This paper explores the analytical solution to heat and mass transfer of a three-dimensional steady flow of Burgers fluid over a bidirectional stretching surface. Additionally, analysis is carried out in the presence of thermal radiation, heat generation/absorption and thermophoretic effects. The governing non-linear problem is developed and transformed into self-similar form by utilizing similarity approach. The resulting non-linear problem is solved analytically by employing the homotpy analysis method (HAM). The obtained results are plotted and discussed in detail for interesting physical parameters. It is seen that increasing values of the thermophoretic parameter leads to a decrease in the concentration field and the corresponding concentration boundary layer thickness. Also, it is noticed that the concentration field decays quickly corresponding with thermophoretic parameter in comparison to Schmidt number.