This study is the first to use the observation data of a fog monitor, a visibility meter, and an automatic weather station to carry out a comprehensive observation experiment from the perspective of microphysics on a severe sea fog process in Beilun District, China, from 14 to 15 June 2021. The results show the following: (1) Temperature is closely related to nucleation, condensation growth, and other processes. The decrease (increase) in temperature is the main reason for the enhancement (weakening) of nucleation and the growth of condensation (evaporation of droplets), which leads to an increase (or decrease) in microphysical quantities, such as droplet number concentration and liquid water content. (2) The average droplet number spectral distribution roughly conforms to the Gamma distribution, and the spectral distribution of the fog process presents a ”multi-peak” structure, with peak diameters of 6 μm, 12 μm, 16 μm, 24 μm, and 44 μm. Droplets with a diameter of less than 16 μm account for 75% of the droplet size distribution. (3) During this sea fog process, three microphysical parameters, namely, number concentration, liquid water content, and average diameter, are all positively correlated in pairs, but the positive correlation between the number concentration and the average diameter is weak. This shows that the condensation nucleation and the condensation growth of droplets are the main processes in this sea fog process and that the collision process occurs but is not the dominant process. The sea fog comprehensive observation experiment provides an important demonstration of the microphysics research of sea fog in the eastern coastal areas of China and provides more reference information for sea fog research and equipment comparisons between different regions. At the same time, it also provides an essential scientific basis for the short-term forecast of sea fog in the future and for the optimization of the microphysical parameters of related models.