demonstrated that the material changed from n-type to p-type under doping. Chronoamperometry spectra were obtained for sample Sr1-xCexTiO3 (x = 0, 0.005, 0.01, 0.03, 0.05) when an electrical voltage of 0.8 V was applied versus NHE. The plots indicate an increase in the current density under "light ON" conditions and a decrease under "light OFF" conditions. As Ce3+ concentration increases, the photocurrent increases until about 3 mol%, after which it decreases abruptly.

Optimization of Thermal and Rheological Performance in Non-Polar Binary Fluids Using Hybrid CuO Nanoparticles

Abstract Nanofluid is a novel type of technological fluid with numerous applications. Copper oxide (CuO) nanoparticles were dispersed in the binary fluids (Cyclohexane + Diethyl amine (DEA) and (1-4 dioxane + DEA) to create a nonpolar hybrid CuO nanofluid. The thermal conductivity (K) and viscosity (ῃ) of a nonpolar hybrid CuO nanofluid were determined at low concentrations (0.01M to 0.06M) and temperatures ranging from 298K to 318K. The transient hotwire approach is utilized for K measurements, while the viscometer is employed for viscosity measurements. As concentration increases, K drops, yet there is an increase owing to uniform variance in temperatures (T).ῃ changes with concentration and temperature. The results show that the hybrid CuO nanofluid has a phenomenal heat transfer improvement compared to the binary mixtures. The non-polar hybrid CuO nanofluid’s thermal conductivity increases by 15% to 20%, while its viscosity increases by 18% to 25%.

Early acute kidney injury after tacrolimus administration in heart transplant recipients receiving basiliximab induction therapy.

In this study, we aimed to analyze the association among the timing of tacrolimus initiation, time required to reach the target blood concentration, and early acute kidney injury (AKI) after tacrolimus administration in heart transplant recipients who received basiliximab induction therapy. 88 patients treated with tacrolimus-based immunosuppressive therapy were retrospectively reviewed. Induction therapy was administered to 52 patients. AKI was evaluated within 7 days of tacrolimus administration. The rate of increase in tacrolimus trough concentration to the target trough concentration of 10 µg/mL early after its administration was set to be similar in the basiliximab induction and non-induction group; 8 and 2 patients developed AKI in the induction and non-induction group, respectively. In the induction group, there was no significant difference in the timing of tacrolimus initiation and the time required to reach the target concentration between patients who developed and did not develop AKI. In contrast, the cumulative incidence of AKI was significantly different between patients with an estimated glomerular filtration rate below and those with an estimated glomerular filtration rate above 43 mL/min/1.73m2 at the start of tacrolimus administration (37.5% and 11.4%, respectively; p=0.045). In patients receiving basiliximab induction therapy, the timing of tacrolimus initiation and the time to reach the target concentration are unlikely to be associated with early AKI after tacrolimus administration. However, the recovery of sufficient renal function after heart transplantation is important for determining the start time of tacrolimus.